Depression and Anxiety

You have been officially diagnosed with Major Depressive Disorder (MDD) — either a single episode or a recurring episode — confirmed using a standard diagnostic interview tool Your current episode of depression started at least 42 days before joining the trial, but no more than 18 months ago Your depression symptoms…

You have been diagnosed with moderate to severe alcohol use disorder (AUD) based on standard psychiatric guidelines (DSM-5) You currently have a diagnosis of Major Depressive Disorder (MDD) based on standard psychiatric guidelines (DSM-5) You are motivated to cut down or stop drinking alcohol In the month before…

The pregnancy involves a baby diagnosed with a heart condition where only one of the heart's two main pumping chambers has developed properly (called single ventricle congenital heart disease). This heart condition was identified between 16 and 30 weeks of pregnancy. The pregnancy involves only one baby (not twins or…

People who currently live in Australia and do not plan to move or travel overseas during the study period. People who can read and understand English well enough to complete the study questionnaires. People who are willing to create an account and agree to the terms and conditions of the Unforgettable.Me platform.…

People who were diagnosed with a Major Depressive Episode (a formal diagnosis of serious depression) during the period of depression for which they received their rTMS treatment. People whose depression has responded to or gone into remission following their rTMS treatment, meaning their depression symptoms have…

People who have been assessed and found to have an adjustment disorder (a stress-related condition) based on specific questionnaire scores, including a distress score of 4 or higher on a standard scale. People whose anxiety has been measured as moderate or higher on a standard anxiety rating scale. Adults aged 18 to…

You are a parent of a child under 18 years old who is seen at an outpatient clinic at the Royal Children's Hospital (specifically in the neuromuscular or diabetes clinics) You are able to read and complete a consent form in English without needing an interpreter

The person identifies as trans, non-binary, or gender diverse The person is between 12 and 17 years old (inclusive) The person has completed primary school by the time the study begins The person is currently experiencing moderate or higher levels of psychological stress, as measured by a specific questionnaire called…

You have been diagnosed with depression that keeps coming back (moderate or severe) or long-lasting depression. Your current depression has not improved enough with antidepressant pills you have taken by mouth. You have been taking antidepressant pills for at least 8 weeks and are willing to keep taking the same…

Children who are between 5 and 15 years old (up to but not including their 16th birthday) Children who are having planned (non-emergency) surgery at Perth Children's Hospital or Hospital das Clinicas HCFMUSP, and who are expected to go home the same day or stay no longer than one night after the operation

People who have been diagnosed with major depressive disorder (a form of clinical depression) according to recognised diagnostic standards. People who are already taking a stable, prescribed medication for major depressive disorder. People who are willing and able to commit to the full duration of the study, attend…

You have been diagnosed with long-term, widespread muscle or body pain lasting at least 3 months, affecting both the upper and lower body, both sides of the body, and at least one central area like the head, neck, spine, or back. You are willing to keep taking the same medications without changing them for the 8 weeks…

You are 60 years of age or older You have been diagnosed with Bipolar Disorder (Type I or Type II) and are currently experiencing a depressive episode You have scored above 18 on a standard depression rating scale, indicating a significant level of depression symptoms Having a close friend or family member who can…

You have been diagnosed with depression (either minor or major depression) — this trial is for the Behavioral Activation treatment group

Incoming first-year doctors (interns) in training programs for internal medicine, general surgery, pediatrics, obstetrics/gynecology, neurology, or psychiatry at participating hospitals or universities, as well as fourth-year medical students at participating medical schools.

Adults between the ages of 18 and 65 who have been diagnosed with a current episode of major depressive disorder, as defined by standard diagnostic criteria (DSM-V). People whose depression has not responded to at least two different antidepressant medications, each taken at an appropriate dose and for an appropriate…

The person is between 8 and 20 years old. The person has screened positive for depression (for example, based on certain depression questionnaire scores), has expressed thoughts of suicide or self-harm, or is currently receiving treatment for depression. The person (and their parent or guardian, if under 18) is…

People who are male or female and between 18 and 60 years old. People who have been diagnosed with Major Depressive Disorder (MDD). People who show depressive symptoms as measured by one of three standard questionnaires (PHQ-9, HDRS, or SHAPS). People who are able to understand, agree to, and sign a consent form, and…

Adults over 18 years old who have been referred to and accepted for treatment at an ECT (electroconvulsive therapy) unit.

People who score 10 or higher on a depression screening questionnaire (PHQ-9) or 8 or higher on an anxiety screening questionnaire (GAD-7). People who have access to the internet through a smartphone or home broadband, and either have basic comfort using technology or are willing to complete a short technology…

People who are right-handed, as measured by a standard assessment called the Edinburgh Inventory. People who are able to attend the scheduled TMS (brain stimulation) sessions. People who have given their consent to take part in the trial. People who are independent in their day-to-day activities.

The parent or guardian identifies themselves as Black, African American, African, Latino, Hispanic, or Chicano. The parent or guardian has an infant who was or is currently admitted to the NICU (newborn intensive care unit) at Oregon Health & Science University, Randall Children's Hospital, or Providence Health in…

People who are at least 18 years old and live in Rotterdam Zuid. People who have access to a smartphone or tablet. People who agree to take part and provide informed consent.

Adults aged 18 to 65 years old at the time of joining the study People with a primary diagnosis of major depressive disorder (MDD), as defined by standard psychiatric guidelines (DSM-5) People whom the clinic has determined are eligible for ketamine treatment and who agree to receive it People who agree to start…

People who have tried two or more antidepressant medications (working in different ways) that did not work well enough, and who have been on a stable dose of an antidepressant for more than 6 weeks before joining — with "not working well enough" defined as less than a 50% improvement on a standard depression rating…

People between 18 and 55 years of age. People with a body mass index (a measure of body weight relative to height) between 18.5 and 30. People who are able to provide a legally valid signed consent to participate. For the depression group: people currently experiencing a major depressive episode as diagnosed using…

People who can read and write in English or Spanish. People who are between 18 and 20 weeks and 0 days pregnant with a single baby that has no known life-threatening abnormalities, and who have no plan to end the pregnancy, attending a prenatal visit. People with any history of depression or anxiety, meaning: a record…

People who are female. People who live in the Guadalajara Metropolitan Area (GMA). People who are between 18 and 40 years old at the start of the trial. People whose Body Mass Index (BMI) is between 25 and 40 kg/m² at the start of the trial (BMI is a number calculated from height and weight). People whose blood…

People between 15 and 24 years old People who have at least mild social anxiety, based on a score of 25 or higher on a standard social anxiety questionnaire called the Social Phobia Inventory People who own a smartphone with the WeChat app installed and have basic ability to use the internet

People who have been diagnosed with major depressive disorder (a form of serious depression) and/or generalised anxiety disorder. People who are receiving care as an outpatient (meaning they visit a clinic but do not stay overnight in hospital). People who are willing and able to give their informed consent to take…

People aged 12 to 18 years old People who identify as a racial or ethnic minority, including Black or African American, American Indian or Alaska Native, Asian American, Native Hawaiian or Other Pacific Islander, or Hispanic or Latinx People who have at least moderate depression symptoms, as measured by a recognised…

Physical Therapy students enrolled at a specific university in the southern United States during the fall 2024 semester

You must be 21 years of age or older You must be able to speak English You must be a registered attendee of the advanced 7-day meditation retreat You must be willing to wear a Garmin wearable device for the entire duration of the retreat You must agree to and sign the research consent form to take part in the study…

People who successfully completed either the CYB003-002 APPROACH or CYB003-003 EMBRACE trial and received both doses of the trial medication in that study. People who stayed on the same antidepressant medication at the same dose throughout the APPROACH or EMBRACE trial. People who are willing and able to give written…

People aged 18 to 30 years old People currently enrolled in any program at the Autonomous University of Baja California People who are able to complete all of the study's assessment procedures People who are able to attend at least 80% of the intervention sessions People who are interested in taking part voluntarily

People whose scores on two standard mental health questionnaires (measuring depression and anxiety) fall within a mild-to-moderate range (between 5 and 14 points on each scale) People who have a reliable internet connection People who are willing and able to give their agreement to take part in the trial

People who have been clinically diagnosed with depression in older adults, meeting recognised diagnostic guidelines (DSM-5 criteria). People aged 60 years or older who are fully conscious and alert. People who are able to communicate in Mandarin, with a basic ability to understand and express themselves. People who…

The parent or caregiver has a healthy baby between 1 and 3 months old A breastfeeding problem has been identified The parent or caregiver has completed at least primary school education The parent or caregiver is able to have conversations by telephone The parent or caregiver is able to attend a Family Health Centre…

People who are over 18 years old. People who have been diagnosed with Stage 1, 2, or 3 of their condition. People who are aware of their own diagnosis. People who are able to read and write in Turkish. People who have no history of seizures. People who do not have cancer that has spread to the brain. People who have…

People aged between 25 and 35 years who have been diagnosed with mild to moderate depression and have been referred by a psychiatrist, with no other psychiatric conditions, attending Creek General Hospital or Dr. Ziauddin Hospital. People who are currently taking mental health medications such as antidepressants or…

People who are between 16 and 60 years old. People who are currently being assessed, or have been referred for assessment, for a mental or behavioural health condition (such as ADHD, autism, bipolar disorder, anxiety, depression, OCD, PTSD, or schizophrenia spectrum disorders, among others). People who are fluent in…

People who are scheduled for a planned (non-emergency) surgery People who have sufficient language skills to take part in an interview People between the ages of 16 and 85 People rated as ASA I, II, or III — a medical classification meaning they are in generally good to moderately managed health (confirm with trial…

People who have been diagnosed with a depressive episode or recurrent depression (medical codes F32 or F33), or generalised anxiety disorder (medical code F41.1), as their main diagnosis. People who are willing and able to give their consent to take part in the trial. People who have access to the internet. People who…

Children whose parents or the children themselves report that they are having difficulties at school, either with taking part in school activities or with how they are functioning there. Children who show higher-than-usual levels of anxiety and/or sadness, as measured by a questionnaire called the RCADS-47.

The main reason for being admitted to hospital is a current episode of depression (without psychosis) Currently staying as an inpatient on the MUSC Senior Care Unit Aged 60 years or older A depression symptom score of 8 or higher on a standard rating scale called the HAMD-17 (confirm with trial site)

People who are 18 years of age or older who are patients. People who are 18 years of age or older, are healthy volunteers without a blood disorder diagnosis, and are scheduled for a bone marrow examination (which may involve a needle to draw out fluid and/or remove a small tissue sample) at the Hematology Out-Patient…

People who have been diagnosed with an anxiety disorder.

People experiencing at least a moderate level of depression, based on a score of 20 or higher on a standard depression rating scale called the MADRS. People aged between 18 and 65 years. People with sufficient thinking and memory abilities to understand and follow the study's requirements, based on a cognitive…

People between 18 and 60 years of age. People who have been diagnosed with an anxiety disorder by a doctor or psychologist. People who score 11 or higher on a standard anxiety questionnaire called the Beck Anxiety Inventory (BAI) at the start of the study. People who are available to attend all 10 planned sessions.…

People who have already completed treatment in a related study called SPT-300-2024-203 (also known as the BUOY-1 Study), specifically those who attended the final scheduled visit (Visit 8, Day 42) of that study. Women who could become pregnant must not be currently breastfeeding, must not be planning to become…

Children who are between 6 and 10 years old Children who have never had dental treatment before Children who do not have any ongoing or long-term medical conditions Children who do not have an intellectual disability Children who do not have a psychiatric condition, based on results from specific screening…

A person must have been diagnosed with Somatic Symptom Disorder (a condition where physical symptoms cause significant distress and are linked to excessive thoughts or feelings) according to standard psychiatric guidelines, confirmed through an interview with a qualified psychiatrist. A person must be receiving…

People who have been diagnosed with depression People who are 18 years of age or older People who score above 12 on a standard depression questionnaire called the Beck Depression Inventory at the screening stage People who score above 6 on another standard depression scale called the MADRS at the baseline stage

Healthcare providers and staff who are members of a participating pediatric primary care team at one of the clinics involved in this study, and who are being recruited to complete surveys, focus groups, and/or interviews. People in this provider/staff group must be at least 18 years old. People in this provider/staff…

People who are hospital inpatients or outpatients who have a planned, non-emergency open heart surgery scheduled.

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may be included if available and appropriate, but this is not required for everyone. Healthy volunteers who do not have a muscle or nerve disease diagnosis…

Adults receiving care at a university-affiliated dental clinic who are legally able to give consent and are willing to take part voluntarily. People who are able to read and independently fill in short questionnaires before and after their dental visit.

Pregnant people admitted to Stanford Children's Hospital's antepartum (pre-birth) unit for medical reasons that are likely to require more than 3 weeks in hospital (for example, certain placenta conditions, early water breaking, or severe high blood pressure during pregnancy). People who can read and write in English…

People aged between 16 and 60 years old. People who are presenting at a psychiatric hospital or the mental health department of a general hospital. People who are willing to cooperate and take part in the study. People who have signed an informed consent form (for teenagers, a parent or guardian must also provide…

People who have been admitted for treatment of a psychiatric condition at the Child and Adolescent Mental Health Services at Haukeland University Hospital (known in Norwegian as Psykisk helsevern for barn og unge, Helse Bergen)

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may also be used if available, though this is not required as it is not suitable for everyone. People without a muscle disease or neurological disease diagnosis…

People aged 22 to 85 years, male or female. People who have been diagnosed with major depressive disorder (a serious form of depression) by a psychiatrist, without psychotic features, based on recognised diagnostic guidelines (DSM-5). People whose depression has not improved despite trying antidepressant medication at…

Children who show fearful, reluctant, or uncooperative behaviour at the dentist, based on a specific behaviour rating scale used by dental professionals (called Frankl's scale, scores 2 or 3). Children between 5 and 8 years old who need to have a baby tooth removed. Children who are otherwise healthy and do not have…

Occupational therapists (OTs) or occupational therapy assistants (OTAs) who hold a current state license to practice in the United States OTs or OTAs who work in home or community brain rehabilitation settings and provide care to adults aged 18 or older who have had a brain injury (including any injury to the brain…

People who currently work as a practicing therapist providing psychotherapy. People who are providing treatment to clients with anxiety conditions.

People aged 18 years or older. People who have mild, moderate, or severe symptoms of anxiety, depression, or stress, as measured by a questionnaire called the DASS-42. People who do not have any medical reasons that would prevent them from following a personalised diet. People who do not have cognitive impairment…

Adults between 18 and 60 years of age. People who are right-handed. People who have been diagnosed with Gambling Disorder according to standard diagnostic guidelines (DSM-5). People who score 5 or higher on a standardised gambling assessment tool called the South Oaks Gambling Screen (SOGS). People with normal vision…

People who have applied for support through The Student Welfare Organization in Oslo and Akershus (SiO Mental Health) via their website. People who meet SiO Mental Health's general eligibility requirements, which includes an individual review of applications — SiO's general policy is to offer help to all applicants…

Women between 28 and 70 years old at the time of joining the trial. Women who have been diagnosed as being in the perimenopausal stage, based on specific medical criteria — this may include irregular periods, certain hormone levels found on blood tests, and/or symptoms such as hot flushes, sleep problems, mood…

People who are aged 60 years or older People who identify themselves as a Korean immigrant People who are able to read and understand Korean or English People who own or have access to a smartphone that works with the study's mobile app People who are willing and able to give their formal agreement to take part People…

People who have stayed in a residential treatment program for at least four weeks People who have completed at least three measurement check-ins over time as part of the study People who are able to read, understand, and fill out self-report questionnaires written in Spanish People who are able to take part in…

General practitioners (family doctors) who do not speak Turkish are eligible to take part. Patients must be 18 years of age or older. Patients must be fluent in Turkish but not in Dutch or French.

The person has scored 25 or higher on a standard anxiety questionnaire (called the SCARED) and has previously been diagnosed with an anxiety disorder by a doctor. The person is between 9 and 17 years old. If the person is taking any medication that affects mood or mental health, the dose must have been stable for at…

People aged 21 to 85 years old People who have been diagnosed with Stage I, II, or III cancer, confirmed by laboratory tissue testing People who are currently receiving, or have received within the past year, cancer treatment involving radiation therapy and/or chemotherapy People with moderate to severe depressive…

People aged 18 to 64 who are scheduled for a planned (non-emergency) surgery at Cedars-Sinai Medical Center and will be receiving regional anesthesia (numbing a specific part of the body rather than being fully put to sleep) People who are able to read and understand information well enough to give their written…

People who are able to give informed consent to participate. People who are available for the full length of the study and willing to follow all study procedures. People aged 18 to 90 years old. People who have been diagnosed with major depressive disorder according to DSM-5 standards. People whose depressive symptoms…

Pregnant women who have been admitted to the antepartum ward at the Lois Hole Hospital because of a risk of giving birth early (before 34 weeks of pregnancy). People who can speak, read, and write in English. People whose hospital stay is expected to last at least 4 weeks after joining the study. People who are…

People who have had chronic pancreatitis (long-term inflammation of the pancreas) for at least 3 years. People who have experienced at least 3 episodes of pain in the past 3 months. People between 18 and 60 years of age. People of any gender.

Adults between 18 and 80 years old who are legally able to make their own decisions. People who have been diagnosed with depression based on recognised medical diagnostic guidelines (ICD-10 or DSM).

Women who are not currently taking any medication and are experiencing a moderate to severe episode of major depression, with symptoms starting either before giving birth or between two weeks and six months after giving birth (based on a specific depression rating scale). Women between 18 and 45 years of age. Women…

People of any gender are eligible. People who are being treated as outpatients (not admitted to hospital) are eligible. People who are voluntarily choosing to participate and are able to give informed consent are eligible. People who have been formally diagnosed with Major Depressive Disorder (MDD) — either a single…

People who are British mothers of African and Caribbean heritage People who are experiencing emotional distress related to childbirth or parenting, and have scored 5 or above on a standard mental health questionnaire called the PHQ-9 People who have at least one child aged between 0 and 3 years old People who live in…

People who have been diagnosed with a depressive disorder according to standard psychiatric diagnostic guidelines (DSM-5). People between the ages of 18 and 60, of any gender, who have at least one guardian available to check in on them for 2 months. People who are willing to give their informed consent (and whose…

People who have been diagnosed with hepatocellular carcinoma, cholangiocarcinoma, gallbladder carcinoma, or breast, ovarian, or colorectal cancer that has spread to the liver, confirmed by biopsy and/or imaging, with a life expectancy of at least one year. People aged 21 years or older. People who do not show or…

Adults aged between 18 and 75 years, with no restriction based on gender. People who have been diagnosed with major depressive disorder according to the DSM-5 diagnostic criteria. People whose depression severity scores 17 or higher on a standard clinical rating scale called the Hamilton Rating Scale for Depression…

The person is planning to enroll in a clinical trial (self-reported). The person has been diagnosed with social anxiety. The person is 18 years of age or older.

Adults between 18 and 65 years old. People who have a good understanding of the French language. People who have been diagnosed with major depressive disorder according to standard diagnostic guidelines (DSM-V). People whose depression symptoms score above 19 on a standard rating scale called the MADRS, indicating at…

People who have been diagnosed with treatment-resistant depression (a form of depression that has not responded to standard treatments). People who are 18 years of age or older and are able to sign a written consent form before the study begins. People who have not previously received any treatment specifically for…

People aged 18 or older who live in Norway and have been assessed and approved to receive treatment in a specialist mental health service, either as an inpatient (staying in a facility) or outpatient (attending appointments without staying overnight).

People between the ages of 18 and 99 People who are currently admitted as a patient at Stanford Health Care People who speak English

People who have been diagnosed with anxiety, schizoaffective disorder, bipolar disorder, ADHD, dementia, or other psychological conditions, OR autoimmune conditions such as fibromyalgia, lupus, or thyroid disease, OR neuropathy or chronic fatigue syndrome People who are able to swallow tablets

People who are able to read and write People who are 18 years of age or older People who can speak and understand Turkish Women who are having a vaginal examination for the first time Women who have chosen to volunteer to take part in the study

People who have been diagnosed with generalised anxiety disorder. People who are 18 years of age or older. People who are able and willing to attend scheduled visits, follow the treatment schedule, complete lab tests, and meet other study requirements.

People who have been diagnosed with one of the following anxiety disorders, based on standard psychiatric guidelines (DSM-5): panic disorder, agoraphobia, social anxiety disorder, generalised anxiety disorder, separation anxiety disorder, or specific phobia. People whose anxiety has not responded to previous…

Adults of any gender between 18 and 60 years old. People who have been diagnosed with primary insomnia by a psychiatry specialist, using standard DSM-5 diagnostic guidelines. People who are able to give written consent to participate. People who are willing to follow the study procedures and attend follow-up…

People who identify as Black or African American, regardless of ethnicity People who identify as male, regardless of sex assigned at birth People who are living with HIV and have been prescribed a daily HIV treatment (antiretroviral therapy) routine People who are 18 years of age or older People who have sex with men…

People who have been diagnosed with colon, rectal, colorectal, or anal cancer. People who are at least 20 years old. People who finished their cancer treatments within the five years before joining the study. People who agree to participate and provide written consent. People who are able to attend sessions online…

Children and adolescents between 8 and 18 years old. People who have been diagnosed with an anxiety disorder based on a structured clinical interview or the judgment of an experienced, qualified clinician.

People who have been diagnosed with anxiety, depression, or a substance use disorder. People who live on or near the Turtle Mountain or Spirit Lake reservation. People who are enrolled members of a federally recognized tribe.

People aged between 18 and 55 years. People who have their own smartphone available for personal use over the next year.

The person must have enough English language ability to give informed consent, complete questionnaires and tasks, and participate in treatment. The person must have a diagnosis of one of the following anxiety-related conditions, confirmed by a specific screening tool (Quick-SCID): Generalised Anxiety Disorder, Social…

People who have been diagnosed with Major Depressive Disorder based on standard psychiatric diagnostic guidelines (DSM-5). People who score 15 or higher on a standard depression rating scale called the Hamilton Depression Rating Scale (HAMD), indicating at least moderate depression. For people with depression that is…

The child must be between 9 and 12 years old (as the anxiety measurement tool used in this trial is designed for this age group) The child has been diagnosed with type 1 diabetes The child does not have an intellectual disability The child is receiving insulin injections under the skin for the first time Both the…

People aged 18 or older who are already part of the MESANTIDEP study and for whom a type of antidepressant medication called an SSRI is being planned as part of their treatment. People who have been fully informed about how the study works and have signed a written consent form agreeing to take part (or, if the person…

People who live in Alaska People who speak English People who are between 14 and 26 years old People who have access to a smartphone or computer to complete surveys and use the study tool

People who have been diagnosed with a current episode of unipolar depression, according to standard psychiatric diagnostic guidelines (DSM-5). People whose psychiatrist or referring doctor has prescribed an antidepressant from one of two specific types — an SSRI or an alpha-2 antagonist — for their current depressive…

People who have completed at least a primary school level of education Caregivers who have the ability to use a chatbot application on their phone (the trial site will install the app and check that it is being used) People who are willing to take part in the study People who are open to communicating and working with…

People who are pregnant and have been classified by an anaesthesiologist as having a physical health status of ASA II or III (a standard medical rating system used before surgery — confirm with trial site if unsure which category applies). People who are having their first caesarean section, and it is planned in…

People of any gender identity (male, female, or diverse) People aged between 18 and 65 years People diagnosed with moderate to severe major depression according to standard psychiatric criteria (DSM-5) People with a depression symptom score of 20 or more on a standard rating scale called the MADRS People whose current…

Teenagers who are enrolled in one of the selected secondary schools may be eligible. Parents of teenagers who are enrolled in one of the selected schools may be eligible. Teachers and school staff who work at one of the selected schools may be eligible. People of any gender may be eligible. Teachers and school staff…

People who have been diagnosed with Social Anxiety Disorder (SAD) according to the standard psychiatric diagnostic guidelines known as the DSM-5 People who are between 18 and 75 years old People who have regular access to a suitable internet-connected device People who live in Pakistan and are able to read, write, and…

People who score between 11 and 18 on a standard postnatal depression screening questionnaire called the Edinburgh Postnatal Depression Scale (EPDS). People who are 18 years of age or older. People who have access to the internet.

Adults aged 21 to 50 years (male or female) are eligible to be considered. People who report experiencing mild to moderate stress, based on a standard stress questionnaire (PSS score of 26 or below). People who are willing to take part in a clinical trial and have read, understood, and signed a consent form. People…

People who have a parental role in relation to a child aged 0–17 years old (this does not have to be a biological parent or legal guardian — for example, a partner of a parent may also be eligible). A child welfare report has been filed for the child involved, or the parent has contacted the child welfare services…

People aged between 18 and 25 years old. People who have been living in the local area for more than one month. People who are currently enrolled as college students at Qingyuan Vocational Education City. People who have signed a consent form and are willing to provide survey information and stool samples. For the…

People who have never visited a dental clinic before. People who need dental treatment, such as tooth fillings, root canal treatment, gum treatment, tooth extraction, or similar procedures. People (and their guardians, where applicable) who are able to understand what the study involves and are willing to take part…

People who work at one of the participating units involved in the trial. People who have a parental role in relation to a child aged 0–17 years old (this does not have to be a biological parent or legal guardian — for example, a partner of a parent may also be eligible). Cases where a child welfare report has been…

Women over 18 years of age who live in the Galicia region of Spain Currently pregnant and no more than 16 weeks along in the pregnancy Able to understand and speak Spanish fluently Willing to give formal consent to take part in the study Has access to the internet and a digital device such as a computer, tablet, or…

Children between the ages of 5 and 14 who are Hispanic or Latino and speak Spanish Children who are scheduled to have surgery in the Doernbecher Operating Rooms

People of any ethnic background are welcome to participate. People who have significant depression symptoms, as measured by a score above 40 on a specific depression rating scale for children (the Children's Depression Rating Scale-Revised). People who have been prescribed more than 5mg of Fluoxetine (also known as…

Adults aged 18 to 64 who have been diagnosed with their first or second episode of major depression (also called unipolar major depressive disorder). People whose depression is rated as moderate to severe based on clinical assessment and standard measurement tools. People who are willing to take part and sign a…

People aged 18 to 65 years old People who are physically able-bodied People who are fluent in English People who are able to give written and verbal consent to take part in the experiment People who are able to understand the study process, its potential risks, and its benefits People who have been diagnosed with…

Adults aged 18 or older. People who are scheduled to have a surgical procedure inside the uterus (called operative hysteroscopy) under anesthesia in an operating room, following an earlier diagnostic procedure that identified something in the uterus.

Doctors who are doing their post-graduation training (residency) in a hospital. Doctors doing their residency training at hospitals located in Upper Egypt.

Children aged 5 to 17 years old. Children who have stopped wearing soft contact lenses for at least 1 week, soft toric (astigmatism-correcting) or hard contact lenses for at least 3 weeks, and orthokeratology ("OK") lenses for at least 3 months before joining. Children whose best corrected vision (with glasses or…

The child is between 6 and 12 years old The child has been admitted to hospital because of a sudden (acute) medical diagnosis The child has been in hospital for at least 3 days The child's treating doctor has given approval for the child to take part in the sessions The child is awake, alert, and fully aware of their…

People between the ages of 55 and 70. People who have been diagnosed with major depressive disorder or bipolar disorder (type I or type II), either currently or at some point in the past, according to standard psychiatric diagnostic guidelines (DSM-5). People who have read and signed an informed consent form before…

People who are between 18 and 45 years old People who are between 20 and 24 weeks pregnant People who are at some risk of depression but not experiencing severe depressive symptoms, based on a score of between 5 and 12 on a standard depression screening tool called the Edinburgh Postnatal Depression Scale (EPDS)…

People who are 18 years old or older People who speak and understand Turkish People who are having a total knee replacement surgery People who will be staying in the hospital ward for approximately 96 hours (about 4 days) after surgery People who are willing to take part in the study on their own accord People who do…

Aged between 10 and 19 years old (as defined by the World Health Organization) Has a confirmed HIV-positive diagnosis Currently taking HIV medication (antiretroviral therapy) Is aware of their own HIV status Lives in the Lower Manya Krobo district Able to communicate in English or the local language Willing to take…

People who have been diagnosed with Panic Disorder and are being seen at Muğla Training and Research Hospital Psychiatry Outpatient Clinics People aged between 18 and 65 who agree to take part in the research People whose mood was considered stable at the time of their interview, as assessed by a doctor People who…

People who have been diagnosed with major depressive disorder that is at least moderate in severity. People who are able to read, understand, and sign a written consent form.

People who have been diagnosed with a spinal cord injury (SCI), confirmed by a CT or MRI scan, according to recognised international classification standards. People who are at least 18 years old. People whose spine is stable, whose general health signs (such as heart rate and breathing) are normal, who are living in…

Adults between the ages of 21 and 65. People who are willing and able to sign a consent form before any study-related activities begin, as approved by an ethics review board. People who meet the medical definition (DSM-5) for moderate or severe alcohol use disorder within the past 12 months. People who have had at…

People who have been diagnosed with Major Depressive Disorder (MDD) according to standard diagnostic guidelines (DSM-5-TR). People who still have ongoing depression symptoms, shown by a score above 7 on a standard depression rating scale called the Hamilton Depression Rating Scale. People who are 18 years of age or…

People who are having a one-sided keyhole lung surgery (called VATS) under general anaesthesia to investigate or remove spots found on the lung. People aged between 18 and 65 years old. People whose general health has been rated by an anaesthesiologist as falling into category II or III on a standard health scale…

Adults who are going through their first egg retrieval procedure.

People who have given birth for the first time People who are 18 years of age or older People who are willing to take part voluntarily

Adults aged 18 years or older at the time of giving consent. People who have been taking beta-blocker medications for at least 1 year. People without significant memory or thinking difficulties. People who are willing to take part in the study. People who are able to understand and complete self-assessment…

The person must be an adult. The person must have given verbal agreement to take part after receiving clear information about the trial. The person must be staying in the multipurpose intensive care unit at Rangueil Hospital, with an expected stay of more than 24 hours. The person must be conscious and have an…

People diagnosed with bipolar disorder (BD), major depressive disorder (MDD), and/or schizophrenia. People with bipolar disorder who meet the formal diagnostic criteria for BD (any subtype), have a symptom severity score above 40 on a standard rating scale called the BPRS, and whose condition is not considered mild.…

People who are male People aged between 20 and 90 years old People whose procedure is scheduled between 8am and 12pm People who are having a vasectomy performed under local anaesthesia

Adults aged 18 to 65 years old (inclusive). People who have been diagnosed with depression for the first time, or who have experienced a return of depression, meeting specific recognised diagnostic standards (DSM-5). People whose depression is rated as moderately severe or above on a standard depression rating scale…

People aged 18 or older People who have been told about their own diagnosis People currently receiving 4 to 6 monthly cycles of treatment given before surgery (neoadjuvant treatment) People who are scheduled to have their first mastectomy (breast removal surgery) People whose thinking and understanding ability is…

Adults over 18 years old who are being monitored in the mental health services of the Castellón province and have been diagnosed with both major depression and a substance use disorder. People whose depression has not responded to two or more different medication treatments, where those treatments were completed…

High school students aged 13 and older who are enrolled at Mtshabezi or Matopo High Schools in the Gwanda and Matobo Rural Districts during the five-year project period. Students who are able to understand and answer questions on the Youth Risk Behavior questionnaire and the PHQ-9 scale. Students who have a relevant…

Children who are between 9 and 12 years old may be considered. A parent or family member must give permission for the child to take part in the study. The child themselves must also agree and give their consent to participate.

People with a current or past history of anxiety and/or depression. People who have been referred to give birth at Slagelse Hospital.

People who have had a spinal cord injury for at least 1 year, of any level or severity People who are 18 years of age or older People assessed by a clinical psychologist as having mild to moderate depression, based on a specific standardised interview tool People who are on a stable, consistent dose of medication for…

People who score 55 or above on a measure of death anxiety (fear or worry about death and dying) People who also score 9 or above on a measure of depression, and/or score 9 or above on a measure of anxiety, at a level that is below a formal clinical diagnosis

Children aged 3 to 6 years old, any gender. Children classified as generally healthy or with only mild systemic illness, based on a standard anaesthesia health rating scale (ASA classification I or II). Children with a body mass index (a measure of weight relative to height) between 14 and 25 kg/m². Children who are…

People aged between 13 years old and 25 years and 11 months old. People of any sex (male or female). People who are currently a patient at the CMI clinic or the Fort Health Virtual Outpatient Mental Health Clinic. People whose current symptoms include mild-to-moderate depression, and who are experiencing at least two…

People aged 18 to 50 years old, who are right-handed, and have completed at least nine years of schooling. People who have been diagnosed with depression according to the DSM-5 (a standard set of medical guidelines used to diagnose mental health conditions). People whose depression is rated as moderate to severe or…

A parent or caregiver of a newborn baby born on January 1, 2023 or later, whose baby received special or intensive medical care within the first week of life — such as oxygen support, breathing assistance, incubator care, drips, treatment for infection, pneumonia, a serious gut condition, birth defects, jaundice…

Adults between 18 and 65 years of age (any gender) may be considered. People who have been diagnosed with Major Depressive Disorder (MDD) as their main condition, based on standard diagnostic guidelines, whether it is a first or repeated episode — with the current episode lasting at least 3 months for first-time…

People who are currently experiencing active thoughts of suicide, as measured by specific scores on two standard clinical rating scales (the MADRS and the Beck Scale for Suicide Ideation). People who have a clinical diagnosis of a mild to severe depressive episode without psychotic symptoms. People who are voluntary…

Adults aged 18 or older. People who have been diagnosed with recurrent major depression and have had at least 2 previous depressive episodes. People who are currently in partial remission, meaning they are not in a full depressive episode right now but still have some symptoms above a certain level (as measured by a…

Children between the ages of 6 and under 18 years old. Children who have been diagnosed with either a simple or complex congenital heart condition (a heart condition present from birth). Children who are currently staying in hospital or attending as outpatients (not admitted overnight). Children who are either waiting…

Adults between 18 and 60 years old (any gender). People who have been diagnosed with major depressive disorder according to the DSM-5 diagnostic guidelines. People whose depression has been rated as moderate to severe or above on a standard 17-item depression scale (a score of 18 or higher on the HAMD-17). People…

The person has a severe or profound learning disability, confirmed by a carer completing a standardised assessment called the Vineland Adaptive Behaviour Scales (3rd edition), with a score of 50 or below — this typically means the person has high support needs, limited or no ability to speak or understand speech, and…

People who speak English People who are between 13 and 17 years old People who score 5 or higher on a standard depression questionnaire called the PHQ-8 People who report at least some difficulty with loss of interest, sleep problems, or low energy on that same questionnaire People who own their own personal smartphone

People who speak English.

People aged between 12 and 25 years old (inclusive) People who are currently a client at one of the participating youth mental health services People who are seeking or receiving treatment for depression and/or anxiety People who have a sufficient level of English language skills Clinicians who are employed at a…

People who are 13 years of age or older. People who are awake and able to communicate.

The person is between 13 and 17 years old. The person has been diagnosed with Major Depressive Disorder (MDD) with a current depressive episode, but without psychosis, as confirmed by a standard diagnostic interview tool. The person has a depression severity score of 20 or higher on a standard rating scale called the…

Adults between the ages of 50 and 80. People who are able to give their informed consent to take part in research assessment and treatment. People experiencing significant depression, with a score of 7 or higher on a standard depression questionnaire called the PHQ-9 (indicating mild to moderate symptoms). People who…

People who are 18 years of age or older. People who have noticeable symptoms of an anxiety disorder (not including specific phobias) or depression, as measured by standard questionnaire scores above certain thresholds (confirm with trial site for specific score requirements). People who are proficient in the Danish…

People who have been assessed by their doctor as having a physical health status rated as ASA 1, 2, or 3 (a scale used to measure overall health before surgery — confirm with trial site for clarification on what this means for a specific case) People who are scheduled for a planned, non-emergency total knee…

Adults aged 18 years or older Able to give informed consent to take part in the study Able to understand and follow spoken instructions Has enough movement and control in the hands and arms to use virtual reality (VR) equipment Currently in a stable medical condition Able to speak and understand English Willing to…

People who are scheduled to have a colposcopy (a close examination of the cervix) because of a possible abnormality. People who are willing to take part and agree to sign a consent form after being told about the procedure. People who are considered healthy enough to have a colposcopy and do not have any vision or…

Teenagers between the ages of 13 and 17 years old People who live in New Hampshire People who speak and understand English fluently People who are able to give their own agreement to take part in the study People who have at least mild anxiety, based on a standard anxiety questionnaire called the GAD-7 (a score of 5…

People aged between 12 and 19 years. People who have been diagnosed with a Major Depressive Episode (a single, non-bipolar type of depression) using a structured clinical interview and standard diagnostic guidelines (DSM-5), carried out by experienced evaluators. People who are already receiving standard treatment for…

People who are currently in hospital and scheduled for surgery to treat a hernia or varicose veins. People who are on the hospital's surgical waiting list. People who are willing and able to give their informed consent to take part. People who agree to take part in the study and complete all required assessments while…

People aged 18 or older People with a confirmed diagnosis of lung cancer (either non-small cell or small cell lung cancer) People whose lung cancer is at an advanced stage (stage IIIB–IV) that cannot be surgically removed, has spread, or has come back People who are generally well enough to carry out light activity…

You work as a counselor providing services based in a school You have not previously received formal training in the BRISC program You are not currently being supported to use a different intervention program You are in grades 9 through 12 and are at least 13 years old You are currently receiving mental health…

People who are willing to take part and have given written consent to participate. People who have been diagnosed with Gestational Diabetes Mellitus (a type of diabetes that develops during pregnancy) and are currently staying in hospital. People who are in the third trimester (last three months) of pregnancy. People…

Adults aged 18 or older. Currently enrolled as a full-time medical student at Alfaisal University. Owns a smartphone (iPhone or Android) that is compatible with the "syd" app. Willing to give formal consent to participate and follow the study procedures.

People with a primary diagnosis of depression, confirmed using standard diagnostic guidelines (DSM-5 criteria). People whose depressive symptoms have been measured using one of three recognised rating scales (MADR, BDI, or ZDR). People who are able to give written consent to participate. People who report doing less…

People who are 18 years of age or older Mothers who have a child between 0 and 3 years old People who are able to give their full, informed agreement to take part in the trial People who live within the specific areas covered by the trial People who are able to complete an initial assessment at the start of the trial…

Women between 18 and 70 years of age People who have been diagnosed with breast cancer at an early to intermediate stage (stage I, II, or III) People who have finished their main active breast cancer treatment at least one month ago People whose general physical functioning falls within a certain range, as measured by…

People aged 65 years or older Both men and women are eligible People who are scheduled for a planned (non-emergency) surgical procedure in the abdomen or pelvis area, performed under regional anaesthesia (where only part of the body is numbed) People classified as ASA physical status I or II, meaning they are…

People who are 18 years of age or older People who are alert and responsive enough to open their eyes on their own or when spoken to, and can follow simple movement instructions (as measured by a standard medical alertness scale called the Glasgow Coma Scale, with a score of 13–15) People who have had a tracheostomy…

People who have been diagnosed with an ectopic pregnancy, are 18 years of age or older, and are in good psychological health. People who are planned to have a single-port laparoscopic (keyhole) surgery under general anaesthetic, followed by a self-controlled pain relief drip after the operation. People whose overall…

People who are willing to take part in the study voluntarily People who have been diagnosed with breast cancer and are scheduled to have surgery People who have never taken part in laughter yoga before People who are able to read and write People who do not have a diagnosed psychiatric illness People who do not have…

People who took part in a larger study called the PRIL study, agreed to be contacted about this intervention trial, and were assessed as having a moderate risk of developing depression during pregnancy or after birth, based on a detailed review of biological, psychological, and social factors.

People who are attending a clinic for an intrauterine device (IUD) insertion procedure and/or a uterine tissue sampling procedure (called an endometrial biopsy).

People between 21 and 80 years of age who have clinically significant loss of pleasure or interest (defined by a score of at least 20 on a specific rating scale called the SHAPS). People who have been diagnosed with Major Depressive Disorder according to standard diagnostic guidelines (DSM-5-TR).

Children who are generally healthy with no ongoing or systemic health conditions. Children who need some form of dental treatment or procedure.

A person must meet the medical diagnostic criteria for a depressive episode, as defined by an international classification system called ICD-10. A person must score 14 points or higher on a standard 17-item depression rating scale called the Hamilton Depression Scale. The diagnosis must be confirmed by at least two…

Adults aged 18 or older People who are able to give informed consent to participate People who can understand written and spoken Portuguese People who are willing to have blood samples taken People who are willing to avoid intense physical exercise for 72 hours before their assessment People who have been diagnosed…

Women who are pregnant with their first baby Aged 18 or older At least 37 weeks pregnant Fluent in Hebrew, as a questionnaire written in Hebrew needs to be completed

People who have been diagnosed with at least one emotional disorder — such as anxiety, depression, OCD, a trauma-related condition, or a similar disorder — based on a structured clinical interview called the MINI. People who can understand and communicate in Spanish or Catalan, as these are the languages the treatment…

A person who has been diagnosed with HIV based on Chinese AIDS Diagnosis and Treatment Guidelines (2021), which means at least one of the following applies: a positive HIV antibody screening test confirmed by a supplementary test; two positive HIV nucleic acid tests in someone with relevant history or symptoms; or a…

Adults aged 18 years or older People who score at a moderate or severe level on standard anxiety or depression questionnaires (a score of 10 or higher on either the GAD-7 anxiety scale or the PHQ-9 depression scale) People living in the United States People who are fluent in English People who have an email account…

People who are studying an allied health programme and are either about to start their practical placement or have recently begun one.

People who are aged 60 years or older. People who have been living in their community for more than 6 months. People who have enough reading, writing, and understanding ability to communicate with researchers and either complete assessments on their own or, even if unable to fill out forms independently, can make…

People aged 70 or older. People who have a confirmed depressive episode, measured using a standard depression questionnaire (with a score above 13 at the start of the trial). People who score at least 23 out of 30 on a standard memory and thinking assessment at the start of the trial. People who are enrolled in or…

Adolescents between the ages of 12 and 18 years (Case group) People who have been diagnosed with a primary headache disorder by a pediatric brain specialist, using a standard international classification system called ICHD-3 (Control group) People who have no history of recurring headaches and no history of ongoing…

People aged 18 years or older. People who have been clinically diagnosed with a jaw muscle disorder called temporomandibular disorder (TMD) affecting one or both sides, based on a standard diagnostic system known as DC/TMD. People who have pain or tenderness in the chewing muscles — either felt on their own or when a…

Children between 3 and 12 years old Children who are scheduled for planned (non-emergency) surgery Children whose family has access to a mobile phone Children who are able to speak Urdu Children for whom video games are not medically unsuitable

Children who are cooperative or fairly cooperative during dental visits, as measured by a standard behaviour rating scale (Frankl's scale grade III or IV). Children who need invasive dental treatment on their baby teeth.

People who are currently enrolled as vocational school students People who have given their informed consent to take part in the study People who do not have any language, hearing, intellectual, or psychological impairments People who can speak and understand Turkish People who are willing to participate in the study

Pregnant women who have lived in Jimma City for at least six months. Women who are between 12 and 28 weeks into their pregnancy. Women who scored 13 or higher on a standard screening tool used to check for depression during pregnancy (called the EPDS). Women who are able to take part consistently for eight weeks in a…

Students who are in 12th grade Both the student and their parents have given their consent to participate No language, hearing, intellectual, or psychological disabilities are present Able to speak and understand Turkish Planning to sit the university entrance exam Participation is entirely voluntary Students…

People aged between 20 and 65 years. People who have been diagnosed with Generalised Anxiety Disorder (GAD) by a psychiatrist. People who have been diagnosed with Major Depressive Disorder (MDD) by a psychiatrist, and who do not have an acute (immediate) risk of suicide — this is assessed using a standard…

Women between 18 and 70 years old. People who have been diagnosed with breast cancer at stage I, II, or III (based on tumour classification). People who finished their main active cancer treatment at least one month ago. People with a general health and activity level rated at 0, 1, or 2 on a standard scale used by…

People who are willing and able to give their informed consent to participate. People who have a valid telephone number. People who own a smartphone (Apple or Android) with an internet connection. People who are between 18 and 65 years old. People who have lived in Spain or Chile for more than 6 months per year as…

People aged 65 or older at the time of screening. People who have been diagnosed with Major Depressive Disorder (MDD) and are currently experiencing a major depressive episode, as defined by standard psychiatric guidelines (DSM-5). People whose depression has not responded well enough to antidepressant medications…

People aged over 50 years People who are fluent in Danish People who have completed at least 7 years of schooling People who have been diagnosed with either mild cognitive impairment (MCI) or Alzheimer's disease (AD) at the SUH memory clinic within the 6 months before joining the trial People aged over 50 years People…

People who have been diagnosed with a major depressive episode without psychotic features, based on standard psychiatric diagnostic criteria (DSM-5). People whose depression has not responded to at least two different antidepressant medications, each taken at an appropriate dose for at least 6 weeks. People whose…

People who are between 18 and 65 years old People who have been diagnosed with moderate to severe depression People who live in urban or rural areas of Pakistan People who are willing to attend 12 weekly group therapy sessions and follow the study requirements

People aged 18 or older People who can speak, read, and understand English People who are in generally stable health People who have treatment-resistant depression, meaning they score in the moderate or above range on a standard depression rating scale (called the HDRS) and have tried two or more antidepressant…

The call to emergency services (SAMU Centre 15) must be about a child aged between 3 months and 10 years The child must have a fever as their only symptom, based on a recognised medical definition of fever alone The fever must have started less than 72 hours before the call The child must have no other physical…

People who are 21 years of age or older. People who have been living with ongoing pain for 3 months or more. People who have been scheduled to have an interventional pain procedure.

Teenagers aged 12–17 or adults aged 18 and older who attend a participating primary care clinic or high school in Morocco. People who show meaningful signs of depression and/or anxiety based on screening questionnaires (called the PHQ-9 and/or GAD-7), at the levels set by the study. People who are able to understand…

People who are older than 18 years of age. People who are scheduled to have surgery to remove part or all of a lung due to lung cancer, with the goal of fully removing the cancer. People who have given their agreement to take part in the research study.

People aged between 8 and 18 years old. People currently enrolled in an elementary, middle, or high school in Michigan.

Women between 18 and 45 years of age People who have a baby between 1 and 12 months old People who are experiencing postpartum (after birth) depressive symptoms at a level considered clinically relevant, based on a standard screening score (EPDS score of 10 or higher) People who can read and write in Turkish People…

Women who are scheduled to have a breast biopsy. People who are older than 18 years of age. People who are able to give their informed consent to take part. People with no previous history of severe mental health conditions that could affect the measurement of depression, anxiety, or stress. People who are willing and…

People aged 18 years or older. People who do not currently have a diagnosed mental health condition. People who have not started any mental health treatment or medication for mental health in the past 3 months. People who are able to use the internet and are able to give informed consent to participate.

People aged 22 years or older. People who are currently going through a depressive episode with at least moderate symptom severity, as measured by a standard depression rating scale (HAM-D17 score of 17 or higher). People who have tried at least one antidepressant medication during their current or a previous…

People who are 18 years of age or older People who have had open heart surgery and currently have a chest tube in place People who are able to communicate verbally People who have never received a psychiatric diagnosis or treatment and are not currently taking any psychiatric medication People whose heart and blood…

People who have been diagnosed with a depressive disorder according to a standard international classification system called ICD-11 People aged between 18 and 60 years old People who are able to use a computer or smartphone People who are native Chinese speakers People who are willing to sign a consent form agreeing…

People who can speak and understand Turkish. People who have voluntarily agreed to take part in the study and have signed a consent form. People who are 18 years of age or older. People who are able to read and write. People who have not received any psychiatric diagnosis and are not currently receiving any…

The person must be pregnant at the time of joining the trial. The person must be 18 years of age or older. The pregnancy must be more than 37 weeks along. The pregnancy must involve a single baby positioned head-down, with a plan for a natural (vaginal) birth. The person must have been admitted to hospital during the…

People who have been diagnosed with breast cancer confirmed by a laboratory tissue test and have already had surgery for it People aged 18 to 59 who are currently raising at least one child under the age of 18 People whose breast cancer is classified as stage I, II, III, or IV People who are aware of their diagnosis…

People who are willing and able to give written consent to participate. Adults aged 18 to 45 years old (inclusive), who are healthy males or females, with an equal number of males and females enrolled. People who are willing to use effective contraception as required by the study and who have no plans for pregnancy…

People aged between 18 and 65 years. People who have been diagnosed with a depressive episode according to standard psychiatric guidelines (DSM-5), with mild-to-moderate depression symptoms as measured by a specific rating scale (HAMD-17 score between 8 and 23). People who have had ongoing pain lasting at least 3…

Children who are generally healthy or have only a mild health condition, as assessed by their medical team using a standard health classification system (ASA Class I or II)

Women who are pregnant with one baby (not twins or more). People who have had exactly one previous caesarean birth, where the cut on the uterus was made horizontally at the lower part. People whose doctor has assessed them as suitable for attempting a vaginal birth after their previous caesarean, in line with Israeli…

Adults aged 18 or older People who are fluent in English People who have normal hearing, or hearing that is corrected to normal (for example, with hearing aids) People who have normal vision, or vision that is corrected to normal (for example, with glasses or contact lenses) People who are currently experiencing…

People who consider themselves a caregiver for someone with Alzheimer's disease or a related form of dementia who lives at home People who live in the specific area targeted by this study People who have a cell phone and are willing to receive text messages from the study team People who have an email address where…

People who have previously experienced depression or an anxiety disorder but are currently in full or partial remission (meaning symptoms have been at a lower level for at least 2 months), based on scores from a standard questionnaire called the RCADS-47. People who speak a Scandinavian language fluently or as their…

People who have been diagnosed with Major Depressive Disorder (MDD) as their main condition. People who score 7 or higher on a standard depression rating scale called the MADRS, which measures depression symptoms. People who have normal vision, or vision that is fully corrected (for example, with glasses or contact…

People who are aged between 15 and 17 years old at the time of screening People who are fluent in Portuguese People who have access to a smartphone, tablet, or computer People who have reliable internet access For the clinical groups specifically: people who have a primary diagnosis of at least one anxiety disorder…

Adults aged 18 or older. People who are scheduled to have planned (non-emergency) surgery to remove breast cancer. People who fall into a low-to-moderate health risk category as assessed by their anaesthesia team (known as ASA classification I, II, or III). People who fully understand what the study involves and are…

Children between the ages of 6 and 12 years old. Children who need a dental procedure that requires a numbing injection (local anesthesia). Children who are generally cooperative at dental appointments, based on a standard behavior rating scale used by dentists (Frankl's classification classes 1 and 2). Children whose…

Pregnant women who are 18 years of age or older Women who have a planned (non-emergency) cesarean birth scheduled People who are able to read and understand Turkish and complete the study questionnaires People who are able to give written consent to take part People who have access to a smartphone and are able to use…

People who are able to give written consent to participate before any study procedures begin, and who are able to provide that consent independently. People who are male or female, aged between 21 and 70 years old (inclusive). People who have been diagnosed with Major Depressive Disorder (a serious form of depression)…

People aged 12 to 18 years old. People who have been diagnosed with major depressive disorder (a formal diagnosis of persistent low mood and related symptoms) according to recognised diagnostic guidelines, confirmed through a structured clinical interview, and who are currently experiencing a depressive episode.…

The person is between 12 and 18 years old. The person is a student at a local secondary school or youth service unit that is working with the trial. The person has mild to moderate depressive symptoms, as measured by a standardised questionnaire called the Chinese Depression Anxiety Stress Scale (DASS-Y), with a…

People who are having a bronchoscopy (a procedure where a thin, flexible tube with a camera is passed into the airways) for the first time. People aged 18 years or older. People who are able to read and understand written study materials. People who are willing to take part and can sign a written consent form. People…

People between 40 and 60 years of age. People who are in or around the menopause transition, which includes the following stages: early menopause transition (menstrual cycles becoming noticeably irregular, with periods arriving 7 or more days earlier or later than expected, and this pattern repeating); late menopause…

Women between the ages of 40 and 54 years old. Women who are in the perimenopause stage, as defined by a standard medical classification system called STRAW+10 (confirm with trial site for what this means in practice). People who are able to read and write.

People between 18 and 65 years old. People who are currently receiving chemotherapy through a small needle or tube inserted into a vein (commonly placed in the hand or arm). People who are mentally able to understand and respond to questions about pain, fear, and satisfaction. People who are willing to take part and…

Adults who are 18 years of age or older People who provide unpaid, informal care to someone living with Alzheimer's disease People who provide regular care for at least 10 hours each week People who are able to attend the sessions that are part of the trial program People who are able to understand and follow…

People who are 18 years of age or older People who identify as Latine People who are a caregiver to a child aged 18 years or younger who lives in the same household People who prefer to receive services in Spanish People whose scores for depression, anxiety, and/or PTSD fall in the moderate range, as measured by a…

People who are 18 years old or older. People who have been diagnosed with a depressive disorder, either a single episode or a recurring condition (under the ICD-11 diagnostic codes 6A70 or 6A71). People who are currently taking one of the following antidepressant medications for depression: an SSRI, an SNRI, a…

People between the ages of 18 and 30. People who are currently enrolled in medical school, whether in the early (classroom-based) or later (hospital-based) years of their program. People who own a smartphone. People who are able to read and understand English.

Adults between the ages of 18 and 65. People who are assessed by study staff as having the mental capacity to give informed consent. People who can read and communicate in English well enough to understand the consent form and study questionnaires, as assessed by study staff. People who are willing to follow all study…

People who are between 18 and 25 years old. People who score above 19 on a questionnaire called the Social Phobia Inventory, which measures social anxiety. People whose social anxiety is rated as at least moderately severe based on a standard assessment tool used by clinicians. People who are able to read the study…

People who are between 18 and 65 years old People who currently live in the United States People who are comfortable reading and writing in English People who have regular access to the internet and a desktop or laptop computer People whose main reason for joining the study is wanting to feel more comfortable in…

Children who are between 6 and 9 years old. Children who are scheduled to have a circumcision surgery. Children who have never had surgery before. Children who do not have any problems with their vision, hearing, or speech.

People who are able to give their own consent to participate. People who are right-handed. People who are currently receiving treatment for anxiety must have been on a stable treatment plan for at least 4 weeks before joining the study.

The child identifies as Latino. The child is fluent in English or Spanish. The child is between 5 and 15 years old. The child has been referred to one-on-one therapy with a participating clinician, mainly for anxiety, depression, trauma, or disruptive behaviors.

Medical students between the ages of 18 and 25 years old.

People aged 18 to 25 years old. People who are currently supported by a Mission Locale in Paris as part of a social and/or professional integration program. People who choose to take part voluntarily, after being given clear information about the study and signing a consent form. People who are experiencing severe…

The person must own a smartphone. Social media use must be more than 3 hours per day. The person must be between 12 and 17 years old. The person must be experiencing feelings of anxiety or depression. A caregiver must be able and willing to take part in the study alongside the young person. The person must be able to…

People aged 12 to 18 years old at the time of screening. People who have a current diagnosis of Major Depressive Disorder (a form of serious depression) recorded in their medical file by a licensed clinician. People who live with a parent or legal guardian for at least half of the time. People who are willing to agree…

Adults between 18 and 65 years of age. People who are admitted to hospital and scheduled for planned (non-emergency) lumbar disc herniation (lower back disc) surgery, before the operation takes place. People assessed by an anaesthetist as being in general health categories I, II, or III on the American Society of…

Adults aged 18 or older People who are currently admitted to a hospital addiction unit for acute alcohol withdrawal and who have an anxiety disorder People who are covered by a social security health insurance scheme, either as the main member or as a dependent People who speak and read French, are able to understand…

People who work as academics in the Faculty of Health Sciences at Istanbul Aydın University People who are between 23 and 65 years old People who have at least one year of experience working in an academic role People who are willing to take part and have signed a consent form agreeing to participate

Children between the ages of 6 and 10 who need dental treatment to repair or restore teeth. Children whose dental treatment requires a local anaesthetic (an injection to numb the area). Children who are able to understand and respond to simple rating scales used to measure dental fear and pain. Children who have been…

People who have been diagnosed with Schizoaffective Disorder according to current psychiatric diagnostic standards (DSM-5-TR) People who are currently experiencing an acute manic episode People who have not taken any psychiatric medication for at least one month before being admitted to the study People aged 18 years…

Adults aged 18 years or older People who are able to communicate effectively People having elective (planned, non-emergency) breast surgery for the first time, specifically radical mastectomy, modified radical mastectomy, or simple mastectomy

Female adolescents who have been diagnosed with depression and referred by a psychiatrist. Participants must be between 13 and 18 years old. Participants must have a BMI (a measure of body weight relative to height) between 15.5 and 24.9 kg/m². Participants must have a depression score between 11 and 30 on a standard…

People who are male or female and do not smoke. People who have no significant health concerns found during their screening assessments, as determined by the trial doctor. People whose body mass index (a measure of body weight relative to height) falls between 18.5 and 29.9 kg/m², including those exact values.

People who are willing to voluntarily sign a consent form before the trial begins, understand what the trial involves, and agree to follow the trial procedures throughout. People (and their partners) who are willing to avoid pregnancy from the screening stage until at least 6 months after the last dose of the study…

People who are 65 years of age or older People who are scheduled to have a dental filling People who score 24 or above on a standard memory and thinking assessment called the MMSE People who are able to communicate and understand what the study involves People who do not have a hearing problem that would stop them…

People who are receiving prenatal (before birth) care at one of the participating pregnancy care clinics People who have reported mild to moderate anxiety, based on a specific anxiety questionnaire called the GAD-7, with a score between 5 and 15 People who are currently pregnant and are less than 32 weeks along in…

The birth must have been a full-term live birth (at or after 37 weeks of pregnancy) at Massachusetts General Hospital. Access to the Patient Gateway online portal is required, as this is how a mood questionnaire will be sent electronically. The primary pregnancy care provider must be based at MGH or one of its…

Children who are generally healthy, with no vision or hearing problems. Children who are between 6 and 8 years old. Children who show a positive or cooperative attitude toward dental treatment, as measured by a standard behaviour rating scale (Frankl score of 3 or 4). Children who need to have one of their baby back…

People who are generally healthy and between 12 and 25 years old.

Children between the ages of 7 and 12 years old Children who are scheduled for planned (non-emergency) surgery for a broken bone in the arm, hand, or shoulder area Children whose pain relief plan after surgery involves receiving medication every 8 hours (three times a day) Children who are alert, clear-headed, and…

Adults aged 18 to 85 years People who are scheduled for planned (non-emergency) heart surgery, such as bypass surgery or heart valve repair or replacement People whose heart condition is classified as mild to moderate in terms of how it affects daily life (heart function class I–III) People who are willing and able to…

People aged 25 to 65 years old at the time of screening. People who are able to read, understand, and sign or electronically confirm their consent before screening, and who are expected to follow the study procedures and report any problems to study staff. People who are fluent in English. People who are able to…

Adults aged 18 to 65 years (inclusive), of any gender, and of Han Chinese ethnicity. People who have been diagnosed with a depressive disorder based on a specific set of recognised diagnostic guidelines (DSM-IV), confirmed through a structured psychiatric interview. People who are being treated as outpatients or…

People who are between 18 and 25 years old People who are experiencing mild to moderate depression (based on a standard questionnaire score) or mild to moderate anxiety (based on a standard questionnaire score) People who are able to understand what the study involves and agree to take part People who are willing to…

People aged between 18 and 85 years. People scheduled for a planned major abdominal operation under general anaesthesia, where the surgery is expected to last at least 2 hours and the hospital stay after surgery is expected to be at least 2 days. People whose overall health before surgery falls within a…

The person must be a veteran or a first responder (such as a paramedic, firefighter, or police officer). The person must be between 18 and 70 years of age. The person must have treatment-resistant depression — meaning they are currently experiencing a major depressive episode without psychotic features, and at least…

Adults between 18 and 70 years old (any sex) may be eligible. People who score 5 or higher on a standard anxiety questionnaire (GAD-7) and/or have an elevated score on a cardiac anxiety measure (CAQ) may be eligible. People whose score on a standard depression questionnaire (PHQ-9) is below 20 may be eligible. People…

The person has signed a written consent form agreeing to take part in the trial. The person has been diagnosed with Major Depressive Disorder (a serious form of depression) according to standard psychiatric guidelines known as DSM-5. The person scored 28 or higher on a depression rating scale called the MADRS at the…

People who identify as female athletes, whether recreational or professional People aged 18 to 65 years old People who have been diagnosed with a concussion (at least 72 hours ago) and whose Post-Concussion Symptom Scale (PCSS) score is above 7, or who have more than 4 concussion-related symptoms present People whose…

People who are scheduled to have a type of kidney stone surgery called Retrograde Intrarenal Surgery (RIRS) People who are 18 years of age or older People who are awake and able to communicate People who speak and understand Turkish People whose overall health and vital signs (such as blood pressure and heart rate)…

Pregnant women between 18 and 45 years of age. Women who are giving birth for the first time. Women who are between 37 and 42 weeks pregnant (full-term pregnancy). Women carrying a single baby who is positioned head-down. Women who have a vaginal birth that requires a specific type of surgical cut (called a…

People who have been diagnosed with bipolar depression. People who score 24 or higher on a standard depression rating scale called the MADRS (a tool doctors use to measure how severe depression symptoms are). People who are able to give their informed consent to participate. People who are currently receiving care…

Mothers between 19 and 45 years old who are experiencing a depressive episode that started either during pregnancy or within 12 months after giving birth, and who have a living child aged 0 to 28 months old at the time of joining the trial People who score 13 or higher on a standard depression screening questionnaire…

People who are 18 years of age or older. People who are having eye surgery using topical or local anesthesia (numbing the eye area, while staying awake). People who are awake, able to communicate, and mentally able to answer questions during the procedure. People who do not have any hearing, speech, or language…

Women between the ages of 18 and 45 years old Women who have given birth by caesarean section Women who are within the first 24 hours after giving birth People who are able to communicate in Turkish Women who have given birth to a single, healthy baby Women who are willing to take part and have agreed to participate…

People who are between 40 and 60 years old People who can understand and communicate in English People who have not yet filled out any advance care planning documents (such as a living will or similar paperwork) People who are able and willing to take part in the Die-logue programme and complete surveys

People who are older than 60 years of age. People who show signs of difficulty with executive functions (such as planning, organising, or attention), either through self-reported problems on standardised questionnaires or through results on cognitive performance tests. People who have a diagnosis of a depressive…

People aged 15 years or older People who have been diagnosed with a depressive disorder based on standard psychiatric diagnostic criteria Adults who have depression that has not responded to previous treatments (known as treatment-resistant depression) Adolescents who have a depressive disorder that requires treatment…

People enrolled as a health student at the Faculty of Health, Université de Rouen Normandie, in any program or discipline. People aged between 18 and 30 years. People who meet at least one of the following signs of financial difficulty: not having enough money each month to cover basic living costs; regularly going…

People who are 18 years of age or older People who are currently pregnant (at any stage of pregnancy) or have recently given birth People who have experienced at least one pregnancy complication or difficult pregnancy outcome People who are admitted to hospital for an extended stay People who speak English

People who are patients at the location where the study is being conducted. People whose PHQ-9 depression questionnaire score falls between 10 and 20, indicating moderate to moderately severe depression symptoms. People who are able to follow a self-help program that involves reading materials written in English and…

People who are willing to take part in the study voluntarily People who are currently enrolled as nursing students People who have completed the pre-test required by the trial People whose pre-test results show a stress score that is outside the normal range (meaning their stress levels are higher than normal) People…

People who have been diagnosed with an anxiety disorder according to the ICD-11 diagnostic guidelines (confirm with trial site) People who are between 18 and 60 years of age People who have completed at least 9 years of schooling People who are able to use a computer or smartphone People whose first language is…

Adults aged 18 or older who are currently admitted to the USP - HUS hospital. People with an estimated life expectancy of at least 1 month, as assessed using a specific clinical scoring tool called the Pronopall score. People who score 26 or above on a standard memory and thinking assessment called the Montreal…

The child is between 6 and 12 years of age The child has a baby tooth that needs to be removed using numbing injections on both the cheek side and tongue side of the mouth The child falls into category 2, 3, or 4 on the Frankl Behavior Scale, which is a scale used by dental professionals to rate a child's behaviour…

Adults aged 55 or older who live in the community (not in a care facility or hospital). People who can communicate in Mandarin or Taiwanese and are able to understand the study instructions and take part in group discussions. People who are able to fill out study questionnaires on their own or with help from the…

Adults aged 18 years or older People who need a peripheral intravenous catheter placed (a small needle/tube inserted into a vein, usually in the arm or hand) People who are awake and able to communicate People who agree to take part and sign a consent form

Children who are between 6 and 8 years old. Children who are cooperative during appointments. Children who are developing intellectually at a normal level. Children who are willing to agree to take part, and whose parent or guardian is willing to sign a consent form. Children who are generally healthy with no ongoing…

People who are scheduled to have an implantable port (a small medical device placed under the skin to allow easier access to a vein) fitted in the Radiology Department at CHUGA. People who are 18 years of age or older.

Women aged 18 years or older People who are scheduled to have a mammogram and a breast ultrasound People who have never had a mammogram or breast ultrasound before People who are able to read and understand the study materials People who do not have any condition affecting the movement or feeling in their hands or…

People who are able to give their informed consent to participate in the study. People who are right-handed (this is required to keep certain brain measurements consistent across participants).

People who work in healthcare as a physician, nurse, nurse practitioner, or physician assistant and are currently practising clinically. People aged between 25 and 70 years old. People who feel they used to find deep meaning in their work as a healthcare clinician but that sense of meaning has faded over the past 5…

People aged between 21 and 60 years old. People who are fluent in English. People who are able to swallow capsules. People who are currently experiencing a major depressive episode, or who have a history of major depressive episodes, as defined by standard diagnostic guidelines (DSM-5). People who currently have…

The participant must be female. The participant must be actively enrolled in an undergraduate Nutrition program at the time the study data is being collected. The participant must agree to take part in the study.

People who choose to take part voluntarily and have signed a written consent form People who have been diagnosed with Generalised Anxiety Disorder (GAD) according to standard international diagnostic guidelines (ICD-10) for at least the past one year People who are between 18 and 60 years old People who are able to…

People who are willing and able to give their written agreement to take part voluntarily People who are between 16 and 25 years old People who are currently enrolled at BUAP People who are proficient in the Spanish language People who have access to a mobile device with an internet connection People who are able to…

People who are over 18 years of age People who can speak and understand Turkish People who do not have any cognitive, visual, or hearing difficulties People who have been diagnosed with cancer (Stage I, II, or III, any cancer type) within the last month People who have already started active treatment for their cancer…

Adults aged 18 to 65 years. People who are able and willing to sign a written consent form agreeing to take part. People who have been diagnosed with schizophrenia, bipolar disorder, or major depressive disorder according to recognised diagnostic standards, confirmed through a structured interview tool called the…

You are a junior or senior high school student currently studying in mainland China, between the ages of 10 and 19 Between 6 and 60 months before the study period, you experienced the death of a close family member or friend Your score on a grief symptom questionnaire called the PG-13-R falls between 20 and 29 points…

People who are able to safely receive TMS (a type of brain stimulation) and the study medications being used in the trial People who have been on a stable medication routine for at least one month before the study and are able to stay on that same routine throughout the study People who are not currently receiving…

Girls who are between 13 and 18 years old Girls who are unmarried Girls who are living in selected villages in Uttar Pradesh, India Girls who have higher-than-normal levels of anxiety and/or depression, as measured by a specific screening questionnaire (the RCADS-25) Girls whose family has access to at least one…

People aged 18 years or older. People who are able to read and speak in English. People who are able to understand what the study involves and can sign a written consent form. People who are currently experiencing a major depressive episode lasting at least 2 weeks, confirmed through a structured clinical interview…

People who have no remaining teeth and need their first set of complete dentures.

People who are experiencing symptoms of depression

People who are 18 years of age or older. People who are between 4 weeks and 12 months after giving birth. People who are able to read and understand a Chinese-language questionnaire and can use a smartphone. People who are willing to take part and have signed a written consent form agreeing to participate.

Women who are pregnant and aged 18 years or older Women who are less than 25 weeks pregnant at the time of joining the trial People who are able to communicate in Chinese and agree to take part after being fully informed People who are willing to take part in the study and attend all required follow-up appointments

People who are able to understand the study procedures and are willing to give written consent to participate (or whose legal guardian can give consent on their behalf) People aged 14 years or older, of any sex People who have previously received an allogeneic hematopoietic stem cell transplant (a transplant using…

People who are currently enrolled as medical students at Sohag University Faculty of Medicine People of any gender are eligible People who are willing to give their informed consent to take part in the study

People who have been diagnosed with major depressive disorder by two separate psychiatrists, using a standard set of medical guidelines called the DSM-5. People whose depression symptoms score above 20 on a standard rating scale called the HAMD-24, measured at the start of the trial. People who are between 18 and 65…

Children who are healthy and between six and nine years old. Children who show a specific level of anxious or uncertain behaviour (a score of 2 on a standard dental behaviour scale) when assessed before the procedure. Children who have matching baby molar teeth on both sides of the lower jaw that a dentist has…

Adults aged 18 years or older People who speak Spanish and prefer to receive services in Spanish People who live in a rural or remote community in Montana or New Mexico People who screen positive for symptoms of depression at or above the level required by the study, based on a Spanish-language screening tool People…

People who are seeking treatment primarily because of symptoms of Generalised Anxiety Disorder (GAD) and/or Major Depressive Disorder (MDD), as assessed by a Psychological Well-being Practitioner — a formal diagnosis is not required. People whose symptom scores on a standard screening questionnaire fall within a…

Children between the ages of 3 and 10 years old Children who are scheduled for a planned surgery to remove the adenoids, tonsils, or both Children who are generally healthy or have only mild health conditions, as assessed by an anaesthesiologist using a standard health classification scale (ASA status I or II)…

Adults aged 18 years or older People who are the main unpaid caregiver for a family member (such as a spouse, sibling, parent, or child) or a friend who has a long-term illness and/or disability People who have been providing that unpaid care for at least six months People with normal hearing, including those who use…

People who are currently enrolled as active students in the Faculties of Medicine, Nursing, Pharmacy, Dentistry, or Psychology at Istanbul Nisantasi University People who are between 18 and 25 years old People who have given their voluntary agreement to take part by signing a digital consent form

Mothers aged 18 years or older who have a baby between 0 and 12 months old People who live in or close to the study area and plan to stay in that area for the next 12 months People who show mild to moderate signs of depression based on the study's screening assessment People who are willing and able to give their…

Young people between the ages of 12 and 17 years old. People who have been admitted to an inpatient psychiatric unit following a suicide attempt or because they are having active thoughts of suicide. Both the young person and their parent or guardian must be able to speak and understand English. Both the young person…

People who are 18 years of age or older. People who are caring for someone living with dementia and who score 5 or higher on two depression screening tools called the PHQ-8 and PHQ-9. People who are able to communicate in English. People who have access to an Android or Apple (iOS) phone or tablet that can run the…

People who can read and speak Finnish or Swedish fluently People who have access to a computer or mobile phone with an internet connection People who are between 12 and 22 weeks pregnant People who scored 10 points or higher on a standard depression screening questionnaire (called the EPDS) at the start of the trial

People who are currently a fourth-year anesthesiology resident (PGY4) at Massachusetts General Hospital or Brigham and Women's Hospital. People who are willing to give their informed consent to participate. Each resident may choose one person close to them — such as a partner, family member, friend, or other loved one…

People who are outpatients or inpatients at The Second Xiangya Hospital of Central South University. People who have been diagnosed with generalised anxiety disorder as their main diagnosis by two experienced psychiatrists, using an established international diagnostic system (ICD-11). People with a score of 14 or…

People aged 21 years or older. People who are able to lie comfortably on their back during scanning. People who agree to use one of the contraception methods listed in the trial's appendix. People who are able to give written informed consent and are willing to follow the requirements and restrictions outlined in the…

People who are pregnant and scheduled to give birth by caesarean section People who are 18 years of age or older People who are at least 37 weeks pregnant

People who are 18 years of age or older. People who can communicate in Mandarin Chinese or Taiwanese and are able to complete questionnaires. People who are classified as ASA Physical Status I or II, meaning they are generally healthy or have only mild health conditions (confirm with trial site). People who are…

People aged between 18 and 40 years old People with a BMI between 18.5 and 24.9 (for study groups 1 and 2) or a BMI between 25.0 and 39.9 (for study groups 3 and 4) People who are able to understand what the study involves and agree to take part People who have provided written consent to participate Women in study…

Students who apply for the group intervention program People who own a smartphone that can connect to the internet People where both the participant and their legal guardian agree to take part in the study

People aged 55 years or older. People who score between 7 and 10 on a standard geriatric depression screening tool (GDS-15), or between 35 and 64 on a standard loneliness measurement scale (UCLA Loneliness Scale Version 3). People who are able to understand what the research involves, meet its requirements, and are…

Adults aged between 18 and 55 years (male or female) People who have been diagnosed with Major Depressive Disorder (a formal diagnosis of serious, ongoing depression) People whose depression has not responded well to at least two different antidepressant medications, taken at appropriate doses for an appropriate…

Adults between 18 and 60 years of age People who have been diagnosed with bipolar I depression, identified using a standard set of psychiatric guidelines called the DSM-5 People who have been taking a mood stabiliser (either lithium or valproate) at the same dose for at least 2 weeks People whose depression symptoms…

Adults aged 18 years or older. People who are scheduled to have a planned (non-emergency) gynaecological surgery at a participating centre that is able to offer virtual reality. People who are able and willing to give their written agreement to take part in the study, be randomly assigned to a group, and use virtual…

People who are 18 years of age or older. People who are scheduled for a planned (non-emergency) surgery that requires anesthesia. People who are able to understand Turkish. People who are able to sign a written consent form agreeing to take part.