Phase 3 Uveitis Trial, Completed NCT00333814 Sponsor: Allergan Condition: Uveitis
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Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial involved 229 people in total, split across three groups: one group received a low dose (350 micrograms) of a medicine called dexamethasone injected into the eye, one group received a higher dose (700 micrograms), and one group received a sham (fake) procedure as a comparison. The trial was looking at a condition causing inflammation inside the eye, and the main thing being measured was how many people had no detectable eye inflammation (called a vitreous haze score of zero) at eight weeks after treatment. The reported data shows that at the eight-week mark, 35.5% of people in the low-dose group and 46.8% of people in the higher-dose group had a vitreous haze score of zero, meaning no detectable inflammation was recorded. In the sham group, 11.8% reached that same score. The reported data also shows that when it came to vision improvement — specifically, reading at least 15 more letters on an eye chart than at the start — 39.5% of the low-dose group and 42.9% of the higher-dose group reached that level, compared with 6.6% in the sham group. A separate quality-of-life questionnaire (a survey about how well people could carry out everyday visual tasks, scored from 0 to 100) showed that a meaningful improvement of at least 10 points was reported by 40.8% of the low-dose group and 50.7% of the higher-dose group, versus 15.9% of the sham group. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Phase 3 Uveitis Trial, Completed

NCT00333814
Completed Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years old or older and have been diagnosed with a long-term inflammatory eye condition called chronic intermediate uveitis in at least one eye

Who may not be able to join:

  • You have a serious illness or health condition that is not currently under control
  • You currently have an active infection in one or both eyes

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Medical Director, Allergan

Australian sites

, Sydney,

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Completed
Phase
Phase 3
Sponsor
Registry
ClinicalTrials.gov
Start date
1 May 2006
Est. completion
1 December 2008

Where this trial is recruiting

🇦🇺 Australia 🇦🇹 Austria 🇧🇷 Brazil 🇨🇦 Canada 🇨🇿 Czechia 🇫🇷 France 🇩🇪 Germany 🇬🇷 Greece 🇮🇳 India 🇮🇱 Israel 🇵🇱 Poland 🇵🇹 Portugal 🇿🇦 South Africa 🇰🇷 South Korea 🇪🇸 Spain 🇨🇭 Switzerland 🇬🇧 United Kingdom 🇺🇸 United States

1 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Percentage of Patients With Vitreous Haze (Ocular Inflammation) Score of Zero

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov