Phase 2 Hepatitis B Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part voluntarily and able to follow the study schedule as required
• You are between 18 and 65 years old at the time of signing the consent form
• Your body weight is in a healthy range for your height (BMI between 18 and 30)
• A specific hepatitis B marker in your blood (called HBeAg) tested negative at your screening visit
• You have tested positive for hepatitis B (either HBsAg or HBV DNA) for at least 6 months
• You have been taking a single hepatitis B antiviral tablet consistently for more than 6 months before the study screening
• Your liver enzyme levels (ALT) are within an acceptable range (no more than twice the normal upper limit)
• You are using effective birth control as required by the study

Who may not be able to join:

• You are unable to be treated with Peg-IFN (a type of interferon) or a recombinant hepatitis B vaccine for medical reasons
• You have significant health conditions beyond your chronic hepatitis B infection
• You have another serious liver disease at the same time
• You had a serious infection (other than hepatitis B) in the past month that required intravenous antibiotics or antiviral treatment
• You have tested positive for hepatitis C, HIV, or syphilis
• You have significant liver scarring (fibrosis) or cirrhosis, or your liver stiffness measurement is above a certain level
• You have had or currently have signs of your liver failing to work properly (liver decompensation)
• You have been diagnosed with, or are suspected of having, liver cancer, or a specific protein level in your blood (AFP) is above a certain amount
• Your routine blood or lab test results show clearly abnormal values
• You have a history of, or current signs of, a condition involving inflammation of blood vessels (vasculitis)
• You have an abnormal heart rhythm reading on an ECG (specifically the QT interval)
• You have a history of disease outside the liver that may be linked to your immune response to hepatitis B
• You have had any cancer in the past 5 years, or are currently being checked for a possible cancer
• You have a serious mental health condition or a history of one
• You have had an allergic reaction to any component of the study drug, or you are known to have a tendency toward allergies (confirm with trial site)
• You had a major injury or major surgery in the past 3 months, or you are planning surgery during the study
• You are currently taking part in another clinical trial, or have not completed the required waiting period after a previous trial
• You have used immune-suppressing medications in the past 3 months (with some exceptions for short or topical use), immune-modifying or chemotherapy-type drugs in the past 6 months, or had a vaccination in the past 6 months or plan to receive a live vaccine during the trial
• You regularly take blood thinners or antiplatelet medications long-term
• You have a thyroid condition that affects how your thyroid works
• You have epilepsy that is not well controlled, or another progressive neurological condition
• You have previously received a type of drug known as an antisense oligonucleotide (ASO) or an siRNA drug (confirm with trial site)
• The study doctor decides for any other reason that the study may not be right for you

Important: Always verify eligibility with the trial site directly before applying.