Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were diagnosed with a Major Depressive Episode (a formal diagnosis of serious depression) during the period of depression for which they received their rTMS treatment.
• People whose depression has responded to or gone into remission following their rTMS treatment, meaning their depression symptoms have either largely resolved or reduced by more than half from the start to the end of treatment.
• People whose initial rTMS treatment course included at least 15 rTMS sessions.
• People aged between 18 and 80 at the time of screening, with a written statement from their referring doctor confirming they have the capacity to consent.
• People who are able to read, understand, and sign a consent form, have enough English to complete questionnaires and follow instructions during the study, and are willing to follow all study procedures for its full duration.
• People who are in generally good health based on their medical history.
• People who agree to follow any lifestyle guidelines set out by the study throughout its duration.
• People who are capable of becoming pregnant must have a negative pregnancy test at the screening visit, confirmed by study staff.

Who may not be able to join:

• People who are currently pregnant.
• People who have a current or past diagnosis of a psychotic disorder, or depression with psychotic features.
• People with severe borderline personality disorder, based on clinical assessment.
• People who have a diagnosis of Intellectual Disability or Autism Spectrum Disorder.
• People with a current moderate or severe substance use disorder, or who are showing signs of acute withdrawal from substances.
• People who currently have serious thoughts of suicide that include a plan.
• People who have had more than 8 sessions of electroconvulsive therapy (ECT) without a meaningful clinical improvement during their current depressive episode.
• People who have used certain fast-acting antidepressant treatments, such as ketamine or a course of ECT, in the last 30 days during the current depressive episode.
• People with a significant history of neurological conditions, such as dementia, Parkinson's disease, Huntington's disease, brain tumour, seizure disorder, blood clots under the skull, multiple sclerosis, or significant head injury.
• People with an untreated or insufficiently treated hormone/endocrine disorder.
• People who have medical reasons that make rTMS unsafe for them, such as metal in the head, a history of seizures, or a known brain lesion.
• People who are currently taking part in another clinical trial or receiving an investigational treatment.
• People whose depression returns between the baseline and screening visits, defined as a notable worsening of symptoms based on depression rating scores.
• People who require higher doses of certain sedative medications (benzodiazepines above a specified dose) or most anti-seizure medications (with the exception of gabapentin, pregabalin, and lamotrigine).

Important: Always verify eligibility with the trial site directly before applying.