Rare disease
Pulmonary Hypertension
Clinical trials recruiting in Australia for Pulmonary Hypertension, a rare disease, as the public registries list them.
Also called: PAH
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At a glance
12 trials recruiting in Australia
388 trials recruiting overseas
1-9 / 100 000 (Point prevalence, Europe, Validated) prevalence
All ages age of onset
15 October 2026 date last checked
Trials in Australia
This Australian count is likely to be on the low side. It counts the trials this site files under this condition; the registry’s own search is broader and also returns closely related conditions, some of which have their own page here. If you are searching widely, check the registry as well — every trial below links to its own record.
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By invitation Phase 3
Phase 3 study for people with Pulmonary Hypertension
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Royal Prince Alfred Hospital, Camperdown (NSW) — this site's status is not stated on the record
- St Vincent's Hospital Sydney, Darlinghurst (NSW) — this site's status is not stated on the record
- Macquarie University, Sydney (NSW) — this site's status is not stated on the record
- Westmead Hospital, Sydney (NSW) — this site's status is not stated on the record
- Nepean Hospital, Sydney (NSW) — this site's status is not stated on the record
- The Prince Charles Hospital, Chermside (QLD) — this site's status is not stated on the record
- Princess Alexandra Hospital, Woolloongabba (QLD) — this site's status is not stated on the record
- Royal Hobart Hospital, Hobart (TAS) — this site's status is not stated on the record
- St Vincent's Hospital Melbourne, Fitzroy (VIC) — this site's status is not stated on the record
- The Alfred Hospital, Melbourne (VIC) — this site's status is not stated on the record
- Fiona Stanley Hospital, Perth (WA) — this site's status is not stated on the record
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor United TherapeuticsTimelineStarted 23 September 2019 Today 16 October 2026 Estimated completion 1 December 2026NCT03683186 · Checked 13 October 2026
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Recruiting Phase 2
Phase 2 study for people with Pulmonary Hypertension
Where- The Children's Hospital at Westmead ( Site 0001), Westmead (NSW) — Recruiting
Who can join Age 1 Year to 17 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Merck Sharp & Dohme LLCTimelineStarted 19 January 2023 Today 16 October 2026 Estimated completion 21 September 2028NCT05587712 · Checked 11 October 2026
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By invitation Not a phased study
Study for people with Pulmonary Hypertension
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Royal Children's Hospital Melbourne, Parkville (VIC) — this site's status is not stated on the record
Who can join Age 1 Day and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Prof. Valérie Mc LinTimelineStarted 26 April 2018 Today 16 October 2026 Estimated completion 26 October 2026NCT06041906 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Pulmonary Hypertension
Where- Pulmonary Hypertension Research Queensland, Auchenflower — Recruiting
- St Vincent's Hospital (Melbourne), Fitzroy — Recruiting
- Royal Hobart Hospital, Hobart — Recruiting
Who can join Age 18 Years to 75 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Gossamer Bio USA, Inc.TimelineStarted 3 September 2024 Today 16 October 2026 Estimated completion 1 December 2026NCT06274801 · Checked 15 October 2026
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Recruiting Phase 2
Phase 2 study for people with Pulmonary Hypertension
Where- Novartis Investigative Site, Camperdown (NSW) — Recruiting
- Novartis Investigative Site, Darlinghurst (NSW) — Recruiting
- Novartis Investigative Site, New Lambton Heights (NSW) — Recruiting
- Novartis Investigative Site, Adelaide (SA) — Recruiting
Who can join Age 18 Years to 100 Years. Sex Anyone, regardless of sex. Healthy volunteers Accepted.Sponsor Novartis PharmaceuticalsTimelineStarted 24 October 2024 Today 16 October 2026 Estimated completion 29 November 2028NCT06649110 · Checked 11 October 2026
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Recruiting Phase 2
Phase 2 study for people with Pulmonary Hypertension
Where- Royal Prince Alfred Hospital, Camperdown (NSW) — Recruiting
- Pulmonary Hypertension Research Queensland, Auchenflower (QLD) — Recruiting
Who can join Age 18 Years to 80 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor AllRock Bio, Inc.TimelineStarted 1 October 2025 Today 16 October 2026 Estimated completion 1 March 2027NCT07175038 · Checked 15 October 2026
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Recruiting Phase 3
Phase 3 study for people with Pulmonary Hypertension
Where- AUS001, Camperdown (NSW) — Recruiting
- AUS006, Kingswood (NSW) — Recruiting
- AUS005, New Lambton Heights (NSW) — Recruiting
- AUS003, Westmead (NSW) — Recruiting
- AUS004, Auchenflower (QLD) — Not yet recruiting
- AUS002, South Brisbane (QLD) — Recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Insmed IncorporatedTimelineStarted 7 January 2026 Today 16 October 2026 Estimated completion 30 December 2028NCT07179380 · Checked 15 October 2026
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Recruiting Phase 3
Phase 3 study for people with Pulmonary Hypertension
Where- Royal Hobart Hospital, Hobart (TAS) — Recruiting
Who can join Age 18 Years to 80 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Liquidia Technologies, Inc.TimelineStarted 23 April 2026 Today 16 October 2026 Estimated completion 1 July 2029NCT07285655 · Checked 15 October 2026
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Recruiting Phase 2
Phase 2 study for people with Pulmonary Hypertension
Where- The Prince Charles Hospital, Brisbane (QLD) — Recruiting
- Mater Misericordiae Ltd, South Brisbane (QLD) — Recruiting
- Royal Hobart Hospital, Hobart (TAS) — Recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Regeneron PharmaceuticalsTimelineStarted 6 May 2026 Today 16 October 2026 Estimated completion 27 February 2028NCT07318597 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Pulmonary Hypertension
Where- Pulmonary Hypertension Research Queensland PHRQ, Auchenflower (QLD) — Recruiting
Who can join Age 18 Years to 75 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Inhibikase TherapeuticsTimelineStarted 23 April 2026 Today 16 October 2026 Estimated completion 1 June 2029NCT07365332 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Pulmonary Hypertension
Where- AUS002, Camperdown (NSW) — Recruiting
- AUS003, Westmead (NSW) — Recruiting
Who can join Age 18 Years to 75 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Insmed IncorporatedTimelineStarted 21 July 2026 Today 16 October 2026 Estimated completion 28 December 2028NCT07481981 · Checked 15 October 2026
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Recruiting Phase 2
Phase 2 study for people with Pulmonary Hypertension
Where- Diagonal Investigational Site, Camperdown (NSW) — Not yet recruiting
- Diagonal Investigational Site, Randwick (NSW) — Recruiting
- Diagonal Investigational Site, Herston (QLD) — Not yet recruiting
- Diagonal Investigational Site, Herston (QLD) — Withdrawn
- Diagonal Investigational Site, East Melbourne (VIC) — Recruiting
- Diagonal Investigational Site, Parkville (VIC) — Not yet recruiting
- Diagonal Investigational Site, West Perth (WA) — Not yet recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Diagonal Therapeutics, Inc.TimelineStarted 4 June 2026 Today 16 October 2026 Estimated completion 30 November 2027NCT07623525 · Checked 11 October 2026
Trials overseas
388 trials for this disease are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.
These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.
Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas
Trials not shown here
Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.
Key facts
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com).
About Pulmonary Hypertension
The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.
What is pulmonary hypertension? Pulmonary hypertension, sometimes called PH, is a serious condition that affects the blood vessels in the lungs. It develops when the blood pressure in your lungs is higher than normal. Your heart pumps blood to your lungs so they can add oxygen to the blood. The blood goes back to your heart. From there, it travels to the rest of your body so that your tissues can get the oxygen that they need. The blood moves from your heart to your lungs through blood vessels called pulmonary arteries. If the pulmonary arteries become damaged, narrowed, or blocked, the blood does not flow through them as well. This can increase the blood pressure in the arteries and cause pulmonary hypertension. There are different types of pulmonary hypertension, including pulmonary arterial hypertension (PAH). The different types are based on what caused the disease. What causes pulmonary hypertension? Pulmonary hypertension can develop on its own or be caused by another condition. Sometimes the cause is unknown or is not clear. Some of the possible causes include: - Heart diseases, including left-sided heart failure and congenital heart disease - Lung diseases such as COPD (chronic obstructive pulmonary disease), interstitial lung disease, emphysema, and sleep apnea - Other medical conditions such as: - Liver diseases - Sickle cell disease - Pulmonary embolism (blood clots in the lungs) - Connective tissue disorders like scleroderma Who is more likely to develop pulmonary hypertension? Certain factors can make you more likely to develop pulmonary hypertension, such as: - Your age. The risk increases as you get older. The condition is usually diagnosed between ages 30 and 60. - Your environment. Being exposed to asbestos or having certain infections caused by parasites can raise your risk. - Your family history and genetics. Certain genetic disorders, such as Down syndrome, congenital heart disease, and Gaucher disease, can raise your risk of pulmonary hypertension. So can a family history of blood clots. - Your lifestyle habits. Smoking and illegal drug use can raise your risk of developing pulmonary hypertension. - Certain medicines. For example, some medicines used to treat cancer and depression can make you more likely to develop pulmonary hypertension. - Your sex. Pulmonary hypertension is more common in women than in men. What are the symptoms of pulmonary hypertension? The symptoms of pulmonary hypertension are sometimes hard to recognize and are similar to the symptoms of other medical conditions. So sometimes it can take years for someone to get diagnosed with pulmonary hypertension. The symptoms of pulmonary hypertension may include: - Shortness of breath - Chest pain or pressure - Dizziness that may lead to fainting - Fatigue - Swelling of the abdomen, legs, or feet - Heart palpitations (the feeling that your heart is pounding or beating too fast) What other problems can pulmonary hypertension cause? Pulmonary hypertension can get worse over time and lead to serious problems, including: - Anemia, which can cause your body to not get enough oxygen-rich blood - Arrhythmias, problems with the rate or rhythm of your heartbeat - Blood clots in the pulmonary arteries - Bleeding in the lungs - Heart failure - Liver damage - Pericardial effusion, a collection of fluid around the heart - Serious pregnancy complications How is pulmonary hypertension diagnosed? To find out if you have pulmonary hypertension, your health care provider: - Will ask about your medical history and symptoms - Will do a physical exam, which may include checking your blood oxygen, listening to your heart and lungs, and checking your blood pressure - Will likely order some tests, such as: - Blood tests to look for blood clots, stress on the heart, or anemia - Heart imaging tests, such as a cardiac MRI - Lung imaging tests, such as chest x-ray - An electrocardiogram (ECG or EKG) What are the treatments for pulmonary hypertension? Often there is no cure for pulmonary hypertension, but treatments can help manage your symptoms. Your provider will work with you to come up with a treatment plan. It will be based on your needs and the cause of the pulmonary hypertension. The plan may include: - Healthy lifestyle changes, such as: - Healthy eating, which includes eating less salt - Regular physical activity, which may be done through pulmonary rehabilitation - Medicines, such as: - Blood thinners - Medicines to control the rate blood is pumped throughout the body - Medicines to relax blood vessels and allow the blood to flow better - Medicine to reduce swelling (diuretics) - Oxygen therapy - Procedures to reduce pressure in the heart or pulmonary artery - In some severe cases, a lung transplant NIH: National Heart, Lung, and Blood Institute
US source; availability in Australia may differ.
Source: MedlinePlus Health Topics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.
Sources and dates
- ClinicalTrials.gov – trial records, statuses and site lists
- MedlinePlus – the About text above, reproduced exactly
- Orphanet / Orphadata – prevalence, age of onset, inheritance, genes and alternative names, used under CC BY 4.0
- ClinicalTrials.gov processing date: 14 October 2026.
- This page last checked by Voxsanity: 15 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Orphanet citation
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com). Accessed 20 September 2026.
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