Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have a confirmed diagnosis of stomach (gastric) adenocarcinoma, based on laboratory analysis of a tissue or cell sample
• People whose cancer has spread to the lining of the abdomen (peritoneal metastases), visible on a scan or during a keyhole surgical procedure
• People whose first round of standard chemotherapy treatment (such as FOLFOX, with or without immunotherapy, or a similar combination) has stopped working
• People who have received up to 4 cycles of a second round of treatment, as long as the cancer has not continued to grow during that time
• People aged 18 or older
• People who are generally well enough to carry out light activity or desk work (a measure doctors use called ECOG performance status 0 or 1)
• People who have largely recovered from side effects of previous cancer treatments (minor ongoing effects such as hair loss or mild hearing changes may be acceptable)
• People with urine protein levels within acceptable limits on testing (specific thresholds apply — confirm with trial site)
• People with blood counts, liver function, kidney function, and blood clotting results within the ranges required by the trial, confirmed by tests taken within 28 days before starting treatment
• People who test negative for HIV, or who are HIV-positive but are stable on treatment, have an adequate immune cell count, and have an undetectable level of virus in the blood
• People who have been tested for hepatitis B and C; those with active hepatitis B must have low virus levels and must be on, or willing to start, hepatitis B treatment before joining the trial
• People with hepatitis C must have an undetectable level of virus in the blood
• Women who could become pregnant must have a negative pregnancy test within 28 days before starting treatment
• People who agree to use effective contraception, or to abstain from heterosexual activity, throughout the trial and for at least 14 months after the last dose of trial treatment
• People who agree to provide stored tumour tissue from a previous biopsy (exceptions may be considered with approval from the trial's lead doctor)
• People who have given their informed consent to participate

Who may not be able to join:

• People who have previously had a severe reaction or intolerance to a class of chemotherapy drugs called taxanes
• People who have a bowel obstruction that means they can only receive nutrition through an intravenous drip
• People who have had, or currently have, cancer that has spread to the brain or the area around the brain
• People whose life expectancy is estimated to be less than 3 months
• People who have been treated with therapeutic antibiotics (by mouth or through a drip) within 14 days before starting the trial (people on preventative antibiotics with no signs of active infection may still be eligible — confirm with trial site)
• People who have had another cancer, unless it was an early-stage skin cancer, early cervical cancer that was fully treated, a stage I or II cancer currently in full remission, or any cancer from which the person has been cancer-free for at least two years
• People who have had a serious allergic reaction to drugs with a similar composition to the study medications (such as taxanes)
• People with significant uncontrolled medical conditions, such as uncontrolled high blood pressure
• People who have had a heart attack or stroke
• People who have had a perforation (a hole or tear) in their digestive tract
• Women who are pregnant or breastfeeding
• People who, in the trial doctor's judgement, have another condition that would make participation unsafe
• People who, in the trial doctor's judgement, may not be able to follow all the required trial procedures

Important: Always verify eligibility with the trial site directly before applying.