If you need support right now

This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.

If you or someone else is in immediate danger, call 000.

Lifeline — 24/7 crisis support: 13 11 14
Suicide Call Back Service — 24/7 counselling: 1300 659 467
13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
Beyond Blue — 24/7 mental health support: 1300 22 4636
Kids Helpline — 24/7, free and private for anyone aged 5 to 25: 1800 55 1800
headspace — mental health support for 12 to 25 year olds: headspace.org.au
Emergency: 000

Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.

Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.

Depression and Anxiety

Clinical trials recruiting in Australia for Depression and Anxiety, as the public registries list them.

Also called: Clinical depression; Dysthymic disorder; Major depressive disorder; Unipolar depression; Depressive disorder; Major depression; MDD

Follow this condition

Sources: ClinicalTrials.gov, MedlinePlus Checked: 15 October 2026 Not medical advice

At a glance

18 trials recruiting in Australia

7 states or territories with a listed site

0 started recruiting in the last 30 days

3534 trials recruiting overseas

15 October 2026 date last checked

Where the trials are

Listed sites in each state and territory. Choose one to show only the trials with a site there, and choose it again to show them all.

1 listed site on this page does not say which state it is in, so the counts above are lower than the real number of sites in some states. The trials themselves are all listed below.

Trials not shown here

Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.

Trials overseas

3,534 trials for this condition are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.

These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.

Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas

About Depression and Anxiety

The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.

What is depression? Depression is more than a feeling of being sad or irritable for a few days. It's a serious mood disorder. As one of the most common mental disorders in the United States, depression can affect how you think, feel, and your everyday life. You may not know why you feel this way, but even basic daily activities such as sleeping, eating, or working may become difficult. Depression often needs long-term treatment but getting help at the earliest sign of a problem can help manage your symptoms. What are the different types of depression? The most common types of depression are major depression and persistent depressive disorder. - Major depression symptoms include a depressed mood or a loss of interest. Symptoms affect your daily activities and last for at least two weeks. - Persistent depressive disorder (also called dysthymia or dysthymic disorder) has less severe depressive symptoms, but they last longer, usually for at least two years. Other types of depression can include: - Seasonal affective disorder comes and goes with the seasons. It usually starts in late fall and early winter and goes away during the spring and summer. - Bipolar disorder is sometimes called manic depression. This mood disorder can cause intense mood swings. - Depression with symptoms of psychosis is a severe form of depression that also has delusions (false beliefs) or hallucinations (seeing, hearing, or feeling something that isn't there). What causes depression? There are a variety of things that may cause depression, including genetic, biological, environmental, and psychological factors. Depression can happen at any age and can affect anyone, but it's more common in women. This is often due to the physical and hormonal changes that women have during menstruation, pregnancy, the postpartum period, and menopause. Other mental disorders or chronic medical conditions such as diabetes, cancer, or heart disease may occur with depression. This may make the chronic condition or depression worse. In some cases, there is no clear cause for depression. Who is at risk of depression? You may be at a higher risk of depression if you have a close relative who has it or another mental health disorder. Going through trauma or stressful life events may raise your risk even more. What are the symptoms of depression? Depression doesn't look the same on everyone. The type and number of symptoms of depression can vary and don't always appear like sadness. Depression may affect you differently based on your: - Age. The symptoms of depression may be different in a child, who may appear more irritable than sad. Teens may act out or have excessive sleepiness. The symptoms for an older adult may not be as obvious as other age groups. - Sex. Men often show symptoms and coping behaviors differently than women. Rather than sad, men may appear angry or irritable. - Medical conditions. Some medicines and medical conditions may cause symptoms that look like depression. Chronic conditions may make depression worse. Symptoms of depression are ongoing and affect your day-to-day life. They can include: - Feeling sad or "empty" - Losing interest in favorite activities - Overeating, or not wanting to eat at all - Sleeping too much, or not enough - Feeling very tired - Feeling hopeless, irritable, anxious, or guilty - Having aches and pains, headaches, cramps, or digestive problems - Having thoughts of death or suicide - Changing moods or behaviors - Increasing use of alcohol or drugs - Isolating from family and friends How is depression diagnosed? If you think you have depression, talk to your health care provider or a mental health provider. To be diagnosed with depression, your provider may use many tools: - A medical history will include asking about your symptoms and family history. To be diagnosed with depression, your symptoms must occur most of the day, nearly every day, for at least two weeks. One of the symptoms must be a depressed mood or a loss of interest in most activities. - Medical tests may be done to rule out other medical conditions. Certain medicines and medical conditions (such as viruses or thyroid disorders) may cause symptoms like depression. - A physical exam to make sure another issue isn't causing your symptoms. - A mental health evaluation by your provider or a mental health provider. What are the treatments for depression? Depression may need long-term treatment. Most treatments include medicines and/or psychotherapy (talk therapy): - Medicines such as antidepressants may help control your symptoms. You may need to try several medicines to find which works best for you. Medicine may take time to work and can have side effects. Don't stop taking your medicine without first talking with your provider. Contact your provider if you have any concerns about side effects from the medicine. - Psychotherapy (talk therapy) under the care of a mental health provider can help you recognize and change troubling emotions, thoughts, and behaviors. This may be done one-on-one or in a group setting. It can give you and your family support, education, skills, and coping strategies. - Light therapy has been shown to be effective for seasonal affective disorder (SAD). - Other treatments options may be considered if treatment isn't working or if depression is severe. These may include: - Electroconvulsive therapy (ECT) is a brain stimulation procedure that uses a mild electric current when you are under general anesthesia. ECT is most often used for severe depression that is not getting better with other treatments. - Repetitive transcranial magnetic stimulation (rTMS) is a brain stimulation procedure that uses magnetic waves to relieve depression. It's not as powerful as ECT, but with rTMS, you don't need anesthesia. It also has a low risk of negative effects on your memory and thinking. Can depression be prevented? Most cases of depression can't be prevented, but healthy lifestyle changes can have long-term benefits for your mental health. These can include: - Getting regular exercise - Having a consistent sleep schedule - Controlling stress If you, or someone you love is depressed, see your provider or a mental health provider. It's important to get treatment at the earliest sign of a problem. If you or someone you know has thoughts of hurting themselves or attempting suicide, get help right away. If it is an emergency, dial 911. NIH: National Institute of Mental Health

What is anxiety? Anxiety is a feeling of fear, dread, and uneasiness. It might cause you to sweat, feel restless and tense, and have a rapid heartbeat. It can be a normal reaction to stress. For example, you might feel anxious when faced with a difficult problem at work, before taking a test, or before making an important decision. It can help you to cope. The anxiety may give you a boost of energy or help you focus. But for people with anxiety disorders, the fear is not temporary and can be overwhelming. What are anxiety disorders? Anxiety disorders are conditions in which you have anxiety that does not go away and can get worse over time. The symptoms can interfere with daily activities such as job performance, schoolwork, and relationships. What are the types of anxiety disorders? There are several types of anxiety disorders, including: - Generalized anxiety disorder (GAD). People with GAD worry about ordinary issues such as health, money, work, and family. But their worries are excessive, and they have them almost every day for at least 6 months. - Panic disorder. People with panic disorder have panic attacks. These are sudden, repeated periods of intense fear when there is no danger. The attacks come on quickly and can last several minutes or more. - Phobias. People with phobias have an intense fear of something that poses little or no actual danger. Their fear may be about spiders, flying, going to crowded places, or being in social situations (known as social anxiety). What causes anxiety disorders? The cause of anxiety is unknown. Factors such as genetics, brain biology and chemistry, stress, and your environment may play a role. Who is at risk for anxiety disorders? The risk factors for the different types of anxiety disorders can vary. For example, GAD and phobias are more common in women, but social anxiety affects men and women equally. There are some general risk factors for all types of anxiety disorders, including: - Certain personality traits, such as being shy or withdrawn when you are in new situations or meeting new people - Traumatic events in early childhood or adulthood - Family history of anxiety or other mental disorders - Some physical health conditions, such as thyroid problems or arrhythmia What are the symptoms of anxiety disorders? The different types of anxiety disorders can have different symptoms. But they all have a combination of: - Anxious thoughts or beliefs that are hard to control. They make you feel restless and tense and interfere with your daily life. They do not go away and can get worse over time. - Physical symptoms, such as a pounding or rapid heartbeat, unexplained aches and pains, dizziness, and shortness of breath - Changes in behavior, such as avoiding everyday activities you used to do Using caffeine, other substances, and certain medicines can make your symptoms worse. How are anxiety disorders diagnosed? To diagnose anxiety disorders, your health care provider will ask about your symptoms and medical history. You may also have a physical exam and lab tests to make sure that a different health problem is not the cause of your symptoms. If you don't have another health problem, you will get a psychological evaluation. Your provider may do it, or you may be referred to a mental health professional to get one. What are the treatments for anxiety disorders? The main treatments for anxiety disorders are psychotherapy (talk therapy), medicines, or both: - Psychotherapy can help you recognize and change troubling emotions, thoughts, and behaviors. To be effective, it should focus on your specific anxieties and needs. There are many types; some of the types used for anxiety disorders include: - Cognitive behavioral therapy (CBT), which teaches you different ways of thinking and behaving. It can help you change how you react to the things that cause you to feel fear and anxiety. It may include exposure therapy. This therapy focuses on having you confront your fears so that you will be able to do the things that you had been avoiding. - Acceptance and commitment therapy may help with some anxiety disorders. It uses strategies such as mindfulness and goal setting to reduce discomfort and anxiety. - Medicines to treat anxiety disorders include anti-anxiety medicines and certain antidepressants. Some types of medicines may work better for specific types of anxiety disorders. You should work closely with your provider to identify which medicine is best for you. You may need to try more than one medicine before you can find the right one. Support groups and stress management techniques may also be helpful. NIH: National Institute of Mental Health

US source; availability in Australia may differ.

Source: MedlinePlus Health Topics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.

Sources and dates

ClinicalTrials.gov – trial records, statuses and site lists
MedlinePlus – the About text above, reproduced exactly
ClinicalTrials.gov processing date: 15 October 2026.
This page last checked by Voxsanity: 15 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Questions to ask your doctor

General questions, the same on every condition page. Print this page to take them with you.

Is a clinical trial something I should consider at this point?
What would taking part involve week to week?
What are the risks, and what happens if I change my mind?
Would being in a trial change the care I get now?
Who would I see, and how far would I need to travel?
Are there costs, and is travel or time off work covered?
Can you refer me, or do I contact the trial site myself?

Is a medicine on the PBS?

Search the PBS on the Pharmaceutical Benefits Scheme's own website. Voxsanity does not publish PBS listings.

Where to get support

Beyond Blue is Australia's best known support body for depression and anxiety.

Tell us which conditions matter to you

We use requests to help decide what to add next. Telling us about a condition is not a promise that we will add it, and we cannot say when any condition might appear.

If you need support right now

Depression and Anxiety

At a glance

Where the trials are

Trials for Depression and Anxiety

Phase 4 study for people with Depression and Anxiety

Phase 4 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Trials not shown here

Trials overseas

About Depression and Anxiety

Sources and dates

Tell us which conditions matter to you

If you need support right now

Depression and Anxiety

At a glance

Where the trials are

Trials for Depression and Anxiety

Phase 4 study for people with Depression and Anxiety

Phase 4 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 2 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Phase 3 study for people with Depression and Anxiety

Study for people with Depression and Anxiety

Trials not shown here

Trials overseas

About Depression and Anxiety

Sources and dates

Tell us which conditions matter to you

Related conditions