Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Young people with Type 2 diabetes (ages 12–25):

• People aged 12 to 25 who have been diagnosed with Type 2 diabetes based on blood sugar or A1c test results, along with at least one relevant risk factor such as family history of diabetes, obesity, certain ethnic backgrounds, or other related health conditions — or who have verified medical records showing a Type 2 diabetes diagnosis made at age 25 or younger

Young people who are overweight or have obesity (ages 12–25):

• People aged 12 to 17 whose BMI is at or above the 85th percentile for their age and sex (overweight or obese range)
• People aged 18 to 25 whose BMI is 25 or above
• People in this group who also have prediabetes (based on slightly elevated blood sugar or A1c levels) may still be eligible

Healthy lean young people (ages 12–25):

• People aged 12 to 17 whose BMI is at or below the 85th percentile for their age and sex
• People aged 18 to 25 whose BMI is between 18 and 24.99
• People whose A1c level is below 5.7%

Biological parents of enrolled participants:

• Biological parents of young people already enrolled in the trial (based on self-report)

Who may not be able to join:

For young people with Type 2 diabetes, those who are overweight, or healthy lean participants:

• People who have Type 1 diabetes, or who test positive for more than 2 diabetes-related antibodies
• People with medical, psychiatric, or thinking/cognitive conditions that researchers believe would make it difficult to follow the study procedures (note: certain obesity-related conditions such as high blood pressure, high cholesterol, sleep apnea, and a specific liver condition are allowed)
• People with serious illnesses thought to affect metabolism, including moderate to severe kidney disease, congenital heart disease, Cushing's syndrome, cancer, or other metabolic conditions linked to diabetes or excess weight
• People enrolled at the NIH location who have food allergies, intolerances, or eating patterns that would prevent them from eating the study-specific meals
• People who are unwilling to follow all study procedures and lifestyle guidelines for the full duration of the study
• People who are pregnant at the time of their screening visit
• People with significant anaemia or a low red blood cell level for their age and sex
• People in the overweight/obesity group who meet the diagnostic criteria for Type 2 diabetes (as described in the inclusion criteria above)

Additional restrictions for healthy lean participants only:

• People currently taking prescription or non-prescription medications (some exceptions may apply, such as topical medications, vitamins, and hormonal contraceptives — other exceptions may be considered by researchers)
• People who have used medications or supplements that affect blood sugar or fat metabolism within the past 2 months (for example, niacin, fish oil, or red yeast rice)
• People with a history of diabetes or abnormal blood sugar levels
• People with certain abnormal results on screening blood tests, including elevated liver enzymes, sugar in the urine, or reduced kidney function
• People who meet the diagnostic criteria for Type 2 diabetes

For biological parents:

• No exclusion criteria apply to this group

Important: Always verify eligibility with the trial site directly before applying.