Phase 2 Uveitis Trial, Completed NCT01789320 Sponsor: Clearside Biomedical, Inc. Condition: Uveitis
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Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial enrolled 11 participants, all of whom received an eye injection of a corticosteroid medication called triamcinolone acetonide (brand name Triesence®). Nine participants completed the study, while two did not finish. The trial was measuring changes in eye pressure, vision sharpness, retinal thickness, and the degree of cloudiness inside the eye (called vitreous haze) over a period of up to 26 weeks. The reported data shows that eye pressure (the fluid pressure inside the eye, measured in millimetres of mercury) changed by an average of −0.1 mm Hg from the starting point at week 8 — meaning it was almost unchanged. For vision sharpness, the reported data shows an average change of −0.25 units at week 8 and −0.28 units at week 26 on the scale used (where a negative number indicates an improvement in vision on that particular scoring system). Regarding retinal thickness — a measure of swelling at the centre of the retina — the reported data shows an average reduction of approximately 154 microns at week 8 and 107 microns at week 26, where a negative number indicates the retina became thinner. For vitreous haze (cloudiness inside the eye, scored on a scale where higher numbers mean more cloudiness), the reported data shows an average reduction of 0.75 score points at both week 8 and week 26. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Phase 2 Uveitis Trial, Completed

NCT01789320
Completed Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with a non-infectious form of uveitis (inflammation inside the eye) affecting the middle, back, or entire part of the eye

Who may not be able to join:

  • You have had an injury to the eye being studied in the last 6 months
  • You have received a steroid injection inside the eye, a steroid implant, or an Ozurdex® implant in the last 6 months, or have ever had a Retisert™ implant in the eye being studied
  • You have an uncontrolled illness or health condition that could make it unsafe to participate in the study
  • You have a known HIV infection or another condition that weakens the immune system, where steroid treatment could be harmful
  • You only have one functioning eye
  • You have high pressure inside your eye (a condition sometimes related to glaucoma)
  • You have had any surgery inside the eye being studied at any point in the past
  • You have a condition called anterior staphyloma (a thinning or bulging of the wall of the eye being studied) (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

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Trial details

Status
Completed
Phase
Phase 2
Sponsor
Clearside Biomedical, Inc.
Registry
ClinicalTrials.gov
Start date
1 February 2013
Est. completion
1 March 2015

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Intraocular Pressure (IOP); Best Corrected Visual Acuity

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov