Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been diagnosed with stomach cancer or cancer at the junction of the stomach and esophagus, confirmed by a tissue sample (biopsy)
• Your cancer has been classified as a specific stage (stage IIIA, IIIB, or IIIC) based on pathology results
• Your tumor has a specific genetic feature called dMMR or MSI-H, found through laboratory testing of your tissue sample
• You have already had surgery to remove the cancer, including an extensive removal of surrounding lymph nodes (called D2 or more), and the surgeon was able to remove all visible cancer (called R0 resection)
• You are able to swallow tablets normally
• You are generally well enough to carry out daily activities with little or no limitation (confirm with trial site what this means for you)
• Your doctors expect you to live for more than 6 months
• Your blood counts, liver, kidneys, thyroid, heart enzymes, and clotting are all working at an acceptable level based on recent blood tests
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 3 days before starting the study drug
• You are willing and able to use highly effective contraception during treatment and for 120 days after your last dose of the study drug (or 180 days after your last chemotherapy dose)
• You have signed a form agreeing to take part in the study

Who may not be able to join:

• Your cancer is located in a specific area very close to the junction of the stomach and esophagus (within 2 cm, on the stomach side) (confirm with trial site)
• You have been diagnosed with another type of cancer in the past 5 years, with some exceptions such as certain treated skin cancers or pre-cancerous conditions that were fully removed
• You are currently taking part in another clinical trial or have received an experimental drug or device within the past 4 weeks
• You have previously been treated with certain immune-based cancer therapies, including drugs that target PD-1, PD-L1, CTLA-4, or similar pathways
• You have taken certain traditional Chinese medicines with anti-cancer or immune-boosting effects within the past 2 weeks
• You have an active autoimmune disease (where your immune system attacks your own body) that has required ongoing medical treatment within the past 2 years
• You are currently taking steroid tablets or injections, or other medicines that suppress your immune system (not including nasal sprays, inhalers, or creams)
• You have had an organ transplant from another person (except a cornea transplant), or a bone marrow/stem cell transplant from another person
• You have a known allergy to any of the medicines used in this trial
• You still have significant side effects from a previous treatment that have not fully resolved
• You have a known HIV infection
• You have active hepatitis B that is not being treated, or your hepatitis B virus levels are above a certain threshold (some people with hepatitis B may still be eligible — confirm with trial site)
• You have active hepatitis C infection confirmed by blood tests
• You have received a live vaccine within 30 days before starting the study drug
• You are currently pregnant or breastfeeding
• You have serious or uncontrolled heart problems, such as certain abnormal heart rhythms, unstable chest pain, heart failure, or a heart attack or stroke within the past 6 months
• You have uncontrolled high blood pressure (above 140/90 mmHg)
• You have had lung inflammation (not caused by infection) that needed steroid treatment within the past year, or you currently have active lung disease
• You have active tuberculosis or an active infection requiring treatment
• You have serious bowel or abdominal problems such as bowel blockage or an abscess in the abdomen
• You have significant liver disease such as cirrhosis or active hepatitis
• You have poorly controlled diabetes (high fasting blood sugar levels)
• You have significant protein in your urine confirmed by testing
• You have a mental health condition that would make it difficult to follow the treatment plan
• Your doctor feels there are other reasons that make it unsafe or unsuitable for you to take part

Important: Always verify eligibility with the trial site directly before applying.