Phase 3 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with a specific type of stomach or stomach-oesophagus junction cancer (called adenocarcinoma, in specific locations known as Siewert type II or III), confirmed by a tissue or fluid sample from the tumour
• People whose cancer has spread to the lining of the abdomen (peritoneum), confirmed by a tissue or fluid sample
• People who have had a keyhole surgical assessment of their abdominal cancer spread performed within the four weeks before joining the trial
• People whose cancer cells were found in abdominal fluid during that assessment, but without visible spread to the abdominal lining, may also be eligible if those cancer cells are still present after at least four cycles of standard chemotherapy
• People whose blood counts and organ function (such as kidney and liver) are at an adequate level
• People with a general health and activity level rated as 0 or 1 on a standard medical scale, meaning they are either fully active or have only minor limitations in physical activity
• People aged 18 or older
• People with a life expectancy of at least three months
• People who agree to use adequate contraception during the trial, where this applies

Who may not be able to join:

• People whose other health conditions make treatment with the trial's specific medicines unsafe
• People with confirmed or suspected severe scarring inside the abdomen (adhesions)
• People with a serious blood-clotting disorder that would make surgery unsafe
• People whose cancer has spread to distant parts of the body other than the abdominal lining — except for spread to the ovaries, which is specifically allowed
• People who already have fluid build-up in the abdomen (ascites) that needs draining for symptom relief, or who are expected to need that soon
• People whose stomach cancer has returned in the abdominal lining within six months of surgery that was intended to cure the cancer
• People who have already received more than two cycles of chemotherapy aimed at managing (rather than curing) the current cancer — with a specific exception for those whose cancer cells were found only in abdominal fluid without visible spread
• People who have another cancer that could affect their survival within the next three years
• People with known or suspected allergies to any of the medicines used in the trial
• People with a genetic condition called DPYD deficiency, which affects how certain chemotherapy medicines are processed by the body
• People who are pregnant, have given birth within the last 28 days, or are currently breastfeeding
• People who are sexually active without using a reliable method of contraception
• People who are currently taking part in, or have taken part in, another clinical trial involving an investigational medicine within the last 30 days
• People whom the trial doctor considers unsuitable for participation for any other reason (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.