What changed for Depression and Anxiety
A plain English summary of what recently moved in the public data Voxsanity tracks for Depression and Anxiety. Updated from government registries. Not medical advice.
How to read these changes: every figure on this page is the difference between two snapshots of what Voxsanity had tracked on each date. Voxsanity only began taking daily snapshots in July 2026 and is still ingesting the public registries, so a rise here is mostly our own coverage expanding rather than new research appearing. Read it as our tracked coverage growing, not as a claim about real-world research changing this fast: it overstates how much actually changed.
Comparing the two most recent snapshots, 27 July 2026 and 28 July 2026.
- Trials recruiting worldwide 642 to 665 (+23)
- Late-stage (Phase 3) trials 24 to 26 (+2)
- Trials on record 5,314 to 5,504 (+190)
Newly subsidised on the PBS
No medicines were newly subsidised on the PBS for Depression and Anxiety in July 2026. Voxsanity tracks 14 PBS-subsidised medicines for this condition; none of them was listed for the first time this month.
Source: Pharmaceutical Benefits Scheme (PBS), © Commonwealth of Australia. Data used and redistributed under permission; not modified from its original wording where displayed verbatim.
Past updates
Tracking began in July 2026. Month on month changes will appear here once a second month of data has been recorded. Until then, the comparison above shows the most recent movement.
Recent trend
Weekly, most recent weeks (fills out to a monthly trend as history grows).
Recent trial results
The 30 most recent of 85 trials tracked for Depression and Anxiety that have reported results to a public registry.
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
-
NCT05269186 · results posted 18 June 2026
According to the results reported on ClinicalTrials.gov, this trial involved 256 people in total — 128 in a group who used virtual reality and 128 who received normal care. The trial was measuring levels of anxiety in patients, comparing those who used a virtual reality session against those who received standard care. Most participants completed the study: 120 in the virtual reality group and 122 in the normal care group finished, with a small number (8 and 6 respectively) not completing it. Anxiety was measured using a well-known self-reported questionnaire called the State Anxiety Scale (d...
-
NCT06302868 · results posted 18 May 2026
According to the results reported on ClinicalTrials.gov, this trial enrolled 54 people in total — 29 in a group receiving therapy sessions that used virtual reality delivered via telemedicine, and 25 in a group receiving standard telemedicine-based therapy (without virtual reality). Both groups were being treated for a specific phobia (an intense fear of a particular thing or situation). The trial measured phobia symptom severity as its main focus, and also looked at general anxiety, depression, the relationship between the therapist and the patient, and how satisfied participants were with th...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT05585905 · results posted 18 May 2026
According to the results reported on ClinicalTrials.gov, this trial involved 20 children in total, spread across four groups that each experienced both virtual reality (VR) and basic behaviour guidance (BBG) during dental sealant placement, just in different orders. One participant did not complete the study, leaving 19 who finished. The trial was measuring anxiety and behaviour by tracking changes in heart rate (beats per minute) during the dental procedure compared to each child's heart rate before it began. The reported data shows that heart rate changes were recorded for each group under...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT07253831 · results posted 13 May 2026
According to the results reported on ClinicalTrials.gov, this trial involved 70 people in total — 35 who received hand reflexology massage and 35 who received standard care only. All 70 participants completed the study with no drop-outs. The trial was measuring two things: fatigue levels (using a questionnaire called the FACIT-Fatigue Scale, where a higher score means less fatigue, out of a maximum of 52) and anxiety levels (using a questionnaire called the Beck Anxiety Inventory, where a higher score means more anxiety, out of a maximum of 63). Both questionnaires were completed at multiple p...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT06309277 · results posted 8 May 2026
According to the results reported on ClinicalTrials.gov, this trial enrolled 46 people in total, split across four treatment sequence groups (12, 13, 11, and 10 participants respectively). The study was testing a treatment for depression and was designed in two parts. Part A compared a 140 mg dose against a placebo (an inactive dummy treatment), while Part B looked at two active doses — 140 mg and 210 mg — over a longer period. By the end of the trial, 36 participants were recorded as having completed it, with 10 not completing across the four groups. The reported data shows that the primary...
-
NCT05044546 · results posted 5 February 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT05044546) was conducted in several stages and involved a small number of participants overall. An initial stage (Aim 1) involved 11 people who took part in focus groups or individual interviews. A small pilot study (Aim 3) included 9 people — 3 assigned to a Health and Wellness (HW) program and 6 assigned to a Behavioural Activation (BA) program, with 8 completing that stage. A final randomised stage (Aim 4) included just 6 people — 3 in each group — and all 6 completed it. The trial was looking at two main things: smoking...
-
NCT06954883 · results posted 6 January 2026
According to the results reported on ClinicalTrials.gov, this trial involved 60 children in total — 30 who experienced augmented reality (AR) distraction during a dental procedure involving a local anaesthetic injection, and 30 who received standard care using a common technique called "Tell-Show-Do," where the dentist explains and demonstrates what will happen before doing it. All 60 children completed the trial. The study was measuring pain during the injection, dental anxiety after the procedure, and heart rate (as a physical sign of anxiety) after the procedure. The reported data shows th...
-
NCT05980299 · results posted 3 November 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT05980299) involved two groups: 130 people in the experimental group (residents receiving the intervention) and 70 staff care partners. Of those who started, 93 experimental participants and 60 staff care partners completed the study. The trial was looking at whether certain behaviours and emotional signs of distress — such as physical or verbal behaviours directed at others, wandering, rejecting care, and low interest or pleasure in activities — changed over a six-month period for residents who showed signs of those diffic...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04482244 · results posted 29 July 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 50 adults in total — 25 who received cannabidiol (CBD) and 25 who received a placebo (a dummy treatment with no active ingredient). All 50 participants completed the study with no drop-outs. The trial was measuring changes in anxiety and mood using a standardised scale called the Visual Analog Mood Scale (VAMS), where participants mark how they feel on a line from 0 (neutral) to 100 (extreme). Scores are then converted to a standard number called a T-score to allow comparison across people. The trial also tracked side...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT03698669 · results posted 26 June 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 163 people in total — 82 in a programme called "Treating Opioid Patients' Pain and Sadness" (TOPPS) and 81 in a Health Education (HE) comparison group. All participants were taking buprenorphine (a medication used for opioid dependence) and the trial was looking at three main things: how much pain interfered with daily life, how severe their pain was, and their level of depression. Participants were followed up at 3, 6, and 9 months, with around 60–66 people in each group completing each of those check-ins. The repor...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT06111742 · results posted 8 May 2025
According to the results reported on ClinicalTrials.gov, this trial involved 178 participants across three groups. There were 37 children and 37 of their carers in an "Interactive Gaming Group" (using a system called BERT), another 37 children and 37 carers in a "Standard of Care" group (receiving usual treatment), and 30 healthcare professionals. The trial was measuring anxiety levels in children going into surgery, anxiety in their carers, how smoothly the anaesthetic process went for the children, and what healthcare staff thought about the BERT gaming system. The reported data shows that...
-
NCT06357286 · results posted 15 April 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT06357286) enrolled 390 participants across four groups: a Control group (70 people), a Stable Income group (80 people), a Predictable Instability group (83 people), and an Unpredictable Instability group (157 people). The vast majority completed the study — 384 out of 390. The trial was measuring depression symptoms using a questionnaire called the PHQ-8, which asks eight questions and produces a total score between 0 and 24, where a higher number means more severe depression symptoms were reported. The reported data show...
-
NCT04467164 · results posted 27 March 2025
According to the results reported on ClinicalTrials.gov, this trial involved 20 people split into two groups of 10. It was a crossover study, meaning everyone tried both versions of a nerve-stimulation technique called transcutaneous vagus nerve stimulation (tVNS) — a non-invasive method of stimulating a nerve in the ear — with a one-week break in between. One version delivered the stimulation timed to breathing out (exhalatory-gated), and the other timed to breathing in (inhalatory-gated). The trial was measuring whether the timing of the stimulation made a difference to brain activity, heart...
-
NCT03707158 · results posted 27 March 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 305 children and young people with anxiety, along with their caregivers (parents or guardians). The children were split into two groups: 156 received a guided online cognitive behavioural therapy (CBT) program with minimal therapist involvement, while 149 received CBT led by a therapist, either in person, by video call, or a mix of both. The trial tracked participants at four points in time — before treatment started, during treatment, after treatment finished, and at a follow-up check-in. By the follow-up stage, 80 p...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04891224 · results posted 24 March 2025
According to the results reported on ClinicalTrials.gov, this trial involved 179 people in total — 90 in a "pre-implementation" group (patients seen before a digital tool called the Pathway Platform was introduced) and 89 in a "Pathway Participants" group (patients seen after it was introduced in a primary care setting). The trial was measuring whether introducing the Pathway Platform changed how consistently doctors tracked patients' depression symptoms over time, using a standard questionnaire called the Patient Health Questionnaire (PHQ). Researchers also looked at several other things reco...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT05551195 · results posted 24 February 2025
According to the results reported on ClinicalTrials.gov, this trial looked at two groups of people receiving treatment for postpartum (after-birth) depression. One group used an intervention called WB001 alongside their usual care, and the other group received an educational program called ED001 alongside their usual care. In total, only 7 people took part — 1 person in the WB001 group and 6 people in the ED001 group — and all 7 completed the study. The trial measured changes in depression, anxiety, mother-to-baby bonding, and overall illness severity using several standard questionnaires. Th...
-
NCT03498651 · results posted 19 February 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 1,748 participants across several groups. The study was testing a digital program called CBM-I (Cognitive Bias Modification for Interpretation), which is a type of online training designed to influence how people interpret ambiguous situations. Participants were divided into groups based on which program they received and whether they were considered at risk of dropping out — some of those at higher drop-out risk were also assigned a support coach. A comparison group received psychoeducation (general information about...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT03378570 · results posted 3 February 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 105 people in total — 47 in one group (called the "5.5cm Rule Group") and 58 in the other (called the "F3 Group"). Of those, 41 and 53 respectively completed the study. Both groups received a form of brain stimulation treatment for depression, and the trial was comparing two different methods of targeting that stimulation to see whether one approach produced better results than the other. The study measured changes in depression and anxiety symptoms using three standard questionnaires filled out before and after treat...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT05543746 · results posted 28 January 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 10 participants, all of whom received a treatment called brexanolone. The trial was a feasibility study — meaning it was designed to test whether the study itself could be run smoothly — rather than to draw broad conclusions about the treatment. The researchers were checking three practical things: whether brain-activity recordings (called EEGs) could be successfully collected, whether participants could complete the full study from start to finish, and whether anyone dropped out because of side effects or because tak...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04739956 · results posted 15 January 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 150 people in total — 74 in one group and 76 in another. The study looked at patients who had been given a diagnosis of "pregnancy of unknown location" (meaning early in pregnancy it was not yet clear where the pregnancy was developing). The trial was measuring whether sharing the result of a bedside blood test (called a Point of Care, or POC, test) with patients changed their levels of anxiety and depression compared to patients who were not shown that result. Psychological wellbeing was measured using a standard que...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT01331330 · results posted 14 November 2024
According to the results reported on ClinicalTrials.gov, this trial involved nine people in total — five in a "High Frequency" group and four in a "Low Frequency" group. The trial was comparing two different frequencies of a treatment and measuring changes in depression and anxiety symptoms, as well as overall day-to-day functioning, using several standard rating scales. Not everyone completed the trial: three people from the High Frequency group and three from the Low Frequency group finished, while two and one participant respectively did not complete it. The reported data shows changes in...
-
NCT03668223 · results posted 24 October 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT03668223) looked at a programme called Promoting Resilience in Stress Management (PRISM) compared with usual care, in young people with cancer. A total of 195 participants started the trial — 99 in the PRISM group and 96 in the usual care group. By the end of the study, 69 people in the PRISM group and 76 in the usual care group had completed it, meaning 30 and 20 people respectively did not finish. The trial measured cancer-related quality of life as its main focus, and also looked at anxiety and depression, sense of hope...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04861597 · results posted 19 September 2024
According to the results reported on ClinicalTrials.gov, this trial involved 30 people with inflammatory bowel disease (IBD) — a condition that includes Crohn's disease and ulcerative colitis. Eighteen participants were assigned to an internet-based talking therapy program (called iCBT, which involves structured psychological exercises done online), and 12 were assigned to a digital mood-tracking tool used as a comparison group. Of those who started, 12 people in the iCBT group and 9 in the mood-tracking group completed the study. The trial was primarily measuring psychological distress — that...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04395183 · results posted 23 July 2024
According to the results reported on ClinicalTrials.gov, this trial involved 43 participants in total, split across four groups. Each group received a different combination of two supplements — creatine and/or 5-HTP (a naturally occurring compound) — or dummy pills with no active ingredient (placebo). The trial was measuring symptoms of depression using two standard questionnaires: the Hamilton Depression Rating Scale (a 52-point scale) and the Montgomery Åsberg Depression Rating Scale (a 60-point scale). On both scales, higher scores indicate more severe depression. The trial tracked how many...
-
NCT05084924 · results posted 25 June 2024
According to the results reported on ClinicalTrials.gov, this trial involved 35 people in total, split across three groups: 11 received "Delta-beta tACS" (a type of gentle electrical brain stimulation), 12 received "Theta-gamma tACS" (a different pattern of the same type of stimulation), and 12 received "Active-sham tACS" (a comparison condition designed to mimic the experience of stimulation without the same intended effect). All 35 participants completed the trial. The study was measuring whether different patterns of brain stimulation changed how often people chose to take on a harder physi...
-
NCT03464630 · results posted 20 June 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT03464630) enrolled 184 mothers with young babies in each of two groups — a total of 368 participants. One group used a program called "Mom & Baby Net" and the other used a program called "Depression & Developmental Awareness System." The trial measured two broad things: mothers' depression symptoms (using a standard questionnaire called the PHQ-9, scored 0–27 where higher means more symptoms), and the quality of how mothers and their babies interacted during play and book-reading sessions (using two observation tools, the...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT05462652 · results posted 12 June 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT05462652) enrolled 223 people in total — 111 in the Active Intervention group and 112 in the Usual Care group. The trial was measuring symptoms of depression, using a questionnaire called the PHQ-8, where people rate how often they experience eight common depression-related feelings. Scores on this tool range from 0 to 24, with higher numbers meaning more severe symptoms. By the end of the study, 96 people in the Active Intervention group and 98 in the Usual Care group had completed the trial. The reported data shows that...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT03438656 · results posted 2 May 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT03438656) involved 32 participants who were assigned to a single group called the "Behavioural Activation Arm." The trial was measuring changes in depression symptoms and feelings of loss of pleasure or interest (known as anhedonia) in the participants. Of the 32 people who started the trial, 30 completed it and 2 did not. The reported data shows two main outcomes. The first was depression symptoms, measured using a self-report questionnaire called the PHQ-9, which runs from 0 to 27 — where a higher number means more seve...
Read the full trial page · View reported results on ClinicalTrials.gov ↗
-
NCT00617162 · results posted 8 April 2024
According to the results reported on ClinicalTrials.gov, this trial looked at a treatment called Deep Brain Stimulation (DBS) — a procedure involving a surgically implanted device that delivers electrical signals to specific areas of the brain — for people with depression. A total of 90 people took part: 60 in the active DBS group and 30 in a control group (who received a comparison condition). Of those, 53 and 27 respectively completed the study. The main thing being measured was depression severity, using a standard questionnaire called the MADRS, where a score of 0 means no symptoms and 60...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
-
NCT04014959 · results posted 2 April 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT04014959) enrolled 41 participants in total, with 37 completing all stages of the study. The trial was investigating a brain stimulation technique called TMS (transcranial magnetic stimulation) — a non-invasive method that uses magnetic pulses to stimulate specific areas of the brain. Researchers used brain scans (fMRI) to measure activity in a particular brain region linked to mood, and also asked participants to fill in a questionnaire about their depression, anxiety, and stress levels, before and after a three-day TMS t...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
See all 85 reported results for Depression and Anxiety
These are the results as reported to the registry, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
What is coming
AI generated pipeline summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to NIH funding data, a very large amount of public research funding is currently directed toward depression and anxiety, and the level of that investment has remained broadly steady over recent years. This signals that depression and anxiety continue to be regarded as a serious research priority by one of the world's largest public health funders. For patients, a sustained and substantia...
See the full Depression and Anxiety page
Not medical advice. Voxsanity republishes public government health data in plain English. These figures describe research and registry activity, not the suitability of any treatment for any person. Trial status can change; always verify current status directly with the trial site and confirm Australian availability with your doctor.