Phase 1 Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are male or female, aged 18 to 75 years old at the time of signing the consent form
• People who were diagnosed with type 2 diabetes at least 180 days (about 6 months) before the screening visit
• People who have been taking a stable daily dose of metformin for at least 90 days before screening, at the dose the doctor considers effective or the highest dose the person can tolerate
• People who may also be taking a second diabetes tablet called an SGLT2 inhibitor (a specific type of blood sugar-lowering medication), as long as that dose has also been stable for at least 90 days before screening — no other diabetes medications are permitted
• People whose blood sugar control (measured by an HbA1c blood test) falls within a specific range: between 6.5% and 9.5% if taking metformin only, or between 6.0% and 9.0% if taking metformin together with an SGLT2 inhibitor

Who may not be able to join:

• Women who are pregnant, breastfeeding, planning to become pregnant, or who are able to become pregnant and are not using a highly effective form of contraception
• People who have type 1 diabetes
• People who have had a significant change in body weight (5% or more, based on self-reporting) or who have been on a structured weight loss program within the 90 days before screening
• People who have been taking any medication for type 2 diabetes or weight management — other than those listed above — within 90 days before screening (short-term insulin use of up to 14 days in a row, or past insulin use during pregnancy-related diabetes, may be acceptable — confirm with trial site)
• People who have previously been treated with a GLP-1 receptor agonist (a type of injectable or oral diabetes medication)
• People who have diabetic eye disease (retinopathy or maculopathy) that has required, or is expected to require, certain eye treatments such as laser therapy, eye surgery, or anti-VEGF injections — an eye examination is required to confirm this before joining the trial
• People who have a current or recent history (within the past 180 days) of heart disease, including heart attack, stroke, mini-stroke, chest pain conditions, irregular heartbeat, or significant heart rhythm problems
• People whose kidneys are not functioning well enough, based on a specific blood test result at screening (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.