Early Phase 1 Stomach Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 75 years old (inclusive)
- You are able to make your own decisions and are willing to sign a consent form to take part voluntarily
- You are generally able to carry out light activity and care for yourself (a standard fitness scale called ECOG rates you as 0 or 1)
- Your doctors expect you to live for more than 6 months
- You have been diagnosed with an advanced solid tumour — such as stomach cancer, cancer at the junction of the stomach and food pipe, pancreatic cancer, or bile duct cancer — confirmed by a tissue or cell sample, and your cancer has not responded to first-line treatment or has gotten worse
- You have at least one tumour that can be measured using standard imaging methods
- Your tumour tests positive for a protein called Claudin18.2 on at least 20% of tumour cells at a certain level of intensity (confirm with trial site)
- Any side effects from previous treatments have mostly settled down before starting this trial
- Your bone marrow, liver, kidney, and blood clotting functions meet specific healthy ranges as tested by blood tests within one week before starting treatment (confirm exact values with trial site)
- If you or your partner could become pregnant, you must be willing to use reliable contraception during the study and for 6 months after the last dose
Who may not be able to join:
- You are very underweight (BMI below 18.5) and your doctors feel you would not cope with the treatment
- You have previously had an allergic reaction to the study drug (177Lu-DOTA-SNA040) or similar drugs
- You have received radioactive isotope-based treatments (such as those using lutetium-177 or similar) within the past 4 weeks
- You have received a type of cancer drug called an antibody-drug conjugate (ADC) within the past 4 weeks
- You have taken part in another experimental cancer treatment trial within the past 4 weeks
- You have cancer that has spread to your brain or the lining around your brain or spinal cord
- You have serious heart problems (such as severe heart failure), a known inherited condition affecting heart rhythm, an active serious infection, or another major health condition the doctors consider unsafe for participation
- You have significant stomach bleeding or an untreated stomach ulcer
- You have been diagnosed with another type of cancer that could affect your life expectancy or make it harder to assess your condition
- You are pregnant or breastfeeding
- The trial doctors have another reason they feel you would not be suitable to participate (confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 0512-67229125
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Dose-limiting toxicity(DLT) of the single dose; The safety and tolerance of 177Lu-DOTA-SNA040; The safety and tolerance of 177Lu-DOTA-SNA040; The safety and tolerance of 177Lu-DOTA-SNA040; The safety and tolerance of 177Lu-DOTA-SNA040; The safety and tolerance of 177Lu-DOTA-SNA040
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.