Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have voluntarily agreed to take part and have signed a consent form
• People aged 18 to 70 years (inclusive), of any gender
• People who have been confirmed by tissue or cell testing to have stomach cancer or cancer at the junction of the stomach and oesophagus that cannot be surgically removed and has either spread locally or to other parts of the body
• People who have not previously received any systemic (whole-body) cancer treatment
• People whose cancer tissue tests show a specific protein level (HER2) rated as 1+ or 2+, based on prior test results or a central lab assessment
• People whose cancer was initially considered inoperable for only one specific reason
• People who have at least one measurable tumour, as defined by standard medical imaging criteria
• People with a life expectancy of at least 6 months
• People who are largely able to carry out daily activities with little to no restriction, as rated on a standard medical scale (ECOG score of 0 or 1)
• People whose blood, liver, kidney, and clotting function meet the minimum levels required by the trial, confirmed by blood tests taken within the two weeks before screening

Who may not be able to join:

• People with a history of another cancer, unless it was treated with the intent to cure and has shown no signs of returning for at least 5 years, or unless it was a specific skin cancer, early-stage bladder cancer, or certain other non-invasive cancers that have been adequately treated
• People with conditions that affect how the body absorbs or processes medicines, such as severe vomiting, ongoing diarrhoea, bowel obstruction, or malabsorption
• People who have previously had a stem cell transplant or solid organ transplant from another person
• People who received prior cancer treatment less than 4 weeks before the start of this trial, or whose side effects from prior treatment have not sufficiently resolved
• People with a history of immune system deficiency, whether present from birth or developed later in life
• People with active or previously diagnosed autoimmune or inflammatory conditions (such as lupus, inflammatory bowel disease, certain thyroid conditions, or others) — though some exceptions, such as vitiligo or fully resolved childhood asthma, may be considered by the trial doctor
• People who have used systemic immune-suppressing medications within 2 weeks before joining, or who may need them during the trial — though certain limited uses, such as low-dose steroids or topical treatments, may be exceptions (confirm with trial site)
• People with a known or suspected allergy or sensitivity to the trial drugs or any of their ingredients
• People who have had a blood clot-related event in the past 6 months, such as a stroke, mini-stroke, deep vein thrombosis, or pulmonary embolism
• People considered by their doctor to be at significant risk of bleeding, including those who have had major bleeding or coughed up blood recently, have active bleeding or clotting disorders, or are currently taking blood-thinning or clot-dissolving medications

Important: Always verify eligibility with the trial site directly before applying.