Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with an advanced solid tumour (confirmed by laboratory testing of tumour tissue) that has a high level of a protein called Ly6E.
• People whose tumour cannot be surgically removed and has either spread to other parts of the body or is locally advanced, and has stopped responding to standard treatments, or for whom no suitable standard treatment exists.
• People with one of these specific cancer types who have already received prior treatments where those treatments are available locally: non-small cell lung cancer, triple-negative breast cancer, squamous cell carcinoma of the head and neck, pancreatic ductal adenocarcinoma, gastric (stomach) cancer, or epithelial ovarian cancer.
• People who are generally well enough to carry out basic daily activities, as measured by a standard medical scale called the ECOG Performance Status score of 0 or 1 (meaning fully active or restricted in physically strenuous activity but able to carry out light work).
• People whose blood counts, liver function, and kidney function are within levels considered safe for participation.
• Other criteria set out in the trial protocol may also apply.

Who may not be able to join:

• People who have had another type of cancer diagnosed within the past 3 years (some exceptions may apply, such as certain skin cancers, early-stage cervical changes, benign prostate conditions, or cancers considered cured with very low chance of return — the trial team would assess these on a case-by-case basis).
• People who have previously had a bone marrow or stem cell transplant from a donor.
• People who have cancer that has spread to the brain, unless all brain tumours have been treated locally and have been stable for at least 4 weeks, and the person has no ongoing neurological symptoms related to the brain disease.
• People who have had diarrhoea (loose or liquid stools) or a bowel blockage of a certain severity within the week before treatment starts.
• People who have an active chronic inflammatory bowel condition (such as Crohn's disease or ulcerative colitis) or a bowel obstruction.
• People who have had a serious gastrointestinal bleed within 3 months before treatment starts.
• Other exclusion criteria set out in the trial protocol may also apply.

Important: Always verify eligibility with the trial site directly before applying.