Brain Cancer

**Who might be able to join this trial:** - You have been newly diagnosed with a type of brain tumor called a diffuse intrinsic pontine glioma (DIPG), meaning the tumor is centered in the brainstem and covers a large portion of it — no biopsy is needed to confirm this type; OR you have a brainstem tumor that has been...

**Who might be able to join this trial:** - You are 18 years old or older (male or female) - You have been recently diagnosed with a type of brain cancer called glioblastoma (also known as GBM) - Your tumor test results show a specific characteristic called "MGMT unmethylated" (confirm with trial site if unsure of your...

**Who might be able to join this trial:** - You have breast cancer that has spread (metastasized) to organs, lymph nodes, or bones - Your breast cancer tests positive for a protein called HER2 (known as HER2-positive) - You have a type of breast cancer called triple negative breast cancer (TNBC) that has spread to othe...

**Who might be able to join this trial:** **Fabry Registry:** - People who have a confirmed diagnosis of Fabry disease, meaning they have documented low levels of a specific enzyme (alpha-galactosidase) in their blood or white blood cells, and/or a known change (mutation) in the gene related to that enzyme. - People w...

**Who might be able to join this trial:** - People who are aged 3 years or older and under 30 years old at the time of joining the study - People who have been newly diagnosed with a specific type of brain tumour (called a non-germinomatous germ cell tumour, or NGGCT) located in the suprasellar region (near the base o...

Who might be able to join this trial: **General (most cohorts, ages 2–39):** - People aged 2 to 39 years with a diagnosis of a brain or spinal cord tumour called Diffuse Midline Glioma (DMG), confirmed by imaging and/or tissue testing - People whose body weight is at least 10 kilograms - People whose blood counts, kid...

Who might be able to join this trial: - People who finished primary treatment for medulloblastoma, ependymoma, craniopharyngioma, germ cell tumours, another brain tumour treated with radiation to the head, or radiation for relapsed ependymoma — and at least 3 weeks have passed since that treatment ended. - People aged...

**Who might be able to join this trial:** - People who are able to understand and sign a consent form before any study procedures begin - People who are 18 years of age or older, whether male or female - People who have been diagnosed with glioblastoma (a type of brain tumour) confirmed by laboratory testing of tissue...

Who might be able to join this trial: - People who are under 18 years old (note: in some cases, people aged 19–25 with a childhood cancer such as neuroblastoma may also be considered, at the discretion of the Study Chair or their representative) - People who are expected to live for more than 6 weeks at the time of joi...

Who might be able to join this trial: - People between 12 months and 39 years of age at the time of joining the screening process - People who have been newly diagnosed with a high-grade brain tumour (including a type called DIPG), where the diagnosis has been confirmed through a biopsy or surgical removal of tumour ti...

**Who might be able to join this trial:** - People aged 12 months to 39 years old at the time of initial screening (for the early feasibility part of the trial, only people under 21 years old are eligible) - People who have been newly diagnosed with a high-grade brain tumour (HGG), including a type called DIPG, confir...

**Who might be able to join this trial:** - People who are at least 12 months old and no older than 39 years old at the time of joining the study. - People in Cohort A (newly diagnosed): Those diagnosed with a specific type of brain tumour called DIPG, based on MRI scans showing the tumour in the brainstem area, who h...

Who might be able to join this trial: - Adults aged 18 to 80 who have been admitted to Sir Charles Gairdner Hospital (SCGH) under the neurosurgery team with a confirmed brain tumour diagnosis. - People who undergo a partial or full surgical removal of a brain tumour and are in a medically stable condition. - People who...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of brain tumour called glioblastoma (IDH-wildtype), confirmed by a pathology test and classified according to 2021 WHO guidelines. - People whose glioblastoma has come back or grown for the first time after initial treatmen...

Who might be able to join this trial: - People aged 18 to 80 years old at the time of signing the consent form. - People whose general health is not severely compromised — meaning no life-threatening illness or disability, as assessed by the trial doctor. - People with a history of cancer may be considered if they have...

Who might be able to join this trial: - People who have been newly diagnosed with a type of brain tumour called a supratentorial glioma that needs to be surgically removed - People whose tumour reaches or is close to the surface of the brain - Adults between 18 and 75 years of age - People whose surgery is planned to b...

**Who might be able to join this trial:** - You have been newly diagnosed with a specific type of brain tumor called glioblastoma (Grade IV GBM or Grade IV gliosarcoma), confirmed by a biopsy or tissue sample - Your tumor shows a specific genetic change called EGFR amplification (your doctor can check this from your tu...

Who might be able to join this trial: - People aged 18 years or older. - People who have been diagnosed with a specific type of brain tumour called Glioblastoma multiforme, located in the upper part of the brain, confirmed through tissue testing. - People with a Karnofsky performance score above 60, which means a docto...

Who might be able to join this trial: - People who have acromegaly (a hormonal condition caused by excess growth hormone) that runs in their family, or another type of pituitary tumour that affects multiple family members - People who developed acromegaly at an unusually young age - People who have a pituitary tumour t...

Who might be able to join this trial: - People with a confirmed diagnosis of a pituitary disease (a condition affecting the pituitary gland, a small gland at the base of the brain) Who may not be able to join: - People who do not have a confirmed diagnosis of a pituitary disease Important: Always verify eligibility w...

Who might be able to join this trial: - People who have a suspected or confirmed diagnosis of a high-grade or low-grade brain tumour (glioma), or whose tumour is suspected to have a specific genetic change called an IDH mutation - People who may be receiving radiation therapy as part of their treatment - People who are...

Who might be able to join this trial: - People aged 19 years or older - People who have a brain tumour located in or near areas of the brain that control important functions, where surgery to remove it may be considered - People whose body size and mental state allow them to safely take part in brain mapping procedures...

**Who might be able to join this trial:** - People of any age, gender, race, or ethnic background - People who speak Spanish as their primary language - People who have had brain imaging (such as an MRI) that suggests a brain tumor, or who have had a biopsy of a tumor, before planned surgery to remove it - People who a...

Who might be able to join this trial: - People who have previously been diagnosed with cancer (confirmed by tissue testing), except for small cell lung cancer, lymphoma, or germ cell cancers - People whose MRI scan shows between 1 and 4 tumours that have spread to the brain, with at least one tumour measuring more than...

**Who might be able to join this trial:** - People who are at least 18 years old. - People who are able to understand the study's purpose and risks, and have signed a consent form approved by the relevant ethics committee. - People who have been diagnosed through a tissue biopsy with a Grade III or IV recurrent glioma...

Who might be able to join this trial: **Group 1 – Breast cancer patients receiving chemotherapy:** - You have been newly diagnosed with invasive breast cancer, confirmed by a tissue test (biopsy) - Your treatment plan includes chemotherapy - You are a woman aged 60 or older - Your doctors expect you to live at least 1...

"Who might be able to join this trial: - The person must be willing and able to provide written consent to participate. - The person must be 18 years of age or older. - The person must have previously had surgery to remove a glioblastoma (a type of brain tumour), confirmed by laboratory testing of the tissue. - The per...

**Who might be able to join this trial:** - You have been diagnosed with one of the specific brain or spinal cord tumour types this trial covers (please confirm the exact tumour types with the trial site) - Your tumour can be located anywhere in the body where these tumour types occur - You can be at any stage of your...

**Who might be able to join this trial:** - You are 2 years old or older (both English and non-English speakers are welcome). - You have a weakened immune system, and/or you have a brain infection caused by JC virus (called PML), and/or you have any type of cancer, and/or you have HIV/AIDS, and/or you have had a solid...

Who might be able to join this trial: - People who have been diagnosed with a solid (non-blood) cancer that has been confirmed by laboratory testing, and who have been referred for whole-brain radiation therapy for treatment or prevention purposes. - People who are in reasonably good general health, as measured by stan...

**Who might be able to join this trial:** - People who have been diagnosed with a brain glioma (a type of brain tumour), confirmed by both imaging scans and tissue testing - People with a life expectancy of more than 3 months - People who are receiving their first or second round of treatment for this condition - Peopl...

Who might be able to join this trial: - People who have brain imaging results that suggest they may have a low grade glioma (a type of slow-growing brain tumour) - People who are 18 years of age or older (there is no upper age limit) Who may not be able to join: - People who have a serious neurological or psychiatric...

**Who might be able to join this trial:** - People who have been diagnosed before surgery with a suspected first-time brain tumour known as a low or high grade glioma (including types such as astrocytoma, oligodendroglioma, mixed oligo-astrocytoma, anaplastic astrocytoma, or glioblastoma multiforme) - People whose tumo...

**Who might be able to join this trial:** - Adults aged 18 or older who are reasonably active and able to care for themselves (as assessed by a standard medical scale called ECOG Performance Status 0–2), and who are expected to live for at least 3 months. - People who have a confirmed cancer that has spread to the bra...

Who might be able to join this trial: - People aged 18 or older who are having surgery to remove a brain tumor (either newly diagnosed or returning) at the University of Texas M. D. Anderson Cancer Center, where the tumor is in or near the parts of the brain that control movement or speech. - People who have given thei...

Who might be able to join this trial: - Adults aged 18 or older. - People who have a confirmed diagnosis (from a tissue sample) of a brain tumour that has come back or stopped responding to treatment — specifically glioblastoma multiforme (GBM), anaplastic astrocytoma (AA), or anaplastic oligoastrocytoma (AOA). - Peopl...

**Who might be able to join this trial:** - People who have a primary brain tumour, such as gliomas (slow- or fast-growing), meningiomas inside the brain, pituitary adenomas, craniopharyngiomas, or other rare brain tumours - People whose brain tumour has come back and who have not previously had radiation treatment -...

**Who might be able to join this trial:** - People whose cancer has been confirmed by laboratory testing of a tissue or cell sample — either any solid tumour (Group 1) or breast cancer specifically (Group 2). - People who have at least one measurable brain tumour or brain lesion that is 10mm or larger in size. - Peopl...

Who might be able to join this trial: **Cohort 1 – Newly diagnosed brain tumor (up to 30 participants)** - Children and young people aged 4 to 18 years old - Recently diagnosed with a primary brain tumor of any type or location - Expected to live for at least one year - Able to understand the study and willing to agre...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma or gliosarcoma (specific types of brain tumour) confirmed by laboratory testing of tumour tissue, after having as much of the tumour removed by surgery as possible, where the tumour is located in the upper part of the brain. -...

Who might be able to join this trial: - People who are 75 years old or younger and have a confirmed diagnosis of glioblastoma (a type of brain tumour), proven through a tissue sample test - People whose heart, lungs, liver, kidneys, and other major organs are working well, without serious problems - People who have a W...

Who might be able to join this trial: - People who are adults (aged 18 to 85) having endoscopic (keyhole, through the nose) surgery to remove a pituitary tumour, specifically a non-functioning adenoma, acromegaly-related tumour, or prolactinoma - People who speak English and are able to understand and complete two spec...

**Who might be able to join this trial:** - People who have been diagnosed with a brain tumour (such as glioma, meningioma, or brain metastases) confirmed by imaging, before receiving any chemotherapy or radiation treatment - People between 18 and 70 years of age - People who are able to understand the study and are w...

**Who might be able to join this trial:** - Your brain tumor (high-grade glioma) has come back, and this has been confirmed by a scan, tissue sample, or cell sample — and there is a plan for surgery or biopsy (or, for a sub-part of the trial, surgery or biopsy may not be required). - You are older than 18 years of age...

**Who might be able to join this trial:** *For breast cancer patient participants:* - Women who have been diagnosed with invasive breast cancer that has not spread to other parts of the body (stages I through IIIC) - People who are scheduled to start a chemotherapy treatment plan using the drugs Adriamycin and Cytoxan...

**Who might be able to join this trial:** - Adults aged between 18 and 88 years who have been diagnosed with glioblastoma (a type of brain tumour), confirmed by laboratory testing of tumour tissue, and whose cancer has come back for the first time after standard treatment involving surgery, chemotherapy with temozolom...

**Who might be able to join this trial:** - You have been diagnosed with a solid tumour cancer that has been confirmed by a medical test (not small cell lung cancer or germ cell tumour) - You are reasonably active and able to carry out daily activities, as measured by a standard health scale (confirm with trial site)...

**Who might be able to join this trial:** - People who are able to understand and agree to participate by giving informed consent - People who have been confirmed by pathology testing to have a newly diagnosed Grade IV Glioblastoma Multiforme (a type of brain tumour) - People who have finished the first 6-week phase o...

Who might be able to join this trial: - People who have neurological symptoms such as headaches, seizures, loss of consciousness, weakness, or nerve-related problems. - People who have an abnormality found in the brain on a scan, whether or not it is related to cancer. - People who have a cancer elsewhere in their body...

**Who might be able to join this trial:** - People who have a brain tumor (either non-cancerous or cancerous) that has been confirmed by biopsy, or in some cases diagnosed through scans and clinical assessment without a biopsy, where radiation treatment is considered appropriate without one — common examples include l...

Who might be able to join this trial: - Adults of any ethnic background aged 18 or older (specific age ranges and gender requirements apply depending on which group a person is enrolled in — confirm with trial site) - People aged 60 or older who have been diagnosed with mild cognitive impairment (for one specific grou...

**Who might be able to join this trial:** - Men between 18 and 65 years old - Either healthy volunteers or people who have been diagnosed with a brain tumor - People who have completed senior high school or a higher level of education - People who are willing and able to sign a consent form agreeing to take part **Who...

**Who might be able to join this trial:** - People aged 14 or older - People who have been diagnosed with Cushing's syndrome that is currently active or has been treated, where the cause is a tumor on the pituitary gland, a tumor in another part of the body (ectopic), or a tumor on the adrenal gland - People diagnosed...

**Who might be able to join this trial:** - People aged 18 years or older - People whose general health and ability to carry out daily activities meets a specific fitness level used in cancer research (ECOG performance status 0–1; confirm with trial site) - Men and women (pre- or post-menopausal) who have been diagnos...

**Who might be able to join this trial:** - People who have a suspected or confirmed diagnosis of glioblastoma (a type of brain tumor) — this applies to groups 1, 2, and 3 in the trial - People who have a suspected or confirmed diagnosis of vestibular schwannoma (a non-cancerous tumor near the ear and brain) — this ap...

Who might be able to join this trial: - You are 18 years of age or older, either male or female - Your brain scans suggest you may have glioblastoma (a type of brain tumor) - Your doctors have determined you are suitable for surgery to remove the tumor (fully or partially) - You are planned to receive the standard comb...

Who might be able to join this trial: - People who have been diagnosed with a slow-growing, spread-out type of brain tumour (low-grade glioma) and have had surgery to remove all or part of the tumour, or at least a biopsy to confirm the diagnosis. - People whose doctors recommend brain radiation therapy because of high...

**Who might be able to join this trial:** - People who have between 5 and 15 spots of cancer that have spread to the brain, as seen on a specific type of brain scan (MRI with contrast dye) taken within the last 30 days. - People who have a confirmed diagnosis of a solid tumour cancer (not a blood cancer), confirmed by...

**Who might be able to join this trial:** - People who have a confirmed diagnosis (proven by biopsy) of recurring anaplastic astrocytoma or glioblastoma multiforme, without the tumour appearing in multiple separate areas of the brain or in the brainstem. - People whose brain scans show signs that the tumour has come b...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of brain tumor (anaplastic astrocytoma or glioblastoma multiforme), confirmed by a biopsy taken during surgery, that has not spread to multiple separate areas of the brain or into the brainstem. - Your doctor expects you to live f...

**Who might be able to join this trial:** - Adults over 18 years old who have a known or suspected brain tumour. - People who are able to give written consent themselves, or who have a trusted representative able to give consent on their behalf. - People whose brain tumour lesion is larger than 10 mL in size, as measu...

Who might be able to join this trial: - You must be an adult aged 18 or older - You have a suspected or confirmed brain tumour (glioma) and your doctor has already recommended a biopsy or surgery to remove or sample the brain lesion Who may not be able to join: - Adults who are not able to give their own consent to pa...

**Who might be able to join this trial:** - You are older than 18 years of age - You are generally well enough to carry out normal daily activities with little or no limitation (confirm with trial site) - You have fewer than 4 brain metastases (cancer that has spread to the brain from another part of the body, such as...

**Who might be able to join this trial:** - People who have been confirmed by laboratory testing to have a Grade IV glioma (a type of brain tumour) - People who have been recently diagnosed and are due to receive chemotherapy and/or radiation treatment - People whose general physical functioning falls within a certain...

**Who might be able to join this trial:** - The main brain tumour being treated must be no larger than 4 cm (for single-session treatment) or 7 cm (for multi-session treatment) before surgery - A person must be considered a suitable candidate for a type of targeted brain radiation (called SRS) within 30 days before or...

**Who might be able to join this trial:** - People aged 18 or older - People who have a confirmed solid tumour (confirmed by tissue or cell testing), or who have a known or suspected cancer that has spread, with a brain tumour that doctors believe is a brain metastasis (cancer that has spread to the brain) based on cl...

Who might be able to join this trial: - People who are willing to provide written agreement to take part in the study, including healthy volunteers. - Healthy volunteers who do not have any reason they cannot safely have an MRI scan. - People who are already enrolled in a related study called the Stereotactic RadPath t...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with and are receiving treatment for a type of brain tumour called a glioma (either a fast-growing or slow-growing type) - People whose treatment is taking place at UZ Leuven hospital Who may not be able to join: - No spec...

Who might be able to join this trial: - Adults aged 18 to 90 years old - People whose brain scan (MRI) shows a specific type of brain tumour called Glioblastoma Multiforme, with a particular ring-shaped appearance and signs of dead tissue at the centre, as assessed by the surgeon - People whose tumour is located in or...

**Who might be able to join this trial:** - People who are willing and able to give their consent, attend all study visits, and follow the study schedule - People who have been diagnosed with a returning (recurrent) brain tumour — specifically glioblastoma (GBM), gliosarcoma, a certain type of anaplastic astrocytoma w...

**Who might be able to join this trial:** - You are at least 3 years old and younger than 22 years old - You have a cancerous brain tumor in the cerebellum (the lower back part of the brain) that has been confirmed by a tissue sample, and the tumor has come back or kept growing despite standard treatments like surgery...

Who might be able to join this trial: - People who have been diagnosed with breast cancer that has been confirmed through tissue or cell testing, with the cancer's hormone receptor and HER2 status identified. - People whose breast cancer has spread to distant parts of the body (outside the brain) or has come back in a...

**Who might be able to join this trial:** - People who have been diagnosed with a solid cancer that started outside the brain (confirmed by lab testing of tissue or cell samples) and who have at least one brain metastasis (cancer that has spread to the brain) that was previously treated with a focused form of radiatio...

**Who might be able to join this trial:** - Children and teenagers between 8 and 18 years of age - People who have not previously had radiation treatment to the brain - People who are able to complete repeated thinking and memory tests, each lasting around one hour - People whose corrected vision (with glasses or cont...

**Who might be able to join this trial:** - People with a confirmed brain or central nervous system (CNS) tumour that tests positive for a protein called GD2, or has a specific genetic change called H3K27 alteration — this includes newly diagnosed tumours, as well as tumours that have come back, stopped responding to...

**Who might be able to join this trial:** - People aged 18 or older - People with a general health and activity level rated as reasonably functional (a standard cancer performance scale score of 2 or below) - People of any gender - **For Part A of the trial:** People with one of the listed cancer types that was either...

**Who might be able to join this trial:** *For people with glioma (a type of brain tumour):* - People who have been diagnosed with or are planned to be treated for a WHO grade II, III, or IV diffuse glioma (a range of brain tumour types, from lower to higher severity) - Adults aged 18 years or older - People who are p...

**Who might be able to join this trial:** - People who were between 20 and 75 years old at the time of their brain tumor surgery. - People who have been newly diagnosed with a single, primary Grade IV glioblastoma (a specific type of aggressive brain tumor) that is not located in the brainstem or cerebellum, and who a...

**Who might be able to join this trial:** - People who have a brain tumor located in the upper part of the brain (not the brainstem or deep structures) that imaging suggests is a type of glioma (grade II to IV), and where surgeons plan to remove all or part of the tumor. - People whose tumor has been confirmed as a gr...

**Who might be able to join this trial:** - People who have been diagnosed with a WHO Grade II, III, or IV brain tumour (glioma) that has come back or continued to grow, as shown on a brain scan - People who received radiation therapy as part of their original glioma treatment - People who have not previously had a se...

**Who might be able to join this trial:** - You are between 1 and 26 years old - You have a brain or spinal cord tumor that has come back or stopped responding to treatment and there are no standard treatment options left, OR you have a specific type of brainstem tumor (DIPG or DMG) and have already finished standard t...

**Who might be able to join this trial:** - You have been diagnosed with a primary cancer (confirmed by a biopsy), and brain scans show that the cancer has spread to the brain - At least one of the tumors in the brain is larger than 1 cm across and shows no signs of bleeding on scans - You are 18 years of age or older...

"Who might be able to join this trial: - People who are 18 years of age or older (or 19 and older if living in Nebraska). - People whose overall health and cancer situation falls within a certain range, as measured by standard medical scoring tools used for brain cancer patients, and who have a functional ability score...

**Who might be able to join this trial:** - Healthy people who are able to lie still inside an MRI scanner for up to one hour - People who have been told they may have a growth or mass in their brain that needs further investigation - People who are willing and able to give written consent to take part **Who may not b...

**Who might be able to join this trial:** - People who have been diagnosed with a brain or central nervous system (CNS) tumour that has come back, is getting worse, or has not responded to treatment (except for certain types called diffuse midline gliomas or DIPG). - The tumour diagnosis must have been confirmed by ex...

Who might be able to join this trial: - Adults aged 18 to 70 years old - People who have been diagnosed with a brain tumour called GBM (glioblastoma) or a lower-grade brain tumour (such as oligodendroglioma, astrocytoma, or related types), confirmed by tissue testing - People whose tumour has come back, either confirme...

Who might be able to join this trial: - People who have been newly diagnosed with a suspected brain tumour (WHO Grade 2–4 glioma, based on scans) and are suitable for a surgical procedure that would provide a tumour sample alongside a blood sample. - People who have a previously diagnosed brain tumour (WHO Grade 2–4 gl...

**Who might be able to join this trial:** - People between 35 and 65 years of age - People who are fluent in English - People with sufficient vision and hearing to complete the tests involved in the trial **Who may not be able to join:** - People who have been diagnosed with any form of dementia or memory/thinking dis...

**Who might be able to join this trial:** - People aged 18 years or older - People with one to three brain metastases (tumours that have spread to the brain), each smaller than 3 cm across, whether the tumour is still present or the area has been surgically removed - People who are reasonably well and able to carry ou...

**Who might be able to join this trial:** - Women who are not pregnant, not breastfeeding, and either cannot become pregnant or agree to use acceptable birth control for the full duration of the study and until the study drug is no longer detectable in the blood (which may be several years); a combination of two birth...

**Who might be able to join this trial:** - People who have had surgery to remove as much of a brain tumour as safely possible, with a radiation device called GammaTiles placed in the brain during that same surgery. - People who are willing and able to agree to take part and to attend all required assessments and check...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with glioblastoma (a type of brain tumour) for the first time, confirmed by laboratory testing of tissue - People whose general health and ability to carry out daily activities meets a minimum functional score (called...

**Who might be able to join this trial:** **For patients:** - Adults who have recently been diagnosed with a brain tumour called glioma (graded 2 to 4 on the WHO scale) and are planned to have a 6-week course of radiation treatment after surgery - People who are able to complete questionnaires written in English - Peo...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma (a type of brain tumour) that is confirmed by tissue testing and is located in a single area of the brain. - People who have had surgery that removed nearly all of the tumour, leaving no more than 5 ml of tumour remaining, as...

Who might be able to join this trial: - People who have been diagnosed (confirmed by tissue analysis) with a returning (recurrent) high-grade brain tumour (WHO grade 3 or 4 malignant glioma) located in the upper part of the brain (supratentorial region), including tumours with molecular features of glioblastoma. - For...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who are able to understand what the study involves and have signed an approved consent form. - People who have been diagnosed with a specific type of brain tumour called IDH wild-type glioblastoma (GBM), gliosarcoma, or epith...

**Who might be able to join this trial:** - People aged 8 or older who have been diagnosed with Cushing's disease based on medical records, with lab results confirming the condition - People whose MRI of the pituitary gland either showed no tumor or only a possible tumor (not a confirmed tumor) - People who had an MRI...

**Who might be able to join this trial:** **For adults with GBM (Group 1):** - People aged 21 years or older - People with a newly diagnosed brain tumour called glioblastoma (GBM, Grade IV), confirmed by laboratory testing, that has a specific molecular feature called MGMT low or unmethylated — this is not a tumour th...

**Who might be able to join this trial:** - People diagnosed with certain types of brain tumours called IDH wildtype gliomas, including diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma, or molecularly defined high-grade glioma o...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who are reasonably well and able to carry out daily activities (as assessed by their doctor using a standard scale called the ECOG scale, with a score of 0, 1, or 2) - People who have been diagnosed with cancer that has spread t...

**Who might be able to join this trial:** - People who have any sign of a tumour or growth affecting the brain, spine, nerves, blood vessels, or the membranes surrounding the brain and spinal cord — whether confirmed as cancer, non-cancerous, or not yet classified - People who are 18 years of age or older **Who may no...

**Who might be able to join this trial:** - People aged 18 or older - People who have clinical and imaging evidence suggesting a brain tumor - People who are already planned to have surgery to remove a suspected or confirmed brain tumor as part of their normal medical care - People who are willing to have their brain...

**Who might be able to join this trial:** - You have brain scan (imaging) results that suggest you may have a fast-growing brain tumor called a high-grade glioma - A recent MRI scan with contrast dye (taken within the last 60 days) shows a tumor mass, and a neurosurgeon has confirmed you are a suitable candidate for a...

**Who might be able to join this trial:** - Adults aged 18 to 90 years old - People whose MRI scan shows a brain tumour diagnosed as glioblastoma (GBM) by a neurosurgeon - People whose tumour is located in or near important brain areas that control movement, sensation, speech, or vision, as shown on MRI - People whose...

**Who might be able to join this trial:** *General requirements for all arms:* - Children and young adults aged 2 and above (some arms require age 2–21 for the dose escalation phase, with 2 and above for the dose expansion phase) with a confirmed brain or spinal cord tumour diagnosis, depending on which arm of the tri...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma (a type of brain tumour), confirmed by laboratory testing of tumour tissue, whose cancer has come back or grown after completing standard first-line treatment (chemotherapy with temozolomide combined with radiotherapy). - Peop...

**Who might be able to join this trial:** - People who have been newly diagnosed with glioblastoma (a type of brain tumour) that has been confirmed by tissue testing, and who have had as much of the tumour safely removed as possible (or a biopsy if removal was not possible). - People whose tumour has tested positive f...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with small cell lung cancer (SCLC), confirmed by a tissue or cell sample - People with either limited-stage SCLC (cancer that has not spread widely, classified as Stage I–III, where the tumour and affected lymph...

**Who might be able to join this trial:** - People aged 50 or older at the time of joining the trial - People whose first and only primary breast cancer diagnosis was stage I to IIIa (not stage 0 and not spread to other parts of the body) - People who finished their main cancer treatments (such as surgery, chemotherap...

**Who might be able to join this trial:** - People who have received chemotherapy to treat breast cancer and finished treatment at least 6 months ago - People who have noticed concerns about their own memory or thinking since treatment - People aged between 18 and 65 years - People who are right-handed **Who may not b...

Who might be able to join this trial: - People who have cancer that has spread to the brain (brain metastases), where the original cancer has been confirmed by laboratory testing of tumour tissue - People who have received Gamma Knife (a type of targeted radiation treatment) within the last 4 months before joining the...

**Who might be able to join this trial:** - You are 18 years of age or older - You are generally able to carry out normal daily activities (your doctor has assessed your overall health and function as being at a reasonable level) - You have been newly diagnosed with a single tumor lesion in the brain (either in the mai...

**Who might be able to join this trial:** - People who are at least 18 years old - People who are able to understand the study's purpose and risks, and who have signed a written consent form approved by the ethics committee - People who have been diagnosed with glioblastoma (a type of brain tumour), confirmed through...

Who might be able to join this trial: - People who have been diagnosed with a high-grade brain tumour (classified as grade 3 or 4 by the World Health Organization), either confirmed by tissue testing or strongly suspected based on brain scans (though tissue confirmation will be required to remain in the trial) - People...

**Who might be able to join this trial:** - People who have been diagnosed with, or are suspected to have, a low-grade brain tumour (a slow-growing type of brain tumour), including certain types of neuronal or mixed brain tumours, confirmed by a specialist review of tumour tissue - People whose tumour tissue is availa...

**Who might be able to join this trial:** - People diagnosed with breast cancer that tests positive for hormone receptors (estrogen or progesterone), meaning at least 1% of cancer cells show hormone receptor activity on a lab test. - People whose breast cancer tests negative for a protein called HER2, meaning the canc...

**Who might be able to join this trial:** - People who have been newly diagnosed with a specific type of brain tumor called DIPG or DMG, confirmed either by biopsy or by brain imaging that meets specific criteria (confirm with trial site for details on imaging requirements) - The tumor must have a confirmed histone mu...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have been confirmed by tissue testing to have a primary, returned, or spread brain glioma (a type of brain tumour) - People whose life expectancy is estimated to be more than 3 months - People who have a reasonable level o...

**Who might be able to join this trial:** - People aged 18 or older - People who have been newly diagnosed with a specific type of brain tumour called IDH wild-type glioblastoma (Grade 4), located in the upper part of the brain, confirmed by tissue testing — including a type called gliosarcoma - People whose tumour te...

**Who might be able to join this trial:** - People who had an elective (planned, non-emergency) procedure scheduled between July 1, 2022 and December 28, 2023 - Adults aged 18 or older, of any gender - People who are having their first brain surgery (craniotomy, performed under general anaesthetic) for a suspected high...

Who might be able to join this trial: - People who are 18 years of age or older, of any gender - People who have been diagnosed with breast cancer that has tested negative for the HER2 protein, based on the most recent tumour sample - People with hormone receptor-positive (ER positive) breast cancer who have already re...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with a specific type of aggressive brain tumour called Glioblastoma Multiforme (Grade IV), confirmed by a tissue test - People whose brain tumour has come back or is growing again, and who are already planned to have...

**Who might be able to join this trial:** - People who have signed and dated a consent form agreeing to take part - People aged 12 years or older at the time of signing the consent form - People who have been diagnosed with a specific type of recurring brain tumour (a high-grade astrocytoma confirmed by tissue testing...

**Who might be able to join this trial:** - People who have been diagnosed with a solid tumour (a non-blood cancer) that has spread to the brain, and whose doctor has recommended whole-brain radiation treatment - People aged 18 or older - People with a reasonably good level of physical functioning, as rated by their d...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form agreeing to take part in the study before any study-related procedures begin - People who have been diagnosed with colorectal cancer confirmed through a tissue sample (biopsy) - People whose treatment plan includes one or...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You are able to read and understand a consent form, and are willing to sign it - An MRI scan has shown a tumor (one that does not light up with contrast dye) that is affecting the movement control area on the non-dominant side of your bra...

**Who might be able to join this trial:** - People who have been newly diagnosed with metastatic non-small cell lung cancer (a type of lung cancer that has spread) that cannot be treated with surgery or radiotherapy aimed at a cure. - People whose lung cancer has a specific gene change (EGFR mutation) known to respond...

**Who might be able to join this trial:** - People who were 18 years of age or older when their brain metastases were diagnosed - People whose general physical functioning is relatively good, meaning they are able to carry out most daily activities (confirmed using a standard medical scale called the ECOG score, which...

Who might be able to join this trial: - People who are scheduled to have a brain or spinal cord tumor removed or biopsied - People who are over 18 years old - People who have given their consent to take part in the study - People who are members of the French Social Security system Who may not be able to join: - Peopl...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with a solid (non-blood) cancer - People who have cancer that has spread to the brain (brain metastases), regardless of size - People with any number of brain metastases — whether previously untreated or still growing...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma or gliosarcoma (a type of brain tumour) located in the upper part of the brain, confirmed by laboratory analysis of tumour tissue, and who have had surgery to remove most or all of the tumour (at least 85%) within the past 35...

Who might be able to join this trial: - People who have been previously diagnosed (confirmed by tissue testing) with medulloblastoma or ependymoma that has come back, and are experiencing their first or second relapse. - People whose tumour can be reached and removed or sampled through surgery, with enough tissue expec...

**Who might be able to join this trial:** - Adults aged 18 or older who have been newly diagnosed with a specific type of aggressive brain tumour (Grade IV Glioblastoma or gliosarcoma), confirmed by laboratory testing, who had carmustine wafers placed in the brain during surgery - People who have had no prior treatmen...

**Who might be able to join this trial:** - People aged 22 years or older - People who have been diagnosed with glioblastoma (GBM), confirmed through laboratory testing of tumour tissue - People who have already had surgery to remove as much of the tumour as safely possible, followed by a full course of radiation ther...

**Who might be able to join this trial:** **For people with returning or worsening medulloblastoma (a type of brain tumour) — Stratum I:** - People who are between 3 and 39 years old at the time of joining the trial. - People who have been diagnosed with medulloblastoma that has come back, is getting worse, or is not...

**Who might be able to join this trial:** - Adults aged 18 or older. - People with a general health status rated as fully active or able to carry out light work (WHO performance status 0 or 1). - People who have been recommended for a type of targeted brain radiation treatment called stereotactic radiotherapy (SRT), f...

**Who might be able to join this trial:** - People who have been diagnosed with ependymoma, medulloblastoma, glioblastoma, or another type of primary brain or spinal cord cancer that has come back or stopped responding to treatment, and for which no standard curative treatment options remain. - People whose cancer has...

Who might be able to join this trial: - The person joining (or their legal representative) is able to understand and willing to sign and date a consent form agreeing to take part. - The person is 18 years of age or older. - The person has had or has a scheduled appointment with cancer or brain/nerve specialist services...

**Who might be able to join this trial:** - People aged 18 or older - People who have signed and dated a consent form and are willing to follow all study procedures for the full duration of the trial - People whose general health and ability to carry out daily activities meets a minimum level, as measured by a standar...

**Who might be able to join this trial:** - People who have brain metastases (cancer that has spread to the brain from another part of the body) confirmed by a special type of MRI scan using a contrast dye - People who have at least one brain lesion that has grown back or worsened after previously being treated with f...

Who might be able to join this trial: - People who are over 18 years of age - People who have a suspected brain tumour (such as glioma, glioblastoma, brain metastasis, meningioma, acoustic neuroma, or pituitary adenoma) and who doctors have determined may be suitable for surgery - People who are able to understand and...

**Who might be able to join this trial:** - Children who have been diagnosed with a type of brain tumour called an ependymoma (a tumour that grows inside the skull) - Children who have already received treatment for this condition - Children who are already enrolled in one of three specific study programs: the PEPPI st...

**Who might be able to join this trial:** - Women aged 18 or older who have been diagnosed with a specific type of breast cancer confirmed by tissue testing (triple-negative breast cancer: ER less than 10%, PR less than 10%, HER2 negative), and who have not yet received any treatment for it - People whose breast cance...

**Who might be able to join this trial:** - People aged 18 years or older - People who have brain metastases (cancer that has spread to the brain) that are believed to have come from a cancer in another part of the body, such as the lung, breast, or prostate - People whose brain metastases include at least one untreat...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma (a type of brain tumour) that has been confirmed by laboratory testing of tissue, and the tumour has come back for the first or second time. - People who are taking steroid medication at a stable or reducing dose at the time o...

Who might be able to join this trial: - People who have been diagnosed with a low-grade brain tumour (graded 2 or lower by WHO standards) through medical imaging, either since 1998 (for the past-records group) or recently (for the ongoing group) - People who had no symptoms when they first visited the hospital for this...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have a confirmed diagnosis of a specific type of brain tumour called glioblastoma (GBM), classified according to 2021 world health standards, including certain tumour features seen under a microscope or specific genetic m...

**Who might be able to join this trial:** - People aged 18 years or older (required for all groups in the trial) - People who are scheduled to have a brain MRI scan with a contrast dye injection as part of their regular medical care (Group 1) - People who have been diagnosed with a suspected brain tumour called a glio...

**Who might be able to join this trial:** - People who have been diagnosed with a high-grade brain or central nervous system (CNS) tumour (classified as WHO grade III or IV) or a meningioma (any grade) that has come back, is getting worse, or has not responded to treatment. - People with a type of childhood brainstem...

Who might be able to join this trial: - People between 3 months and 21 years of age - People diagnosed with a type of brain tumour called an optic pathway glioma, confirmed either by a tissue biopsy or by a brain MRI scan combined with typical clinical signs - People whose tumour can be measured on scans, where less th...

**Who might be able to join this trial:** - People who have recently been diagnosed with a brain lesion that imaging suggests is glioblastoma multiforme (a type of brain tumour), where the scan was taken no more than 28 days before enrolling. - People whose brain lesion is larger than 3 cm at its widest point, as seen...

Who might be able to join this trial: - People who have been diagnosed with recurrent glioblastoma (or a related brain tumour type called gliosarcoma), confirmed by MRI scan, biopsy, or advanced imaging such as PET or special MRI techniques. - People whose diagnosis of glioblastoma or gliosarcoma meets the 2021 World H...

Who might be able to join this trial: - You are between 18 and 80 years old (inclusive) - You have been diagnosed with a brain condition, such as a brain tumor or a disease affecting the blood vessels in the brain - You are able to safely have an MRI scan and receive a contrast dye injected through a vein (no known rea...

**Who might be able to join this trial:** - Children and young people aged 5 years old up to (but not including) 18 years old - People who are able to undergo the trial's sound wave treatment and MRI scans without needing sedation - People who have been diagnosed with a certain type of cancerous brain tumour located i...

**Who might be able to join this trial:** - People between 6 months and 30 years of age - People whose brain tumour can be measured or assessed on at least two dimensions using MRI scans taken at the time of joining the trial - People who have had imaging scans done within 14 days before starting treatment - People wi...

**Who might be able to join this trial:** - People aged 18 or older who are willing and able to sign a consent form - People with a life expectancy of at least 12 weeks - People who are willing and able to follow the trial schedule, including tests, procedures, and follow-up visits - People who have a confirmed diagno...

Who might be able to join this trial: - You are between 30 and 79 years old, and you currently live at the same address listed on your official ID or registration documents - You are willing to take part in the study, agree to have your biological information (such as samples or health data) collected, and are happy to...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who are willing to give written consent and follow all study procedures for the full duration of the trial. - People who have a reasonably good level of physical functioning, as measured by standard medical scoring tools (confirm with trial...

**Who might be able to join this trial:** - People who have been newly diagnosed with a specific type of aggressive brain tumour called glioblastoma (WHO grade 4, IDH-1 R132H wild type) - People who have had surgery that removed at least 70% of the tumour - People aged 18 or older - People who are generally able to ca...

**Who might be able to join this trial:** - People who have been newly diagnosed with a brain tumour (called a CNS glioma, grade 2 or 3), confirmed by laboratory testing of tumour tissue. - People whose tumour has a specific genetic change called an IDH mutation, identified through laboratory testing. - People whose t...

**Who might be able to join this trial:** *Prospective (forward-looking) part of the study:* - People aged 18 or older - People who are scheduled to have surgery to remove a brain tumor - People for whom a pre-surgery brain scan using fMRI (a type of imaging that shows brain activity) is already planned as part of the...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been newly diagnosed with a specific type of brain tumour called GBM (Grade IV glioma) for the first time, confirmed by laboratory testing of tumour tissue — people with a secondary form of GBM are not eligible - People whose tumour...

Who might be able to join this trial: - People with a relatively good level of physical functioning, as measured by a standard medical scoring tool called the Karnofsky scale (confirm with trial site) - People who have been diagnosed with, or have a recurrence of, a type of brain tumour called glioblastoma multiforme (...

**Who might be able to join this trial:** - Children and young people between 3 and 21 years old at the time of consent who have been newly diagnosed with a type of blood cancer called ALL (either B-cell, T-cell, or mixed type), confirmed by laboratory testing - Children and young people between 3 and 21 years old at...

Who might be able to join this trial: - People who have been diagnosed with a cancerous condition, confirmed through laboratory testing of tissue samples - People who have between 4 and 15 suspected brain lesions (abnormal areas) visible on MRI scans - People who are 18 years of age or older - Women who could become pr...

**Who might be able to join this trial:** - You have been diagnosed with a type of brain tumor called Glioblastoma (GBM, WHO grade 4), confirmed by a tissue sample (biopsy or surgery) - You are 18 years of age or older - Your doctors expect you to live for more than 6 months - Your tumor can be reached by surgery, and...

**Who might be able to join this trial:** - People aged between 18 and 89 years old - People who have been diagnosed with, or are suspected to have, a brain tumour called a glioma (Grade II through IV, based on World Health Organization classification), as confirmed by a doctor - People who have not yet received any tr...

**Who might be able to join this trial:** - People who have signed a consent form before any study-related activities begin, in line with local guidelines. - Adults aged 18 or older at the time of signing the consent form. - Women who are post-menopausal (defined as being aged 60 or over; or under 60 with no menstrual...

Who might be able to join this trial: - People who have previously been diagnosed with hemianopia (a condition where vision is lost in half of the visual field) confirmed through a type of vision test called microperimetry, along with any other tests needed - People aged between 18 and 90 years old - People who are abl...

Who might be able to join this trial: - People who have been diagnosed with a typical brain meningioma (a type of brain tumour) confirmed by imaging scan, showing specific characteristics such as uniform contrast uptake or attachment to the brain's protective lining - People whose tumour requires treatment because it h...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma multiforme, a type of brain tumour classified as WHO Grade IV (the most serious grade) - People whose doctors have determined they are suitable for surgery, with the goal of removing more than 80% of the tumour - People who ha...

**Who might be able to join this trial:** - You must be willing and able to give your agreement to participate before any study activities begin. - You must be an adult (18 or older) who has been diagnosed with a specific type of brain tumour called IDH-wild type glioblastoma, and your tumour has come back for the fir...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of brain tumor called glioblastoma (with particular molecular features: IDH wild-type and MGMT promoter methylated), confirmed by a tissue sample, and the tumor has come back for the first time and been surgically removed or biops...

**Who might be able to join this trial:** - People who have been newly diagnosed with glioblastoma (a type of brain tumour) based on the 2021 World Health Organization classification - People whose diagnosis was confirmed no more than 4 weeks before being enrolled in the trial - People aged 70 years or older - People...

**Who might be able to join this trial:** - People who are at least 18 years old at the time of screening. - People who are able to understand the purpose and risks of the study and have signed a written consent form approved by the relevant review board. - People who have a brain tumour called glioma (confirmed by bi...

**Who might be able to join this trial:** - People who are able to understand the study and are willing to sign a written consent form. - People who are able to follow the visit and dosing schedule, and are willing to keep an accurate daily diary of when they take their medication. - People who are at least 18 years o...

Who might be able to join this trial: - People who have been admitted to the Nuclear Medicine and Molecular Imaging department at ICANS (Institut de Cancérologie Strasbourg Europe) for a combined PET/MRI scan - People having this scan to assess a brain lesion before surgery - People having this scan to check whether a...

**Who might be able to join this trial:** - People aged 18 or older. - People who have been diagnosed (confirmed by tissue testing) with a specific type of aggressive brain tumour called Grade IV IDH wildtype glioblastoma (including types called molecular glioblastoma and gliosarcoma) that has come back or kept growin...

**Who might be able to join this trial:** - People who have been diagnosed with a high-grade brain tumor (WHO Grade IV), such as glioblastoma or related types, confirmed by a tissue sample, tested as IDH wild-type, where the tumor has come back or grown after standard first-line treatment. - People whose tumor has ret...

**Who might be able to join this trial:** - You (or your child) have been diagnosed with a type of brain tumor called DIPG or a related midline brain tumor (DMG), either based on scans and symptoms, a tissue sample (biopsy), or a liquid sample from the blood or spinal fluid. - A tissue sample (biopsy) has been done, o...

Who might be able to join this trial: - People who have a tumor inside the skull (any type) - People who have a cavernoma (a cluster of abnormal blood vessels in the brain) - People who have an arteriovenous malformation (an abnormal tangle of blood vessels in the brain) - People who have had a spontaneous (non-injury-...

Who might be able to join this trial: - People who have a confirmed diagnosis of a brain tumor that either started in the brain (primary) or spread to the brain from another part of the body (metastatic), confirmed through a tissue sample or medical imaging as appropriate. Who may not be able to join: - No exclusion c...

**Who might be able to join this trial:** - People who have been confirmed to have cancer through a tissue or cell sample test. - Depending on which part of the trial a person joins: people with any solid tumour type (dose escalation phase); people with a brain cancer called glioblastoma, or GBM (Cohort 1); people wit...

**Who might be able to join this trial:** - People who have been diagnosed with a primary brain tumor that has come back, where no curative treatment is available, OR a solid tumor that has returned or stopped responding to treatment, where no curative option exists and at least two lines of prior treatment have been...

**Who might be able to join this trial:** - The child must have a suspected or confirmed new diagnosis of a brain tumour called medulloblastoma. - The child must be under 60 months (5 years) of age at the time of joining the study. - During the initial screening stage, the child must be either under 36 months old, or...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with breast cancer that has come back or spread to other parts of the body, and your cancer has tested negative for HER2 (a specific protein) - You have at least one measurable area of cancer in the brain that is...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who have a solid tumour (a type of cancer that forms a lump or mass) confirmed by tissue testing or imaging scans - People for whom doctors have recommended surgery to remove one brain metastasis (a cancer growth that has sp...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected of having, a cancerous brain tumour that needs treatment - People where the medical team is uncertain, based on standard MRI scans, whether the tumour has come back after previous treatment - People who are expected to live fo...

**Who might be able to join this trial:** - People aged 18 or older - People whose general health and ability to carry out daily activities falls within a certain range, as measured by a standard oncology scale called ECOG 0–3 (confirm with trial site) - People who have been diagnosed with brain metastases (cancer tha...

Who might be able to join this trial: - People who have been diagnosed with a low-grade brain tumour (Grade I or II) located in the brainstem or the upper part of the brain, confirmed by a biopsy (or, for those with a condition called NF1, by the typical appearance of the tumour on scans). - People whose tumour measure...

Who might be able to join this trial: **Healthy volunteers (for certain parts of the study):** - You are 18 years old or older - You are able to understand and agree to participate in the study - You have not been diagnosed with cancer **Patients (for certain parts of the study):** - You are 18 years old or older - Y...

**Who might be able to join this trial:** - People aged between 18 and 80 years old - People whose general health and ability to carry out daily activities meets a minimum level, as measured by a standard medical scoring system called the Karnofsky Performance Score (a score of 50 or above is required — confirm with tr...

**Who might be able to join this trial:** - People who have brain scan (MRI) findings that appear to show a high-grade glioma (a fast-growing type of brain tumour, WHO Grade 3 or 4, including a type called GBM), or people who have already been diagnosed with this type of brain tumour and are having surgery to remove a...

**Who might be able to join this trial:** - People who have signed an informed consent form before any trial procedures begin - People who have a confirmed diagnosis of glioblastoma (a type of brain tumour), confirmed through a tissue sample - People for whom doctors have recommended a course of fractionated radiation...

Who might be able to join this trial: - You are 18 years of age or older - You are generally able to carry out normal daily activities with at least some level of independence (confirm with trial site) - Your doctors expect you to live for at least 1 year or more - You have a primary brain tumor and are scheduled to re...

**Who might be able to join this trial:** - People aged between 18 and 70 years old (inclusive). - People who have a history of glioblastoma (a type of brain tumour) and have been diagnosed with a recurrence of glioblastoma, with some tumour remaining after surgery or biopsy performed at Beijing Tiantan Hospital. - Pe...

Who might be able to join this trial: - People who have been diagnosed with a type of brain tumour called diffuse glioma (WHO grades 2–4), confirmed by tissue testing at the NCI Laboratory of Pathology. - People whose tumour has a specific genetic change called an IDH1 or IDH2 mutation, confirmed by a specific genetic...

**Who might be able to join this trial:** - Adults between 18 and 85 years old - People who have been diagnosed with stage I–IV Hodgkin's or non-Hodgkin's lymphoma, or stage I–III breast cancer - People who are expected to receive certain cancer treatments, including specific types of chemotherapy (such as anthracycli...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose brain tumor tissue tests positive for a specific genetic change called IDH1R132H - People with a Grade 2 or Grade 3 glioma (a type of brain tumor) that has come back or grown, with a certain amount of tumor visible on scans that does no...

**Who might be able to join this trial:** - People who have been diagnosed with, or are suspected to have, a type of adult brain tumour called an adult-type diffuse glioma (including glioblastoma, astrocytoma, or oligodendroglioma, as classified by World Health Organization guidelines) - People who are willing to prov...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of brain tumour called glioblastoma (GBM) that has certain molecular features — specifically, MGMT promoter methylation and IDH wild type — confirmed by a laboratory test. - People whose brain tumour has come back for the f...

**Who might be able to join this trial:** - People aged 18 years or older who are not suitable for a standard intensive treatment protocol (called the STUPP protocol), and who fall into one of two groups: - **Group 1:** People aged 18–70 who cannot have surgery, have a functioning level score (Karnofsky Index) of 50...

**Who might be able to join this trial:** - You are over 18 years old - You have been diagnosed with glioblastoma (a type of brain tumour), Grade IV, confirmed by a tissue sample (biopsy or surgery) - You are reasonably active and able to care for yourself, with a performance level rated 0, 1, or 2 (a standard scale do...

**Who might be able to join this trial:** - You are an adult who is scheduled to have endoscopic (minimally invasive, through the nose) surgery to remove a pituitary tumor, including non-functioning adenoma, acromegaly-related tumors, prolactinoma, or Rathke's cleft cyst - You are between 18 and 85 years old - You spea...

**Who might be able to join this trial:** *General criteria that apply to all groups:* - People aged 18 or older. - People whose cancer is not located only in the lower back part of the brain (posterior fossa) or only within the spinal cord itself. - People who have recovered from most side effects of previous cancer...

Who might be able to join this trial: - People who have been diagnosed with glioblastoma or grade 4 astrocytoma, confirmed by a pathology (laboratory) test - People between the ages of 18 and 75 years old - People who have had surgery to remove (resect) the tumour - People who are scheduled to receive radiation and che...

**Who might be able to join this trial:** - People who have been diagnosed with a high-grade brain tumour (specifically a WHO grade 4 malignant glioma, such as glioblastoma or astrocytoma), confirmed by a recent biopsy or surgery. - People aged 18 or older. - People who have a reasonable level of physical functioning,...

**Who might be able to join this trial:** - People who have been previously diagnosed with a high-grade brain tumour called glioblastoma or anaplastic astrocytoma, and whose brain scans show signs that the tumour has come back or grown - People who are 18 years of age or older and are able to give informed consent and...

Who might be able to join this trial: - People who are 18 years of age or older. - People diagnosed with a specific type of lung cancer (non-squamous) that is locally advanced, classified as stage IIIA, IIIB, or IIIIC according to standard cancer staging guidelines. - People whose lung cancer tissue analysis shows a mi...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have cancer that has spread to the brain, and whose cancer is one of the following types: advanced BRCA1 or BRCA2 gene-mutated cancer, advanced cancer with certain DNA repair gene changes (but not BRCA1/2), advanced small...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been recently diagnosed with glioblastoma (a type of brain tumour), with the diagnosis confirmed by a tissue test within the last 2 months - People who have not yet started standard chemotherapy or radiation treatment for glioblasto...

**Who might be able to join this trial:** - Parents or the patient (depending on age) have given written consent to participate. - The patient is able to follow all the study procedures, in the opinion of the study doctor. - The patient is between 1 and 18 years old. - Female patients who are able to become pregnant h...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with a primary brain tumour or a tumour at the base of the skull - People whose tumour is suitable for a standard course of radiation therapy (using either conventional X-ray-based or proton-based radiation) **Who may not be ab...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of joining the study - People who have been newly diagnosed with a specific, high-grade brain tumour (called glioblastoma, or GBM, WHO grade 4, IDH wildtype, MGMT unmethylated) that still shows some visible disease on a brain scan after in...

Who might be able to join this trial: - People who are able to understand and agree to participate in the study (give informed consent) - People who are scheduled for and attending brain surgery - People whose surgery will be performed under general anesthesia (fully asleep during the procedure) - People whose surgery...

**Who might be able to join this trial:** - People who have brain scan (MRI) results showing what appears to be a high-grade brain tumour, and who are willing to have surgery if the initial tissue test during the operation confirms it is glioblastoma or gliosarcoma - People who have already been diagnosed with gliobla...

**Who might be able to join this trial:** - Children and young people between the ages of 4 and 21 years old. - People who have been diagnosed with a specific type of brain tumour called Diffuse Midline Glioma, confirmed either by brain scan or by laboratory testing of tumour tissue, and whose disease has shown signs...

**Who might be able to join this trial:** - Parents or caregivers of a child with complex medical needs, where the child is between 2 and 18 years old - People who own and use a smartphone - People who can speak and read Chinese - People who live at home together with their child **Who may not be able to join:** - Peo...

Who might be able to join this trial: - People who have been newly diagnosed with a specific type of brain tumour called glioblastoma (GBM), confirmed using the latest medical classification system (WHO 2021). - People who have undergone the safest possible level of surgery to remove the tumour — any amount of surgery...

**Who might be able to join this trial:** - People who have been diagnosed with non-small cell lung cancer, confirmed through a tissue or cell sample test - People who have been newly diagnosed with a small number of brain metastases (cancer that has spread to the brain) — specifically fewer than 5 spots in the brain,...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with advanced breast cancer that has been confirmed by lab testing to be HER2-positive or HER2-low - You have at least one measurable tumor in the brain that has not yet been treated locally (for example, not yet treated...

**Who might be able to join this trial:** - Adults aged 19 years or older at the time of agreeing to participate - People who have been diagnosed with glioblastoma (GBM) according to World Health Organization criteria - People whose GBM has come back or gotten worse after receiving the standard initial treatment - Peo...

Who might be able to join this trial: - You are an adult with a brain lesion that doctors suspect may be a type of brain tumor called GBM (glioblastoma), and you are scheduled for surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy. - You are able to understand the study i...

Who might be able to join this trial: - People aged 18 or older - People whose general health and ability to function meets a minimum level, as measured by a standard scale called the Karnofsky Performance Scale (score of 60 or above) (confirm with trial site) - People who have previously been diagnosed with a specific...

**Who might be able to join this trial:** - Adults aged 18 years or older (male or female) - People who have long-term, ongoing ACTH-dependent Cushing's syndrome (a hormonal condition where the body produces too much cortisol due to excess ACTH hormone) - People whose Cushing's syndrome has been actively causing sympto...

Who might be able to join this trial: - You must be an adult aged 18 or older - You must be able to understand and agree to take part in the trial yourself - You must have a brain tumor, either one that started in the brain or one that has spread to the brain from elsewhere in the body - You must need brain surgery or...

**Who might be able to join this trial:** - People aged 21 years or younger at the time of joining, of any gender, race, or ethnicity - People with a suspected or confirmed cancer that has come back or has not responded to previous treatment - People who are scheduled to have, or have recently had, a biopsy or surgical...

**Who might be able to join this trial:** - You must be 18 years of age or older - You must have a type of brain tumor called an IDH-wildtype glioma (grade 2, 3, or 4), confirmed by a tissue sample test - Your tumor must have a specific genetic change called an FGFR-TACC gene fusion, found through an approved genetic...

Who might be able to join this trial: - People who have been diagnosed with a type of brain tumour called glioma, confirmed through tissue testing - People who have a complete set of MRI scans with clear, usable images - People who have signed a form agreeing to take part in the study Who may not be able to join: - Pe...

Who might be able to join this trial: - People who have been recently diagnosed with a gynecologic cancer (such as uterine, cervical, ovarian, primary peritoneal, vulvar, or vaginal cancer) and are currently receiving chemotherapy - People who own a smartphone or tablet that is capable of downloading a cognitive traini...

**Who might be able to join this trial:** - You have been recently diagnosed with a specific type of brain tumor called glioblastoma, confirmed by a lab test, with a particular genetic profile (called "IDH wild-type") - Your tumor has a specific genetic marker called "MGMT unmethylated" (a lab test your doctor can che...

**Who might be able to join this trial:** - People who have been diagnosed with breast cancer confirmed by laboratory testing of tissue samples - People whose breast cancer is "triple-negative," meaning the cancer tests negative for oestrogen receptors, progesterone receptors, and HER2 protein (less than 10% of tumour...

**Who might be able to join this trial:** - People who have had a type of precise brain radiation treatment called stereotactic radiosurgery (SRS — including Gamma Knife or CyberKnife) for cancer that has spread to the brain - People with between one and ten newly diagnosed brain tumours that are suitable for this typ...

Who might be able to join this trial: - People who are willing to take part voluntarily, fully understand the study, and are willing to sign a consent form. - People who are generally well enough to carry out daily activities with little to no limitation (based on a standard fitness scale scored 0 or 1). - People with...

**Who might be able to join this trial:** - You have been newly diagnosed with a specific type of brain tumor called glioblastoma (GBM), confirmed by a tissue sample (biopsy or surgery), with specific genetic features called "IDH wild-type" and "MGMT unmethylated" (confirm with trial site for testing details) - You ar...

Who might be able to join this trial: - People who have been diagnosed with a specific type of brain tumour — either a grade 4 glioblastoma (GBM) with a particular genetic profile (IDH-wildtype), or a grade 3 astrocytoma with certain genetic markers — classified according to the 2021 World Health Organization system. -...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma (a type of brain tumour), confirmed by tissue testing, with a specific genetic result showing no IDH mutation - People who have already received first-line treatment that included brain surgery or a biopsy, plus a course of ra...

**Who might be able to join this trial:** - People who have signed a written consent form before joining the trial, as required by international research guidelines. - People whose glioblastoma has come back or progressed for the first time after standard chemotherapy and radiation treatment, with that progression hap...

Who might be able to join this trial: - People who have been diagnosed with glioblastoma (a type of brain tumour) or brain metastasis (cancer that has spread to the brain) confirmed through laboratory testing of tissue, where the tumour appears to have grown or returned on a standard MRI scan after completing first-lin...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed (confirmed by tissue testing) with one of the following brain tumours: Glioblastoma (IDH-wildtype), or a Grade 3 or 4 astrocytoma with an IDH1 or IDH2 mutation (based on 2021 WHO classification) - People whose tumour i...

Who might be able to join this trial: - Adults over 18 years old who have been diagnosed with a brain disease (either newly diagnosed or returned after previous treatment) and are considered suitable for, and willing to have, surgery to remove the affected tissue. Who may not be able to join: - People who are unable t...

Who might be able to join this trial: - People who have been newly diagnosed with a specific type of brain tumour called glioblastoma (GBM, WHO grade IV, IDH wild type) and have had surgery to remove or reduce the tumour - People who have had a specific gene marker on the tumour (called MGMT methylation status) tested...

**Who might be able to join this trial:** - You have been diagnosed with a type of brain tumor called glioblastoma in the upper part of the brain, based on imaging scans (such as an MRI), OR your glioblastoma has come back for the first time after previously being confirmed by a tissue biopsy - You are scheduled to hav...

**Who might be able to join this trial:** - People who are starting radiation treatment for a brain tumor - People who are between 8 and 22 years old at the time of joining the trial - People whose primary language is English or Spanish - People (and one of their parents) who are willing to take part and give their agr...

Who might be able to join this trial: **Cohort A ("Survivors" group):** - People who have had head and neck, skull base, or brain tumours and have been monitored for at least 5 years with no signs of the disease getting worse - People who are able to give their own consent to participate **Cohort B (Treatment group):...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who are scheduled to have surgery to remove a known or suspected brain tumour called glioblastoma (GBM) - People with a general health and functioning level of 70% or higher on a standard medical scale called the Karnofsky Perf...

**Who might be able to join this trial:** - People who have a confirmed tissue diagnosis of a relapsed or returning brain tumour — specifically glioblastoma multiforme (GBM), anaplastic astrocytoma, fibrillary astrocytoma, pilomyxoid astrocytoma, oligodendroglioma, or anaplastic mixed oligoastrocytoma — or a radiologi...

"Who might be able to join this trial: - Adults between 18 and 80 years of age - People who are scheduled to undergo any type of brain or nervous system surgery (neurosurgery) Who may not be able to join: - People who do not wish to take part in the trial Important: Always verify eligibility with the trial site direc...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People with Cushing's syndrome confirmed to be coming from the pituitary gland, shown by consistently high cortisol levels in urine tests, plus normal or raised ACTH hormone levels in the blood, AND either a pituitary tumour larger th...

Who might be able to join this trial: - Adults aged 18 or older - People who are patients at the Massachusetts General Hospital Cancer Center - People who have been diagnosed with a primary malignant brain tumor within the last 6 weeks - People who are able to speak and read in English Who may not be able to join: - P...

Who might be able to join this trial: - Adults aged over 18 years - People who have been diagnosed with primary lung cancer confirmed by a tissue sample (biopsy) - People who have brain metastases (cancer that has spread to the brain), whether confirmed by tissue sample or not - People whose brain metastases have been...

Who might be able to join this trial: - You are willing and able to sign a consent form agreeing to take part in the study and allowing your personal health information to be used (for children, a parent or guardian can provide this consent) - You have been diagnosed with a tumor located in the brain or spinal cord (ce...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who are scheduled to have surgery to remove a known or suspected brain tumour called glioblastoma (GBM) - People whose general health and functioning is rated at 70% or above on a standard medical scoring scale (confirm with tr...

**Who might be able to join this trial:** - People who have been diagnosed with Stage II, III, or IV breast cancer that is hormone receptor-positive (a type that responds to hormones) - People who are post-menopausal — meaning their periods stopped at least one year ago, or they are taking medication to suppress their...

Who might be able to join this trial: - People who are older than 18 years of age - People who have a relatively good level of physical functioning, as assessed by a standard medical scale called the Karnofsky performance status (score above 60) (confirm with trial site) - People who are willing and able to provide wri...

Who might be able to join this trial: - People who have been diagnosed with glioblastoma (a type of brain tumour) based on imaging scans or a needle biopsy tissue sample - People who have not previously had radiotherapy, chemotherapy, or any other treatments for tumours in the brain - People who have no medical reasons...

**Who might be able to join this trial:** - People who are regularly attending and being followed up at the relevant medical department - People who have been diagnosed with at least one of the following conditions: coronary artery disease, an abnormal heart rhythm (arrhythmia), heart valve disease, aortic dissection,...

**Who might be able to join this trial:** - Adults diagnosed with glioblastoma (a type of brain tumour) that has come back, and where the tumour has a specific characteristic called "IDH wildtype" - The tumour has returned after completing the standard first treatment, which involves both radiation therapy and chemothe...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of a high-grade brain tumour (grade III or IV glioma, including glioblastoma, gliosarcoma, anaplastic astrocytoma, anaplastic oligodendroglioma, or H3K27M mutant glioma) that has continued to grow or returned after treatment with bevaciz...

**Who might be able to join this trial:** - People who have been diagnosed with a pituitary neuroendocrine tumour (a type of growth on the pituitary gland) based on medical imaging, whether or not the tumour produces hormones (confirmed by hormone testing) **Who may not be able to join:** - People whose previous tissu...

Who might be able to join this trial: - People who have been diagnosed with a type of brain tumour called diffuse glioma, confirmed through a tissue sample (biopsy). - People who have imaging results showing radionecrosis (a type of tissue damage that can occur after radiation treatment to the brain) along with new or...

Who might be able to join this trial: - People who had a brain or spinal cord (central nervous system) tumour that was treated with radiation therapy at Tata Memorial Centre (TMC) between January 2010 and December 2022. Who may not be able to join: - People whose radiation therapy was carried out at a hospital or cent...

**Who might be able to join this trial:** - People with suspected returning glioblastoma (a type of brain tumour) that can be clearly seen and measured on imaging scans, with at least one area of the tumour that shows up with contrast dye, sized between 2 cm³ and 20 cm³ - People whose tumour is located in a part of th...

**Who might be able to join this trial:** - People who have been diagnosed with cancer that has spread to the brain, confirmed by imaging scans. - People whose brain tumours (however many there are) are all 2 cm or smaller in size. - People whose medical team has already planned for them to receive a type of targeted...

**Who might be able to join this trial:** - Be older than 5 years of age - Be younger than 18 years old at the time they received radiation therapy - Have received radiation treatment to the brain or spine for a brain tumor within the last 7 years - Be using an adequate form of birth control throughout the entire treat...

**Who might be able to join this trial:** - People who have been clinically suspected of having, or diagnosed with, one or more tumours that have spread to the brain (brain metastases) - People aged 18 years or older - People with a known history of cancer - People who have had a brain MRI scan within the past 2 month...

Who might be able to join this trial: - People diagnosed with stage IV lung adenocarcinoma (a type of lung cancer that has spread to other parts of the body) that has been confirmed by tissue or cell testing, and where surgery or radiotherapy to fully remove the cancer is not possible - People who have cancer that has...

Who might be able to join this trial: - People who are over 18 years old - People who have been newly diagnosed with glioblastoma (a type of brain tumour) or whose glioblastoma has come back, and whose doctors have recommended surgery to remove the tumour Who may not be able to join: - People for whom MRI or FDG PET s...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a specific type of brain tumour called glioblastoma (GBM, IDH-wildtype), confirmed by a tissue test - Your brain tumour has come back for the first or second time after you received radiation therapy and a chemo...

Who might be able to join this trial: - People who have an active diagnosis of ER+ (estrogen receptor positive) breast cancer, confirmed by biopsy, and who have brain metastases (cancer that has spread to the brain) that are either new or have come back, confirmed by biopsy or suspected based on an MRI scan - People wh...

Who might be able to join this trial: - People who have a growth or abnormality in the brain that requires surgery to remove it - People scheduled for surgery to remove a type of brain tumor that is likely to be high grade (fast-growing or aggressive) and invasive - People scheduled for surgery to remove other types of...

Who might be able to join this trial: - People who are older than 18 years of age - People who have been newly diagnosed with, are suspected of having, or have a returning form of a brain tumor called glioblastoma (GBM), where the tumor is actively growing (shown by enhancement on scans), is larger than 1.5 mL, and sur...

Who might be able to join this trial: - People who are 18 years of age or older - People who are patients at the Massachusetts General Hospital Cancer Center - People who have been diagnosed with a cancerous brain or spinal cord tumor within the last 6 months - People who speak English Who may not be able to join: - P...

Who might be able to join this trial: - Adults (male or female) aged 18 or older - People with a brain tumour confirmed by laboratory testing to be a grade 4 astrocytoma or glioblastoma (GBM), as defined by the 2021 WHO brain tumour classification guidelines - People whose tumour tests positive for a specific protein c...

Who might be able to join this trial: - Adults aged 18 or older, of any sex or racial background. - People who have been diagnosed with a specific type of brain tumour called glioblastoma multiforme (confirmed by tissue testing or by medical history, symptoms, and brain scan results that strongly point to this diagnosi...

Who might be able to join this trial: - Adults aged 18 or older who are having surgery to remove a tumor in the brain or spinal cord (central nervous system) - People without a brain or spinal cord tumor who are taking part as a comparison group (controls) may also be eligible Who may not be able to join: - People und...

Who might be able to join this trial: - People aged 18 to 90 years old - People whose MRI scan has been assessed by a neurosurgeon and shows a high-grade brain tumour (classified as WHO grade III or IV) - People who are able to provide written agreement to take part in the trial Who may not be able to join: - People w...

**Who might be able to join this trial:** - People who are older than 35 years of age - People of any sex (male or female) - People who have recently been diagnosed with glioblastoma (a type of brain tumour) based on a scan - People who are largely able to carry out daily activities with little to no limitation (as as...

Who might be able to join this trial: - Adults aged 18 or older. - People with a confirmed advanced or spreading solid tumour (not melanoma) that has a TP53 gene mutation or loss, and whose cancer has come back or stopped responding to at least one previous systemic treatment. - People with prostate cancer that has spr...

Who might be able to join this trial: - People diagnosed with diffuse midline glioma (a type of brain or spinal cord tumor) according to the 2021 World Health Organization classification, including a specific type called diffuse intrinsic pontine glioma (DIPG). If there is no confirmed tissue diagnosis, people with a h...

**Who might be able to join this trial:** - You have been recently diagnosed with glioblastoma (a type of brain tumour), confirmed by a tissue sample and classified according to standard medical guidelines - You are between 18 and 70 years old and are generally able to carry out most daily activities with minimal limi...

**Who might be able to join this trial:** - People aged 18 years or older - People who are able and willing to give their formal consent to take part in the study - People who have been diagnosed with brain metastases (cancer that has spread to the brain) and have at least one visible affected area showing up on a bra...

Who might be able to join this trial: - People who have been diagnosed with a primary brain or spinal cord (central nervous system) tumour, confirmed by a pathology report, that fits one of the specific tumour types listed for each study group (cohort). - People in the Phase I group: those with any primary brain or spi...

**Who might be able to join this trial:** - You have a brain tumour (glioma) located in the temporal region of the brain and are scheduled for planned brain surgery - You are 18 years of age or older - You are willing and able to give written consent to take part in the trial **Who may not be able to join:** - You hav...

**Who might be able to join this trial:** - People aged 18 or older - People who are able to give written consent to participate, and who are able to follow the study requirements - People who have a good general level of functioning, as measured by a standard medical scale called the Karnofsky Performance Scale (scor...

**Who might be able to join this trial:** - People who have been diagnosed with metastatic breast cancer that has been confirmed by a pathologist to be HER2-negative, based on 2018 testing guidelines. - People whose metastatic disease has been confirmed by imaging (such as a scan). - **For Groups A and B:** People who...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of joining the study - People who have been confirmed by laboratory tissue analysis to have a recurring glioblastoma brain tumour (a specific high-grade brain cancer) that is located in the upper part of the brain - People...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with a specific type of brain tumour called IDH-wildtype glioblastoma, confirmed through laboratory testing of tissue removed during surgery or biopsy - People who have been referred to a radiotherapy outpat...

Who might be able to join this trial: - People between 8 and 21 years of age (inclusive) - People who have been newly diagnosed with a primary brain tumor of any location or type, and who will be treated with proton radiation therapy - People with a life expectancy of at least one year - People who are able to understa...

Who might be able to join this trial: - Adults aged 18 or older with a brain tumour diagnosis of glioblastoma (GBM) that tests positive for a specific protein marker called EGFRvIII, confirmed by an approved laboratory test - People with a performance status score showing they are reasonably functional in daily life (...

**Who might be able to join this trial:** **General eligibility (applies to all participants):** - People who have been diagnosed with certain brain tumors — either a new diagnosis of specific childhood brain tumors (including medulloblastoma, embryonal tumor with multilayered rosettes, pineoblastoma, atypical teratoi...

**Who might be able to join this trial:** - People who are over 18 years of age - People who are willing to take part in the study and attend all required appointments and assessments - People who have previously been treated for a brain tumor, have a new suspicious finding on a brain scan, and are being considered fo...

Who might be able to join this trial: - People who are adults (18 years of age or older) - People diagnosed with a grade 4 diffuse glioma (a specific type of aggressive brain tumour) - People who had their brain surgery performed at the neurosurgery department of Caen University Hospital - People who are enrolled in a...

Who might be able to join this trial: - People diagnosed with sarcoma (a type of cancer) affecting soft tissues or internal organs - People whose cancer cannot be removed by surgery and has either spread to other parts of the body or has grown significantly in a local area - People for whom a doctor has recommended tre...

**Who might be able to join this trial:** - People who have been diagnosed with glioblastoma (a type of brain tumour), confirmed by tissue testing, where the cancer has come back either based on imaging scans or further tissue testing - People aged 18 or older - People who are at least 12 weeks past completing radiati...

**Who might be able to join this trial:** - People who have been diagnosed with diffuse intrinsic pontine glioma (a type of brain tumour in the brainstem) at any point after finishing standard radiation treatment - Children and young people between 1 and 18 years old - Both males and females are eligible - People who...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of joining the study - People who have been recently diagnosed with glioblastoma (a type of brain tumour) for the first time - People for whom a treatment plan involving radiation therapy, chemotherapy, and TTFields (a devic...

Who might be able to join this trial: - Adults between 18 and 80 years of age (either male or female) - People who are already scheduled to have a craniotomy (a type of brain surgery) to remove a tumor - People who have given written consent to participate, or whose legal decision-maker has given written consent on the...

Who might be able to join this trial: - People who are able to understand the research, are willing to take part, and can sign a consent form - People with a general health status rated as reasonably functional (on a standard scale used by doctors to measure how well a person can carry out daily activities — confirm wi...

**Who might be able to join this trial:** - People diagnosed with advanced non-small cell lung cancer (either at an advanced stage from the start, or cancer that has come back), confirmed by laboratory testing of tissue or cell samples. - People who have cancer that has spread to the brain and are being considered for...

**Who might be able to join this trial:** - People whose general physical functioning is rated as reasonably good by their doctor (on a standard scale used in cancer care, scored 0–2) - People who have been diagnosed with small cell lung cancer, confirmed through a tissue or cell sample - People who have had a full se...

Who might be able to join this trial: - People aged 18 years or older, of any gender. - Tumor tissue collected during the screening process is available for testing. - People who have been diagnosed with a specific type of returning or growing brain tumor called IDH-mutant 1p/19q co-deleted Oligodendroglioma (Grade 2 o...

**Who might be able to join this trial:** - People aged 18 to 75 years old. - People who have a laboratory-confirmed diagnosis of high-grade glioma (a type of brain tumour) that has come back or grown for the first or second time. - People whose brain tumour is either able to be surgically removed or not able to be su...

Who might be able to join this trial: - Adults aged 18 to 90 years old - People who have a previously diagnosed glioblastoma (a type of brain tumour), classified according to the 2021 World Health Organisation brain tumour guidelines, that has come back after earlier treatment - People whose tumour is located in or clo...

Who might be able to join this trial: - People who are 18 years of age or older, of any gender. - People who have been diagnosed with brain metastases (cancer that has spread to the brain) that are newly found, confirmed through a tissue sample (biopsy), and originated from a known or suspected solid tumour elsewhere i...

Who might be able to join this trial: - People who are considered suitable candidates for a type of minimally invasive surgery performed through the nose using a small camera (transnasal endoscopic surgery). - People who have had specific detailed brain scans — an MRI and a CTA (a type of scan that looks at blood vesse...

Who might be able to join this trial: - People who feel their physical fitness is lower than it should be, based on their own assessment - People who are at least 18 years old - People who have been diagnosed with a primary brain tumor (a tumor that started in the brain) - People whose disease is currently stable, mean...

Who might be able to join this trial: - Adults aged 18 to 90 years old - People who have been previously diagnosed with glioblastoma (a type of brain tumour) based on current medical classification standards, and whose tumour has come back, as confirmed by specific medical imaging guidelines called RANO criteria - Peop...

**Who might be able to join this trial:** - You (or your child) have been diagnosed with a specific type of brain tumor (a form of glioblastoma or related high-grade brain tumor) confirmed by laboratory testing, including cases where the tumor has spread or affects multiple areas of the brain - This is a first-time di...

Who might be able to join this trial: - You are between 18 and 80 years old - You have been diagnosed with a lesion (abnormal area) in the brain that your doctors have recommended removing through surgery - You are willing and able to give written consent to take part in the study - You are able to safely have an MRI s...

**Who might be able to join this trial:** *For patients:* - People aged 65 or older - People who have been diagnosed with Alzheimer's disease or a related form of dementia (including vascular dementia, Lewy body dementia, frontotemporal dementia, or dementia of unknown type) - People who have also been diagnosed with...

"Who might be able to join this trial: - People aged 18 years or older. - People who have had surgery on a brain lesion, such as a brain tumour (including glioma, primary central nervous system lymphoma, meningioma, or a rare brain tumour), or who are currently being monitored for one of these conditions. - People who...

**Who might be able to join this trial:** - People who are able to understand the study's purpose and have signed a written consent form before any study procedures begin. - People who are 18 years of age or older at the time of signing the consent form. - People who are able to swallow capsules whole, without chewing...

Who might be able to join this trial: - People who are 18 years of age or older. - People whose general health and ability to carry out daily activities meets a minimum level, as measured by a standard medical scale (Karnofsky Performance Status of 60% or higher). - People who have been newly diagnosed with a specific...

Who might be able to join this trial: - Children who have a chronic condition, rare disease, or disability that has led to a reduced ability to exercise - Children who are attending the CMPRE centre for a program focused on returning to physical activity Who may not be able to join: - Children who are younger than 8 y...

Who might be able to join this trial: - There must be clinical signs and scan results suggesting the presence of a brain tumor. - A biopsy of a suspected or previously diagnosed brain tumor must already be planned as part of routine care at Mayo Clinic in Rochester, Minnesota. - The patient must be willing to give info...

**Who might be able to join this trial:** - People aged 18 to 59 years old (any sex) - People whose MRI scan shows clear evidence of a brain tumour called glioma - People whose brain tumour tissue, tested after surgery, has been classified as Grade 4 Glioblastoma according to the 2021 WHO classification system - Peopl...

**Who might be able to join this trial:** - People who have been diagnosed with cancer that has spread to the brain (brain metastases), regardless of where the original cancer started - People who are planned to receive a type of radiation treatment called whole-brain radiation therapy (a version that protects a part o...

**Who might be able to join this trial:** - People aged 18 or older at the time of joining the trial. - People with a body mass index (a measure of body weight relative to height) of 17 or above. - People who have been diagnosed with glioblastoma (a type of brain tumour) that has clearly come back, confirmed by a spec...

**Who might be able to join this trial:** - You have been diagnosed with a high-grade brain tumour (confirmed by biopsy), have already had surgery followed by standard radiation and chemotherapy, and scans show the tumour has come back. - You are between 18 and 70 years old (any gender). - If you are taking the steroi...

Who might be able to join this trial: - People who have been diagnosed with breast cancer - People who have had curative surgery to remove brain metastases (cancer that has spread to the brain and was treated with an operation aimed at removing it) Who may not be able to join: - People who have had Gamma Knife surgery...

**Who might be able to join this trial:** - People who have been diagnosed with a type of brain tumour called glioblastoma or gliosarcoma (either as a first diagnosis or one that developed from a lower-grade brain tumour), confirmed by laboratory testing of tumour tissue. - People aged 18 or older. - People who have a...

**Who might be able to join this trial:** - People aged 18 or older - People who are able to give their own consent to participate - People who are willing to share their health data for up to one year after their surgery - People who own and are able to use a smartphone (Android or iPhone) - People who have the langua...

Who might be able to join this trial: - Adults aged 18 years or older - People who are having surgery to remove a pituitary adenoma (a type of non-cancerous brain tumour) through the nose Who may not be able to join: - People who have existing long-term pain conditions that require certain medications, including antid...

**Who might be able to join this trial:** - You have been diagnosed with glioblastoma multiforme (a type of brain tumour), confirmed by a tissue biopsy. - Your brain tumour has shown signs of growing again on an MRI scan, after you have already been treated with the standard treatment combining radiotherapy and a chem...

**Who might be able to join this trial:** - People who have been clinically diagnosed with a brain tumor - People who are at least 18 years old - People whose tumor tissue can be obtained and examined in a laboratory through surgery or biopsy - People who are able to give their consent to participate and are able to at...

**Who might be able to join this trial:** - People diagnosed with early Alzheimer's disease — specifically, mild cognitive impairment (Stage 3) or mild Alzheimer's dementia (Stage 4), as defined by the FDA in 2018 - People who have had a brain scan (amyloid PET) or specific lab tests (spinal fluid or blood) showing ab...

Who might be able to join this trial: - People aged 20 years old or younger, including healthy individuals and patients, who had imaging examinations (such as brain MRI scans to look into the cause of developmental delay) done at the Department of Rehabilitation Medicine at the relevant hospital between January 2010 an...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with a brain tumor that requires or has required radiation treatment to the head (enrollment may happen during radiation treatment or up to 5 years after it has finished) - People whose general health and ability to fu...

Who might be able to join this trial: - People diagnosed with glioblastoma (a type of brain tumour) or head and neck cancer who are receiving a long course of radiotherapy - People receiving radiotherapy as a follow-up treatment after their main cancer treatment (such as surgery) - People receiving a combination of rad...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who have been diagnosed with a type of brain tumor called glioblastoma (GBM), confirmed by a lab test using the most current brain tumor classification system. - People whose brain tumor has clearly come back or grown, as shown on a specific...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form. - People who are generally well enough to carry out light activity and care for themselves (a doctor will assess this using a standard fitness scale). - People with an estimated life expectancy of 12 weeks or m...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of brain tumor (grade 2–4 glioma, IDH wild type, or glioblastoma) confirmed through lab testing of tumor tissue - Your brain tumor has come back (recurred) after receiving standard or investigational first-line treatment, such as...

**Who might be able to join this trial:** - People who are female and aged 18 or older - People whose doctors expect them to live for at least 3 months - People with locally recurrent or metastatic breast cancer that has been confirmed through tissue or cell testing to be HER2-negative (specific test result categories...

Who might be able to join this trial: - People who have been newly diagnosed with a type of brain cancer called glioblastoma or gliosarcoma, with a specific genetic profile called "IDH wild type" - People whose tumor has a particular genetic marker called a "methylated MGMT promoter," which is determined through testin...

Who might be able to join this trial: - People who are older than 18 years of age - People who had surgery for glioblastoma (a type of brain tumour) — either a first diagnosis or a return of the tumour — at the CHU de Bordeaux hospital between 2005 and 2023 Who may not be able to join: - People who received systemic t...

**Who might be able to join this trial:** - People aged 18 to 75 years old - People who have been diagnosed with leptomeningeal metastasis (cancer that has spread to the fluid and membranes surrounding the brain and spinal cord), either confirmed through spinal fluid testing or through a combination of medical history...