What changed for Osteoarthritis
A plain English summary of what recently moved in the public data Voxsanity tracks for Osteoarthritis. Updated from government registries. Not medical advice.
How to read these changes: every figure on this page is the difference between two snapshots of what Voxsanity had tracked on each date. Voxsanity only began taking daily snapshots in July 2026 and is still ingesting the public registries, so a rise here is mostly our own coverage expanding rather than new research appearing. Read it as our tracked coverage growing, not as a claim about real-world research changing this fast: it overstates how much actually changed.
Comparing the two most recent snapshots, 27 July 2026 and 28 July 2026.
- Trials recruiting worldwide 410 to 421 (+11)
- Late-stage (Phase 3) trials 22 to 21 (-1)
- Trials on record 4,117 to 4,218 (+101)
Newly subsidised on the PBS
No medicines were newly subsidised on the PBS for Osteoarthritis in July 2026. Voxsanity tracks 6 PBS-subsidised medicines for this condition; none of them was listed for the first time this month.
Source: Pharmaceutical Benefits Scheme (PBS), © Commonwealth of Australia. Data used and redistributed under permission; not modified from its original wording where displayed verbatim.
Past updates
Tracking began in July 2026. Month on month changes will appear here once a second month of data has been recorded. Until then, the comparison above shows the most recent movement.
Recent trend
Weekly, most recent weeks (fills out to a monthly trend as history grows).
Recent trial results
The 30 most recent of 113 trials tracked for Osteoarthritis that have reported results to a public registry.
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
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NCT05579665 · results posted 22 May 2026
According to the results reported on ClinicalTrials.gov, this trial enrolled 45 people with knee osteoarthritis, split evenly into three groups of 15. One group received platelet-rich plasma (PRP) injections — a preparation made from the patient's own blood — another received a substance called MSC secretome (a liquid derived from stem cell cultures), and the third received hyaluronic acid (HA), a gel-like substance sometimes injected into joints. All 45 participants completed the trial with no drop-outs. The trial measured two things: self-reported pain using a simple 1–10 scale (called the V...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04864392 · results posted 30 March 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT04864392) enrolled 576 participants across five groups, all of whom had knee osteoarthritis. Four groups received different doses or schedules of an investigational injection called LNA043, and one group received a placebo (an inactive injection). The trial was primarily measuring whether LNA043 affected the thickness of cartilage — the cushioning tissue inside the knee joint — over about two years (104 weeks). It also measured participants' self-reported knee pain and physical function using a standard questionnaire calle...
Read the full trial page · View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03737149 · results posted 23 March 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT03737149) looked at a digital care programme called Mymobility, used alongside an Apple Watch, for people recovering from knee or hip replacement surgery. The trial ran across three phases. The first phase was a small pilot study involving 143 knee and 63 hip patients. The second phase was a randomised controlled trial — meaning participants were randomly assigned to either the Mymobility with Apple Watch programme or standard physical therapy — with 210 knee and 174 hip patients in the Mymobility group, and 245 knee and 2...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04886258 · results posted 28 January 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT04886258) enrolled 115 people with knee problems — 58 received the investigational drug DFV890 and 57 received a placebo (an inactive dummy treatment). The trial was primarily measuring changes in knee pain using a standard questionnaire called the KOOS Pain Scale, where a score of 100 means no pain and 0 means extreme pain. It also tracked several secondary measures, including signs of joint inflammation seen on a specialised MRI scan, a blood marker of body-wide inflammation (hsCRP), white blood cell counts (neutrophils)...
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NCT03299959 · results posted 5 December 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT03299959) enrolled 251 people with knee cartilage damage. Participants were placed into one of two groups: 167 people received a device called Agili-C™ (an implant designed to support cartilage repair), and 84 people received what the trial called "Surgical Standard of Care" — meaning the usual surgical treatment a doctor would normally offer. The trial followed participants for up to 60 months (five years), and it measured changes in knee-related scores covering pain, quality of life, daily function, symptoms, and sports...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05838742 · results posted 10 November 2025
According to the results reported on ClinicalTrials.gov, this trial tested an investigational medicine called GSK3858279 in people with knee pain from osteoarthritis (a condition where the cartilage in joints breaks down over time). A total of 314 people started the trial across five groups: one group received a placebo (an inactive dummy injection), and the other four groups received different doses or dosing schedules of GSK3858279. The main thing being measured was how much knee pain scores changed after 12 weeks, using an 11-point self-reported scale where 0 means no pain and 10 means the...
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NCT07112885 · results posted 22 September 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 50 people with knee osteoarthritis, split evenly into two groups of 25. One group received a procedure called microfracture (where small holes are made in the bone to stimulate the joint) combined with an injection of stromal vascular fraction (SVF — a preparation of cells taken from a person's own fat tissue), while the other group received SVF alone. All 50 participants completed the trial. The trial was measuring changes in knee symptoms and cartilage appearance on MRI scans over time. The reported data shows that...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04748510 · results posted 8 August 2025
According to the results reported on ClinicalTrials.gov, this trial involved 100 people who were having a total knee replacement. They were split into two equal groups of 50: one group received a surgical technique called "functionally aligned" placement of the knee implant, and the other received a technique called "mechanically aligned" placement. The trial was measuring how each group's knee felt and moved two years after surgery compared to before it. A total of 48 people in the functionally aligned group and 44 in the mechanically aligned group completed the study. The reported data show...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05765435 · results posted 3 July 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled a very small number of participants — two people in each of three groups: a Control group, a group receiving Neuromuscular Electrical Stimulation (NMES, a technique that uses mild electrical impulses to activate muscles), and a group receiving both NMES and Functional Electrical Stimulation (FES, a related electrical stimulation approach). In total, six people started the trial, but one person from the NMES group and one from the NMES and FES group did not complete it. The trial was measuring changes in thigh muscle s...
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NCT04399928 · results posted 11 April 2025
According to the results reported on ClinicalTrials.gov, this trial followed 478 people who received a hip replacement component called the R3™ Acetabular System — a cup-shaped implant used in total hip replacement surgery. The trial set out to track how long the implant stayed in place without needing to be surgically revised (removed and replaced), and also to measure how participants felt about their hip function and activity levels over time, across check-in points up to 10 years after surgery. Of the 478 people who started, 350 completed the full study period. The reported data shows tha...
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NCT04168593 · results posted 27 March 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 120 people in total, split evenly across four groups of 30. The study was looking at knee osteoarthritis (a condition causing joint pain and stiffness) and compared four combinations of acupuncture and cupping therapy — some participants received real versions of one or both treatments, while others received "sham" (pretend) versions used as a comparison. By the end of the trial, between 26 and 29 people in each group had completed the study. The reported data shows two main pain measures were used. The first was the...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04124042 · results posted 27 March 2025
According to the results reported on ClinicalTrials.gov, this trial tested an investigational injection called XT-150 for knee pain. The trial was run in two stages (Stage A and Stage B), with participants receiving either a lower dose of XT-150 (0.15 mg/mL), a higher dose (0.45 mg/mL), or a placebo (an inactive injection) in Stage A, and then one of the two XT-150 doses in Stage B. A total of 286 people started the trial across the six treatment groups, with between 39 and 43 people in each group completing the full study. The main things being measured were changes in knee pain scores using...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04797897 · results posted 25 March 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT04797897) compared two approaches to a type of partial knee replacement surgery called a unicompartmental knee arthroplasty (UKA) — one using a robotic-assisted system called CORI, and one using conventional (standard, non-robotic) surgical techniques. A total of four people took part, two in each group. However, only one person in each group completed the trial, with one person in each group not finishing. The main thing the trial was measuring was how well each approach achieved a target leg alignment after surgery, chec...
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NCT03889925 · results posted 24 February 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 64 people with knee problems — 32 in each of two groups. One group received a treatment called Autologous Conditioned Plasma (a preparation made from the patient's own blood), and the other received the same treatment combined with Hyaluronic Acid (a substance sometimes injected into joints). By the end of the study, 21 people in the first group and 22 in the second group had completed the trial, with 11 and 10 people respectively not finishing for reasons the data does not specify. The trial was measuring how partici...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05698368 · results posted 13 February 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT05698368) enrolled 458 people in total across three groups: a Mindset Intervention Group (151 people), an Active Comparator Education Group (152 people), and a Survey-only Control Group (155 people). The trial was looking at whether a mindset-based program influenced several things in people with knee osteoarthritis, including knee pain, physical activity levels, attitudes toward physical activity, and how participants thought about their osteoarthritis (for example, whether they saw it as a catastrophe, something manageab...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT00753090 · results posted 30 January 2025
According to the results reported on ClinicalTrials.gov, this trial involved two groups of people who had received knee replacement implants. The trial group ("VG DDRP") started with 209 participants, and the control group ("VG CR") started with 117 participants — a total of 326 people across both groups. The trial was measuring knee function and pain using a standard scoring tool called the Knee Society Score (KSS), as well as looking at X-ray results and how many implants remained in place (unrevised) over time. It is worth noting that a large number of participants did not complete the stud...
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NCT03023410 · results posted 29 January 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT03023410) was set up to look at the causes of early knee replacement revision surgery — that is, cases where a knee replacement needed to be redone not long after the original operation. The study aimed to compare two groups of patients: those who had a "partial revision" (where only some parts of the knee replacement were replaced) and those who had a "total revision" (where all components were replaced). It also planned to measure patients' knee function and general quality of life using two standard questionnaires. The...
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NCT05349500 · results posted 14 January 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 60 people with osteoarthritis — 30 in a group receiving something called "OA CARE" and 30 receiving "Usual Care." By the end of the study, 23 people in the OA CARE group and 24 in the Usual Care group had completed it. The trial was measuring changes in participants' osteoarthritis symptoms — specifically pain, stiffness, and physical function — using a questionnaire called the WOMAC. On this questionnaire, scores range from 0 to 96, where a higher number means worse symptoms, and a lower (more negative) change score...
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NCT04343716 · results posted 9 January 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT04343716) enrolled 19 women with osteoarthritis — 3 White women and 16 Black women. The trial was measuring changes in knee pain and physical function over six weeks, comparing results between these two groups. Of the 19 who started, 16 completed the study (1 White woman and 15 Black women); 2 White women and 1 Black woman did not complete it. Two standard questionnaires were used to track pain: the WOMAC (a 0–20 pain scale, where higher numbers mean more pain) and the BPI (a 0–40 pain scale, where higher numbers also mean...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05986617 · results posted 17 December 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 60 people in total — 30 in a group that used a wearable device (described as a band) and 30 in a control group who did not. The trial was looking at how long it took participants to reach the point where surgery was considered appropriate, as well as changes in body composition and surgical complication rates. The reported data shows that very few participants formally completed the study — only 1 person in the wearable device group and 5 in the control group were recorded as having completed it, with the remainder re...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03098563 · results posted 11 December 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 58 participants, each of whom took part in multiple experimental sessions. It was a crossover study, meaning each person received different combinations of treatments across those sessions — specifically: a placebo paired with another placebo (an inactive dummy substance), the opioid pain medicine hydromorphone paired with a placebo, the cannabinoid medicine dronabinol paired with a placebo, and hydromorphone combined with dronabinol. The trial was measuring whether any of these combinations changed participants' self...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT02154516 · results posted 6 December 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 26 people in total — 20 in the investigational hip replacement device group and 6 in the control (standard comparison) device group. Of those, 16 and 4 participants respectively completed the study. The trial was measuring things like whether the hip implant needed to be surgically revised (replaced or adjusted), the levels of metal particles released into the bloodstream, patient-reported hip pain and function scores, and X-ray findings around the implant. The reported data shows that 1 participant in the investigat...
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NCT05139030 · results posted 24 October 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 167 people in total — 85 in the EXPAREL admix group and 82 in the standard bupivacaine HCl group. The trial was looking at pain levels and painkiller use after surgery, comparing two types of local anaesthetic (pain-numbing) injections given at the time of the procedure. The main thing being measured was overall pain intensity across the first 96 hours (four days) after surgery, using a standard 0–10 pain scale, where 0 means no pain and 10 means the worst possible pain. The reported data shows that, for the primary...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03524729 · results posted 19 September 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT03524729) looked at people with ankle osteoarthritis and compared three different devices: an ankle-foot orthosis (AFO, a brace that supports the foot and lower leg), a rocker-bottom shoe (RB, a shoe with a curved sole), and a control condition (C, meaning no special device). Participants with ankle osteoarthritis tried all three conditions in different orders, so the study could compare how each one related to their daily activity and physical function. One healthy person without ankle osteoarthritis also took part as a c...
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NCT03969875 · results posted 7 May 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 90 people in total across three groups (31, 29, and 30 participants respectively), with 72 completing the study (24 in each group). The trial compared three different nerve-block approaches used to manage pain after shoulder surgery: a continuous catheter (a small tube that delivers ongoing local anaesthetic near a nerve in the neck), a single injection of a standard local anaesthetic combined with a steroid (dexamethasone), and a single injection of a longer-acting form of local anaesthetic (liposomal bupivacaine). T...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03005873 · results posted 22 April 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT03005873) involved 76 people in total, split across three groups: a lower-dose TLC599 group (26 people), a higher-dose TLC599 group (24 people), and a placebo group (26 people). The trial was measuring changes in knee pain related to osteoarthritis over 12 weeks, using a standard questionnaire called the WOMAC Pain subscale. This questionnaire asks five questions about pain, and the answers are combined into a score ranging from 0 to 4, where a higher number means more pain and a lower number means less pain. Not everyone...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT01063751 · results posted 16 January 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 275 people who received a hip replacement using a device called the Tritanium® Primary Acetabular Shell — a cup-shaped implant placed in the pelvis as part of a total hip replacement. The main thing the trial was measuring was how many of those implants needed to be surgically revised (removed or replaced) within five years. The trial also tracked participants' self-reported quality of life, pain, physical function, and activity levels using several standard questionnaires. Of the 275 people who started, 41 were recor...
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NCT04612036 · results posted 29 November 2023
According to the results reported on ClinicalTrials.gov, this trial (NCT04612036) enrolled 60 people in total who had received one of three types of knee replacement implants: 25 received the Journey II Bi-Cruciate Stabilized (BCS), 25 received the Journey II Cruciate Retaining (CR), and 10 received the Journey II Bi-Cruciate Retaining (BCR). All 60 participants completed the study. The trial was measuring how the bones in the replaced knee actually moved during a deep knee bend — specifically, how far the thigh bone shifted forward or backward over the shin bone, how much the knee rotated, an...
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NCT04627038 · results posted 2 November 2023
According to the results reported on ClinicalTrials.gov, this trial enrolled 202 people in total — 135 in the group receiving a 600 mg dose of the investigational medicine LY3556050, and 67 in the group receiving a placebo (a dummy treatment with no active ingredient). The trial was measuring changes in pain and physical function in people with osteoarthritis, using several questionnaires and rating scales completed by participants themselves. Of those who started, 81 people in the LY3556050 group and 53 in the placebo group completed the study. The reported data shows that for the main (prim...
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NCT05080660 · results posted 6 September 2023
According to the results reported on ClinicalTrials.gov, this trial enrolled 160 people in total — 107 received a drug called LY3526318 (at a dose of 250 mg) and 53 received a placebo (a dummy treatment with no active ingredient). The trial was measuring changes in pain and joint symptoms, primarily in people with osteoarthritis. The main thing being tracked was how participants rated their average pain over the previous 24 hours using a numbered scale from 0 (no pain) to 10 (the worst pain imaginable). By the end of the study, 94 people in the LY3526318 group and 51 in the placebo group had c...
See all 113 reported results for Osteoarthritis
These are the results as reported to the registry, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
What is coming
AI generated pipeline summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to NIH funding data, a substantial amount of public research money is currently being directed toward osteoarthritis, and encouragingly, that investment has been rising year on year. This suggests that researchers and public health bodies are treating osteoarthritis as a meaningful scientific priority. For patients, a growing funding base generally means more studies are being supported,...
See the full Osteoarthritis page
Not medical advice. Voxsanity republishes public government health data in plain English. These figures describe research and registry activity, not the suitability of any treatment for any person. Trial status can change; always verify current status directly with the trial site and confirm Australian availability with your doctor.