Early Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• A tumor tissue sample must be available for testing.
• The patient must be 6 years old or younger at the time their brain or spinal tumor was confirmed by a tissue test (biopsy or surgery).
• The patient must have one of the following specific types of brain or spinal tumors: atypical teratoid rhabdoid tumor (ATRT), group 3 or group 4 medulloblastoma, pineoblastoma, CNS neuroblastoma, embryonal tumor with multi-layered rosettes (ETMR and related subtypes), medulloepithelioma, CNS embryonal tumor with rhabdoid features (INI-1 intact), or CNS embryonal tumor not otherwise specified — including cases where the cancer has spread or where only part of the tumor was removed.
• The patient must have had MRI scans of the brain and spine, both before and after surgery, using contrast dye.
• A spinal fluid sample (lumbar puncture) is strongly recommended but not required, and not having one will not disqualify the patient.
• The patient must be expected to live for more than 8 weeks from the time of diagnosis.
• The patient must be well enough to carry out at least half of normal daily activities, as measured by a standard childhood health score (Lansky score of 50 or above).
• The patient's kidneys must be working well enough (confirmed with a urine or scan test).
• The patient's heart must be functioning adequately (confirmed by an ultrasound or scan of the heart).
• The patient must be breathing comfortably at rest with an acceptable oxygen level (above 94% on room air).
• The patient's bone marrow must be producing enough blood cells (specific blood count levels required — confirm with trial site).
• The patient's liver must be working adequately (specific blood test levels required — confirm with trial site).

Who may not be able to join:

• Patients who are currently receiving any other cancer treatments or experimental treatments.
• Patients who have already received radiation therapy or chemotherapy for this tumor (steroid medications are the only exception).
• Patients who have another active cancer that is currently causing problems or requires treatment.
• Patients who are taking certain medications that affect how the body processes drugs, including some anti-seizure medicines (such as phenytoin, phenobarbital, or carbamazepine), certain antifungal medicines, rifampin, or St. John's Wort (confirm with trial site for the full list).
• Patients with serious uncontrolled health conditions such as uncontrolled diabetes, chronic kidney disease, active serious infections, liver disease, very high cholesterol, heart failure, irregular heartbeat, overactive parathyroid glands, or mental health conditions that would make it difficult to follow the study requirements.
• Patients who are known to have HIV, hepatitis B, or hepatitis C.
• Patients whose tumor type does not qualify — this includes certain other types of brain tumors such as SHH or WNT medulloblastoma, ependymoma, choroid plexus carcinoma, high-grade gliomas, diffuse midline gliomas, brain germ cell tumors, brain sarcomas, brain lymphomas, and certain leukemia-related growths.
• Patients (or their parents/guardians) who, in the doctor's opinion, would not be able to follow the study schedule and requirements.

Important: Always verify eligibility with the trial site directly before applying.