Irritable Bowel Syndrome Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 60 years old
• People who have been diagnosed with diarrhoea-predominant irritable bowel syndrome (IBS-D) according to a standard set of diagnostic guidelines called Rome IV criteria
• People who have had recurring abdominal pain at least once a week over the last three months, with symptoms that began at least six months before diagnosis
• People whose abdominal pain is linked to going to the toilet or to changes in how often they go or what their stools look like
• People whose stools are mostly loose or watery (more than 25% of the time), and rarely hard or lumpy (less than 25% of the time), based on a standard stool classification chart
• People with moderate to severe IBS symptoms, measured by a standard scoring tool (a score above 175 out of 500)
• People who eat non-vegetarian food and have kept their eating habits stable for at least one month before joining the trial
• People aged over 50 who can provide results from a normal colonoscopy carried out within the past three years

Who may not be able to join:

• People who did not complete their daily symptom diary at least 50% of the time during the screening period
• People with a history of a diagnosed gut disease such as inflammatory bowel disease
• People who have had surgery to remove part of their digestive tract or their gallbladder
• People diagnosed with a Helicobacter pylori infection within the past two years
• People with a history of gluten or lactose intolerance
• People with a history of cancer
• People with a history of neurological or psychiatric conditions
• People with serious ongoing health conditions such as uncontrolled diabetes, an overactive thyroid, or severe liver, kidney, or heart problems
• People who have used probiotics, prebiotics, antibiotics, gut-motility medications, anti-diarrhoea medications, certain antidepressants (tricyclic antidepressants), or immune-suppressing medications within four weeks before the screening period
• People who are pregnant, breastfeeding, or within 12 months of giving birth
• People with a severe fear of needles, an allergy to metal, an implanted cardiac pacemaker, or a known history of serious allergic reactions

Important: Always verify eligibility with the trial site directly before applying.