Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Children and young people aged 2 years old up to (but not including) 18 years old
• People who have a confirmed diagnosis of a tumour that tests positive for a specific protein called the somatostatin receptor (SSTR)
• People whose tumour has come back or has stopped responding to at least one previous cancer treatment
• People whose tumour tissue sample has confirmed SSTR protein, shown through a laboratory test on a biopsy or surgical sample
• People whose tumour shows a certain level of radioactive uptake on a specific type of scan (SPECT/CT or PET/CT), measured as higher than the uptake seen in the liver (confirm with trial site)
• People who have recovered from the side effects of previous cancer treatments before joining the trial (most side effects must be mild or resolved, with some specific exceptions such as hair loss or stable, treated hormone or electrolyte issues)
• People who have completed a required waiting period after previous treatments before starting the trial treatment (confirm with trial site for timing details)
• A parent or legal guardian must be willing to sign a screening consent form, and the young person's own agreement (assent) will also be sought where appropriate

Who may not be able to join:

• People with a known allergy or sensitivity to Lutetium Lu 177 Edotreotide or its related components
• People with a previous history of acute leukaemia, unless it has been in remission for at least two years
• People with extensive cancer involvement in the bones or bone marrow, unless a sufficient supply of stem cells is available and stored
• People who have previously received a systemic targeted radiation therapy of the same type used in this trial
• People who have previously received a treatment called MIBG, if the total radiation dose to the bone marrow or kidneys would exceed certain safety limits
• People who have previously received external beam radiation therapy, if the total radiation dose to the bone marrow or kidneys would exceed certain safety limits
• People who have previously received an immune cancer vaccine or a treatment called CAR-T cell therapy
• People with a large volume of tumour spread within the brain or spinal cord area
• People with serious problems affecting the kidneys, liver, heart, blood, or electrolyte levels
• People who have received a live-attenuated vaccine (a type of vaccine made with a weakened live virus or bacteria) within four weeks before joining the trial
• People who are pregnant or breastfeeding
• People with another known cancer diagnosis
• People with a serious non-cancer illness

Important: Always verify eligibility with the trial site directly before applying.