Phase 2 Multiple Sclerosis Trial, Recruiting

Written by an AI model from the ISRCTN registry eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

People with multiple sclerosis (MS):

• Adults diagnosed with primary progressive, secondary progressive, or relapsing-remitting MS.
• People whose MS-related disability falls within a specific range — roughly meaning they can walk up to 500 metres without an aid at the lower end, or need two walking aids to walk about 20 metres at the upper end (confirm with trial site for exact scoring).

Carers or support people:

• People who provide informal or formal care to someone with MS involved in the study, including helping with hospital visits, using the muscle stimulation device, or recording health and activity information.

Healthcare staff:

• Clinical and non-clinical staff who were involved in setting up or running the study.

Who may not be able to join:

People with multiple sclerosis (MS):

• People diagnosed with clinically isolated syndrome (an early MS-like episode, not yet confirmed as MS).
• People currently experiencing an MS relapse, or who have had a relapse within the past 8 weeks.
• People with a nerve injury in the lower limbs.
• People with fixed stiffness or tightening of muscles in the lower limbs that cannot be moved (fixed contractures).
• People for whom electrical muscle stimulation on the skin would not be safe, including those who are pregnant, have uncontrolled epilepsy, have a lower-limb nerve injury, have an unstable bone or joint condition in the lower limbs, have cancer in the area where the device pads would be placed, or have a skin infection or damaged skin at that site.
• People who are unable to operate the electrical stimulation device and leg braces on their own or with carer help.
• People with other conditions that significantly affect mobility, such as a history of stroke (note: a heart pacemaker or cardiac history alone is not automatically disqualifying, but a cardiologist's approval would be required — confirm with trial site).

Carers or support people:

• Carers or support people who were not directly involved in the study are not eligible to participate as carers in this trial.

Healthcare staff:

• Healthcare practitioners or staff who were not involved in setting up or delivering the study are not eligible to participate in this capacity.

Important: Always verify eligibility with the trial site directly before applying.