Phase 2 Uveitis Trial, Completed NCT02406209 Sponsor: Aldeyra Therapeutics, Inc. Condition: Uveitis
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Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial (NCT02406209) enrolled 45 people across three groups to compare different eye drop treatments for eye inflammation. The three groups were: NS2 eye drops (0.5%) alone (15 people); NS2 (0.5%) combined with Pred Forte® (0.1%) eye drops (16 people); and Pred Forte® (1%) eye drops alone (14 people). Roughly half of the participants in each group completed the study — 7, 7, and 6 people respectively — while the remainder did not finish. The main thing the trial measured was a score called the "anterior chamber cell grade" — a scale from 0 to 4 that rates the level of inflammatory cells visible inside the eye, where 0 means none and 4 means severe. The reported data shows the change in this score from the start of the trial to week 8. The NS2-only group showed an average change of −0.7 units on that scale; the NS2 combined with low-dose Pred Forte® group showed a change of −0.9 units; and the standard Pred Forte® (1%) group showed a change of −0.5 units. A negative number means the score went down (i.e., moved toward fewer cells) compared to the starting point. No secondary outcome data was reported in the submitted results. It is worth noting that the relatively small number of people who completed each group makes these numbers difficult to draw broad conclusions from. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Phase 2 Uveitis Trial, Completed

NCT02406209
Completed Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with non-infectious anterior uveitis (inflammation at the front of the eye that is not caused by an infection)
  • The level of inflammation in the front part of your eye falls within a certain range (graded 1 to 3 by your eye doctor)
  • The pressure in your study eye is below 25 mmHg at the start of the trial, and you need no more than one eye drop medication to control that pressure
  • Your vision in the study eye is at least 20/200 (this means you can see at 20 feet what someone with typical vision can see at 200 feet)

Who may not be able to join:

  • You have a serious or severe eye disease or condition affecting the study eye
  • You currently have active inflammation in the middle or back parts of your eye
  • You had a previous episode of anterior uveitis in the study eye within the 4 weeks before your first trial visit
  • You have taken steroid tablets or pills by mouth within the 14 days before your first trial visit
  • You have received a steroid injection into or around your study eye within the past 6 months

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

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Trial details

Status
Completed
Phase
Phase 2
Sponsor
Aldeyra Therapeutics, Inc.
Registry
ClinicalTrials.gov
Start date
1 March 2015
Est. completion
1 April 2016

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Anterior Chamber Cell Grade at Week 8

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov