Phase 2 Brain Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 2 years old or older (both English and non-English speakers are welcome).
- You have a weakened immune system, and/or you have a brain infection caused by JC virus (called PML), and/or you have any type of cancer, and/or you have HIV/AIDS, and/or you have had a solid organ transplant (such as a kidney or liver), and/or you have a specific type of skin cancer called Merkel cell tumor that can be measured on a scan.
- You have blood in your urine (found under a microscope), or a confirmed kidney infection caused by BK virus, or a brain or organ infection caused by JC virus or polyomavirus, shown by a urine or blood test.
- Your doctors are able to reduce your steroid medication (such as prednisone) to a low enough dose during the study.
- You are currently taking antiviral medications (such as cidofovir or leflunomide) that are not working for you.
- You (or your parent or guardian) are able to give written consent to participate; patients with cognitive (thinking or memory) difficulties are also eligible.
- If you are a woman who could become pregnant, you have a negative pregnancy test and are willing to use effective birth control during the study.
- You may be taking part in other research studies at the same time, at the lead doctor's discretion.
- If your infection comes back after treatment, you may be able to join the trial again if you still meet all the requirements at that time.
Who may not be able to join:
- You are currently taking a high dose of prednisone (above 0.5 mg/kg per day), or you have received certain immune-suppressing treatments — specifically ATG within the last 14 days, or donor lymphocyte infusion or Campath within the last 28 days.
- You have another active infection that is not under control (HIV/AIDS is an exception) — for example, a bacterial infection that has not been stable for at least 3 days, or a fungal infection that has not been stable for at least 1 week, on appropriate treatment.
- You are currently experiencing a significant reaction where donated cells are attacking your body, known as acute graft-versus-host disease (GVHD) at a moderate to severe level (grades II–IV) (confirm with trial site if unsure).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: George Chen, MD, M.D. Anderson Cancer Center
Phone: 713-792-3630
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Response, defined as response (R) = (best response [R1] or second best response [R2]); Incidence of acute graft-versus-host disease (GVHD); Incidence of adverse events
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.