Phase 1 Irritable Bowel Syndrome Trial, Recruiting NCT06737666 Sponsor: Xiyuan Hospital of China Academy of Chinese Medical Sciences Condition: Irritable Bowel Syndrome
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Phase 1 Irritable Bowel Syndrome Trial, Recruiting

NCT06737666
Recruiting Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D), as well as healthy volunteers who meet the study's diagnostic criteria
  • People aged between 18 and 70 years old
  • People who have not taken antibiotics, steroids or other hormones, herbal preparations (including tablets or injections), or probiotic products such as yogurt in the week before joining
  • People who are willing to sign a consent form, receive appropriate treatment (for patients), and provide blood, urine, stool, or other samples (for volunteers)

Who may not be able to join:

  • People with serious diseases affecting the heart, liver, kidneys, blood, nervous system, or mental health
  • People with other digestive system conditions such as peptic ulcers, tumours found on a recent colonoscopy, or other illnesses that affect how the digestive system moves (such as an overactive thyroid or diabetes)
  • People who need to keep taking medications that may affect gut function, such as anti-diarrhoea drugs, antidepressants, anti-anxiety medications, gut bacteria regulators, or antibiotics
  • People with a known history of drug allergies or severe food allergies related to the study treatments
  • People under 18 or over 75 years of age, or women who are pregnant or breastfeeding
  • People who have experienced a major distressing life event during the treatment period
  • People who are currently undergoing any form of psychotherapy
  • People who are unwilling to cooperate with the study requirements

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: +86 (010)-62835610

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

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Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Registry
ClinicalTrials.gov
Start date
29 May 2023
Est. completion
8 October 2025

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Fecal metagenomic detection of bacteria associated with Trp metabolism; Serum detection by Elisa; Serum Trp metabolism was measured by metabolomics; Th17/Treg ratio in peripheral blood was measured by flow cytometry; Colon tissue was detected by immunofluorescence and histochemistry analysis

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov