Phase 3 Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with pulmonary hypertension (high blood pressure in the lungs) related to a scarring lung disease, such as idiopathic interstitial pneumonia, chronic hypersensitivity pneumonitis, connective tissue disease-associated lung disease, or combined pulmonary fibrosis and emphysema.
• A CT scan (a detailed X-ray of the lungs) has confirmed you have a fibrotic (scarring) lung disease, either at screening or within the past 12 months.
• A procedure called a right heart catheterization has confirmed your pulmonary hypertension, showing specific pressure and resistance readings in your lungs, either at screening or within the past 12 months (confirm with trial site for exact values).
• You are able to walk between 100 and 500 meters in a 6-minute walking test, with two tests done at least 4 hours apart giving similar results.
• If you are already taking long-term medicines for your condition (such as anti-scarring drugs, immune system medicines, or certain blood pressure medications), you have been on them for at least 90 days and at the same dose for at least 30 days before screening.
• You are able to understand and sign a consent form agreeing to take part in the trial.

Who may not be able to join:

• You have a different type of pulmonary hypertension not caused by scarring lung disease (WHO Groups 1, 2, 4, or 5, or other Group 3 subtypes).
• Your main diagnosis is chronic obstructive pulmonary disease (COPD), or breathing tests show a specific pattern associated with COPD (confirm with trial site).
• You have significant heart problems on the left side of your heart, such as serious valve disease, weak heart pumping, a certain type of heart failure, signs of pressure coming from the left heart affecting the lungs, unstable angina, or uncontrolled irregular heartbeat.
• You have evidence of blood clots in the lung arteries (chronic thromboembolic disease), or you have had a sudden lung blood clot within the past 6 months.
• You have a known allergy or medical reason why you cannot take the study drug (treprostinil/TPIP) or its ingredients, such as mannitol or leucine.
• You currently smoke cigarettes or use e-cigarettes regularly or occasionally, and have smoked at least 100 cigarettes in your lifetime.
• You have used inhaled marijuana (for any reason) at least once in the past 30 days, or expect to use it during the study.
• You have any other medical or mental health condition that, in the doctor's opinion, could put you at risk, affect your ability to complete the trial, or make the results harder to interpret (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.