What changed for PTSD
A plain English summary of what recently moved in the public data Voxsanity tracks for PTSD. Updated from government registries. Not medical advice.
How to read these changes: every figure on this page is the difference between two snapshots of what Voxsanity had tracked on each date. Voxsanity only began taking daily snapshots in July 2026 and is still ingesting the public registries, so a rise here is mostly our own coverage expanding rather than new research appearing. Read it as our tracked coverage growing, not as a claim about real-world research changing this fast: it overstates how much actually changed.
Comparing the two most recent snapshots, 27 July 2026 and 28 July 2026.
- Trials recruiting worldwide 371 to 368 (-3)
- Trials on record 2,348 to 2,343 (-5)
Newly subsidised on the PBS
No PBS-reviewed medicines are tracked for PTSD yet, so new PBS listings cannot be reported for it. This is a gap in what Voxsanity has mapped, not a statement that no medicines are subsidised — check the PBS directly.
Past updates
Tracking began in July 2026. Month on month changes will appear here once a second month of data has been recorded. Until then, the comparison above shows the most recent movement.
Recent trend
Weekly, most recent weeks (fills out to a monthly trend as history grows).
Recent trial results
The 30 most recent of 173 trials tracked for PTSD that have reported results to a public registry.
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
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NCT04044534 · results posted 13 July 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT04044534) involved 6 participants, all of whom completed the study. It used a crossover design, meaning each participant tried both treatments at different times — in this case, intranasal insulin and a placebo (an inactive substitute). The trial was measuring changes in PTSD symptoms using a standardised clinician-administered questionnaire called the CAPS-5, which covers 20 symptoms across four areas: intrusive memories, avoidance, negative thoughts and mood, and being on edge or reactive. Scores on this scale range from...
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NCT05862467 · results posted 2 July 2026
According to the results reported on ClinicalTrials.gov, this trial enrolled 28 autistic adults who received a treatment called Written Exposure Therapy — a structured approach where participants write about traumatic experiences over several sessions. The trial was measuring changes in post-traumatic stress disorder (PTSD) symptoms as its main focus, and also tracked changes in depression, anxiety, loneliness, general psychological wellbeing, and a pattern called "experiential avoidance" (a tendency to avoid distressing thoughts or feelings). Of the 28 people who started, 23 completed the tre...
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NCT05280691 · results posted 30 June 2026
According to the results reported on ClinicalTrials.gov, this trial involved 885 family members of patients in an intensive care unit (ICU). Of these, 412 people received a special family support intervention on top of usual care, while 473 received usual care only. The trial was measuring things like how satisfied families felt with the care provided, how well staff communicated with them, how supported they felt by nurses, how well the family was functioning as a unit, how resilient families felt, and their overall satisfaction with life — all tracked using standardised questionnaires. The...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03974503 · results posted 9 April 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT03974503) enrolled 48 adults in total — 23 in a group receiving a therapy called Exposure, Relaxation, and Rescripting Therapy (ERRT) and 25 in a group receiving a programme called Sleep and Nightmare Management. Of those, 18 and 21 people respectively completed the study. The trial was measuring things like sleep quality, a heart-rate signal during sleep (called Respiratory Sinus Arrhythmia, or RSA — a measure of how the nervous system influences the heart overnight), nightmare frequency and severity, and symptoms of post...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04228289 · results posted 11 March 2026
According to the results reported on ClinicalTrials.gov, this trial (NCT04228289) looked at whether oxytocin (a hormone sometimes given as a nasal spray) made a difference to symptoms of post-traumatic stress disorder (PTSD) compared to a placebo (an inactive dummy treatment). A total of 92 people were assigned to receive oxytocin and 88 to receive placebo at the start of the study. By the end, 68 people in each group had completed the trial, meaning 24 people in the oxytocin group and 20 in the placebo group did not finish. The reported data shows that PTSD symptom severity was measured in t...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04395157 · results posted 25 February 2026
According to the results reported on ClinicalTrials.gov, this trial enrolled 100 veterans who were engaged in mental health rehabilitation or recovery programs through the VA (Veterans Affairs) health system in the United States. The study was measuring several things at the same time: how well participants performed on a standardised brain and thinking skills test (called the MCCB), how they performed on a one-hour computerised listening and sound-recognition training exercise, their day-to-day functioning (using a World Health Organization disability questionnaire), and their overall quality...
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NCT06271733 · results posted 20 February 2026
According to the results reported on ClinicalTrials.gov, this trial looked at the use of Transcranial Magnetic Stimulation (TMS) — a non-invasive procedure that uses magnetic pulses directed at the brain — in people with post-traumatic stress disorder (PTSD). Six participants took part, and all six completed the study. The trial measured PTSD symptom severity as its main focus, and also looked at depression symptom severity as a secondary measure. The reported data shows that at the end of the study, the average score on the PTSD Checklist (PCL-5) — a self-reported questionnaire where 0 means...
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NCT03760731 · results posted 29 December 2025
According to the results reported on ClinicalTrials.gov, this trial compared two talking therapies for people experiencing what the researchers called "moral injury" — a term for distress that can arise when someone feels they have witnessed, done, or failed to prevent something that goes against their deeply held values. The two therapies compared were Acceptance and Commitment Therapy for Moral Injury (ACT-MI) and Present Centred Therapy for Moral Injury (PCT-MI). A total of 74 people were enrolled across both groups (38 in ACT-MI and 36 in PCT-MI). The main focus of the trial was not to tes...
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NCT03466346 · results posted 2 December 2025
According to the results reported on ClinicalTrials.gov, this trial looked at two treatments for depression and post-traumatic stress disorder (PTSD) in people who had experienced trauma: a talking therapy called Interpersonal Psychotherapy (IPT) and an antidepressant medication called fluoxetine. The trial ran in two stages. In the first stage, 1,082 people were assigned to IPT and 1,080 to fluoxetine. Those who did not respond well enough in the first stage moved into a second stage, where they were assigned to either switch treatments or combine both — 68, 104, and 160 people started in tho...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04293341 · results posted 6 November 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 304 participants in total — 153 in a group receiving a "Transdiagnostic Behaviour Therapy" (a single therapy designed to address multiple mental health conditions at once) and 151 in a group receiving "Disorder Specific Therapies" (separate therapies each targeting one particular condition). Of those who started, 90 and 87 participants respectively completed the trial. The trial was measuring symptoms of three conditions across both groups using standard questionnaire scores: PTSD (post-traumatic stress) using the PCL...
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NCT03937713 · results posted 21 October 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT03937713) enrolled 53 people in total — 26 in a group that received a combination of a brief behavioural sleep programme (called BBTI) plus a sleep medication (eszopiclone), and 27 in a group that received the behavioural programme alone. By the end of the study, 22 and 21 participants respectively had completed it. The trial was measuring changes in sleep quality, insomnia severity, PTSD symptom severity, and depression symptom severity, as well as how consistently participants used a CPAP machine (a device used for breat...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04143243 · results posted 8 October 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT04143243) enrolled 176 participants in total — 90 in a programme called "ACT on Life" and 86 in a comparison group called "Education, Resources, and Support." Of those, 83 and 77 participants respectively completed the study. The trial was designed to measure symptoms of depression, anxiety and stress, as well as how difficult veterans found it to readjust to civilian life after military service. It also tracked a range of other experiences, including post-traumatic stress symptoms, pain, and how well participants felt the...
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NCT05849454 · results posted 22 September 2025
According to the results reported on ClinicalTrials.gov, this trial tested a program called "Messy Memories," which appears to be a digital intervention involving a memory processing module — a tool where participants could record and replay personal memories. The trial was designed as a feasibility study, meaning its main purpose was to find out whether the program could be practically delivered and whether people would engage with it, rather than to test whether it treated a specific condition. Of the 69 people initially considered, 45 were found eligible, 29 agreed to take part, 25 complete...
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NCT05374408 · results posted 9 September 2025
According to the results reported on ClinicalTrials.gov, this trial looked at a mobile phone app called BounceBack Now (BBN), which was designed for people who have experienced trauma. The study had two main aims: first, to get feedback on educational materials about the app from patients and behavioural health providers (mental health staff); and second, to test whether the app could realistically be used in a real-world healthcare setting. In total, 29 people took part across four groups — 5 patients and 2 behavioural health providers in the first aim's focus groups, and 12 patients and 10 s...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04999852 · results posted 5 September 2025
According to the results reported on ClinicalTrials.gov, this trial looked at whether adding a listening-based program called the Safe and Sound Protocol (SSP) to regular psychotherapy made a difference for people with trauma-related difficulties. A total of 45 participants took part — 32 in the group that received psychotherapy combined with SSP, and 13 in the group that received psychotherapy alone (treatment as usual). Of those who started, 19 from the SSP combination group and 12 from the psychotherapy-only group completed the trial. The trial measured changes in PTSD symptoms and anxiety...
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NCT05419999 · results posted 29 May 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 25 people in total — 12 in a group that received transcranial direct current stimulation (tDCS, a mild electrical brain stimulation) combined with a talking therapy called Written Exposure Therapy (WET), and 13 in a group that received a sham (inactive/pretend) version of the stimulation combined with the same talking therapy. Twenty-four of the 25 participants completed the study. The trial was measuring whether it was practical to run this combination treatment, and tracking scores on several questionnaires that ass...
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NCT02512445 · results posted 9 May 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 145 people in total — 74 in a group receiving Trauma Informed Guilt Reduction Therapy and 71 in a group receiving Supportive Care Therapy. Of those, 48 and 50 people respectively completed the study, meaning a number of participants in both groups did not finish. The trial was measuring changes in feelings of guilt related to traumatic experiences, as well as related measures including PTSD symptom severity, depression, shame, quality of life, and general psychological distress. The reported data shows that, for the...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05168267 · results posted 8 April 2025
According to the results reported on ClinicalTrials.gov, this trial looked at delivering a talking therapy called Cognitive Processing Therapy (CPT) — a structured program designed for people who have experienced trauma — inside correctional facilities. A total of 69 people started the intervention: 35 women at one facility and 34 men at another. The trial was measuring three main things: how many people stuck with the program from start to finish, how much self-reported trauma (PTSD) symptoms changed during the program, and how satisfied participants were with the therapy. The reported data...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03068325 · results posted 8 April 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT03068325) involved a single group of participants called "EAT-PTSD." A total of 63 people started the study, 58 completed it, and 5 did not finish. The trial was measuring changes in post-traumatic stress disorder (PTSD) symptoms over 8 weeks, using a standardised clinical interview tool called the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). This scale runs from 0 to 80, where a higher number means more severe PTSD symptoms. The reported data shows that, on average, participants scored 38.6 on the CAPS-5 scale a...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04597190 · results posted 26 March 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 700 people in total across three treatment groups. One group (169 people) started on an SSRI medication and then had a talking therapy called WET added on top; a second group (179 people) started on an SSRI and then switched to a different type of antidepressant called an SNRI; and a third group (352 people) started with WET talking therapy and then switched to an SSRI. The trial was measuring PTSD symptom levels, mental health-related quality of life, and depression symptom levels across these groups. By the end of t...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT06081309 · results posted 19 March 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 30 adults who received a brain stimulation treatment called TMS (Transcranial Magnetic Stimulation) that was personalised using EEG (a recording of the brain's electrical activity). All 30 participants completed the study — none dropped out. The trial was looking at unwanted events (called adverse events) that occurred during the study, as well as changes in PTSD symptom scores on a standard checklist called the PCL-5, which runs from 0 to 80, where a lower number means fewer or less severe symptoms. The reported dat...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT05305235 · results posted 5 March 2025
According to the results reported on ClinicalTrials.gov, this trial involved 60 people in total — 27 assigned to a program called "RISE Guide" and 33 assigned to a "Relaxation Control" group. The trial was testing whether it was practical and acceptable to run a study using these two approaches, rather than measuring whether a treatment cured or treated a condition. By the time the study ended, 19 people in the RISE Guide group and 17 in the Relaxation Control group had completed it, meaning a notable number of participants did not finish in both groups. The reported data shows that participa...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04889755 · results posted 17 February 2025
According to the results reported on ClinicalTrials.gov, this trial — called SibACCESS — enrolled a very small number of participants: 3 siblings and 3 parents. All 6 people who started the study completed it. The trial was looking at how siblings of children with cancer were faring emotionally and psychologically, using a range of questionnaires filled out by both the siblings themselves and their parents. The reported data shows the following scores across the questionnaires used. On the main measure — the Child PTSD Symptom Scale, which tracks stress symptoms related to traumatic experienc...
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NCT04937504 · results posted 14 February 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 60 people in total — 31 in a group receiving an in-person programme called STAIR-PC, and 29 in a group using an online version called WebSTAIR. Both programmes are designed to support people experiencing symptoms of post-traumatic stress (PTSD). The trial was measuring three main things: changes in PTSD symptom scores over time, how many people stuck with the programme (called "feasibility"), and how satisfied participants were with it. A number of additional measures tracked general mental wellbeing, difficulties man...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT03841773 · results posted 6 February 2025
According to the results reported on ClinicalTrials.gov, this trial (NCT03841773) looked at a tablet called TNX-102 SL (5.6 mg), placed under the tongue, compared to a placebo (a dummy tablet with no active ingredient) in people with PTSD. A total of 192 people took part — 93 in the placebo group and 99 in the TNX-102 group. The trial ran for 12 weeks and measured changes in PTSD symptom severity using several questionnaires and rating scales. The reported data shows the following numbers after 12 weeks of treatment. For the main measure — a PTSD symptom scale called the CAPS-5, which runs fr...
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NCT05520190 · results posted 10 January 2025
According to the results reported on ClinicalTrials.gov, this trial enrolled 42 participants in total, with 33 completing the study and 9 not completing it. The trial was designed to look at whether a program could influence deaf or hard-of-hearing people's willingness to seek professional help for behavioural health concerns (such as alcohol use). It measured things like participants' attitudes toward treatment, their sense of what others in their community thought about seeking help, how much control they felt they had over seeking treatment, and whether they actually went ahead and booked o...
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NCT05938816 · results posted 5 November 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT05938816) compared two group programmes — Mindfulness-Based Stress Reduction (MBSR) and a Health and Wellness Education programme — in people with PTSD (post-traumatic stress disorder). The trial was primarily designed to explore whether MBSR was feasible and acceptable to participants, meaning it was looking at practical questions like what got in the way of people completing the programme and whether participants felt the content was relevant to their lives. Secondary measurements included self-reported questionnaires ab...
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NCT02774642 · results posted 8 October 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT02774642) enrolled 94 people in total — 52 in one group called CBTI-PE (a combination of cognitive behavioural therapy for insomnia and prolonged exposure therapy) and 42 in a comparison group called Hygiene-PE (sleep hygiene education combined with prolonged exposure therapy). Of those, 43 and 35 participants respectively completed the study. The trial was measuring two main things over time: changes in PTSD (post-traumatic stress disorder) symptom severity, and changes in sleep efficiency (the proportion of time in bed a...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04889664 · results posted 8 October 2024
According to the results reported on ClinicalTrials.gov, this trial (NCT04889664) looked at a combination of ketamine infusions and a talking-based approach called Written Exposure Therapy (WET) for people with PTSD. A total of 16 people went through the initial screening phase, 14 of those moved on to receive the study treatment, and 13 completed the full treatment period. The reported data shows that the trial measured PTSD symptom severity using a tool called the CAPS-5 (Clinician Administered PTSD Scale for DSM-5). This is a structured interview where a clinician rates the frequency and i...
View reported results on ClinicalTrials.gov ↗ · Linked publication on PubMed ↗
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NCT04236986 · results posted 26 September 2024
According to the results reported on ClinicalTrials.gov, this trial enrolled 34 people across two groups: 18 people who had experienced trauma but did not have PTSD (the "healthy control" group), and 16 people who had experienced trauma and did have PTSD. Of those, 15 people in each group completed the study. The trial was measuring activity of a protein in the brain called TSPO — a marker linked to brain inflammation — using a specialised brain scan technique. Participants were scanned twice: once at their normal baseline, and once after receiving a small dose of a substance called LPS (lipop...
See all 173 reported results for PTSD
These are the results as reported to the registry, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
What is coming
AI generated pipeline summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to NIH funding data, public investment in PTSD research in the United States is at a very large level, and that investment has been rising year on year. This suggests that PTSD is treated as a serious research priority by major government health funders. For patients, a growing funding base generally means more studies are being supported, which can translate into a broader pipeline of p...
Not medical advice. Voxsanity republishes public government health data in plain English. These figures describe research and registry activity, not the suitability of any treatment for any person. Trial status can change; always verify current status directly with the trial site and confirm Australian availability with your doctor.