What changed for Chronic Fatigue Syndrome
A plain English summary of what recently moved in the public data Voxsanity tracks for Chronic Fatigue Syndrome. Updated from government registries. Not medical advice.
How to read these changes: every figure on this page is the difference between two snapshots of what Voxsanity had tracked on each date. Voxsanity only began taking daily snapshots in July 2026 and is still ingesting the public registries, so a rise here is mostly our own coverage expanding rather than new research appearing. Read it as our tracked coverage growing, not as a claim about real-world research changing this fast: it overstates how much actually changed.
Comparing the two most recent snapshots, 27 July 2026 and 28 July 2026.
- Trials recruiting worldwide 38 to 45 (+7)
Newly subsidised on the PBS
No PBS-reviewed medicines are tracked for Chronic Fatigue Syndrome yet, so new PBS listings cannot be reported for it. This is a gap in what Voxsanity has mapped, not a statement that no medicines are subsidised — check the PBS directly.
Past updates
Tracking began in July 2026. Month on month changes will appear here once a second month of data has been recorded. Until then, the comparison above shows the most recent movement.
Recent trend
Weekly, most recent weeks (fills out to a monthly trend as history grows).
Recent trial results
Trials tracked for Chronic Fatigue Syndrome that have reported results to a public registry.
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
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NCT05200858 · results posted 16 July 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT05200858) enrolled 30 people in total — 15 in an active treatment group and 15 in a placebo (dummy treatment) group. The trial ran in two back-to-back four-week periods: a blinded phase (where participants did not know which group they were in) and an unblinded phase (where they did know). The main thing the trial was measuring was how much pain interfered with daily functioning, using a standard questionnaire called the Brief Pain Inventory, scored from 0 (no interference) to 10 (complete interference). Secondary measures...
Read the full trial page · View reported results on ClinicalTrials.gov ↗
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NCT03674541 · results posted 4 October 2022
According to the results reported on ClinicalTrials.gov, this trial enrolled 45 people in total — 23 received the study drug pyridostigmine and 22 received a placebo (a dummy treatment with no active ingredient). All 45 participants completed the trial. The trial was investigating how pyridostigmine affected the body's ability to take up and use oxygen during exercise, measured using a specialised exercise test called an invasive cardiopulmonary exercise test (iCPET). This type of testing is relevant to ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome), a condition where patients oft...
Read the full trial page · View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03853148 · results posted 29 July 2022
According to the results reported on ClinicalTrials.gov, this trial enrolled 50 people across four groups. Three groups included older adults trying different combinations of exercise programs: one group did the Otago exercise programme alone (a balance and strength routine), a second group did Otago plus gentle yogic breathing, and a third group added behavioural activation (a structured approach to increasing positive daily activities) on top of both. A fourth group of 20 caregivers did gentle yoga and yogic breathing. The trial measured changes in pain intensity, pain-related behaviours, fa...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT01318356 · results posted 23 June 2021
According to the results reported on ClinicalTrials.gov, this trial enrolled 155 people across three groups: 51 received Cognitive Behavioural Therapy (CBT), 52 received an antibiotic called doxycycline, and 52 received a placebo (a dummy treatment with no active ingredient). The trial was measuring fatigue severity and its impact on daily life in people who were experiencing significant fatigue. By the end of the study, 43 people in the CBT group, 49 in the doxycycline group, and 50 in the placebo group had completed the trial. The reported data shows that fatigue was measured using a questi...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT02055898 · results posted 18 November 2020
According to the results reported on ClinicalTrials.gov, this was a small crossover trial — meaning participants tried both treatments at different times — involving 13 people in total (7 in one group, 6 in the other). The trial was looking at two main things: brain wave activity during sleep (specifically a type of slow electrical activity measured by a brain scan called an EEG) and daytime sleepiness (measured by how quickly participants fell asleep during a daytime test). One treatment was sodium oxybate, a medication, and the other was a placebo (a dummy treatment with no active ingredient...
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NCT02530515 · results posted 29 October 2019
According to the results reported on ClinicalTrials.gov, this trial (NCT02530515) enrolled 8 participants, all of whom were placed in Arm C. Arms A and B had no participants enrolled. The trial was looking at whether it was possible to give patients with chronic lymphocytic leukaemia (a type of blood cancer) an infusion of their own specially prepared immune cells called activated T-cells, and whether this could be done without causing serious side effects (called dose-limiting toxicities, or DLTs — meaning severe reactions judged to be caused by the T-cell treatment). The reported data shows...
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NCT00598585 · results posted 27 June 2017
According to the results reported on ClinicalTrials.gov, this trial looked at whether sildenafil (compared to a placebo, or dummy pill) had any effect on fatigue in a small group of participants. A total of 12 people took part — 6 in the sildenafil group and 6 in the placebo group. By the end of the study, 5 people in the sildenafil group and all 6 in the placebo group had completed the trial; one person in the sildenafil group did not finish. The main thing being measured was a change in something called the Fatigue Impact Scale — a questionnaire with 42 questions where people rate how much...
Read the full trial page · View reported results on ClinicalTrials.gov ↗
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NCT00810368 · results posted 18 August 2016
According to the results reported on ClinicalTrials.gov, this trial looked at whether a supplement called carnosine had any effect on people with Chronic Fatigue Syndrome (CFS). A total of 33 people were enrolled — 18 in the carnosine group and 15 in a placebo (dummy treatment) group. By the end of the 12-week study, 12 people in the carnosine group and 13 in the placebo group had completed it. The trial measured several things, including overall CFS symptom severity, fatigue levels, bodily pain, anxiety, diarrhoea symptoms, and a thinking/speed task. The reported data shows the following num...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT00498485 · results posted 21 April 2016
According to the results reported on ClinicalTrials.gov, this trial compared a medication called Xyrem against a placebo (a dummy treatment with no active ingredient) in a small group of participants. A total of 17 people took part — 7 in the placebo group and 10 in the Xyrem group. The trial was measuring two things: how participants felt their overall condition had changed during the study, and how they rated the quality of their sleep over the past week. The reported data shows that for the first measure — the "Global Assessment of Change" — participants were asked to rate whether they fel...
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NCT00252629 · results posted 11 December 2014
According to the results reported on ClinicalTrials.gov, this trial involved 29 participants in total across three groups. Nine people received therapeutic nasal CPAP (a device that delivers steady air pressure during sleep), nine received a sham (inactive) version of the same device, and eleven were healthy comparison participants. The trial was looking at two main things: whether a particular breathing pattern during sleep — called inspiratory flow limitation (IFL), where airflow becomes restricted during breathing in — was more common in veterans with Gulf War Syndrome (GWS) compared to vet...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT00506454 · results posted 15 August 2011
According to the results reported on ClinicalTrials.gov, this trial (NCT00506454) involved 22 people in total — 11 in the active treatment group and 11 in the placebo group. One person from each group did not complete the study, leaving 10 in each group who finished. The trial was measuring something called endotoxin levels — endotoxins are substances that can be released by bacteria and found in the bloodstream. Specifically, the trial looked at whether these levels went down after a session of haemodialysis (a kidney filtering treatment) in people receiving the active treatment compared to t...
These are the results as reported to the registry, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
What is coming
AI generated pipeline summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to NIH funding data, a substantial amount of public research money is currently being directed toward Chronic Fatigue Syndrome, and encouragingly, that investment has been rising year on year. This suggests that researchers and funding bodies are taking the condition increasingly seriously, which is a positive signal for patients who have long felt the condition was overlooked. Growing i...
See the full Chronic Fatigue Syndrome page
Not medical advice. Voxsanity republishes public government health data in plain English. These figures describe research and registry activity, not the suitability of any treatment for any person. Trial status can change; always verify current status directly with the trial site and confirm Australian availability with your doctor.