Bipolar Disorder

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with Bipolar I Disorder according to standard medical guidelines - You have had at least one manic, mixed, or depressed episode in the past 2 years - Your mood symptom scores are at or above a certain level on standard ra...

**Who might be able to join this trial:** - People who previously took part in one of the related double-blind studies (CN0120036, CN0120037, or CN0120046) and completed the full treatment period of that study. - People who did not take part in the earlier studies but have a confirmed primary diagnosis of Bipolar I di...

**Who might be able to join this trial:** - People who have been formally diagnosed with Bipolar I disorder through a full psychiatric evaluation - People who are currently experiencing an acute manic episode or a manic episode with mixed features that has lasted 3 weeks or less - People whose condition requires them...

Who might be able to join this trial: - People aged 3 to 99 years old may be considered for this trial. - People who are able to understand the purpose of the screening process and are willing to take part in research approved by the NIMH ethics board. For children, the child will be asked if they agree to participate,...

Who might be able to join this trial: **Children and teenagers with a condition called DMDD (severe mood dysregulation) or a milder form of it:** - Children aged 7 to 17 at the time of joining, with follow-up continuing until age 25 - Children who experience abnormal mood — such as ongoing anger, sadness, or irritabil...

Who might be able to join this trial: - Adults who have been admitted (to the relevant facility) and have given written agreement to take part in the study Who may not be able to join: - People who do not have the mental or legal capacity to give their own informed consent to participate Important: Always verify elig...

Who might be able to join this trial: - You must be between 9 and 21 years old and already taking part in the FORBOW (Families Overcoming Risks and Building Opportunities for Well-Being) study. - You must show at least one of the following: experiences that feel like psychosis (such as unusual perceptions or beliefs),...

Who might be able to join this trial: - People who have been having nightmares at least once a week for the past month - People who have been formally diagnosed with Bipolar Disorder (Type I or Type II) - People who have experienced a traumatic event that happened at least one month ago - People who have been on stable...

**Who might be able to join this trial:** - You are a man or woman between 18 and 65 years old (inclusive) - You have been diagnosed with Bipolar Disorder Type I or Type II (according to DSM-IV criteria) - You are able to read and sign a consent form to participate in the study - You have been taking an approved medica...

Who might be able to join this trial: - You must be able to speak and understand English - You have been diagnosed with Bipolar Disorder - You are able to read, understand, and sign a consent form agreeing to take part Who may not be able to join: - You have significant problems with memory, thinking, or understanding...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder or Schizophrenia, based on the DSM-IV diagnostic standard Who may not be able to join: - People who are pregnant - People who have received a vaccine in the 4 weeks before joining the trial - People with a serious neurological...

Who might be able to join this trial: - You are aged 19 or older but under 70 years old at the time you give your consent to join. - You are able to understand the information given to you and agree to take part in the study. - You have been taking a mood stabilizer medication — either lithium or valproic acid. - You h...

**Who might be able to join this trial:** - People who have been diagnosed with Bipolar I or Bipolar II disorder, confirmed through a structured clinical interview - People between 18 and 65 years of age - People currently experiencing a depressive episode that scores 25 or above on a standard depression rating scale...

Who might be able to join this trial: - People who are already enrolled in a study called FORBOW (Families Overcoming Risks and Building Opportunities for Well-being). - People between the ages of 12 and 21 years old. - People with enough understanding of English to take part in and benefit from the program. - People w...

Who might be able to join this trial: This trial has five separate groups. People may be considered for one group depending on their situation: **Group 1 – Bipolar disorder without current anxiety or substance use disorder:** - Adults aged 18 or older of any gender - People who have been diagnosed with bipolar I or I...

Who might be able to join this trial: - You have freely agreed to take part and given your informed consent - You are a man or a woman aged between 18 and 80 years old - You have normal vision, or vision that is corrected with glasses or contact lenses - You can read and speak French - You do not have severe memory pro...

Who might be able to join this trial: - People who are at least 18 years old at the time of joining the trial - People who have been diagnosed with a depressive episode, either unipolar depression or bipolar depression, according to standard diagnostic guidelines (ICD-10) - People for whom electroconvulsive therapy (EC...

Who might be able to join this trial: - People who are older than 65 years of age - People who have been diagnosed with bipolar disorder for more than 10 years - People who are currently in a stable phase of their bipolar disorder (not currently experiencing a mood episode) - People who understand and speak French - Pe...

Who might be able to join this trial: **For people with Bipolar Disorder (Patient Group):** - People aged 18 to 75 years old, male or female - People who have been diagnosed with Bipolar Disorder type I or type II - People currently experiencing a depressive episode that has not responded to treatment, lasting at leas...

**Who might be able to join this trial:** - You have been officially diagnosed with Bipolar I Disorder (confirmed using a specific structured interview tool used with children and adolescents). - Your current depressive episode (period of low mood) has been going on for more than 2 weeks but less than 12 months. - You...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder (either Type 1 or Type 2, based on standard diagnostic guidelines known as DSM V) - People who score lower than 7 on a mood screening tool called the Mood Disorder Questionnaire (MDQ) - People who have problems with sleep or di...

**Who might be able to join this trial:** - You have given written agreement (consent) to take part in the study - You have been diagnosed with schizophrenia (based on DSM-V medical guidelines), with or without signs of cognitive decline - You have been diagnosed with bipolar disorder (based on DSM-V medical guidelines...

**Who might be able to join this trial:** - People between the ages of 18 and 65 years - People who have been diagnosed with moderate or severe cannabis use disorder in the past 3 months, test positive for cannabis on a urine screen at the start of the study, and consider cannabis their main substance of concern - Peo...

**Who might be able to join this trial:** - You must be able to speak and understand English - You must be between 13 years old and 23 years and 11 months old - You have been diagnosed with bipolar disorder (BD) using a standard diagnostic interview, OR you have a biological parent or sibling who has been diagnosed wit...

**Who might be able to join this trial:** - You speak English - You are between 13 years old and 23 years and 11 months old - You have been diagnosed with bipolar disorder (BD) through a clinical interview, OR you have a biological parent or sibling who has been diagnosed with bipolar disorder (type I or II) - If you h...

**Who might be able to join this trial:** **For patients:** - You are 18 years old or older - You have been diagnosed with bipolar disorder (type I, II, or unspecified) based on standard diagnostic guidelines - You are able to understand what the study involves, why it is being done, and how it works - You have a care...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder and experience a noticeable loss of interest or pleasure in activities (anhedonia) - People who are currently experiencing mild symptoms of depression Who may not be able to join: - People who have a history of substance abuse...

**Who might be able to join this trial:** - People who have given their signed agreement to participate in the study. - People who have been voluntarily admitted to a psychiatric ward around the time of the initial screening appointment. - People aged between 18 and 65 years old on the day of their screening appointme...

**Who might be able to join this trial:** - Young people aged 13 to 17 who have been diagnosed with schizophrenia, or aged 10 to 17 who have been diagnosed with bipolar I disorder, based on standard diagnostic guidelines (DSM-5) - People who are already receiving care as an outpatient, or who the trial doctor believes...

Who might be able to join this trial: - People who are experiencing their first episode of psychosis - People aged between 15 and 30 years old - People who are able to give consent and have signed a consent form (for those under 18, a parent or guardian must also give consent) Who may not be able to join: - People who...

Who might be able to join this trial: - People who are 18 years of age or older - People currently experiencing a major depressive episode, as defined by standard psychiatric diagnostic guidelines (DSM-5) - People who have not been treated with lithium-based medication in the past 12 months - For the suicidal attempter...

Who might be able to join this trial: - Young people between 9 and 19 years old - Young people who have been diagnosed with Bipolar Disorder (Type I, Type II, or Other Specified) or Cyclothymic Disorder by the study team during a screening interview - Young people who can read and communicate in English well enough to...

Who might be able to join this trial: - People who are willing and able to give their informed consent to participate - People aged between 18 and 65 years old - People who are fluent in English - People who have been diagnosed with bipolar disorder (type I or type II) according to standard diagnostic guidelines - Peop...

**Who might be able to join this trial:** - Both biological parents are of Han Chinese nationality - People aged 16 to 65 years old - People who have been clinically diagnosed with a depressive episode of major depressive disorder (MDD) or bipolar disorder (BD), based on DSM-5 diagnostic criteria - People who have not...

**Who might be able to join this trial:** **For patients:** - People who have been diagnosed with bipolar disorder, unipolar depression, schizophrenia, or autism spectrum disorder (based on recognised diagnostic standards called DSM IV criteria) - People aged 18 or older - People enrolled in the French social security...

**Who might be able to join this trial:** *For Veterans:* - You are a Veteran who has had thoughts of killing yourself in the past month and/or made a suicide attempt in the past 3 months - You have been diagnosed with a serious mental illness, such as schizophrenia, a psychotic disorder, bipolar disorder, or a mood d...

**Who might be able to join this trial:** - People who are inpatients or outpatients aged at least 18 up to 70 years old (for the schizophrenia group), at least 18 up to 65 years old (for the depression group), or at least 18 with no upper age limit (for the bipolar disorder group). - People who are willing and able t...

Who might be able to join this trial: - You must have already taken part in a specific related study called DB1 (049-2021) or DB3 (009-2021) - You must be able to speak and understand English - You must be between 14 years old and 26 years and 11 months old - You must have a diagnosis of bipolar disorder confirmed thro...

Who might be able to join this trial: - The patient is willing to take part and able to complete all parts of the study - A parent or legal guardian is willing and able to give consent on the patient's behalf - The patient is between 12 and 17 years old (inclusive) - The patient has been clinically diagnosed with eithe...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been informed of the results of their initial medical assessment - People who are covered by a social health insurance plan (either as the main member or as a family member of a main member) - People who have been dia...

Who might be able to join this trial: - People aged between 18 and 25 years old. - People who have a primary diagnosis of an anxiety disorder, depressive disorder, or bipolar disorder, confirmed by a specific clinical assessment tool used by the trial team. - People diagnosed with bipolar disorder must currently be in...

**Who might be able to join this trial:** - You currently have significant depression, confirmed by a standard depression questionnaire score and a structured clinical interview - You are currently having thoughts of death or wishing to be dead, as shown by your score on a standard questionnaire - Your depression has...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder I or II according to standard diagnostic guidelines (DSM-5) - People aged 18 to 65 years old - People who have not had a major mood episode (such as a severe depressive or manic episode) for at least 3 months before joining, co...

**Who might be able to join this trial:** - Adults between 18 and 50 years of age - People who have been diagnosed with Bipolar I Disorder (using the DSM-5 criteria), where the illness began within the last 10 years - People who are currently experiencing at least two specific depression-related symptoms, such as depr...

**Who might be able to join this trial:** - You are between 21 and 26 years old - In the past year, you have had at least 4 drinks (if male) or at least 3 drinks (if female) on a single occasion - You are in a stable, balanced mood at the time of joining the study - *(For people with bipolar disorder only)* You have be...

**Who might be able to join this trial:** - People aged 18 to 60 years old, of any gender. - People who have been diagnosed with bipolar disorder or schizophrenia (according to ICD-10 diagnostic standards), and whose condition is currently in remission or is stable enough to participate in research. - People who are c...

Who might be able to join this trial: - People aged 19 to 70 years old (inclusive), of any sex. - People who have been diagnosed with Bipolar I or Bipolar II disorder and are currently experiencing a major depressive episode, confirmed by a structured clinical interview. - People who are currently taking a mood-stabili...

**Who might be able to join this trial:** - People who have been diagnosed with Bipolar Disorder Type 1 (BD-1) according to standard psychiatric guidelines (DSM-5) - People aged between 18 and 70 years old - People who have been taking lithium as part of their treatment for more than one year - People whose mood is cur...

Who might be able to join this trial: - You have been diagnosed with bipolar disorder (type 1 or type 2) and are currently going through a depressive episode, as defined by standard diagnostic guidelines (DSM-5). - Your depression is scored as at least 21 out of 50 on a self-reported depression questionnaire called the...

**Who might be able to join this trial:** - People who are adults (18 years of age or older) - People who have been diagnosed by a psychiatrist with one of the following conditions: a depressive episode with psychotic features, Bipolar Disorder Type I, Bipolar Disorder Type II, Schizoaffective Disorder, Schizophrenia,...

Who might be able to join this trial: - People aged between 18 and 65 years old - People who have been diagnosed with unipolar or bipolar depression (whether related to seasons or not), confirmed through a structured psychiatric interview - People who are currently experiencing a depressive episode, shown by a score of...

**Who might be able to join this trial:** - Adults aged 18 or older, whether currently in hospital or being treated as an outpatient. - People who are able and willing to sign a consent form agreeing to take part (a legal guardian may co-sign if needed). - Women who could become pregnant must use effective contracepti...

**Who might be able to join this trial:** - People who are between 18 and 65 years old - People who have been diagnosed with Bipolar I Disorder (type 1) and are currently experiencing a depressive episode, according to standard psychiatric diagnostic guidelines - People who have been on a stable dose of certain mood-r...

Who might be able to join this trial: - People who score in the clinical range for depression on a standard self-report questionnaire called the PHQ-9 - People who have been diagnosed with depression based on a structured diagnostic interview called the DIAMOND - People who have been diagnosed with Bipolar I or Bipolar...

Who might be able to join this trial: - People diagnosed with a specific type of dementia affecting behaviour and personality (called behavioural variant frontotemporal disorder), based on recognised medical diagnostic standards - People who show early or possible signs of frontotemporal dementia but have no abnormalit...

Who might be able to join this trial: - You are going through your first experience of psychosis and are being evaluated at one of the following clinics: McLean Hospital OnTrack Clinic, Massachusetts General Hospital FEPP Clinic, Boston Medical Center WRAP Clinic, Cambridge Health Alliance RISE Clinic, UMass Memorial H...

Who might be able to join this trial: **All participants must meet these criteria:** - People aged between 18 and 40 years old - People who are not currently following a ketogenic (very low carbohydrate) diet **For the Bipolar Disorder (BD) – Hypomanic group:** - People with a diagnosis of Bipolar I or Bipolar II dis...

Who might be able to join this trial: - People aged 18 to 55 years, of any gender - People who have been diagnosed with bipolar disorder according to standard diagnostic criteria (DSM-V) - People who are currently experiencing a major depressive episode - People whose depression is severe enough to score above 11 on a...

Who might be able to join this trial: - People aged 18 years or older - People who have been clinically diagnosed with bipolar disorder type I or type II - People whose lithium levels in the blood have reached a stable therapeutic range (0.6–1.0 mM for those under 65, or 0.4–0.8 mM for those aged 65 and over) within th...

Who might be able to join this trial: - You have been diagnosed with Bipolar Disorder Type II, confirmed through a specific structured interview called a SCAN interview - You are between 18 and 70 years old - You are able to understand and give your own informed consent to take part in the trial Who may not be able to...

**Who might be able to join this trial:** - You have been diagnosed with Bipolar I or Bipolar II disorder (not cyclothymia or other related conditions) - You are currently experiencing sleep problems, such as trouble sleeping, sleeping too much, or issues with your body clock (like going to sleep very late or at irreg...

Who might be able to join this trial: - People who are older than 18 years of age - People who have been diagnosed with schizophrenia, psychosis, or bipolar affective disorder - People who are receiving treatment at Vestre Viken healthcare company, specifically at either Asker District Psychiatric Center or Blakstad Ho...

**Who might be able to join this trial:** - You are a Veteran who has been formally diagnosed with Bipolar I Disorder, Bipolar II Disorder, or a similar bipolar condition (confirmed through a structured interview and/or medical records) - You have experienced at least one bipolar episode in the past 12 months, based o...

Who might be able to join this trial: - You are between 18 and 45 years old. - You are able and willing to follow the specific diets required by the study. - You have been diagnosed with bipolar I disorder or schizoaffective disorder, and your illness began within the last 7 years. - Your mental health condition is cur...

**Who might be able to join this trial:** - You are able to understand and agree to take part in the study on your own. - You have been diagnosed with Bipolar Disorder I or II. - You tend to feel most alert and active in the evening rather than the morning (based on a specific questionnaire score). - You are experienci...

**Who might be able to join this trial:** - People of any gender between the ages of 24 and 65 - People who have been diagnosed with bipolar I or bipolar II disorder (as defined by standard psychiatric guidelines) - People who are currently experiencing a depressive episode, confirmed by a standard mood rating scale -...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose general health and ability to carry out daily activities meets a certain minimum level (known as an ECOG performance status of 2 or below — confirm with trial site if unsure what this means for a specific situation) - People who have be...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder type I or type II, as defined by the DSM-5 (a standard medical guide used to classify mental health conditions) - People who are currently experiencing depressive symptoms, based on a score above 12 on a standard depression rat...

**Who might be able to join this trial:** - You are able to understand and agree to participate in the study on your own - You are currently being treated as an outpatient (not staying in hospital) - You have been diagnosed with bipolar disorder (type I or II) and are currently in a depressive episode, confirmed by a...

**Who might be able to join this trial:** - People who have been diagnosed with bipolar disorder using a standardised clinical interview based on the DSM-5 diagnostic guidelines - People with bipolar disorder whose condition is currently stable and not in an active mood episode, with no hospital admissions in the four...

Who might be able to join this trial: - People who have been diagnosed with a psychotic disorder or bipolar disorder, as classified by the ICD-10 (an international medical classification system) - People between the ages of 18 and 65 - People who are able to read, understand, and sign a written consent form - People wh...

Who might be able to join this trial: **For people with a mood disorder:** - People aged 16 years or older - People who have been diagnosed with a bipolar disorder or depressive disorder, as defined by standard psychiatric guidelines (DSM-5) - People who are fluent enough in English to complete interviews and question...

**Who might be able to join this trial:** - You are 12 years old or older, male or female, right-handed, and of Han ethnicity - You have been diagnosed with depression according to standard diagnostic guidelines (DSM-5), with depression scores above a certain level and mood/mania scores below a certain level (confirm w...

**Who might be able to join this trial:** - You are a woman between the ages of 20 and 80 - You are scheduled for surgery that removes only part of the breast (not the whole breast) and includes a procedure to check nearby lymph nodes - You have a body mass index (BMI) over 25, or you have already received chemotherapy...

**Who might be able to join this trial:** - People aged 18 years or older - People who have already signed consent for a related NIH study called Protocol 01-M-0254 (The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers) - People who are able to give informed consent to participate - People...

**Who might be able to join this trial:** - You have been diagnosed with Bipolar Disorder Type I or Type II - You are an adult between 18 and 60 years old (any gender) - You have been taking medication for Bipolar Disorder for at least one month - You are willing to take part and sign a consent form **Who may not be a...

Who might be able to join this trial: - You must be 18 years old or older - You must have been diagnosed with bipolar disorder and received care (either as an outpatient, in a day hospital, or outside of a hospital setting) between January 1, 2022 and February 29, 2024 - There must be no record in your medical file sho...

Who might be able to join this trial: - Adults between 18 and 65 years old. - People who are considered able to make their own informed decisions about taking part in research. - People who are willing to sign and date a consent form and follow all study procedures. - People who can read and communicate in English well...

Who might be able to join this trial: - People aged between 18 and 65 years, of any gender, who are experiencing a moderate to severe major depressive episode (based on standard psychiatric criteria and a specific symptom score of 19 or above on a rating scale called the MADRS) - People who have health insurance covera...

Who might be able to join this trial: - People who have a confirmed diagnosis of bipolar depression - People between 18 and 65 years of age - People whose depression symptoms are rated as moderately severe or above on a standard assessment scale (a score of 17 or higher on the 17-item Hamilton Depression Rating Scale)...

**Who might be able to join this trial:** - People for whom ECT (electroconvulsive therapy) has already been recommended by their primary psychiatrist as a clinically appropriate treatment - Adults aged 18 to 90 years old, of any gender - People who currently meet the diagnostic criteria for a major depressive episode...

**Who might be able to join this trial:** - People who have been diagnosed with bipolar I disorder or bipolar II disorder (not other related conditions such as cyclothymia), confirmed through a structured diagnostic interview used by the study team - People who are currently experiencing sleep problems, such as troubl...

Who might be able to join this trial: - People who have been diagnosed with Bipolar Disorder Type I or Type II, as defined by the DSM-5 diagnostic guidelines - People aged between 18 and 55 years old - People who have completed primary school education - People whose bipolar disorder is currently stable (not in a manic...

**Who might be able to join this trial:** - Be between 18 and 55 years old - Have a confirmed diagnosis of bipolar I or bipolar II disorder, verified through a specific structured interview - Currently have depression symptoms that fall within a specific range, based on two standard mood rating scales (confirm with tri...

Who might be able to join this trial: - You are a Veteran who has been diagnosed with a serious mental illness such as schizophrenia, schizoaffective disorder, bipolar disorder, or PTSD, and are receiving treatment at a Psychosocial Rehabilitation and Recovery Center (PRRC) or a related rehabilitation service. - You ar...

**Who might be able to join this trial:** - People between 15 and 59 years of age. - People who have been diagnosed with a mood disorder (such as bipolar disorder or major depressive disorder) based on a clinical interview and the DSM-5 diagnostic guidelines. - People who are also experiencing symptoms of anxiety. - Pe...

**Who might be able to join this trial:** **Mental Health group:** - You have an electronic health record with a primary care (e.g. GP) or secondary care (e.g. hospital) service - You have been diagnosed with, or received treatment or a referral for, major depression, bipolar disorder, or schizophrenia - You are 18 ye...

**Who might be able to join this trial:** - You have a slow urine flow rate (less than 15 ml/sec), or a faster flow rate but with a special bladder test showing that a blockage is still present in the urinary tract - You have moderate to severe urinary symptoms (such as difficulty urinating, frequent urination, or a we...

**Who might be able to join this trial:** - You have been diagnosed with Bipolar Disorder Type I or Type II, and are currently experiencing a depressive episode related to bipolar disorder - You have been taking a mood stabilizer (such as lithium, lamotrigine, or valproic acid, alone or in combination) and/or an approv...

**Who might be able to join this trial:** *For young people with bipolar disorder:* - People whose bipolar disorder has been diagnosed according to standard diagnostic guidelines (DSM-V), covering bipolar type I, type II, or a related form, confirmed through a structured interview - People currently experiencing any m...

Who might be able to join this trial: **For people experiencing psychosis symptoms:** - People aged 18 to 65 years old - People currently experiencing psychosis symptoms that a psychiatrist involved in their care has confirmed need treatment from specialist mental health services - People whose psychosis symptoms are...

**Who might be able to join this trial:** - People who have signed a written consent form agreeing to take part in the study. - People who are aged 25 to 69 years old at the time of screening. - People who have a confirmed diagnosis of Bipolar II Disorder (a specific type of bipolar disorder), verified through clinica...

**Who might be able to join this trial:** This trial has three separate groups. People may be considered for one of the following: **Group 1 – Behavioral Frontotemporal Dementia (bvFTD) group:** - Adults aged 18 or older of any sex who have been diagnosed with behavioral variant Frontotemporal Dementia based on curre...

**Who might be able to join this trial:** *For Schizophrenia:* - People aged 18 to 65 years, of Han ethnicity, of any gender, with a confirmed diagnosis of schizophrenia based on standard diagnostic criteria (DSM-5) - People whose schizophrenia symptoms score at or above a set level on a standard symptom rating scale...

**For patients with bipolar disorder or depressive disorder:** Who might be able to join this trial: - People aged between 18 and 65 years old, men or women - People who have been diagnosed with bipolar disorder or depressive disorder - People whose treatment has not changed significantly in the two weeks before joini...

**Who might be able to join this trial:** - You are a male or female of any race or ethnicity - You are between 18 and 40 years old - You have been diagnosed with a psychotic disorder, such as schizophrenia, schizoaffective disorder, bipolar I disorder with psychotic features, major depression with psychotic features,...

Who might be able to join this trial: - You are between 18 and 65 years old (inclusive). - You have been diagnosed with schizophrenia, schizoaffective disorder, or Bipolar I, II, or Not Otherwise Specified (NOS) disorder. - Your Body Mass Index (BMI) is between 18.0 and 40.0 (a measure of body weight relative to height...

Who might be able to join this trial: - You are between 18 and 45 years old - You have been diagnosed with a schizophrenia-related condition or a mood/affective disorder (such as bipolar disorder or major depression) (confirm with trial site for your specific diagnosis) - You have been taking antipsychotic medication e...

Who might be able to join this trial: - You are over 50 years old - Your prostate is larger than 80 ml in size - You have tried medication for your prostate/urinary symptoms but it either did not work or you were unable to stick with the treatment - Your urinary symptom score (a standard questionnaire called IPSS) is h...

**Who might be able to join this trial:** - You have been officially diagnosed with a specific type of facial nerve pain called classical trigeminal neuralgia (TN), based on recognised international medical guidelines. - Your pain comes in sudden sharp attacks, or you have those attacks along with ongoing continuous pa...

Who might be able to join this trial: - You are between 14 and 60 years old (ages 14 and 60 are included), and any gender is welcome - You have scored 14 or higher on a standard depression rating scale called the HAMD, which measures the severity of depression symptoms - You are willing and able to sign a consent form...

Who might be able to join this trial: - You have been diagnosed with Bipolar Disorder (Type I, Type II, or a related type) - You have been in contact with mental health services at least once in the past year - You are between 18 and 65 years old - You have read and signed a form agreeing to take part in the study Who...

**Who might be able to join this trial:** - You are 18 years of age or older - You are able to give written consent to take part in the study - You have enough thinking and language ability to understand and take part in the study tasks and assessments - You have been diagnosed with major depression, bipolar disorder,...

**Who might be able to join this trial:** - You are between 70 and 85 years old and live in your own home (not a nursing home) - You have been diagnosed with a specific type of older-adult bipolar disorder (types 1, 2, or 3, assessed using standard diagnostic guidelines called DSM-5) - Your bipolar disorder has been st...

**Who might be able to join this trial:** - You are between 12 and 21 years old and can speak English - You are suitable for outpatient care, meaning you are not currently in crisis, not at risk of harming yourself or others, and do not need hospitalization - You have been diagnosed with a bipolar spectrum disorder (s...

Who might be able to join this trial: - People who are 18 years of age or older - People for whom a doctor has determined that starting, changing, adjusting the dose of, or adding a psychiatric medication is appropriate - People whose treating doctor believes that pharmacogenomic (genetic) testing could be beneficial a...

**Who might be able to join this trial:** - People who have been formally diagnosed with Bipolar I disorder through a thorough psychiatric assessment. - People who are currently experiencing an acute episode of mania or mania with mixed features that has lasted 3 weeks or less. - People whose symptoms are severe enoug...

Who might be able to join this trial: - People who have urinary problems (such as difficulty urinating or a weak stream) caused by an enlarged prostate - People whose prostate symptom score is above 8 on a standard medical questionnaire called the IPSS - People whose maximum urine flow rate is less than 10ml per second...

Who might be able to join this trial: - You are 18 years of age or older - You have completed at least primary school education - You are able to hear, understand spoken language, and hold a conversation - You have been the main person caring for someone for at least 6 months and are willing to take part voluntarily W...

Who might be able to join this trial: - People who are able to understand and agree to participate in the study on their own (have capacity to give informed consent) - People who are currently being seen as outpatients (not admitted to hospital) - People who have a diagnosis of bipolar disorder (type I or II) with a cu...

Who might be able to join this trial: - People who have been diagnosed with a non-cancerous enlarged prostate that has been assessed as needing surgery. - People whose prostate has been measured at 40 cc or larger using an internal ultrasound scan. - People with no previous diagnosis of prostate cancer. Who may not be...

**Who might be able to join this trial:** - You are right-handed and have completed at least nine years of basic schooling. - You have been diagnosed with bipolar depression, as defined by the DSM-5 (a standard medical guide used to diagnose mental health conditions). - You score 18 points or higher on a standard depre...

**Who might be able to join this trial:** - People aged 18 to 65 years who are legally able to make their own decisions and give informed consent - People who have been diagnosed with a depressive episode, either as part of major depressive disorder (MDD) or bipolar disorder, based on recognised diagnostic guidelines (...

Who might be able to join this trial: - You are 18 years old or older at the time of joining the trial. - You have been diagnosed by a doctor with either unipolar depression (depression on its own) or bipolar depression (depression as part of bipolar disorder), based on recognised medical guidelines. - You are willing...

Who might be able to join this trial: **For children/teens who have a parent with bipolar disorder ("high-risk offspring"):** - You are between 6 and 18 years old (boys and girls are both eligible) - Both you and your parent(s) are willing and able to sign a consent form - At least one of your parents has been diagnos...

**Who might be able to join this trial:** - You identify as a cis man, cis woman, trans man, trans woman, or non-binary person - You are between 18 and 65 years old - You have been diagnosed with moderate to severe major depressive disorder (according to standard diagnostic guidelines) and are considered suitable for a...

**Who might be able to join this trial:** - People who have given their written consent to participate - People who are covered by social security - *(For the depressive disorder group)* People who have been diagnosed by a psychiatrist with a depressive episode (including recurring or persistent forms) according to IC...

Who might be able to join this trial: - People who have been diagnosed with bipolar I disorder (with or without psychotic symptoms), confirmed through a structured clinical interview, including cases where the episode has mixed features (a mix of manic and depressive symptoms). - People who have had at least one previo...

**Who might be able to join this trial:** - You are between 18 and 65 years old (inclusive). - You are willing and able to give your consent to take part and can attend all required study visits, as agreed by both a psychiatrist and a surgeon involved in the study. - You have been diagnosed with Bipolar Disorder Type 1...

**Who might be able to join this trial:** - You are between 18 and 50 years old - You are willing to switch to a high-fat, low-carbohydrate (ketogenic-style) diet - You have been diagnosed with Bipolar I disorder, Bipolar II disorder, or schizoaffective disorder (bipolar type), confirmed through a structured medical i...

**Who might be able to join this trial:** - You are between 22 and 70 years old - You have been diagnosed with Bipolar II Disorder and have been experiencing a depressive episode lasting at least 1 year that has not responded to treatments - You have not had a manic or hypomanic (elevated mood) episode in the last 2 y...

Who might be able to join this trial: - People who have been formally diagnosed with Bipolar I disorder, confirmed through a full psychiatric assessment using standard diagnostic guidelines and a recognised psychiatric interview tool. - People who are currently experiencing a sudden worsening or relapse of a manic epis...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with bipolar disorder - People who are currently receiving care at the bipolar disorder outpatient clinic at AUHP - People who are being treated with lithium - People who are able to give consent to particip...

**Who might be able to join this trial:** - You are between 18 and 74 years old, and your first episode of serious depression happened before you turned 50. - Your Body Mass Index (BMI) is between 18 and 40 (confirm with trial site if unsure of your BMI). - You have been diagnosed with bipolar I or bipolar II disorder...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with bipolar disorder type 1 and are currently experiencing a manic episode (a period of unusually high energy, mood, or activity), with or without psychosis (such as hallucinations or delusions), as defined by standard medi...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with bipolar disorder (either Bipolar I or Bipolar II) - You are currently experiencing depression, based on a standard questionnaire score (confirm with trial site) - Your body mass index (BMI) is over 30, which i...

Who might be able to join this trial: - People aged 65 years or older - People who have been clinically diagnosed with a mood disorder, such as depression or bipolar disorder - People who are currently receiving care from a psychiatrist - People who have at least two ongoing physical health conditions (such as diabetes...

**Who might be able to join this trial:** - Adults between 18 and 65 years old. - People who have been formally diagnosed with bipolar disorder (type I or II) or schizoaffective disorder, bipolar type, confirmed through a structured clinical interview (SCID IV). - Women who have a negative pregnancy test taken within...

**Who might be able to join this trial:** - Your Body Mass Index (BMI) — a measure of body weight relative to height — must be between 18.0 and 40.0. - You must have been diagnosed with bipolar I or II disorder (without psychotic features) according to standard psychiatric guidelines, and currently be going through a...

Who might be able to join this trial: - People aged between 18 and 65 years old - People of any gender - People with a body weight in the healthy to moderately overweight range (BMI between 18.5 and 38.0) at the initial screening appointment - People who are able to understand and follow the study requirements - People...

**Who might be able to join this trial:** - People between 12 and 18 years of age - People who have been diagnosed with bipolar disorder using standard diagnostic guidelines, confirmed through a structured clinical interview - People who are currently experiencing a moderate or severe depressive episode, based on spec...

Who might be able to join this trial: - People who have been given information about the study and have signed a consent form agreeing to take part. - People who have been diagnosed with bipolar disorder and for whom a doctor has planned treatment with the medication olanzapine. - People who are able to understand the...

**Who might be able to join this trial:** - Adults between 18 and 65 years old (both male and female) - People who are able to understand what the study involves, follow the study procedures throughout, and agree in writing to take part - People currently experiencing a major depressive episode linked to major depress...

**Who might be able to join this trial:** - You have been diagnosed with Bipolar Disorder I or Bipolar Disorder II - You are willing and able to commit to attending all required study visits for the full length of the study - You are willing to give yourself injections of the study medication as instructed - You are ab...

**Who might be able to join this trial:** - You have been diagnosed with bipolar I disorder as your main condition. - You have had at least one manic episode in the past that needed medical treatment. - You are currently going through a manic episode (with or without mixed or psychotic symptoms) at the time of the tria...

**Who might be able to join this trial:** **If you are a patient:** - You are 18 years old or older - You have been diagnosed with a psychiatric condition (such as a mental health disorder) by a psychiatrist, or a neurological condition (such as a brain or nervous system disorder) by a neurologist - You are willing an...

Who might be able to join this trial: - People who are willing to give written consent to participate (for those under 18, a parent or legal guardian must also give consent, and the young person may need to give their agreement depending on their age) - People who are older than 6 years and younger than 60 years old -...

**Who might be able to join this trial:** - You are between 18 and 45 years old - You have been diagnosed with Borderline Personality Disorder (BPD) but do NOT have bipolar disorder (both checked using a structured clinical interview) - You have been diagnosed with bipolar disorder but do NOT have Borderline Personalit...

Who might be able to join this trial: - People who are currently admitted as a patient at Worcester Recovery Center and Hospital (WRCH) - People who are at least 18 years old - People who report having had some involvement with the legal system, either now or in the past - People who speak English - For people without...

**Who might be able to join this trial:** - Adults between 18 and 65 years old who have signed a written consent form agreeing to take part in the research. - People who have been taking a mental health medication prescribed by a doctor or healthcare professional for more than 3 months. - People who have normal vision,...

Who might be able to join this trial: - People who are between 18 and 50 years old - People who are not currently considered at high risk of suicide - People who do not currently have a serious substance use disorder or alcohol use disorder - People whose native language is Romanian - People who have the cognitive abil...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of bipolar disorder or recurring depression that is currently in partial or full remission (meaning symptoms are low or absent based on standardised rating scales) - People who either personally feel their memory or thinking has been affe...

Who might be able to join this trial: - You are 18 years of age or older - You have been referred to the participating medical center because your doctor has recommended a specific throat/esophagus procedure called POEM — this may be due to conditions such as achalasia (a swallowing disorder), a previous surgery on the...

**Who might be able to join this trial:** - You have been diagnosed with bipolar disorder (either type I or type II), confirmed through a structured clinical interview - You are currently going through a moderate or severe depressive episode related to your bipolar disorder - At least two different medication treatment...

Who might be able to join this trial: - People who have been diagnosed with bipolar disorder, where the diagnosis has been confirmed using a structured clinical interview called a SCAN interview - People who are between 18 and 70 years of age - People who are able to read and understand participant information written...

**Who might be able to join this trial:** - People who have been diagnosed with Bipolar I disorder and are currently going through a depressive episode (without psychosis or mixed features), as confirmed by a structured clinical interview - People whose current depressive episode started at least 4 weeks ago but no mo...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with breast cancer, confirmed through a tissue or lab test - You are scheduled to have a specific type of underarm lymph node removal surgery (called ALND) performed by one of the surgeons involved in this study *...

Who might be able to join this trial: - People who are already scheduled to receive Electroconvulsive Therapy (ECT) as a planned, non-emergency procedure. - People whose overall physical health falls within a low-to-moderate risk range as assessed by their anaesthetist (confirm with trial site). Who may not be able to...

**Who might be able to join this trial:** - People diagnosed with Bipolar I Disorder (BD1) who are between 18 and 65 years old and in reasonably good general physical health, as assessed by the trial doctor - People whose BD1 symptoms are currently stable — meaning mood rating scale scores fall within specific low ran...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with bipolar disorder and are currently going through a depressive episode, confirmed through a structured clinical interview - Your depression symptoms are at least moderate in severity, based on a specific rating scale...

**Who might be able to join this trial:** **For people with bipolar disorder:** - You have been diagnosed with bipolar disorder (or previously were), your condition is currently stable, and you are willing to take part in assessments - You are aged 18 or older but under 65 - You are of Han Chinese ethnicity - You have...

**Who might be able to join this trial:** - Both of your biological parents are of Han Chinese ethnicity - You are between 18 and 45 years old (any gender) - You have been diagnosed with bipolar disorder according to the DSM-5 (a standard medical guide used to diagnose mental health conditions) - You are either overwei...

**Who might be able to join this trial:** - You are currently experiencing a depressive episode (whether related to depression alone or bipolar disorder) - You are currently admitted to a participating department within the Mental Health Services of the Capital Region of Denmark - Your psychiatrist has referred you for...

**Who might be able to join this trial:** This trial has three separate groups. People may be considered for one of the following: **Group A – Parents with Bipolar Disorder:** - Adults aged 18 or older - People who have been diagnosed with Bipolar I or II disorder at some point in their lifetime, confirmed by a clini...

**Who might be able to join this trial:** - People who are male and have been diagnosed with an enlarged prostate (a condition called BPH) - People who have been diagnosed with BPH and are experiencing bothersome urinary symptoms - People whose urinary symptom score is 20 or higher on a standard questionnaire, meaning...

Who might be able to join this trial: - Men who have urinary problems caused by a non-cancerous enlarged prostate, where medication has not helped after at least 3 months of treatment - Men who are sexually active and in an ongoing relationship with the same partner - Men whose urinary symptom score is rated 8 or highe...

**Who might be able to join this trial:** - You are male and aged 50 years or older - You have been diagnosed with a non-cancerous enlarged prostate that is causing moderate to severe urinary symptoms - Your prostate symptom score on a standard questionnaire (called the IPSS) is 13 or higher - Your prostate is a certai...

**Who might be able to join this trial:** - People aged 18 or older - People who have depression (either unipolar or bipolar) that has not responded well to standard treatments, but who did respond to a previous course of TMS (Transcranial Magnetic Stimulation) therapy — meaning their depression score improved by at le...