Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People with a history of heart or blood vessel disease, or those suspected of having it based on clinical findings or imaging tests such as ultrasound or specialised scans
• People who have risk factors for hardening of the arteries (atherosclerosis), such as smoking, obesity, high cholesterol, low "good" cholesterol levels, high blood pressure, a close family member who developed heart disease at a young age, or diabetes
• Healthy volunteers, as well as people with known or suspected conditions affecting the chest, abdominal organs, or organs affected by metabolic conditions such as excess body fat
• People aged over 18 years old
• People who are willing to take part and are able to give informed consent
• People who are medically stable and able to travel to the Clinical Center to participate

Who may not be able to join:

• People who cannot have an MRI scan due to having certain implanted devices, including a pacemaker or defibrillator, cochlear implants, an implanted nerve stimulator, a medical infusion pump, metal fragments in the eye or body, brain aneurysm clips, or any other implant that is not compatible with MRI
• People whose general health or condition means they would not be able to tolerate lying in an MRI scanner — for example, those with unstable chest pain or severe breathlessness at rest, as determined by their referring doctor
• People who would require sedation in order to undergo an MRI scan
• People who cannot physically enter an MRI scanner, for example due to severe obesity or claustrophobia (fear of enclosed spaces)
• Women who are pregnant or breastfeeding
• People with severe back pain or movement difficulties that would prevent them from lying still in the MRI scanner for the duration of the scan
• People who are unable to have a CT scan within 2 months of the MRI scan portion of the study, or cannot be scheduled for a heart catheterisation procedure within 2 months of the MRI scan (confirm with trial site)

For the part of the study involving gadolinium-based MRI contrast dye only:

• People who have previously had an allergic reaction to gadolinium contrast agents, even after receiving antihistamine and steroid pre-medication
• People with reduced kidney function below a certain level (eGFR less than 60 ml/min/1.73m²) (confirm with trial site)

For the CT scan (coronary CTA) portion only:

• People with kidney function above a certain creatinine level, a history of multiple myeloma (a type of blood cancer), or a previous allergic reaction to CT contrast dye even after pre-medication
• People who have taken a diabetes medication containing metformin within 24 hours before the contrast dye would be given
• People who cannot take a type of heart-rate-slowing medication called a beta blocker, due to conditions such as asthma, active airway spasm, moderate to severe chronic lung disease, certain heart rhythm problems, heart failure, beta blocker allergy, low blood pressure, or pregnancy/breastfeeding

For the part of the study involving nitroglycerin:

• People with a history of any of the following: severe narrowing of the aortic heart valve, a thickened heart muscle condition (hypertrophic cardiomyopathy), a heart attack involving the right side of the heart, fluid around the heart (cardiac tamponade), scarring around the heart (constrictive pericarditis), very low blood pressure, low blood volume, raised pressure in the brain, glaucoma (increased eye pressure), severe anaemia, or sensitivity/allergy to nitroglycerin
• People currently taking certain medications used for erectile dysfunction, including sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra)

Important: Always verify eligibility with the trial site directly before applying.