Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (or 19 or older, depending on local rules) at the time of screening
• You are willing and able to sign a consent form before any study-related procedures begin
• Your doctor believes you are likely to live for more than 12 weeks
• Your blood counts and organ function meet required levels — including healthy enough levels of white blood cells, platelets, red blood cells, liver function, and kidney function (confirm specific values with trial site)
• Your heart is pumping blood at a normal or near-normal level (confirm with trial site)
• You have at least one measurable tumor that can be tracked on scans
• For Part A of the trial: You have an advanced solid tumor cancer and there are no good standard treatment options available or suitable for you, in your doctor's opinion
• For Part B of the trial: You have an advanced solid tumor cancer and your doctor considers you a suitable candidate for treatment with a chemotherapy drug called docetaxel — this may include certain types of breast cancer, head and neck cancer, lung cancer, prostate cancer, or stomach/esophageal cancer
• For Part B only: You have not previously been treated with docetaxel for advanced-stage disease

Who may not be able to join:

• You have received cancer treatment (such as chemotherapy, immunotherapy, or targeted therapy) within approximately the last 28 days or longer, depending on the specific drug
• You still have significant side effects from a previous cancer treatment that have not largely resolved (with some exceptions, such as stable nerve pain or stable hormone-related conditions — confirm with trial site)
• You have previously been treated with a specific type of drug called an EP2 or EP4 antagonist (confirm with trial site)
• You have had major surgery or extensive radiation therapy within the last 28 days, or limited palliative radiation within the last 7 days
• You have active cancer that has spread to your brain and is causing symptoms (those with previously treated, stable, symptom-free brain metastases may still be eligible — confirm with trial site)
• You are currently taking high-dose steroid medications (such as prednisone above a certain level) or immune-suppressing drugs within 7 days before starting the study (some exceptions apply — confirm with trial site)
• You are currently taking certain anti-inflammatory medications such as NSAIDs, COX-2 inhibitors, or synthetic prostaglandins close to the start of the trial (low-dose aspirin may be permitted — confirm with trial site)
• You are pregnant, breastfeeding, or planning to become pregnant during the study
• You have another active cancer, or had a different cancer within the past 2 years (some early-stage or fully treated cancers may still be eligible — confirm with trial site)
• You have a history of bleeding disorders, including bleeding in the stomach or digestive tract (those whose bleeding from their primary tumor is currently controlled may still be eligible — confirm with trial site)
• You have a certain type of irregular heart rhythm or a heart condition that affects a specific electrical measurement of your heart called the QTc interval (confirm with trial site)
• For Part B only: Your liver function tests are above certain levels at the same time (confirm specific values with trial site)

Important: Always verify eligibility with the trial site directly before applying.