Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with stomach cancer or cancer at the junction of the stomach and food pipe, confirmed by a tissue sample (biopsy), that is HER2-negative (a specific cancer type), and you have not had surgery to remove the cancer
• You are 18 years of age or older
• Your cancer has spread to the lining of the abdomen (peritoneum), requires a keyhole surgical procedure (laparoscopy) to confirm this, and you do not have a blockage in your stomach or intestines
• Your cancer tests positive for a protein called Claudin 18.2 at a certain level (confirmed by lab testing)
• You are generally able to carry out light activity and care for yourself (your doctor will assess this using a standard scale)
• Your doctors expect you to live for more than 3 months
• Your blood tests show your bone marrow, liver, and kidneys are working well enough to tolerate treatment

Who may not be able to join:

• Your cancer has spread to parts of the body other than the abdominal lining at the time of joining the trial
• You are pregnant or breastfeeding
• You have previously received treatment that specifically targets the Claudin 18.2 protein
• You have had another type of cancer in the past 5 years, unless it was a fully treated skin cancer or a very early-stage cervical condition
• You have uncontrolled epilepsy, a brain or nervous system condition, or a mental health condition that could affect your ability to consent to the trial or follow the treatment plan
• You have significant active heart problems, such as chest pain from heart disease, moderate-to-severe heart failure, serious irregular heartbeat needing medication, or a heart attack in the past 12 months
• You have a blockage or digestive condition in your upper stomach area that may stop you from properly absorbing one of the study medications
• You have nerve damage in your hands or feet (beyond a very mild level), though you may still be considered if you only have reduced reflexes (confirm with trial site)
• You have had an organ transplant and need medication to prevent rejection
• You have a severe infection or other serious uncontrolled health condition
• Your kidneys are not working well enough, based on specific blood and urine test results
• You have a known lack of a specific enzyme called DPD, which affects how your body processes certain chemotherapy drugs
• You have active hepatitis B or hepatitis C, based on specific blood test results
• You have a psychiatric (mental health) condition that would make it difficult for you to follow the treatment plan
• You are allergic to paclitaxel (a chemotherapy drug) or any other ingredient in the study medications
• You have any other health condition, past treatment, or test result that the trial doctor believes could affect the study results or your safe participation (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.