Phase 3 Multiple Sclerosis Trial, Recruiting

Written by an AI model from the ISRCTN registry eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have been diagnosed with relapsing-remitting multiple sclerosis (RRMS), confirmed using recognised diagnostic guidelines (the 2017 or 2024 McDonald criteria)
• People who have already completed 4 or more 6-monthly treatment cycles of ocrelizumab (given either by drip or injection under the skin), following approved UK prescribing guidelines
• People whose level of physical disability, as measured by a standard MS scale (called the EDSS), falls within a specific range at the start of the trial (confirm exact score range with trial site)
• People who wish to continue receiving ocrelizumab
• People who are willing and able to give written consent to take part
• People who have had a qualifying brain scan (MRI) taken within 6 weeks of their initial screening visit, which has been checked and approved for quality

Who may not be able to join:

• People who have had one or more MS relapses in the 12 months before joining the trial
• People whose most recent brain scan (MRI) shows new lesions compared to an earlier scan taken at least 3 months before, while they were already on ocrelizumab
• People who are currently taking other medications that suppress the immune system alongside ocrelizumab
• People who have any condition or circumstance that would prevent them from having regular MRI scans during the trial
• People who are pregnant or who plan to become pregnant during the study period

Important: Always verify eligibility with the trial site directly before applying.