Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years
• People who have had surgery to fully remove their stomach cancer, including removal of surrounding lymph nodes (called D2 or wider dissection), with no cancer left behind after surgery
• People who did not receive any cancer treatment (such as chemotherapy) before their surgery
• People whose cancer has been confirmed by laboratory testing to be a type called gastric adenocarcinoma (a specific type of stomach cancer)
• People whose cancer is classified as stage III gastric or gastroesophageal junction adenocarcinoma (where the stomach meets the oesophagus), according to a standard cancer staging system (AJCC 8th edition)
• People whose cancer shows a moderate-to-high level of a protein called HER2 (confirmed by a specific lab test result of IHC 3+ or 2+)
• People who are largely able to carry out daily activities, with only minor limitations (rated 0 or 1 on a standard activity scale called ECOG PS)
• People whose life expectancy is estimated to be at least 3 months
• People who are able to understand the study, are willing to take part voluntarily, and can sign a consent form
• People who are willing and able to follow the treatment plan required by the study
• People who have complete medical imaging and pathology records available
• People whose liver, kidneys, and blood counts are functioning well enough to safely participate (confirm with trial site)

Who may not be able to join:

• People whose stage III stomach or gastroesophageal junction cancer has not been confirmed by laboratory tissue or cell testing
• People who are unable to receive the specific treatments used in this trial (a drug called disitamab vedotin or a chemotherapy regimen called SOX)
• People who are unable to attend the required follow-up appointments
• People who are unwilling or unable to follow the treatment plan set out in the study
• People who are unable or unwilling to have required scans during the study (such as CT scans)
• People who have an active autoimmune disease (where the immune system attacks the body's own tissues)
• People with a history of substance abuse that cannot be stopped, or who have a severe or poorly controlled mental health condition, or a severe or poorly controlled serious illness affecting the whole body
• People who have another medical condition that the study doctor believes could put them at significant risk or prevent the study from being completed safely
• People who have had another type of cancer in the past 5 years, unless it was a type considered fully cured by treatment — such as thyroid cancer, a very early-stage cervical condition, certain skin cancers, or early breast duct cancer treated with surgery (confirm with trial site)
• Women who are currently breastfeeding
• People who received cancer treatment before surgery (neoadjuvant therapy) or chemotherapy delivered directly into the abdomen during surgery

Important: Always verify eligibility with the trial site directly before applying.