Printed from Voxsanity (voxsanity.com.au) — NCT07013331 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Epilepsy Trial, Recruiting
NCT07013331
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
Group 1 – People with Dravet Syndrome
- Adults aged 18 to 59 years old with a diagnosis of Dravet syndrome, confirmed through medical history, seizure type, brain wave testing (EEG), and genetic testing
- There is no requirement related to how often seizures occur
- The person, or their legal guardian, has agreed in writing to take part in the study
- Women who are able to become pregnant must meet additional conditions (confirm with trial site)
Group 2 – People with drug-resistant focal epilepsy
- Adults aged 18 or over who have focal epilepsy that has not responded to medication, as defined by international medical guidelines
- People for whom doctors are considering surgery as a possible next step in their care
- There is no requirement related to how often seizures occur
- The person has agreed in writing to take part in the study
- Women who are able to become pregnant must use highly effective contraception during the study
Group 3 – Healthy volunteers
- Adults who do not have significant symptoms of anxiety or depression (based on a specific questionnaire score) (confirm with trial site)
- Adults who are not currently taking a type of antidepressant called an SSRI (selective serotonin reuptake inhibitor)
- Adults who are able to have an MRI scan without any concerns (no metal implants, no claustrophobia)
- Adults who are affiliated with a social security or equivalent scheme
Who may not be able to join:
For people with Dravet Syndrome:
- People currently in an exclusion period from another research study
- People who cannot have an MRI scan due to metal implants in the body, claustrophobia, or an inability to stay still enough during the scan
- People who have a vagal nerve stimulator (a device implanted to help control seizures)
- Women who are pregnant, in labour, or breastfeeding
- People with severely reduced kidney function (confirm with trial site)
- People with a known allergy or sensitivity to the imaging substance used in the study, called [18F] MPPF
- People whose freedom has been restricted by a legal or administrative order
- People currently receiving psychiatric care
- People who are not covered by a social security or equivalent scheme
For people with drug-resistant focal epilepsy:
- People currently in an exclusion period from another research study
- People who cannot have an MRI scan due to metal implants in the body or claustrophobia
- People who have a vagal nerve stimulator (a device implanted to help control seizures)
- People currently taking medications that affect serotonin levels, including SSRIs (a type of antidepressant)
- Women who are pregnant, in labour, or breastfeeding
- People with severely reduced kidney function (confirm with trial site)
- People with a known allergy or sensitivity to the imaging substance used in the study, called [18F] MPPF
- People whose freedom has been restricted by a legal or administrative order
- People currently receiving psychiatric care
- People staying in a health or social care institution for reasons other than this research
- Adults who are under a legal protection measure such as guardianship or curatorship
- People who are not covered by a social security or equivalent scheme
For healthy volunteers:
- People who have significant symptoms of anxiety or depression based on a specific questionnaire score (confirm with trial site)
- People currently taking SSRIs (a type of antidepressant)
- People who cannot have an MRI scan due to metal implants in the body or claustrophobia
- Women who are pregnant, in labour, or breastfeeding
- People with severely reduced kidney function (confirm with trial site)
- People with a known allergy or sensitivity to the imaging substance used in the study, called [18F] MPPF
- People whose freedom has been restricted by a legal or administrative order
- People currently receiving psychiatric care
- People staying in a health or social care institution for reasons other than this research
- Adults who are under a legal protection measure such as guardianship or curatorship
- People who are not covered by a social security or equivalent scheme
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
Contact this trial
Phone: 0472357106
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Recruiting
Phase
Not Applicable
Sponsor
Registry
ClinicalTrials.gov
Start date
4 May 2026
Est. completion
4 January 2028
Where this trial is recruiting
🇫🇷 France
Primary endpoints
Comparison of the brainstem BPND of [18F]-MPPF across patients groups (DS and focal epilepsy)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.