Phase 3 Interstitial Lung Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with Langerhans cell histiocytosis (LCH) confirmed by a biopsy.
• People who are between 0 and 21 years of age.
• People who have a general health and functioning score of at least 50% on a standard medical scale used to measure daily activity ability.

Who may not be able to join:

• People who have previously received systemic chemotherapy or similar drug treatments for LCH or any other cancer, with some exceptions: short courses of steroid medications (such as prednisone or dexamethasone) taken briefly before starting the trial do not affect eligibility, and people who have only had surgery, radiation therapy, steroid injections directly into a lesion, inhaled steroids, or steroid creams applied to the skin may still be considered eligible.
• People whose disease is limited to only a single skin or bone site, unless that single site is in a location near the brain or spine that requires full-body treatment as standard care, or the single lesion is in a location where local treatment such as surgery would cause serious harm, or the person previously had LCH in at least one other location in the past (confirm with trial site for these exceptions).
• People with severely reduced kidney function, based on specific blood and urine test results (confirm with trial site).
• People with severely reduced liver function, based on specific blood test results, unless the liver problems are caused by LCH itself.
• People who are currently pregnant or breastfeeding.
• People who are able to have children but are not willing to use an adequate form of birth control for the entire duration of the study.
• People who are HIV positive.

Important: Always verify eligibility with the trial site directly before applying.