Sickle Cell Disease

**Who might be able to join this trial:** - You can be male or female. - You must be 12 years old or older at the time of signing the consent form. - You must have a confirmed diagnosis of sickle cell disease (such as HbSS, HbSβ0-thalassemia, or a similar type), shown through past or current blood test results. - You m...

Who might be able to join this trial: - You have been diagnosed with a significant sickle cell condition, including Hemoglobin SS, Hemoglobin S-beta thalassemia, or a related hemoglobin variant - You are between 16 and 60 years old - You have one or more ulcers on your lower leg or ankle that have not healed for at lea...

**Who might be able to join this trial:** - You have been diagnosed with, or are suspected to have, sickle cell disease - You are 2 years of age or older - You (or your parent or legal guardian, if applicable) are willing and able to give permission to take part in the study - You receive care at a sickle cell outpatie...

Here is the eligibility information in plain English: **Who might be able to join this trial:** - People who carry the sickle cell trait (meaning they carry one copy of the sickle cell gene but may not have the full disease) - People who have a blood disorder involving one or two sickle cell genes (such as sickle cell...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with homozygous SS sickle cell disease or S-β0 Thalassemia (specific types of sickle cell disease confirmed by a doctor) - People who were unable to tolerate a medication called hydroxyurea, chose not to take it, or di...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease of any type. - *(For the PK sub-study only)* You are a patient at St. Jude Children's Research Hospital and have already joined the main study (SCCRIP, version 6.1 or later). - *(For the PK sub-study only)* You are currently ta...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease, specifically the Hemoglobin SS (HbSS) or Sβ⁰-thalassemia type - You are between 7 and 21 years old - You weigh at least 25 kg (about 55 lbs) - You are currently in an acute care setting (such as an emergency room, hospital war...

**Who might be able to join this trial:** - You have been diagnosed with one of the following blood disorders: Homozygous Sickle Cell Disease (HbSS), Hemoglobin S Beta Thalassemia, Hemoglobin SC Disease, or Beta Thalassemia Intermedia/Major. - You have had a stroke or a neurological problem lasting more than 24 hours...

"Who might be able to join this trial: - People who are receiving treatment or specialist medical advice for a non-cancerous blood disorder, or for a blood condition known as myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN). - Biological (blood-related) family members of someone who meets the first c...

Who might be able to join this trial: - People who are 12 years of age or older at the time of signing up for the trial - People who have a confirmed diagnosis of Sickle Cell Disease, specifically the HbSS type, or related forms called HbSC or HbSβ-thalassemia, shown by one or more clinical signs or features - People (...

Who might be able to join this trial: - People diagnosed with sickle cell disease who have experienced at least one of the following complications: a stroke or nervous system event lasting more than 24 hours; frequent severe pain episodes (3 or more per year needing emergency care, hospital admission, or home bedrest c...

**Who might be able to join this trial:** - You have a non-cancerous condition that requires a bone marrow transplant, such as bone marrow failure, a metabolic disorder, an immune system disorder, or a blood disorder like sickle cell disease or thalassemia - If you have sickle cell disease, you must also have at least...

**Who might be able to join this trial:** - The patient must be at least 12 months old and under 19 years old at the time of joining the study. - The patient must have a confirmed diagnosis of sickle cell disease, specifically one of these types: homozygous sickle cell disease (HbSS), sickle-Hb C disease (HbSC), sickl...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell anemia (a specific type called Hgb SS or SB° Thalassemia) with a high level of the abnormal hemoglobin S in your blood. - You have had a stroke or a neurological problem (such as weakness or other symptoms) lasting more than 24 hours,...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part in the study - You currently live in Germany, Austria, or Switzerland - You have been diagnosed with sickle cell disease, confirmed by a blood test or genetic test — this includes several types, such as HbS...

**Who might be able to join this trial:** - You have sickle cell disease (any type), and this is recorded in your St. Jude medical records. - You are coming to St. Jude Children's Research Hospital because you are in a pain crisis (called a vaso-occlusive crisis, or VOC). - You are between 6 and 25 years old. - You are...

**Who might be able to join this trial:** *For people with sickle cell disease genotypes HbSS or Sβ0 thalassemia, at least one of the following must apply:* - A history of abnormal blood flow measurements in the brain's arteries (measured by a special ultrasound test), recorded on at least two separate occasions - A...

**Who might be able to join this trial:** - The patient, their parent, or legal guardian must have signed a consent form agreeing to take part in the study. - Participants must be between 5 and 40 years old at the time of signing the consent form. - People with a diagnosis of Sickle Cell Disease (specifically the SS o...

Who might be able to join this trial: - You are between 18 and 80 years old. - You are African or of African descent. - You are able to understand and agree to taking part in the trial (give informed consent). Who may not be able to join: - You have had a blood transfusion in the last 8 weeks. - You have a condition c...

**Who might be able to join this trial:** - You are between 16 and 17 years old - You have been diagnosed with a major form of sickle cell disease, specifically one of the following types: SS (homozygous), SC, or Sβ-thalassemia (confirm with trial site for exact type) - You receive long-term health coverage through a...

**Who might be able to join this trial:** - You are between 18 and 70 years old. - You are able to understand and agree to participate by giving your consent. - You are willing to allow samples of your body fluids or tissues (such as saliva, urine, or blood) to be stored for future research. - You are willing to provid...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with a major form of sickle cell disease (specifically the SS, SC, Sβ0, or Sβ+ types) - People who are currently experiencing a pain crisis — meaning acute pain or tenderness in at least one area of the body (such...

**Who might be able to join this trial:** - You previously had a stem cell transplant from a related donor to treat sickle cell disease (SCD) or beta thalassemia - Your sickle cell disease or beta thalassemia has come back after the transplant, causing symptoms such as pain crises, chest problems, dependence on blood...

**Who might be able to join this trial:** - People aged 18 years or older. - People who are willing and able to provide written consent before the study begins. - People who have a confirmed diagnosis of sickle cell disease (SCD), confirmed through specific blood tests (hemoglobin electrophoresis or liquid chromatogra...

**Who might be able to join this trial:** - People whose medical records from before June 20, 2019 show they were pregnant and had sickle cell disease (a blood disorder), including those whose pregnancy ended in miscarriage, stillbirth, or delivery at any stage of pregnancy, and who were exposed to a medication called...

**Who might be able to join this trial:** - People diagnosed with high-risk Acute Lymphoblastic Leukemia (ALL) — a type of blood cancer — including cases with certain genetic changes, where initial treatment did not work well, or where the disease has come back after earlier treatment - People diagnosed with Acute Mye...

Who might be able to join this trial: - You identify as African American - You have been diagnosed with sickle cell anemia (note: healthy volunteers who are African American and do not have sickle cell anemia may also be eligible to join as a comparison group) - You are 18 years old or older Who may not be able to joi...

**Who might be able to join this trial:** - You (or your child) must be older than 6 months of age - You (or your child) must have been diagnosed with Sickle Cell Disease (a blood condition), of any type - You (or your child) must need ongoing regular blood transfusions as part of their treatment - You, your parent, or...

**Who might be able to join this trial:** *For Healthy Controls:* - You are between 3 and 50 years old and do not have a serious health condition - You are able to have an MRI scan while awake, without needing sedation - You are not currently pregnant - You do not have a significant or severe mental health diagnosis (...

**Who might be able to join this trial:** This trial has four separate groups. People may be considered for one of the following: - **Group 1 (Healthy volunteers):** Children and teenagers aged 8–18 who do not have sickle cell disease (SCD). - **Group 2 (SCD patients without certain treatments):** Children and teenag...

**Who might be able to join this trial:** - People aged between 2 and 35 years old - People diagnosed with a specific type of sickle cell disease — either homozygous hemoglobin S (HbSS), hemoglobin SC (HbSC), or hemoglobin S beta-thalassemia (HbSβ0 or HbSβ+) - People who have given consent to participate in this speci...

Who might be able to join this trial: - People of any age who have a congenital (present from birth) or acquired (developed over time) blood disorder - People who have unusual or excessive bleeding and score above the normal range on a standard bleeding questionnaire (called the ISTH Bleeding Assessment Tool), even if...

**Who might be able to join this trial:** **For healthy participants (without sickle cell disease):** - You are between 4 and 21 years old - You are able to have an MRI scan without needing sedation (sleep medicine) - You are not currently pregnant - You do not have a serious mental health diagnosis (the trial team wi...

**Who might be able to join this trial:** *Group 1 – Survey and Interview:* - Parents of a child (aged 12 months to 18 years) who has been diagnosed with a specific type of sickle cell disease (HbSS, HbS/β0 thalassemia, or HbSC), regardless of how severe the condition is, or patients aged 13–18 with one of these diagn...

**Who might be able to join this trial:** - You have been diagnosed with Sickle Cell Disease (SCD), including types such as HbSS, HbSC, HbS-beta-0 thalassemia, or HbS-beta+ thalassemia - You have experienced moderate to severe pain (rated more than 3 out of 10) related to your SCD within the last 24 hours - You use opi...

**Who might be able to join this trial:** - You are an adult (or a minor whose parent/guardian can provide consent) and are willing to sign a consent form to take part in this follow-on study - You are already taking part in a Novartis-sponsored study receiving crizanlizumab, have completed all the required steps in th...

Who might be able to join this trial: - People between 12 and 21 years old - People with any type of sickle cell disease - People who have been taking hydroxyurea at a stable dose for at least 2 months - People who own or have access to a smartphone throughout the study period Who may not be able to join: - People who...

**Who might be able to join this trial:** - You are between 12 and 34 years old (at the time of signing consent) - You have sickle cell disease of the HbSS type (the most common form) and have experienced one or more of the following serious complications: - Two or more episodes of a lung complication called "acute...

**Who might be able to join this trial:** - People aged 12 to 40 years old - People with sickle cell disease who have had at least one of the following despite receiving appropriate care: four or more severe pain crises in the past 2 years, OR two or more episodes of acute chest syndrome in the past 2 years with at lea...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease (a specific confirmed type, such as HbSS, SC, S/β-thalassemia, SD, SE, or SO) confirmed by a blood test. - You are 18 years old or older. - You are able to understand the study information and agree to take part by signing a co...

**Who might be able to join this trial:** - You have been diagnosed with Sickle Cell Disease (SCD) - You are between 8 and 16 years old - You have been receiving monthly blood transfusions regularly for at least 3 months - To move into the active part of the trial, you would need to score above the 75th percentile on s...

Who might be able to join this trial: - You have been diagnosed with Sickle Cell Disease (SCD) confirmed by a laboratory test - You are able to understand and sign a consent form agreeing to take part in the study - You are able to provide medical records or data from both before and after your treatment - You have bee...

**Who might be able to join this trial:** - You are willing to take part in all parts of the study for its entire duration - You are 18 years of age or older at the time of signing up - You have been officially diagnosed with Sickle Cell Disease (SCD), confirmed through your medical records, or have one of the followin...

Who might be able to join this trial: - People who have been diagnosed with Sickle Cell Disease (specific types include SS, SC, Sß-thalassemia, SD, or SOArab) - People who are 12 years old or older - People who have given their legal consent to take part in all parts of the study Who may not be able to join: - People...

**Who might be able to join this trial:** - You are willing to follow all study procedures and are available for the full length of the study. - You are 18 years old or older, of any gender. - You have been diagnosed with sickle cell disease (any type, including HbSS, HbSC, HbSβ0-thal, or HbSβ+-thal), and either plan...

**Who might be able to join this trial:** - People diagnosed with sickle cell anemia (specifically the HbSS or HbS/B0-thalassemia types) - Children between 6 months and 12 years old at the time of enrollment - Children whose parent or guardian is willing and able to provide written consent on their behalf - Children wh...

Who might be able to join this trial: - You have been diagnosed with sickle cell disease (any type/form) - You are currently receiving care and being monitored at Children's of Alabama Hospital - You are between 10 and 18 years old - You speak English Who may not be able to join: - You have a history of seizures or a...

**Who might be able to join this trial:** *For young people with Sickle Cell Disease (SCD):* - People between Tanner stages 1–5 (roughly ages 10–17) with a diagnosis of sickle cell disease in any relevant form - People considered to be in relatively good health for someone with SCD, with no SCD complications that a do...

Who might be able to join this trial: - You visited the emergency department for a pain crisis related to sickle cell disease that was not complicated by other serious problems - You have been diagnosed with sickle cell disease - You received at least one opioid (strong painkiller) during your emergency department visi...

Who might be able to join this trial: - You have been diagnosed with sickle cell disease Who may not be able to join: - You are under 18 years old - You are currently pregnant - You are under a legal protective arrangement such as guardianship or curatorship (where someone else has been appointed to help manage your a...

Who might be able to join this trial: - You are the mother of a baby or infant who has been diagnosed with sickle cell disease - You live in Birmingham, Alabama, or somewhere nearby Who may not be able to join: - You are currently taking certain medications that can cause harm to a developing baby (confirm with trial...

Who might be able to join this trial: - You are between 12 and 24 years old and need to be admitted to hospital for pain caused by a sickle cell pain crisis (when blood flow is blocked, causing severe pain) Who may not be able to join: - You have previously had bad reactions or side effects to ketamine given through a...

Who might be able to join this trial: - Patients aged 15 to 25 years who have been diagnosed with Sickle Cell Disease (SCD) and are receiving care at Nemours, along with their caregivers - Patients whose SCD healthcare provider has determined they are candidates to start one or more treatments that can change the cours...

**Who might be able to join this trial:** - A person who has given informed consent (or whose legal guardian has given consent), and who has been registered in the required safety monitoring program for this study - People between the ages of 12 and 40 years old - People whose general physical functioning meets a cert...

**Who might be able to join this trial:** - You are 18 years of age or older - You have a half-matched (haploidentical) family donor available — this means a donor who shares about half of their tissue type markers with you, such as a parent, child, or sibling - You have sickle cell disease (SCD) that is considered se...

**Who might be able to join this trial:** - People who are at least 18 years old and, as a boy before puberty, had testicular tissue removed and frozen as part of a fertility preservation program at the time of a cancer or blood disorder diagnosis - People who have a female partner who is under 43 years of age (if app...

**Who might be able to join this trial:** - You have sickle cell disease (SCD) - Your hemoglobin (a measure of red blood cells) levels are considered stable by your doctor - If you are taking hydroxyurea and/or L-glutamine, your dose has been unchanged for at least 90 days before joining and is not expected to change...

**Who might be able to join this trial:** - You have been diagnosed with transfusion-dependent beta-thalassemia (TDT) or severe sickle cell disease (SCD), and your doctor believes you are a suitable candidate for a stem cell transplant using your own stem cells. - *(For TDT patients)* You have a confirmed diagnosis of...

**Who might be able to join this trial:** - You must be older than 18 years of age - You must have been diagnosed with Sickle Cell Disease (SCD) in one of several specific forms (confirm with trial site if unsure which type you have) - Your pain must be affecting your daily life at a certain level, based on a specific...

Who might be able to join this trial: This trial has three groups. You may qualify for one of them: **Group A – Sickle cell disease with heart stiffness (diastolic dysfunction):** - You are between 18 and 21 years old - You identify as Black - You have been diagnosed with sickle cell disease of the HbSS or HbSβ0 thal...

**Who might be able to join this trial:** - People aged 12 years or older - People who have already been diagnosed with sickle cell disease (specific types include Hb SS, Hb SC, Hb Sβ+, and Hb Sβ0) **Who may not be able to join:** - People who are currently pregnant or breastfeeding - People who have previously receiv...

**Who might be able to join this trial:** - People aged 14 to 21 who have Sickle Cell Disease - People who are willing to take part in a group therapy program called ACT (Acceptance and Commitment Therapy), offered jointly by two hospital departments - People who are current patients, on the waitlist, or new patients...

**Who might be able to join this trial:** - People aged 2 to 50 years old. - People who have a suitable half-matched (haploidentical) donor available. - People who have a reasonable level of physical functioning, as measured by standard medical scoring tools. - People whose kidneys are working well enough, based on bl...

Who might be able to join this trial: - You have been diagnosed with an inherited blood disorder affecting hemoglobin, such as sickle cell disease, beta-thalassemia, or alpha-thalassemia (all types are considered). - You are 2 years old or older at the time your health information is collected for the study. - People o...

**Who might be able to join this trial:** *This study has several different groups. You may qualify for one of the following:* - **Group 1 – Gene therapy received (for a rare genetic disease):** You are a parent or caregiver of a child who has received gene therapy, OR you are a patient aged 8 or older who has receiv...

**Who might be able to join this trial:** - People who have signed a written consent form before any study procedures begin. - People aged between 18 and 65 years old. - People with a confirmed diagnosis of sickle cell disease (specifically the HbSS or HbSBeta^0 type), confirmed by a blood test — and if the person has...

**Who might be able to join this trial:** - A parent, legal guardian, or legal representative has given written permission for the patient to participate, and the patient themselves has also agreed to take part in an age-appropriate way - The patient is between 12 and 16 years old (inclusive) at the time of screening...

Who might be able to join this trial: - You are between 18 and 80 years old and have been diagnosed with sickle cell disease (any type, confirmed by a blood test) - You are able to read and sign a consent form agreeing to take part in the study - You are able to lie still on a special bone density scanning machine (cal...

**Who might be able to join this trial:** - You are an adult woman - You have been pregnant at some point, for any length of time - You are willing to sign a consent form agreeing to take part - You may have had one or more pregnancies (first-time or experienced mothers are both welcome) - You are covered by health in...

Who might be able to join this trial: - People who have a diagnosis of any type of sickle cell disease (SCD) recorded in their medical records - People who own a mobile device that works with the study's app or tool - People who have access to the internet Who may not be able to join: - People who are planning to move...

Who might be able to join this trial: - You are willing to take part voluntarily and sign a consent form agreeing to participate. - You know or suspect you have sickle cell trait (SCT) and are willing to get tested to confirm or find out your sickle cell trait status. - You are 18 years of age or older. Who may not be...

**Who might be able to join this trial:** - You are between 15 and 40 years old and can give written consent (or a parent/guardian can give consent if you are under 18) - You have been diagnosed with sickle cell disease (specifically SS, SC, S beta+ thalassemia, or S beta0 thalassemia) - You have had at least one sickl...

**Who might be able to join this trial:** - People who have signed an informed consent form agreeing to participate. - People aged 14 to 55 years old. - People who have tested negative for Hepatitis B, Hepatitis C, HIV, and COVID-19 (those who test positive for COVID-19 at screening may be re-tested at least four week...

Who might be able to join this trial: - Adults over 18 years old who are being seen in an emergency department - People who have been diagnosed with sickle cell disease - People who came to the emergency department because of severe pain from sickle cell disease, specifically a type of pain episode called a vaso-occlus...

**Who might be able to join this trial:** - A parent, legal guardian, or legal representative has given written consent, and the child has given age-appropriate agreement to participate. - The child is between 6 months and 17 years old at the time of enrolment, placing them in one of four age groups: 12–17 years, 6–11...

Who might be able to join this trial: - People aged 15 to 40 years old - People who have been diagnosed with Sickle Cell Disease (either the SS type or the S Beta-zero Thalassemia type) - People who are currently in a "steady state," meaning at least 2 weeks have passed since their last pain crisis - Both males and fem...

**Who might be able to join this trial:** **For adult caregivers (enrolling on behalf of a child):** - The caregiver speaks English. - The caregiver has a child between 1 and 10 years old who has been diagnosed with sickle cell disease (any type) and has had hydroxyurea prescribed for at least 180 days before joining...

Who might be able to join this trial: - You are a patient at one of the clinics taking part in this study - You have been diagnosed with Sickle Cell Disease (SCD) - You are between 13 and 21 years old Who may not be able to join: - You have another long-term illness in addition to Sickle Cell Disease (confirm with tri...

Who might be able to join this trial: - Samples may be collected from up to 1,000,000 individuals between the years 2015 and 2030, based on ongoing surveillance findings. Who may not be able to join: - If you have already provided a sample during this study period, any additional samples from you would not be included...

**Who might be able to join this trial:** - People aged 18 or older who have a confirmed diagnosis of sickle cell disease (any type), thalassemia (alpha or beta), or another inherited blood disorder affecting haemoglobin - People whose blood disorder is currently stable, or who have previously had a bone marrow transp...

Who might be able to join this trial: - Adults aged 18 or older with Sickle Cell Disease (SCD) who have given their written consent to participate - Children with SCD aged 12 months to 17 years whose guardian is present and has given consent, or who have given their own agreement (assent) to participate - People whose...

**Who might be able to join this trial:** - People with sickle cell disease (SCD) between the ages of 2 and 24 years old who have a healthy brother or sister with a matching immune system type (HLA-identical), where there is a major blood type mismatch between the patient and donor, OR where the patient has developed...

Who might be able to join this trial: - The child has been diagnosed with sickle cell disease (any type/form of the condition) - The child is already enrolled in a specific hospital program called the Sickle Cell Clinical Research Intervention Program (SCCRIP) - The child is between 3.5 and 6.5 years old at the time of...

Who might be able to join this trial: - You are between 16 and 30 years old at the time of joining the trial - You have been diagnosed with sickle cell disease (any type/form) - You experience ongoing pain at least 4 days a week for the past 3 months or more, OR you have been prescribed pain medication taken at least 4...

Who might be able to join this trial: - You must be 18 years of age or older. - You must have a confirmed diagnosis of Sickle Cell Disease (SCD). - You must not have seen a Sickle Cell Disease specialist in more than a year (give or take about 3 months). - You, or your parent/guardian if applicable, must be able to rea...

**Who might be able to join this trial:** - People who have been diagnosed with sickle cell disease (SCD) with one of these specific genetic types: βS/βS, βS/β0, or βS/β+. - People who are between 2 and 50 years old at the time of signing consent. - People who weigh at least 6 kg. - People who have a reasonable level...

Who might be able to join this trial: - Adults (18 years or older) - People who need surgery to remove the pancreas tail and spleen together, or who are planned to have their spleen removed for any reason or by any surgical method Who may not be able to join: - People who have told their doctor that they do not want t...

**Who might be able to join this trial:** - People aged 12 years or older at the time of signing the consent form, including both adolescents (12 to under 18 years) and adults (18 and older). - People who have a confirmed diagnosis of sickle cell disease (SCD), based on specific blood tests (Hb electrophoresis or HPLC...

**Who might be able to join this trial:** - You are 18 years of age or older and have been diagnosed with severe sickle cell disease (SCD), meaning you are currently on regular blood transfusion therapy due to SCD complications, or you qualify for (or are already enrolled in) a bone marrow transplant program - Your si...

Who might be able to join this trial: - You have been diagnosed with sickle cell disease (any type) - You are already a participant in the Sickle Cell Clinical Research and Intervention Program - You are between 12 and 25 years old at the time of joining the trial - English is your main language - You have access to a...

**Who might be able to join this trial:** **Healthy Volunteers (Cohort A):** - People who are generally healthy, as assessed by the study doctor based on medical history and other checks. - Women who are not able to become pregnant — either because they have not had a period for at least 12 months (with no other medic...

Who might be able to join this trial: - The patient has sickle cell disease and is between 1 month and 17 years old - The patient is currently admitted to the Pediatric Intensive Care Unit (PICU) at Robert-Debré Hospital - Doctors suspect the patient may have a condition called acute chest syndrome (a serious lung comp...

**Who might be able to join this trial:** - You are between 18 and 24 years old (up to age 24 years and 11 months). - You have been diagnosed with sickle cell disease with one of these specific genetic types: Hb SS, Hb SB0, or Hb SB+. - You have had either 2 or more sickle cell-related pain crises or serious complicat...

Who might be able to join this trial: - Children between 9 and 14 years old. - Children who are able to follow instructions given to them. - Children with sickle cell anemia who are medically stable and taking their medications as prescribed. - Children with sickle cell anemia who have experienced ongoing pain lasting...

**Who might be able to join this trial:** **For the Healthy Volunteer part of the trial (Part 1):** - Men and women who cannot become pregnant, aged between 18 and 55 years old - People who are in good general health, as confirmed by the study doctor through a check-up, health history review, and basic tests - People...

**Who might be able to join this trial:** - You are between 8 and 25 years old at the start of the study - You have been diagnosed with Sickle Cell Disease (including types HbSS, HbSC, HbS-Beta Thalassemia, or a related blood disorder) - You currently receive your medical care at the Dana-Farber Cancer Institute / Bos...

**Who might be able to join this trial:** - You must be between 12 and 35 years old (inclusive); if you are under 18, a parent or legal guardian must also give written permission. - You must have a confirmed diagnosis of sickle cell disease with a specific genetic type: βS/βS, βS/β0, or βS/β+. - You must have experien...

**Who might be able to join this trial:** - Parents or legal guardians must have signed and dated a written consent form, and children should give their own agreement to participate if they are able to - Children diagnosed with a specific form of sickle cell disease — either HbSS or HbSβ0 type - Children aged between...

Who might be able to join this trial: - You have sickle cell disease - You are between 2 and 18 years old - You are covered by social security (or a similar health insurance/coverage scheme) Who may not be able to join: - You had a neurological problem or condition before the study began - You or your guardian are not...

**Who might be able to join this trial:** - People who are currently taking part in a related ("parent") study of a drug called etavopivat for sickle cell disease or thalassaemia, and who have completed at least the main treatment period of that study. - People whose doctor (the investigator) has determined that they...

Who might be able to join this trial: - The patient must be under 18 years of age - The patient must have sickle cell disease - The patient must be admitted to a specific short-stay or monitored care unit at the Women's Mother and Child Hospital (Hospices Civils de Lyon) for treatment of a vaso-occlusive crisis (a pain...

Who might be able to join this trial: - People who have sickle cell disease, of any type - Children and young people between the ages of 4 and 21 years old with sickle cell disease - People who are currently in hospital because of a sickle cell pain crisis that requires pain relief given through a drip or injection - P...

**Who might be able to join this trial:** - People who have been diagnosed with sickle cell disease (specific types: HbSS, HbS/B0 thalassemia, HbSD, or HbSO) or transfusion-dependent beta-thalassemia, confirmed by genetic testing. - People aged 13 to 40 years. - People with sickle cell disease who have had at least tw...

**Who might be able to join this trial:** - People who have given their verbal agreement to take part in the study - People who have been diagnosed with a major sickle cell syndrome, of any genetic type (for example, SS, SC, or Sbeta) - People who have a strong enough understanding of spoken and written French to compl...

**Who might be able to join this trial:** - You are willing and able to sign and date a consent form agreeing to take part - You are female and between 18 and 50 years old - You have been diagnosed with sickle cell disease (one of these types: SS, SBeta0, SBeta+, or SC) - You have had at least 1 pain crisis per month o...

**Who might be able to join this trial:** **For children and teenagers:** - The child or teen is between 8 and 17 years old and has been referred for a stem cell or cellular therapy treatment - They have been diagnosed with either a cancerous or non-cancerous condition - They are scheduled to meet with a doctor to tal...

**Who might be able to join this trial:** - The adolescent (and their caregiver, if applicable) must sign and date a consent form agreeing to take part - For young people under 18, both the young person's agreement and a parent or guardian's signed permission are required - Participants must be willing to follow all s...

Who might be able to join this trial: - People who are 18 years of age or older at the time of giving consent to join the study. - Adolescents aged 12 to under 18 may also be eligible, but only if the trial sponsor and an independent safety committee have approved enrollment for that age group. - People who have been d...

Who might be able to join this trial: - People of any gender between the ages of 14 and 17 (teenagers) or 18 and 80 years old - People who are right-handed - People who are being treated as outpatients, inpatients, or moving between both types of care - People who have been diagnosed with sickle cell disease (any type,...

**Who might be able to join this trial:** **For people with sickle cell disease:** - You are older than 15 years and 6 months, OR between 3 years old and 15 years and 6 months old - You have been diagnosed with a specific type of sickle cell disease (known as SS or Sβ0 type) **For people joining as a comparison/contr...

Who might be able to join this trial: - You have been diagnosed with sickle cell disease - You are not obese Who may not be able to join: - You have any widespread body illness, chest condition, kidney disease, liver disease, or neurological (brain/nerve) condition - You are currently pregnant or breastfeeding - You a...

Who might be able to join this trial: - People who have been diagnosed with sickle cell disease (any type or form of the condition). - Children between the ages of 7 and 16 years old. - Children who score low enough on at least one working memory test (a type of memory used to hold and use information in the short term...

Who might be able to join this trial: - You are between 8 and 21 years old - You came to the CHNOLA emergency room or another hospital with a sickle cell pain crisis that is serious enough to need a hospital stay for pain treatment - You do not have any known thinking or brain-related difficulties - A parent or guardia...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease of any type (such as SS, SC, S/β0, S/β+, or similar) - You are 2 years old or older - You are currently in hospital with Acute Chest Syndrome (ACS), which means you have a new abnormal finding on a chest X-ray, ultrasound, or...

**Who might be able to join this trial:** - You may be eligible if you have been evaluated for a blood disorder, or if there is a possibility you have a blood disorder, and you have had an appointment with an ATHN Affiliate (a connected healthcare provider). - People of any age can take part in this trial. - You can jo...

**Who might be able to join this trial:** - You are older than 15 years and 3 months - You can be male or female - You have been diagnosed with sickle cell disease (specifically the types known as HbSS or HbS-βthal0) - You are covered by a social security/health insurance system - You have freely agreed to take part an...

**Who might be able to join this trial:** - People who are 14 years of age or older - People who have a diagnosis of sickle cell disease (SCD) recorded in their medical records - People whose sickle cell disease diagnosis has been confirmed by laboratory (blood) tests - People who have had ongoing pain on most days ov...

**Who might be able to join this trial:** - People diagnosed with Sickle Cell Disease (a blood disorder affecting red blood cells) - People with Sickle Cell Disease who have a fully matched brother or sister available as a donor — this applies regardless of how often or how severely symptoms occur - People with Transf...

Who might be able to join this trial: - You (or your child) must be between 0 and 25 years old - You must have a confirmed diagnosis of sickle cell disease (any type or form of the condition) - You must currently be admitted to hospital because of a complication related to sickle cell disease, such as a pain crisis Wh...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease (specifically the SS type or S-beta zero thalassemia type) - You are either in a stable phase of your condition (no crisis for at least 1 year, or currently stable), or you are currently experiencing a pain crisis or a complica...

Who might be able to join this trial: **For adults with sickle cell disease (SCD):** - People who have been receiving care at the sickle cell disease clinic for the past 12 months - People who have been diagnosed with sickle cell disease (specifically the types known as Hgb SS, SC, or Sβ-thal) - People who are able to...

**Who might be able to join this trial:** This trial has two groups: one group receiving a new medicine (Xromi®), and a comparison group not receiving it. Criteria for each are listed below. **Group 1 – Children prescribed Xromi®:** - Children aged 9 months to under 2 years old at the time they enter the study - Chil...

**Who might be able to join this trial:** - You are older than 18 years of age - You have been diagnosed with sickle cell disease (one of several specific types, including HbSS, HbSC, or related variants — confirm with trial site if unsure which type you have) - Your pain levels, as measured by a specific questionnair...

**Who might be able to join this trial:** - Children and young people between the ages of 3 and 20 years old (up to 20 years and 11 months) - People diagnosed with sickle cell anemia (specifically the types known as HbSS or HbSβ0 thalassemia) - For one group in the study: children who are suitable candidates to receive...

Who might be able to join this trial: - People older than 2 years of age who have a confirmed diagnosis of Sickle Cell Disease (SCD), AND who meet at least one of the following conditions: - A history of more than ten transfusion episodes, or 20 or more transfusion units received (where this information is known) - A h...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease (SCD). - You have had at least 2 but no more than 10 painful crises (called vaso-occlusive crises) that were recorded by a doctor in the past 12 months. - You are either not currently taking hydroxyurea and/or L-glutamine (and...

**Who might be able to join this trial:** - You are female - You have been diagnosed with sickle cell disease (any type, such as HbSS, HbSC, or HbSβ thalassemia) - You are 18 years of age or older - You are currently pregnant, between 6 and 20 weeks along - You are able to understand what the study involves and are wil...

Who might be able to join this trial: - You have sickle cell disease (specifically the SS or SC type), or you are a healthy person with normal hemoglobin (hemoglobin AA) who could join as a comparison volunteer - Your sickle cell disease was confirmed by a specialist lab test (such as electrophoresis or HPLC) - You are...

Who might be able to join this trial: - Adults aged 18 years or older - People who are currently experiencing a vaso-occlusive crisis (a painful episode caused by blocked blood flow, commonly associated with sickle cell disease) Who may not be able to join: - Women who are pregnant or currently breastfeeding - People...

**Who might be able to join this trial:** - You or your child has been officially diagnosed with Sickle Cell Disease (SCD) - The child is between 6 and 18 years old - The child reports pain that significantly interferes with daily life, based on scores above a set threshold on a standard pain questionnaire (parents ans...

**Who might be able to join this trial:** - You have a brother or sister whose tissue type (HLA) closely matches yours and who could be a donor - You have been diagnosed with sickle cell anemia (specifically Hb SS, Sβ0 thalassemia, or severe SC disease) and are between 12 and 50 years old - You have had a stroke or a...

**Who might be able to join this trial:** - You are at least 18 years old - You have been diagnosed with sickle cell disease (any type or form) - Your blood test shows a ferritin (iron) level of 400 ng/mL or higher — OR — your ferritin level is below 400 ng/mL but you have heart-related symptoms such as shortness of br...

Who might be able to join this trial: - You are 18 years of age or older (but under 66) - Your kidneys are functioning at a certain minimum level, specifically an eGFR (a measure of kidney function) of 15 or above (confirm with trial site) - You have been diagnosed with a blood condition called a hemoglobinopathy (such...

Who might be able to join this trial: - You are a woman of African descent - You are 50 years of age or older - You have not had a menstrual period for at least 12 months in a row (which typically indicates menopause) Who may not be able to join: - You are currently taking medications that are known to affect bone hea...

**Who might be able to join this trial:** - You have been diagnosed with sickle-cell anemia (specifically the type called HbSS) - Your outer ear has a normal shape and your skin around the ear is healthy and unbroken (this is needed for placing a small device on the ear) - You are currently in the hospital because of a...

Who might be able to join this trial: - You have been diagnosed with sickle cell anemia. - You are at least 8 years old at the time of joining the trial. - You are already enrolled in either the EXTEND or SACRED study. - You are able to give your consent (or a parent/guardian can give consent on your behalf) to take pa...

Who might be able to join this trial: - You are between 12 and 80 years old - Your doctor has decided that you are a suitable candidate for a bone marrow transplant from a donor (called an allogeneic transplant) - Your doctor has determined that the possible benefits of the transplant outweigh the possible risks for yo...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of sickle cell disease (called HbSS or HbSβ0-thalassemia), confirmed by genetic testing - Your urine tests show a certain level of kidney protein leakage (called albuminuria), within a specific range measured at your screening app...

Who might be able to join this trial: - People who have been diagnosed with sickle cell anemia (HbSS) or a related condition called sickle-β0-thalassemia (HbSβ0). - People who are at least 6 months old at the time of joining the trial. - People whose patient, family, and doctor have together decided to start treatment...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing the consent form - You have been diagnosed with sickle cell disease, specifically the HbSC or HbSS type - You have experienced at least one of the following sickle cell-related complications: between 1 and 10 pain crises i...

**Who might be able to join this trial:** - You are older than 18 years old and have been formally diagnosed with Sickle Cell Disease (SCD) - You are currently experiencing a pain crisis (a sudden episode of severe pain caused by SCD, sometimes called a vaso-occlusive crisis) - Your pain is rated higher than 5 out of 1...

**Who might be able to join this trial:** - You have been diagnosed with, or are suspected to have, a hereditary (inherited) type of anemia where red blood cells break down too easily — this includes conditions such as: - Sickle cell disease - Thalassemia (a group of inherited blood disorders) - Congenital dyserythrop...

Who might be able to join this trial: - Adolescents who are between 11 and 18 years old at the time of joining and able to give their agreement to participate - People who have been diagnosed with any type of sickle cell disease - People who are currently receiving care at a pediatric (children's) health centre - Peopl...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People who have a confirmed diagnosis of sickle cell disease (SCD), of any type - People who have had between 1 and 12 pain crises in the past 12 months that required a visit to a medical facility and treatment...

**Who might be able to join this trial:** - You have been diagnosed with sickle cell disease (any type) - You are already enrolled in a program at the institution called SCCRIP (Sickle Cell Clinical Research Intervention Program) - You are between 8 and 17 years old (up to your 18th birthday) - In the past 2 years, yo...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with a known type of sickle cell disease (SS, SC, S-beta+, or S-beta0) - You are currently admitted to an intensive care unit (ICU) - You have been clinically diagnosed with a pain crisis (vaso-occlusive crisis) and/or a...

Who might be able to join this trial: - The child or teenager must be between 2 and 17 years old on the day they join the study. - They must have an official diagnosis of sickle cell disease recorded in their medical records. - If the participant could become pregnant, they must not currently be pregnant or breastfeedi...

**Who might be able to join this trial:** - People aged 12 to 45 years who have any type of sickle cell disease (SCD), and who also have at least one of the following: a history of stroke or blood vessel problems (including silent brain changes in younger patients); repeated serious lung complications known as acute c...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with sickle cell disease with one of these specific genetic types: SS, SC, Sβ, or Sβ+ - People who have been admitted to an Intensive Care Unit primarily because of a sickle cell pain crisis (sudden severe pain a...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been diagnosed with sickle cell disease. - People who live within 90 minutes of Philadelphia. Who may not be able to join: - People who have severe depression or thoughts of suicide. Important: Always verify eligibility with the...

Who might be able to join this trial: - You (or your child) must have a confirmed diagnosis of Sickle Cell Disease - The participant must be between 6 months and 6 years of age and be due for a measles vaccine within the next 3 months, based on national vaccination guidelines - You (or a parent/guardian) must be willin...

**Who might be able to join this trial:** - You are between 5 and 20 years old - You have been diagnosed with sickle cell disease (any of the following types: HbSS, HbSC, HbSBeta Thal Plus, or HbSBeta Thal Zero) - You are currently having a pain crisis related to sickle cell disease and need pain medicine given through...

Who might be able to join this trial: - You must have already received the treatment called BEAM-101 as part of a previous study called BTX-AUT-001, and be in the process of finishing that study's final visit. - You must be willing and able to sign a written consent form agreeing to take part, following the rules set b...

Who might be able to join this trial: - You have sickle cell disease (any type), OR you are a healthy sibling, relative, person living in the same household, or a female of similar racial/ethnic background to someone with sickle cell disease - You are between 10 and 18 years old at the time of joining the trial - You a...

Who might be able to join this trial: - You are between 15 and 39 years old - You have been diagnosed with Sickle Cell Disease (SCD) - You can speak and understand English - You are able to fill out questionnaires on your own or with very little help from a caregiver - You experience pain and/or sleep problems, as meas...

**Who might be able to join this trial:** - People between the ages of 12 and 35 years old. - People who are willing to have a bone marrow sample taken (a procedure called a myelogram/bone marrow aspiration). - People who have been diagnosed with a specific type of sickle cell disease called HbSS, confirmed by blood p...

Who might be able to join this trial: - You have been diagnosed with sickle cell disease (any type), confirmed by lab tests - You can understand and speak English - You are 35 years old or older Who may not be able to join: - You currently need oxygen to help you breathe - You have an unstable heart condition - You re...

Who might be able to join this trial: - People who are pregnant and have been confirmed by a laboratory test to have sickle cell disease - People whose pregnancy has been confirmed by an ultrasound scan - People who are 34 weeks pregnant or less at the time of joining - People who are between 18 and 45 years of age - P...

**Who might be able to join this trial:** - You are 16 years of age or older - You have been diagnosed with chronic kidney disease (CKD) at any stage from 1 to 5 - You own a smartphone and are able to use apps on it - You are willing and able to give your consent to take part in the study **Who may not be able to join...

**Who might be able to join this trial:** - You are between 18 and 70 years old. - You have a confirmed diagnosis of sickle cell disease (one of these types: HbSS, HbSC, HbSβ+ or HbSβ0), proven by a specific blood test. - You have not had a blood transfusion in the 60 days before signing the consent form, or your bloo...

**Who might be able to join this trial:** **For patients with sickle cell disease:** - People who have sickle cell disease and have had a stroke confirmed by brain MRI - People who have an abnormal result on a special brain blood flow test called a transcranial Doppler (reading of 200 cm/s or higher) - People who have...

Who might be able to join this trial: - Healthcare workers who provide child health and maternity services at the selected hospitals - Babies who are born at or attending child health and maternity services at the selected hospitals - Babies may be enrolled at birth or when they come in for their vaccination appointmen...

**Who might be able to join this trial:** *For the person receiving the transplant (recipient):* - People aged 22 years or younger. - People who do not have a fully matched sibling donor available, but do have a partially matched (at least half-matched) family member who is willing to donate stem cells. - People who h...

Who might be able to join this trial: - People aged 11 to 18 years old who have been diagnosed with sickle cell anaemia (a serious inherited blood disorder) - People who are already taking part in a related study called the NOHARM MTD Study at the Mulago Hospital Sickle Cell Clinic and have agreed to continue into this...