Wilson Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with Wilson Disease, confirmed by a scoring system called the Leipzig score (score of 4 or higher)
- You are willing and able to sign a consent form agreeing to take part in the study
- You are willing to follow all study requirements, including collecting urine samples over 24-hour periods and attending follow-up visits for the full length of the study
- You have been receiving treatment for Wilson Disease for at least 12 months before joining the study
- Your liver enzyme levels (ASAT and ALAT) are not more than twice the normal upper limit
- Your blood clotting level (INR) is below 1.5, or has been stable for at least 6 months if it was previously elevated, and you are not on blood-thinning medication
- Your kidneys are working at a sufficient level (eGFR above 30 cc/min)
- Your Wilson Disease treatment has not changed in the 6 months before joining the study
Who may not be able to join:
- You are currently taking two Wilson Disease treatments at the same time (for example, zinc combined with d-penicillamine or trientine)
- You are currently pregnant or breastfeeding
- You have used estrogen-based treatment (such as certain contraceptives or hormone therapies) within the last month
- You have liver cirrhosis and have had a serious liver-related complication in the last 6 months, such as fluid build-up in the abdomen, a serious infection, bleeding from the food pipe, or episodes of confusion related to liver problems
- The trial team believes you may not be able to complete the required urine collections or attend follow-up visits as needed
- You have previously not followed your treatment plan or low-copper diet in a way that could affect the reliability of the study results
- You are of childbearing age and test positive on a urine pregnancy test taken before the start of the study (confirm with trial site for full details on testing requirements)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Michael L Schilsky, MD FAASLD, Yale University
Phone: 203 737 2702
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Mean concentration of OT-UCE for each standard of care WD treatment; Mean NCC concentration for each WD treatment
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.