Phase 2 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with sickle cell disease, specifically the Hemoglobin SS (HbSS) or Sβ⁰-thalassemia type
- You are between 7 and 21 years old
- You weigh at least 25 kg (about 55 lbs)
- You are currently in an acute care setting (such as an emergency room, hospital ward, or clinic) with pain from sickle cell disease that is severe enough to need pain medicine given through a needle or IV (not caused by something unrelated to sickle cell disease)
Who may not be able to join:
- You are being sent home from the acute care setting rather than being kept for further treatment
- You have a different type of sickle cell disease, such as HbSC, HbSD, HbSE, HbSO, Hb-Beta Thal, or you are an HbAS carrier
- Your hemoglobin (red blood cell) level is very low (below 5 gm/dL)
- You are expected to need a red blood cell transfusion right away
- You have kidney problems above a certain level (confirm with trial site)
- You are experiencing changes in your mental state or nervous system function
- You are having or are suspected to be having a stroke
- You are pregnant
- You are allergic to arginine (a type of amino acid)
- You were hospitalized less than 7 days ago
- You have used inhaled nitric oxide, sildenafil, or arginine in the past 14 days
- The doctor running the trial does not feel you are a suitable candidate for any other reason
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Claudia Morris, MD, Emory University
Phone: 404-785-4525
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Pharmacokinetics of IV arginine, measured by plasma arginine concentration over time; Change in nitric oxide metabolites
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.