Interstitial Lung Disease

**Who might be able to join this trial:** - Children and young people who are at least 12 months old and no older than 21 years of age at the time of joining the study. - Patients who have a solid tumor, non-Hodgkin lymphoma, a histiocytic disease (such as Langerhans cell histiocytosis or histiocytic sarcoma), or a br...

**Who might be able to join this trial:** - You are 40 years of age or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF — a type of lung scarring disease) within the last 5 years, following recognised international guidelines - Your lung scans (and lung tissue sample results, if you have had one)...

**Who might be able to join this trial:** - You are between 40 and 80 years old (inclusive). - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) confirmed by a specific type of chest scan (HRCT) or, in some cases, by a lung biopsy taken within the last 4 years. - Your IPF was first diagnosed 5 years ago...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part before any study activities begin - You are male or female and aged 40 years or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a type of lung scarring disease — within the last...

Who might be able to join this trial: - People aged 40 years or older at the first study visit - People who have been diagnosed with idiopathic pulmonary fibrosis (IPF) — a type of lung scarring disease — within the last 6 years before the first study visit, based on established international medical guidelines - Peopl...

**Who might be able to join this trial:** - You are between 18 and 85 years old - You have been diagnosed with a scarring lung disease (fibrosing ILD) that specialists, after a team review, could not confidently identify as a specific known type of lung disease - Your lung disease has been getting worse in the past 6...

**Who might be able to join this trial:** - Children and adolescents between 6 and 17 years old at the time of the second study visit. - A parent or guardian (and the child, where appropriate) must have signed and dated a consent form before the trial begins. - Both boys and girls are eligible; girls who could become...

**Who might be able to join this trial:** - You are 18 years of age or older at the time of signing consent - You have been diagnosed by a doctor with a progressive fibrosing interstitial lung disease (a scarring lung condition that keeps getting worse), but NOT the type called IPF - You are either currently taking a...

**Who might be able to join this trial:** - You have been diagnosed with IPF (idiopathic pulmonary fibrosis) by a doctor following standard medical guidelines. - You have rated your cough severity as 4 or higher (out of 10) on a cough scale during the screening and baseline period. - You have had a chronic cough for a...

**Who might be able to join this trial:** - You have been diagnosed with lung cancer (either small-cell or non-small-cell type), confirmed by a tissue sample test - You have been referred for radiation treatment with the goal of curing the cancer - You are planned to receive a radiation dose of 60–66 Gy in standard-siz...

**Who might be able to join this trial:** - Children and young people aged 180 days (about 6 months) up to under 22 years old at the time of joining the study - People with a body surface area (a measure of body size based on height and weight) of at least 0.3 m² - People who have been diagnosed with Langerhans cell h...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing the consent form. - You have been officially diagnosed with systemic sclerosis (SSc) based on recognized medical classification guidelines. - Your SSc has caused skin thickening in areas above the elbows and/or knees, as w...

**Who might be able to join this trial:** - You are willing and able to give your consent to take part in the study. - You are 18 years of age or older. - A recent chest scan (within the last 12 months) shows that more than 10% of your lungs are affected by scarring (fibrosis), as confirmed by a central review team. -...

Who might be able to join this trial: - You have been diagnosed with a fibrotic interstitial lung disease (a type of scarring lung condition) (confirm with trial site) - You own a smartphone or tablet and have an email address - You can read and speak English - You are comfortable enough with technology to complete the...

**Who might be able to join this trial:** - People aged 18 years or older - People with a general health and activity level rated between 0 and 2 on a standard oncology scale (meaning able to carry out at least some daily activities — confirm with trial site) - People who have been diagnosed with Stage II, III, or IV n...

Who might be able to join this trial: - People who completed treatment in one of the related earlier trials (numbered 1305-0014, 1305-0023, or 1305-0035) without permanently stopping treatment early — temporary breaks from treatment are acceptable. - People who have signed and dated a consent form agreeing to take part...

**Who might be able to join this trial:** - People whose lung disease (ILD) linked to a connective tissue disorder has not improved enough, has stayed unstable, or has gotten worse despite standard treatment — or who could not tolerate standard treatment - People who have been formally diagnosed with one of the follow...

**Who might be able to join this trial:** - You have been diagnosed with a type of lung scarring condition (called fibrotic ILD), either recently or in the past - You receive your care through the lung service at Fiona Stanley Hospital or Sir Charles Gairdner Hospital - Your lung condition was diagnosed through a speci...

**Who might be able to join this trial:** - You have been diagnosed by a specialist doctor with at least one of the following conditions: rheumatoid arthritis, systemic sclerosis (but only if a specific blood test called anticentromere antibody came back negative), inflammatory muscle disease (myositis), Sjögren's dis...

**Who might be able to join this trial:** - People aged 18 to 80 years who have been diagnosed with a specific type of scarring lung disease (fibrosing ILD) — specifically one linked to a connective tissue disorder, a condition called fibrotic hypersensitivity pneumonitis, or a non-IPF type of scarring lung disease —...

**Who might be able to join this trial:** - People who previously took part in an Avalyn-sponsored inhaled antifibrotic clinical study for either idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF), completed the final visit of the treatment period while on the full dose of the study drug (whet...

**Who might be able to join this trial:** - People of any gender aged 40 or older at the time of signing the consent form who have been diagnosed with IPF (idiopathic pulmonary fibrosis). - People who are able to understand the study and sign a written consent form in the study's language. - People who have been diagn...

**Who might be able to join this trial:** - People aged 40 years or older, of any sex. - People who are willing and able to sign a written consent form. - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) within the last 5 years, confirmed by a specific type of chest scan (called an HRCT), where...

**Who might be able to join this trial:** - You are 40 years of age or older at the time of signing the consent form - You have agreed to take part by signing and dating a consent form before the trial begins - You are male, or if female, you are no longer able to become pregnant — either because you have had surgery...

**Who might be able to join this trial:** - You are 40 years old or older at the time of signing the consent form - You have been diagnosed with idiopathic pulmonary fibrosis (IPF) — a condition where the lungs become scarred over time — within the last 5 years, according to recognised international guidelines - Your d...

Who might be able to join this trial: - You are 40 years of age or older at the time of signing the consent form. - You have at least one close blood relative (a parent, brother, sister, or child) who has been diagnosed with a form of pulmonary fibrosis (scarring of the lungs), including IPF, NSIP, or a genetically cau...

Who might be able to join this trial: - People who are 40 years of age or older at the time of joining the trial. - People who have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis) within the last 7 years, confirmed by a specialist and a specific type of chest scan (HRCT) showing a patter...

**Who might be able to join this trial:** - Children and teenagers between 2 and 17 years old (at the second study visit). - Participants who have signs of scarring lung disease (fibrosing ILD) shown on a special type of lung scan (CT scan) taken within the past 12 months, confirmed by study reviewers. - For children...

**Who might be able to join this trial:** - People who are permanently unable to have children (reproductively sterile) - People with a body mass index (BMI) between 18.5 and 32, and who weigh at least 50 kg at the start of the study - People who are generally in good health, with no significant medical concerns found...

**Who might be able to join this trial:** - People who are 40 years of age or older - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF), a type of lung scarring disease - People with IPF who are either currently taking an approved anti-scarring medication at a steady, unchanged dose, or who are no...

Who might be able to join this trial: - You have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis) within the last 5 years or less before the screening visit. - Your IPF diagnosis has been confirmed using clinical assessment, a special type of lung scan (HRCT), and possibly a surgical lung...

**Who might be able to join this trial:** - Women must be unable to become pregnant (either through surgery or menopause for at least 1 year), or must agree to use highly effective birth control from the time of signing the consent form until 3 months after the last study injection; men must also agree to use highly e...

**Who might be able to join this trial:** - You have been diagnosed with a lung disease called IPF (idiopathic pulmonary fibrosis) in the last 7 years, following recognised medical guidelines. - A recent detailed lung CT scan shows a specific amount of scarring in your lungs — between 10% and 50% scarring (reticulatio...

**Who might be able to join this trial:** - You are at least 40 years old (male or female) - You have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis) based on specific medical guidelines - Your lungs are working at 45% or more of the expected capacity for someone your age and size (based...

**Who might be able to join this trial:** - You must be able to understand and sign a consent form agreeing to take part in the study - You must understand how important it is to follow the study rules, including restrictions on other medications, throughout the entire study - You must be willing to travel to an appro...

**Who might be able to join this trial:** - You are 40 years of age or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a type of lung scarring disease — within the last 5 years, following the most up-to-date international guidelines - Your lung scans (and lung biopsy results, if you have had...

**Who might be able to join this trial:** - You have been diagnosed with a cancer in or near the chest (such as a lung, breast, or lymphoma cancer), or cancer that has spread to the lungs, and were treated with the goal of curing or fully controlling the disease at Memorial Sloan Kettering (MSK). - You completed chest...

**Who might be able to join this trial:** **If you do NOT have a diagnosed lung disease but may be "at risk":** - You are 35 years old or older (those aged 40 and above will have a high-resolution CT scan, and those aged 40–65 may also be offered a bronchoscopy procedure) - You have a parent, sibling, or child who has...

**Who might be able to join this trial:** - You have been diagnosed with IPF (idiopathic pulmonary fibrosis) based on clinical assessment, imaging, and tissue analysis. - Your blood oxygen level is 90% or higher when measured at rest while breathing normal air. - Your lung capacity (the amount of air you can breathe in...

Who might be able to join this trial: - You have been prescribed and started on a medication called Ofev (nintedanib), following the approved guidelines for its use in Korea - You have signed a form giving permission for your data to be used in the study Who may not be able to join: - You are not able to take nintedan...

**Who might be able to join this trial:** - You have been diagnosed with a scarring lung disease (called fibrosing Interstitial Lung Disease, or ILD) on at least two separate occasions recorded on different dates - You are 18 years old or older at the time your records are reviewed for the study - Your medical records...

Who might be able to join this trial: - The child must be between newborn age and 17 years old. - The child has been diagnosed with a lung disease or is currently being checked for one. - During their planned bronchoscopy (a procedure to look inside the airways), it must be possible to collect at least an extra 2 ml of...

**Who might be able to join this trial:** - You have been diagnosed with rheumatoid arthritis according to standard international diagnostic guidelines (confirm with trial site) - You have had at least one appointment at a rheumatology outpatient clinic in the last two years, either for diagnosing or monitoring your rh...

**Who might be able to join this trial:** **For patients:** - You are 18 years of age or older at the time of signing the consent form - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a specific type of lung scarring disease — confirmed by a chest scan and, if available, a lung tissue sample - You...

Who might be able to join this trial: - You have been diagnosed with Systemic Sclerosis (also called Scleroderma) according to specific medical guidelines from 2013. - You are 18 years of age or older. Who may not be able to join: - You are not willing to take part in the study. - You have another autoimmune disease (...

Who might be able to join this trial: - You have a lung condition called IPF (idiopathic pulmonary fibrosis) and previously completed a full course of treatment with a drug called HSK44459 in an earlier study, without stopping the treatment early for permanent reasons - The medical team running the trial has assessed t...

**Who might be able to join this trial:** - You have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis) - You are able to follow and take part in guided exercise or technique training sessions - You are between 40 and 85 years old - You are able to use a smartphone or computer on your own o...

**Who might be able to join this trial:** - You are between 20 and 85 years old - You have been officially diagnosed with pneumoconiosis (a lung disease caused by dust) confirmed by the Pneumoconiosis Compensation Fund Board - You are willing to have blood tests, fill in questionnaires, and take medication as scheduled...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have been diagnosed with a widespread lung condition affecting the tissue and space around the air sacs (called diffuse interstitial lung disease) - After standard tests, a tissue sample (biopsy) is still needed to help with your diag...

**Who might be able to join this trial:** - You have been diagnosed with a lung condition called interstitial lung disease, based on recognised medical guidelines. - You are willing to take part in the study and sign a consent form agreeing to participate. **Who may not be able to join:** - You currently have any kind...

Who might be able to join this trial: - You are aged 18 or older but under 80 years old - You carry a specific genetic change (variant) in one of several genes linked to lung disease — including SFTPA1, SFTPA2, SFTPC, NKX2-1, SFTPB, or ABCA3 — that has been identified as harmful or likely harmful by a specialist geneti...

**Who might be able to join this trial:** - People aged 40 or older, of any gender - People who have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis), confirmed according to 2022 international medical guidelines, before or during the screening process - People who have not taken either o...

**Who might be able to join this trial:** - Children between 2 and 18 years old who have a type of lung disease caused by the immune system (called immune-mediated interstitial lung disease) - Children whose lung disease is linked to certain conditions affecting the joints, muscles, skin, or connective tissues — such a...

Who might be able to join this trial: - You are 18 years old or older and have a suspected or confirmed lung condition called interstitial lung disease (ILD), which causes scarring or inflammation in the lungs - You are already scheduled to have a bronchoscopy (a procedure to look inside the airways) as part of your no...

**Who might be able to join this trial:** - **COPD group:** Adults aged 40 or older who either have a confirmed COPD diagnosis (based on symptoms like breathlessness, long-term cough, or mucus production, plus breathing test results showing a persistent airflow problem) or who have symptoms suggesting possible COPD ba...

**Who might be able to join this trial:** - You have been diagnosed with rheumatoid arthritis (RA) based on standard medical criteria. - A special lung scan (called an HRCT) has shown that you have a type of lung scarring or inflammation called interstitial lung disease (ILD), affecting at least 20% of your lungs, and...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with pulmonary sarcoidosis (a lung condition) within the past 3 months, and it is at an early stage (stage I or II based on a chest scan) - Your diagnosis was confirmed through a tissue sample (biopsy) taken during a br...

**Who might be able to join this trial:** - You are 18 years old or older - You speak English or Spanish - You have been diagnosed at UCSF with one of the following lung conditions: Idiopathic Pulmonary Fibrosis, Chronic Hypersensitivity Pneumonitis, Connective-tissue disease related ILD, Sarcoidosis, or Familial Fibro...

"Who might be able to join this trial: - People diagnosed with Hermansky-Pudlak Syndrome (HPS) between the ages of 1 and 80 years old may be eligible. - Family members who are caregivers for someone with HPS, between the ages of 1 and 80, may also be eligible. - A diagnosis of HPS can be confirmed either through a spec...

Who might be able to join this trial: - People diagnosed with alpha-1 antitrypsin (AAT) deficiency who have a confirmed high-risk genetic type, along with symptoms, chest x-ray results, and breathing test results that show lung disease — this includes both current smokers (at least 1 pack per day for 2 or more years) a...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with pulmonary fibrosis (scarring of the lungs), confirmed through a physical exam, breathing tests, chest X-ray, and CT scan - You are seeking treatment at the Dorothy P. and Richard P. Simmons Center for Interstitial Lu...

Who might be able to join this trial: - You are an adult (18 years old or older) - You are seeking treatment at the UPMC Simmons Center for Interstitial Lung Disease Who may not be able to join: - There are no specific exclusion criteria listed for this trial (confirm with trial site) Important: Always verify eligibi...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (a specific type of lung scarring condition) - You are receiving your care and treatment at the Simmons Center Who may not be able to join: - You have another lung condition or illness in...

Who might be able to join this trial: - People who have been diagnosed with interstitial lung disease (a group of conditions that cause scarring or inflammation in the lungs) Who may not be able to join: - People who do not have a diagnosis of interstitial lung disease Important: Always verify eligibility with the tr...

Who might be able to join this trial: - You are currently on the waiting list to receive a lung transplant Who may not be able to join: - You are not willing to give your consent to take part in the trial Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: **If you are a healthy volunteer:** - You have no diagnosed lung conditions - You have not smoked in the past 5 years - If you have smoked in the past, your total smoking history is 5 pack-years or less (roughly 5 years of smoking one pack per day, or equivalent) **If you have a...

Who might be able to join this trial: - Adults aged 18 or older of any race or gender - People who are receiving a kidney transplant (either their first or a repeat transplant) from a deceased or living donor - People who are able to give their informed consent (or have a guardian who can do so on their behalf) - Peopl...

Who might be able to join this trial: - You are 21 years old or older and have been diagnosed with a suspected lung disease that affects the tissue of the lungs (showing up as widespread patches or shadows across multiple areas of both lungs on imaging) Who may not be able to join: - There are no stated reasons that w...

Who might be able to join this trial: **Healthy Volunteers (Group 1.1):** - You are 18 years of age or older, of any sex, race, or background - You do not have lung disease (smokers and non-smokers are welcome, including those who use cigarettes, e-cigarettes, pipes, or waterpipes) - You are able to give your own cons...

**Who might be able to join this trial:** - People who are willing and able to give their informed consent to participate. - People aged 21 or older who have been newly diagnosed with IPF (a type of lung scarring disease) within the last 12 months by the enrolling centre. - People diagnosed with a non-IPF interstitial...

Who might be able to join this trial: - Adults aged 18 or older, as well as minors aged 12 to 17 years old. - Women who could become pregnant must agree to use contraception, unless they have been through menopause or have had a hysterectomy. - People who have already been diagnosed with a condition called non-cirrhoti...

Who might be able to join this trial: - People who have been diagnosed with Langerhans cell histiocytosis (LCH) confirmed by a biopsy. - People who are between 0 and 21 years of age. - People who have a general health and functioning score of at least 50% on a standard medical scale used to measure daily activity abili...

Who might be able to join this trial: - People between 19 and 90 years old, both male and female, may be considered. - People who have had a health check-up that included a chest X-ray may be considered. - People who have given their formal written agreement to take part may be considered. Who may not be able to join:...

Who might be able to join this trial: - People who are 45 years of age or older - People who have been diagnosed with rheumatoid arthritis using a specific set of medical guidelines called the 2010 American College of Rheumatology criteria Who may not be able to join: - People who are unable to give their informed con...

**Who might be able to join this trial:** - You have been diagnosed with Erdheim-Chester Disease, Langerhans cell histiocytosis, Rosai-Dorfman disease, or another similar rare disease affecting cells called histiocytes — this diagnosis can be based on tissue samples (biopsy), scan results, or your own report supported...

**Who might be able to join this trial:** - People who are a blood relative of someone diagnosed with Idiopathic Interstitial Pneumonia (IIP), where at least two members of the same family have been diagnosed with IIP - People who have not themselves been diagnosed with IIP or IPF (a type of lung scarring condition) -...

Who might be able to join this trial: - You are at least 18 years old - You have a family member who has been diagnosed with IPF (Idiopathic Pulmonary Fibrosis, a type of lung disease) Who may not be able to join: - You do not have a family member who has been diagnosed with IPF (Idiopathic Pulmonary Fibrosis) Import...

Who might be able to join this trial: - You have been diagnosed with a lung condition involving scarring or stiffening of the lungs (such as interstitial lung disease or another fibrotic lung disease), or you have been diagnosed with pneumonia - You are willing and able to sign a form giving your consent to take part i...

**Who might be able to join this trial:** - You must be able to understand and agree to take part in the study by signing a consent form. - You must be between 18 and 60 years old (inclusive) at the time you give consent. - You must already qualify to be listed for a lung transplant under national transplant guideline...

Who might be able to join this trial: **Group 1 – Healthy volunteers:** - You are over 18 years old - A doctor or nurse practitioner has confirmed you are in good health based on a physical exam, medical history, and vital signs check - You are able to sign a written consent form - You have no known history of lung di...

"Who might be able to join this trial: - People between the ages of 18 and 70 - People who are willing to sign an informed consent form - People who have been diagnosed with bronchiectasis (a lung condition affecting the airways) in a stable phase, confirmed by a detailed type of CT scan called a High-Resolution CT (HR...

**Who might be able to join this trial:** **For people with interstitial lung disease (ILD):** - People aged between 40 and 80 years old - People who have been diagnosed by a specialist team with one of the following lung conditions: idiopathic pulmonary fibrosis (IPF), a type of lung scarring called fibrotic NSIP, ch...

**Who might be able to join this trial:** - People diagnosed with non-small cell lung cancer (a specific type of lung cancer) that cannot be removed by surgery and has either spread locally or to other parts of the body (classified as stage IIIA, IIIB, or IV). - People whose lung cancer treatment plan involves chemoth...

**Who might be able to join this trial:** - People aged at least 6 months, with the upper age limit depending on the group being enrolled (some groups are open to people under 21, one group is for people aged 21 and older — confirm which group applies with the trial site). - People who are able to take medication by m...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with a connective tissue disease (a condition where the immune system affects the body's connective tissues, such as joints, skin, and organs) - People who have agreed to take part by signing an informed consent form Who may not be...

"Who might be able to join this trial: - People aged 24 years or younger who are receiving a stem cell transplant (either using their own stem cells or stem cells donated by another person). Who may not be able to join: - People who are older than 24 years of age. Important: Always verify eligibility with the trial s...

**Who might be able to join this trial:** - You have been diagnosed with a lung condition called Idiopathic Pulmonary Fibrosis (IPF), and that diagnosis was confirmed by a team of different medical specialists working together. **Who may not be able to join:** - You have a different type of scarring or inflammatory lu...

**Who might be able to join this trial:** - People who have been diagnosed by a specialist team with one of the following lung conditions: idiopathic pulmonary fibrosis (IPF), a type of lung scarring called idiopathic fibrotic nonspecific interstitial pneumonia (NSIP), chronic hypersensitivity pneumonitis (HP), or an...

"Who might be able to join this trial: - You must have been recently diagnosed with a specific type of scarring lung disease (called fibrotic interstitial lung disease, or F-ILD), confirmed by a team of specialists using recognised medical guidelines - Your diagnosis must have been made no more than 6 months before joi...

**Who might be able to join this trial:** - People aged between 40 and 85 years old. - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) within the last 5 years, using recognised international medical guidelines from 2018. - People who are willing and able to give their consent to participate and...

Who might be able to join this trial: - You have been admitted to hospital because your breathing symptoms have gotten worse - You are already taking part in a related study called PFBIO, or you are joining both PFBIO and PFBIO-EXA at the same time - You are at least 18 years old Who may not be able to join: - You are...

Who might be able to join this trial: - Children under 18 years old who have been clinically diagnosed with a rare lung condition called chILD (children's interstitial lung disease) - People whose chILD has been confirmed through genetic testing, showing a change in one of several specific genes (such as SFTPC, SFTPB,...

Who might be able to join this trial: - You are 18 years of age or older - You have had a lung transplant at Baylor University Medical Center within the past 10 years - You are able to understand and sign a consent form agreeing to take part in the study Who may not be able to join: - You have been diagnosed with sign...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with PLCH (Pulmonary Langerhans Cell Histiocytosis), either confirmed by a tissue biopsy, OR based on a combination of: matching symptoms, a specific pattern seen on a detailed lung CT scan, and other possible diagnoses bein...

Who might be able to join this trial: - You must be 18 years old or older - You have been diagnosed with a systemic (whole-body) disease that carries a risk of causing lung scarring or inflammation (known as interstitial lung disease, or ILD) - You are willing and able to sign a consent form agreeing to take part (for...

Who might be able to join this trial: - You have been diagnosed by a doctor with a type of scarring lung disease (called interstitial lung disease or ILD), confirmed using standard medical guidelines - You have had a persistent cough lasting more than 8 weeks Who may not be able to join: - You regularly cough up moder...

**Who might be able to join this trial:** - You have been diagnosed with a specific immune system condition called Common Variable Immunodeficiency (CVID), confirmed using international guidelines. - You are 4 years old or older. - Your blood tests show your immune protein levels (IgG) are significantly lower than nor...

**Who might be able to join this trial:** - People whose tumour tissue and/or blood samples show a mutation in the BRAF gene, found at any point during treatment or follow-up - People whose disease has not responded to, or has come back after, standard first- and second-line treatments (such as Vinblastine, prednisolo...

**Who might be able to join this trial:** - Children and young people who are under 18 years old at the time of joining the trial - People who have been diagnosed with, or are suspected of having, a condition called histiocytosis, based on previous test results - People (or their guardians) who have signed a consent fo...

**Who might be able to join this trial:** - People whose tumor tissue and/or blood samples show no BRAF gene mutation at any point during treatment or follow-up, OR people with a BRAF mutation whose previous Vemurafenib treatment has stopped working. - People whose disease has not responded to, or has progressed throu...

**Who might be able to join this trial:** - You are aged 40 years or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF), a type of lung scarring condition, confirmed by a specialist team following current medical guidelines - You may already be taking approved anti-fibrotic (anti-scarring) medicat...

Who might be able to join this trial: - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (a condition that causes scarring of the lungs) - People who are able to understand and are willing to sign a written consent form Who may not be able to join: - People who currently have an active infection - Peo...

Who might be able to join this trial: - You have a long-term lung condition that requires treatment, such as COPD, asthma, or pulmonary fibrosis - You are over 18 years old - You are willing to sign a consent form agreeing to take part in the study Who may not be able to join: - You are not able to fully understand an...

**Who might be able to join this trial:** - You are at least 18 years old - You developed serious breathing problems (a condition called ARDS, which is moderate or severe) within the last week, caused by a known illness or injury - A chest X-ray shows cloudiness or shadows in both lungs that cannot be fully explained...

**Who might be able to join this trial:** - You are over 18 years old - You have signed a written consent form before any study activities begin - You have been diagnosed with a specific type of interstitial lung disease (ILD), which includes: idiopathic pulmonary fibrosis (IPF), chronic hypersensitivity pneumonitis-re...

Who might be able to join this trial: - People who have pulmonary fibrosis with a specific pattern of lung scarring known as UIP (usual interstitial pneumonia) - People who are on a breathing machine (ventilator) through a tube placed in the throat, due to sudden and severe breathing failure - People whose doctors are...

**Who might be able to join this trial:** - People who have been diagnosed with interstitial lung disease (a group of conditions that cause scarring or inflammation in the lungs), according to established medical guidelines - People who have had a persistent cough for at least 3 months before the initial screening vis...

Who might be able to join this trial: - You have been diagnosed with, or doctors suspect you may have, pulmonary fibrosis (scarring of the lungs) - You are willing and able to sign a consent form agreeing to take part in the study Who may not be able to join: - You are currently pregnant - You are currently breastfeed...

**Who might be able to join this trial:** - People aged 18 or older who are willing to volunteer and sign a consent form. - People diagnosed with pulmonary fibrosis (scarring of the lungs) of known or unknown cause — except for the specific type called IPF — who have already received standard treatment or monitoring f...

Who might be able to join this trial: - People who are over 18 years old - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (a condition that causes scarring in the lungs) - People who are able to read and write in Turkish Who may not be able to join: - People who have had a sudden worsening of their...

**Who might be able to join this trial:** - People who are willing to participate and sign a written consent form - People who have previously been diagnosed with breast cancer (confirmed by laboratory tissue testing) and received full surgical treatment, followed by chemotherapy and then radiation therapy - People who...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have been diagnosed with a lung condition called IPF (Idiopathic Pulmonary Fibrosis), confirmed using guidelines from major respiratory medical societies - You experience breathlessness or difficulty breathing when you are physically...

Who might be able to join this trial: - You must be critically ill with COVID-19 and have problems with your lung function. - Your COVID-19 must be rated as severe or critical according to the World Health Organization (WHO) severity scale (level 4 or higher), including a serious lung condition called ARDS (Acute Respi...

**Who might be able to join this trial:** - You are between 18 and 70 years old (both ages included), and any gender may apply - You have been officially diagnosed with silicosis or coal worker's pneumoconiosis according to Chinese occupational disease diagnostic standards - Your lung breathing capacity (FVC) is betwe...

Who might be able to join this trial: - People who have been diagnosed with IPF (Idiopathic Pulmonary Fibrosis) with a specific pattern called UIP (Usual Interstitial Pneumonia) - People who need a high-resolution CT scan (a detailed chest X-ray) as part of their care at the Center for Rare Diseases at the Policlinico...

**Who might be able to join this trial:** - You have been diagnosed with a condition called systemic sclerosis (a disease that affects the skin and internal organs), based on specific medical guidelines from 2013 - You have a related lung condition called interstitial lung disease, which has been confirmed by a detaile...

**Who might be able to join this trial:** - People who have been diagnosed with a lung condition called ILD (interstitial lung disease), confirmed by a CT scan at the time of their diagnosis or staging - People who have recently started, or are about to start, a new medication for ILD within 3 months of joining the tri...

**Who might be able to join this trial:** - You are 18 years of age or older - You agree to participate by signing and dating an online consent form - You have been diagnosed with pulmonary fibrosis (PF) or a related lung scarring disease (ILD), including if you have had a lung transplant; OR you are currently or have...

Who might be able to join this trial: - You have been diagnosed with rheumatoid arthritis (RA) Who may not be able to join: - You are currently pregnant or breastfeeding - You have previously been diagnosed with interstitial lung disease (a type of chronic lung condition) (confirm with trial site) - You have previousl...

**Who might be able to join this trial:** - You are a patient at The University of Kansas Health System (TUKHS), or you have agreed to take part in a study approved by the University of Kansas Medical Center's research protection program - You are being seen and monitored for an autoimmune disease, interstitial lung di...

**Who might be able to join this trial:** *Group 1 – Family members of someone with pulmonary fibrosis:* - You are over 40 years old - You are able to read and sign a consent form agreeing to take part - You have a close blood relative (parent, sibling, or child) who has been diagnosed with pulmonary fibrosis - You ha...

Who might be able to join this trial: - People who have been diagnosed with lung cancer confirmed by a tissue sample examination - People who are receiving or planned to receive a radiation treatment dose of at least 45 Gy (a unit used to measure radiation) - People who have a Karnofsky score above 60, which is a ratin...

**Who might be able to join this trial:** - People who have given written informed consent and, in the investigator's judgment, are able to follow the study procedures - People who have been diagnosed with non-small cell lung cancer (a type of lung cancer) and have developed lung inflammation as a complication of radi...

Who might be able to join this trial: - People who have been diagnosed with systemic sclerosis (a condition where the immune system causes hardening and tightening of the skin and connective tissues) based on the 2013 classification guidelines set by two major rheumatology organisations - People whose lungs have been a...

Who might be able to join this trial: - People who have been diagnosed with HP (Hypersensitivity Pneumonitis) by a team of medical specialists following current international guidelines - People who are 18 years of age or older - People who are able to understand and agree to participate by signing a consent form Who...

**Who might be able to join this trial:** - You are 18 years of age or older and have been diagnosed with sarcoidosis - Your diagnosis was confirmed through a tissue biopsy (a small sample of tissue examined in a lab), and other possible causes of your symptoms have been ruled out, following established medical guideli...

Who might be able to join this trial: - People aged 40 years or older, of any gender - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a type of lung scarring disease — confirmed using recognised international medical guidelines - People whose lung scans (taken within 2 months of the study sta...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose interstitial lung disease (a type of scarring/inflammation in the lungs) has gotten worse within the last 24 months, shown by at least one of the following: a significant drop in lung capacity (measured by a breathing test called FVC),...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a specific type of lung scarring disease — based on 2018 international medical guidelines - People who have experienced a sudden, rapid worsening of their IPF...

**Who might be able to join this trial:** - People who need a procedure using a flexible bronchoscope (a thin, flexible tube used by doctors to look inside the airways) - People who are either attending a clinic as an outpatient or who are already admitted to a hospital ward or Intensive Care Unit (ICU) **Who may not...

**Who might be able to join this trial:** - People who are willing and able to give informed consent and follow the study plan - Women and men of any race or ethnicity who are 18 years of age or older - People who have been diagnosed with systemic sclerosis (scleroderma) based on established 2013 classification criter...

**Who might be able to join this trial:** - You are male or female and are 18 years of age or older - You have been diagnosed with one of the following conditions: rheumatoid arthritis, systemic sclerosis (scleroderma), inflammatory muscle diseases (such as dermatomyositis or polymyositis), mixed connective tissue dis...

Who might be able to join this trial: - People who are between 18 and 80 years old - People who have been diagnosed with interstitial lung disease or obstructive sleep apnea - People who are alert and able to understand and sign a consent form - People who are able to wear a sleep monitoring device (polysomnograph) dur...

**Who might be able to join this trial:** - You are at least 18 years old - You have been diagnosed with sarcoidosis confirmed by tissue testing, following internationally recognised medical guidelines - You have a non-severe form of sarcoidosis affecting the eyes that needs treatment taken by mouth or injection (syst...

**Who might be able to join this trial:** - People whose lung fibrosis (IPF) is rated as mild or early-moderate based on a specific disease scoring tool called SCALE-IPF, with a score of 13 points or below - People who are already taking part in the Assiut University IPF Research Program (2022–2026) - People with clin...

Who might be able to join this trial: - You must be at least 21 years old - Both men and women can participate - People of all ethnic backgrounds and races are welcome - People who are scheduled to have a bronchoscopy (a procedure where a doctor looks inside the airways) for diagnosis or treatment - People who do not h...

**Who might be able to join this trial:** - Adults aged 18 to 80 years (inclusive) - People who weigh between 45 kg and 160 kg (approximately 99 to 353 lbs) at the screening visit - People who have been diagnosed with pulmonary sarcoidosis (a lung condition caused by clusters of inflammatory cells) at least 6 months b...

**Who might be able to join this trial:** - You have been diagnosed with systemic sclerosis (scleroderma) based on standard medical criteria - Your scleroderma symptoms (other than Raynaud's phenomenon) started less than 84 months (7 years) before the start of the study - A chest scan (HRCT) shows that scleroderma has...

**Who might be able to join this trial:** - You are between 18 and 80 years old - You are willing to agree to and sign a consent form to take part in the study - You have been diagnosed with an interstitial lung disease (a type of lung condition) that shows signs of scarring in the lungs on imaging scans **Who may not...

**Who might be able to join this trial:** - You have been diagnosed with a histiocytic disorder at any age, which includes any of the following conditions: Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, Xanthogranuloma, Mixed histiocytosis, Malignant histiocytosis (including Histiocytic...

Who might be able to join this trial: - People who have been diagnosed with a condition that causes scarring or inflammation in the lungs (known as interstitial lung disease), based on medical imaging, breathing tests, and/or tissue samples. - People who have chest CT scan image files and breathing test results availab...

**Who might be able to join this trial:** - You are 40 years of age or older - You have been diagnosed with a lung condition called IPF (Idiopathic Pulmonary Fibrosis), confirmed using recognised international medical guidelines - You are in a stable condition, as confirmed by a general health check including heart tra...

Who might be able to join this trial: - People who have recently been diagnosed with ankylosing spondylitis (a type of spinal arthritis) that is also affecting the lungs (known as interstitial lung disease, or ILD) Who may not be able to join: - People whose lung condition has not been clearly identified as ILD, and w...

**Who might be able to join this trial:** - People who have lung cancer or 1–2 small cancer spots in the lung (called oligometastatic lesions) that are planned to be treated with a high-dose course of radiotherapy - A confirmed cancer diagnosis through a tissue sample (biopsy) is strongly preferred, but may not always...

**Who might be able to join this trial:** - People aged 40 years or older. - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to specific international guidelines from 2018. - People whose lungs are still able to hold and move at least 40% of the expected amount of air for someone thei...

**Who might be able to join this trial:** - Children and adolescents between the ages of 2 and 16 (inclusive) - People with a confirmed diagnosis of Langerhans cell histiocytosis (LCH), a rare disease where abnormal cells build up in the body, confirmed by a central laboratory - People whose tumor tissue and blood sam...

Who might be able to join this trial: - People who have been diagnosed with Acute Respiratory Distress Syndrome (ARDS) — a serious lung condition — based on both clinical assessment and medical imaging, meeting a specific set of recognised diagnostic standards, and who require admission to an intensive care unit (ICU)...

**Who might be able to join this trial:** - You have been diagnosed with a type of lung scarring disease (called idiopathic interstitial pneumonia or IIP), confirmed through medical tests, scans, or breathing tests - You have a progressive scarring lung disease (not IPF) where scans show at least 10% of your lungs are...

**Who might be able to join this trial:** - People who have been diagnosed with fibrotic interstitial lung disease (ILD), which is scarring of the lungs — all types of ILD are considered - People whose blood oxygen levels are normal when resting (above 90%), but drop to between 80–89% during a walking test (a standard...

**Who might be able to join this trial:** - You are currently in hospital due to a flare-up of a diffuse interstitial lung disease (a condition where lung tissue becomes inflamed or scarred) (confirm with trial site). - You are currently in hospital with an infectious lung infection that was *not* caused by COVID-19. -...

Who might be able to join this trial: - People who have been diagnosed with malignant breast cancer - People who have read the study information and signed a form agreeing to take part Who may not be able to join: - People who have a reason they cannot safely use inhaled corticosteroids (steroid inhalers), such as hav...

**Who might be able to join this trial:** - You have been diagnosed with Langerhans cell histiocytosis (LCH) affecting the bones, confirmed by a tissue or lab test. - Only your bones are affected by the condition (no other organs or body systems are involved). - Your condition does not require surgery to treat it. - Yo...

Who might be able to join this trial: - People who have been diagnosed with interstitial lung disease (a condition that causes scarring or inflammation in the lungs) by a lung specialist, are between 40 and 65 years old, and have been receiving ongoing care for this condition for at least 6 months following standard in...

Who might be able to join this trial: - People who are able to understand and sign a written consent form agreeing to take part in the study. - People who were diagnosed with IPF (a type of lung scarring disease) less than 5 years before joining the trial. - People whose lung scans (and lung biopsy results, if availabl...

Who might be able to join this trial: - People aged 2 years or older who have been diagnosed with a histiocytic disorder (a rare disease affecting certain immune cells) that needs treatment throughout the body. - People whose diagnosis has been confirmed through a tissue sample (biopsy) reviewed by a specialist patholo...

**Who might be able to join this trial:** **For people with IPF (Idiopathic Pulmonary Fibrosis):** - People who have been diagnosed with IPF within the last 5 years, using recognised international diagnostic standards - People aged 40 or older - People who have never had a lung transplant - People whose lungs are func...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have a scarring/stiffening lung disease (called fibrosing PID) where more than 10% of the lung tissue shows scarring on a chest CT scan - People who are able to attend a physical fitness/exercise program three times per wee...

**Who might be able to join this trial:** - People who are willing to give written consent and are able to follow the trial plan from start to finish - People aged 18 to 75 years old (inclusive), of any gender - People diagnosed with rheumatoid arthritis (RA) based on 2010 ACR/EULAR criteria, or systemic sclerosis (SS...

Who might be able to join this trial: - Adults who have been diagnosed with a fibrotic lung disease, either idiopathic pulmonary fibrosis (IPF) or another type of fibrotic interstitial lung disease (a condition where the lungs develop scar tissue), as defined by international medical guidelines from 2022. Who may not...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People who have been diagnosed with systemic sclerosis (SSc) according to the 2013 international classification guidelines, including those with diffuse, limited, or minimal skin involvement - People whose SSc...

**Who might be able to join this trial:** *For people with LCH (Langerhans Cell Histiocytosis):* - Adults aged 18 or older - People with a confirmed diagnosis of LCH who are seen at the reference centre, regardless of how the condition presents *For people in the control group:* - Adults aged 18 or older - People who...

Who might be able to join this trial: - People who have been diagnosed with active pulmonary sarcoidosis (sarcoidosis affecting the lungs) that is causing symptoms, confirmed according to established medical guidelines. - People who are either new to treatment for sarcoidosis or have been treated for it before. - Peopl...

**Who might be able to join this trial:** - You are between 40 and 75 years old (any gender) - You have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to specific 2022 medical guidelines - Your IPF has been considered stable by your doctor for the past 3 months, and your lung function test results f...

**Who might be able to join this trial:** - Adults over 18 years old who are being treated at the CHU of Tours hospital - People who have been diagnosed with rheumatoid arthritis (RA) according to recognised international classification standards, regardless of how long ago they were diagnosed - People who have had, o...

**Who might be able to join this trial:** - You are 18 years of age or older - You have a suspected lung scarring/inflammation condition (known as interstitial lung disease) - You have had a detailed chest CT scan within the last 3 months - Your lung capacity (the amount of air your lungs can hold) is at least 50% of w...

Who might be able to join this trial: - People who are 40 years of age or older - People who have been prescribed long-term oxygen therapy (oxygen used at home for health reasons) for at least 15 hours per day, and have been on this therapy for at least 28 days, as recorded in a Swedish oxygen registry called Swedevox...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have a condition called progressive pulmonary fibrosis (PPF), which is a lung disease where scar tissue in the lungs continues to worsen over time - People whose lung disease has not been given a specific classification (re...

**Who might be able to join this trial:** - People who fully understand what the trial involves, including its purpose, methods, and possible side effects, and who are willing to sign a consent form agreeing to take part - People whose Body Mass Index (BMI) falls between 19 and 26 kg/m², and who weigh at least 50 kg (...

**Who might be able to join this trial:** - People who are between 18 and 74 years old at the time of signing the consent form - People who are willing and able to sign a written consent form before any study procedures begin - People who have been formally diagnosed with systemic sclerosis (a connective tissue diseas...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), confirmed through structured assessments - You are able to read and sign a consent form agreeing to take part - You are able to commit to taking part for the...

**Who might be able to join this trial:** - Adults aged 40 or older who have been diagnosed by a doctor with a chronic lung disease, and who are within 2 months of finishing a traditional in-person rehabilitation, physical therapy, or exercise program for that condition - People who are able to walk on their own, with...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with any type of interstitial lung disease (a group of conditions that cause scarring or inflammation in the lungs) - People who are fluent in Portuguese - People who are able to give their informed consent...

**Who might be able to join this trial:** - People who are 40 years of age or older - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to established 2018 international guidelines, as confirmed by the doctor running the trial - People who have signed a consent form agreeing to take part...

**Who might be able to join this trial:** - You are willing and able to understand and sign a consent form, and able to follow the study requirements - You are willing to follow all study procedures and are available for the full length of the study - You are male or female and over 18 years old - A doctor has diagnos...

**Who might be able to join this trial:** - You are 18 years of age or older - You experience ongoing shortness of breath, either at rest, during activity, or both - Your shortness of breath has lasted for more than 3 months and continues even with treatment for an underlying condition, such as cancer, COPD, interstiti...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who are being considered as candidates for a lung transplant - People who are currently attending outpatient pulmonary rehabilitation as part of their standard care - People who have been diagnosed with Interstitial Lung Disease or Chron...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have been diagnosed with a scarring lung disease (called fibrotic ILD) confirmed by a detailed CT scan of the lungs — this includes conditions such as idiopathic pulmonary fibrosis, autoimmune-related lung scarring, chronic hypersen...

Who might be able to join this trial: - You have been diagnosed with rheumatoid arthritis-related lung disease (RA-ILD) by a team of different medical specialists, using standard 2010 diagnostic guidelines - You are 18 years of age or older Who may not be able to join: - You have previously received any medication spe...

Who might be able to join this trial: - Children and teenagers between 1 and 18 years of age. - People with a confirmed diagnosis of Cystic Fibrosis, proven through genetic testing or a sweat chloride test. - People with a confirmed diagnosis of ongoing constipation, where stool consistency is measured below a score of...

**Who might be able to join this trial:** - You have agreed to take part and signed a consent form - You have been diagnosed with a progressive scarring lung disease (called progressive fibrosing interstitial lung disease, or PF-ILD) confirmed by a special type of CT scan showing more than 10% of your lung tissue is a...

**Who might be able to join this trial:** - Babies under 12 months of age - Babies who have been diagnosed with a condition called Neuroendocrine Cell Hyperplasia of Infancy (NEHI), confirmed either by a clinical scoring tool (called the Liptzin score) combined with a specific chest scan pattern, or by a clinical asse...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who have been diagnosed with pulmonary sarcoidosis — either confirmed through imaging and tissue samples showing a specific type of inflammation (with no other known cause), or in some cases confirmed through a specialist te...

Who might be able to join this trial: **For people with IPF (Idiopathic Pulmonary Fibrosis):** - People aged 18 to 85 years who have been diagnosed with IPF by a specialist team, following current medical guidelines - People with a mild to moderate level of breathlessness, rated 1 to 3 on the MRC breathlessness scale...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with an interstitial lung disease (a group of conditions that cause scarring or inflammation in the lungs) Who may not be able to join: - People who have emphysema or other lung diseases that cause airflow blockage (known as obstru...

Who might be able to join this trial: - You have been diagnosed with interstitial lung disease (a condition that causes scarring or inflammation in the lungs) - You are able and willing to sign a written consent form agreeing to take part in the trial Who may not be able to join: - You are not able to fully understand...

**Who might be able to join this trial:** - People aged between 18 and 75 years old. - People who have been diagnosed with a scarring lung disease called fibrosing interstitial lung disease, based on recognised medical guidelines. - People who experience breathlessness during physical activity or exercise. - People who...

Who might be able to join this trial: - You are between 18 and 80 years old and have been diagnosed with chronic hypersensitivity pneumonitis, an interstitial lung disease (ILD) linked to a connective tissue condition (such as rheumatoid arthritis, systemic sclerosis, or mixed connective tissue disease), or an undiffer...

**Who might be able to join this trial:** - You are over 18 years old and have been diagnosed with, or are strongly suspected to have, a lung scarring/stiffening condition called interstitial lung disease (ILD), or have a related connective tissue disease diagnosed at least 5 years ago - You are willing and able to sig...

**Who might be able to join this trial:** - You are 18 years old or older, male or female, and have been diagnosed with systemic scleroderma (a connective tissue disease) according to recognised international criteria - You have lung scarring/fibrosis (called ILD) that is either severe — meaning it affects 20% or more...

**Who might be able to join this trial:** - You must be 18 years of age or older - You have previously had radiotherapy to the chest area and are showing signs of radiation pneumonitis (a type of lung inflammation that can develop one to four months after radiotherapy, with symptoms such as breathlessness — especially...

Who might be able to join this trial: - You are of Chinese ethnicity and can read and speak Chinese. - You are 18 years old or older. - You are currently receiving financial compensation for pneumoconiosis (a lung disease caused by breathing in dust). Who may not be able to join: - You have a mental health condition,...

**Who might be able to join this trial:** - People who are willing to sign and date a consent form agreeing to take part in the study - People who are willing to follow all study procedures and are available for the full length of the study - People who are currently being treated for IPF (idiopathic pulmonary fibrosi...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People with non-small cell lung cancer confirmed by tissue testing, where the cancer cannot be surgically removed, and where testing has confirmed that the EGFR and ALK gene mutations are not present - People w...

**Who might be able to join this trial:** - Adults between 20 and 80 years old who have been diagnosed with a connective tissue disease, such as dermatomyositis, polymyositis, scleroderma, lupus, rheumatoid arthritis, or Sjögren's syndrome. - People whose lung disease (a type called fibrotic interstitial lung disease)...

Who might be able to join this trial: **For healthy volunteers (Parts A and C):** - People aged 18 to 55 years old at the time of signing consent - People confirmed to be in good general health through medical history, physical check-up, blood tests, and heart monitoring - People weighing at least 45 kilograms - Peopl...

Who might be able to join this trial: - You have been diagnosed with interstitial lung disease (a condition that causes scarring or inflammation in the lungs) - You are 18 years old or older - You are able to give your own consent to take part in the study without assistance Who may not be able to join: - Your interst...

**Who might be able to join this trial:** - You have been diagnosed with Langerhans cell histiocytosis (LCH) — either newly diagnosed, or your disease has come back or stopped responding to treatment. - You are newly diagnosed or have relapsed/refractory LCH and are taking a liquid form of the drug trametinib. - You h...

**Who might be able to join this trial:** - You are scheduled to have a lung transplant surgery **Who may not be able to join:** - You are not able to give your own consent to take part in the study - You are having a second lung transplant (a re-transplant) - You are receiving more than one organ at the same time (fo...

**Who might be able to join this trial:** - You have been diagnosed with one of the following lung conditions: idiopathic pulmonary fibrosis (IPF), familial pulmonary fibrosis (FPF), another type of scarring lung disease (such as fibrotic hypersensitivity pneumonitis, a specific type called iNSIP, a lung disease linke...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with a condition called interstitial lung disease (ILD), based on recognised international medical guidelines Who may not be able to join: - You are unable to give your informed consent (meaning you are not able to agree to...

Who might be able to join this trial: - You have been diagnosed with a lung condition called interstitial lung disease (ILD), which is a group of conditions that cause scarring or inflammation in the lungs Who may not be able to join: - You do not have a chest CT scan (a detailed X-ray image of your chest) available -...

Who might be able to join this trial: - Adults between 18 and 80 years old, of any gender. - People who have been diagnosed with a connective tissue disease (a group of conditions affecting the body's connective tissues, such as lupus, Sjögren's syndrome, scleroderma, rheumatoid arthritis, or muscle inflammation condit...

**Who might be able to join this trial:** - People who are willing and able to provide written consent to participate. - People who have been diagnosed with a fibrotic interstitial lung disease (a condition where lung tissue becomes scarred) by a team of specialist doctors, and who have one or more family members also...

**Who might be able to join this trial:** - People aged 18 years or older - People whose treating doctor has determined they are not eligible for, or have already tried, standard treatments with established benefits - People diagnosed with one of the following conditions who meet the specific disease-related criteria...

**Who might be able to join this trial:** - People who have been diagnosed with progressive fibrotic interstitial lung disease (a type of scarring lung condition) or progressive idiopathic pulmonary fibrosis (IPF), diagnosed using recognised international medical guidelines - People who are older than 18 years of age...

**Who might be able to join this trial:** - You must have already completed a previous related trial (study 218224 or 221672) up to and including the Week 52 visit, without being considered a "treatment failure." - If you have the skin condition SSc, you must have an area of skin on your abdomen or upper thigh that is...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with a type of lung scarring disease, either idiopathic pulmonary fibrosis or a lung condition linked to a connective tissue disease (such as rheumatoid arthritis or lupus) - You are already being seen and monitored at one o...

**Who might be able to join this trial:** - You are 40 years old or older - You have been diagnosed with idiopathic pulmonary fibrosis (IPF), a type of lung scarring disease, confirmed by a special type of CT scan called an HRCT - Your CT scan shows a specific pattern of lung changes consistent with IPF, as confirmed b...

**Who might be able to join this trial:** - People who have been diagnosed with fibrotic interstitial lung disease (a type of scarring lung condition), of any specific subtype, whether currently receiving treatment or having received treatment in the past - People who have more than 10% scarring visible on a CT scan of...

Who might be able to join this trial: - People who have been diagnosed with a lung condition called IPF (Idiopathic Pulmonary Fibrosis), based on recognised international medical guidelines. - People who are between 18 and 75 years old. - People who are able to walk on a treadmill. - People who are able to follow instr...

**Who might be able to join this trial:** - You have been diagnosed with Hypersensitivity Pneumonitis (a lung condition caused by inhaling certain substances) by your doctor. - You are 18 years of age or older. - You are able to speak and understand English. - You are willing to work with a peer coach as part of the st...

Who might be able to join this trial: - You must be 18 years old or older - You must be willing and able to give your consent to take part in the trial Who may not be able to join: - You currently have an active cancer diagnosis - Your health condition is unstable or getting worse to the point where attending follow-u...

**Who might be able to join this trial:** - People aged 1 year to 70 years old. - People who have a reasonable level of physical functioning, as measured by standard performance scales used by doctors (confirm with trial site). - People who have been diagnosed with a telomere biology disorder, either through a special...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been clinically diagnosed with IPF (idiopathic pulmonary fibrosis, a lung condition) - People who are able to give their informed consent to participate Who may not be able to join: - People who require continuous oxygen...

**Who might be able to join this trial:** - People who are suspected to have a lung condition called pulmonary sarcoidosis and are already scheduled to have a routine procedure called EBUS-TBNA (a type of airway investigation to collect tissue samples) (confirm with trial site) **Who may not be able to join:** - Peopl...

Who might be able to join this trial: - People who are in intensive care because of sudden, severe breathing problems - People who need significant oxygen support, such as high-flow oxygen, a breathing mask, or a breathing machine (ventilator) - People who are 18 years of age or older - People who have been diagnosed w...

Who might be able to join this trial: - People who have been diagnosed with pulmonary fibrosis (scarring of the lungs) by a specialist team, following internationally recognised medical guidelines - People who are 18 years of age or older Who may not be able to join: - People who are not able to speak, read, or write...

Who might be able to join this trial: - People who have been clinically diagnosed with IPF (a specific type of lung scarring disease), another type of interstitial lung disease (ILD, which is a group of conditions that cause inflammation or scarring in the lungs), or lung cancer - People who have signed a form giving t...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of muscle and skin disease called dermatomyositis, confirmed by a positive blood test for the anti-MDA5 antibody, according to 2023 Chinese expert guidelines - You also have a rapidly worsening type of lung scarring/inflammation (k...

**Who might be able to join this trial:** - You are 18 years of age or older - You are willing and able to give your consent to participate in the study - You have been diagnosed with either fibrotic hypersensitivity pneumonitis or idiopathic pulmonary fibrosis (two types of scarring lung disease), and your doctor at...

Who might be able to join this trial: - People who have been diagnosed with interstitial lung disease (a group of conditions that cause scarring or inflammation in the lungs) based on recognised international diagnostic guidelines - People who are between 18 and 75 years of age - People who have had a lung infection in...

**Who might be able to join this trial:** **For patients with a lung condition:** - You have been diagnosed with a condition called interstitial lung disease (ILD), confirmed using standard medical guidelines - You are between 18 and 75 years old - You have had a lung infection in the past month - You are willing to t...

**Who might be able to join this trial:** - You are 40 years of age or older, of any gender - You have been diagnosed with, or are suspected to have, a lung scarring condition called ILD (specifically IPF or CTD-ILD), confirmed by a type of chest scan (CT scan) - Your lung function tests show your lungs are working at...

Who might be able to join this trial: - People aged between 40 and 75 years old. - People who have a confirmed diagnosis of interstitial lung disease (ILD), such as idiopathic pulmonary fibrosis (IPF) or ILD linked to a connective tissue disease. - People whose lung function test (specifically a measure of how well the...

Who might be able to join this trial: - People diagnosed with a scarring lung condition known as fibrosing interstitial lung disease (ILD), based on specific international medical guidelines from 2022. - People aged 65 years or older. - People attending outpatient appointments, such as a scheduled clinic visit, day hos...

Who might be able to join this trial: **Arm A:** - People who were diagnosed with anti-GBM disease (a rare autoimmune condition affecting the kidneys and/or lungs) between 1 January 2010 and 31 December 2027 - Records of what treatment was given at the start of the illness must be available **Arm B:** - People who ha...

**Who might be able to join this trial:** - Children from birth up to age 18 who have been diagnosed with a condition called Langerhans Cell Histiocytosis (LCH), confirmed by specific laboratory markers (CD1a+ and CD207+) - Children whose LCH was recently diagnosed and involves the bone marrow, liver, or spleen - Chil...

**Who might be able to join this trial:** - People who have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis) by a lung specialist, using internationally recognised guidelines. - People whose blood oxygen level, measured by a fingertip sensor after sitting quietly for at least 5 minutes, i...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form. - People who have been diagnosed with systemic sclerosis (a condition also called scleroderma) according to recognised 2013 medical classification standards. - People with the diffuse form of sy...

Who might be able to join this trial: - People who have been diagnosed with pneumoconiosis (a lung disease caused by breathing in dust particles at work) Who may not be able to join: - People whose records of work history and job-related dust or chemical exposure are incomplete or missing - People who have previously...

**Who might be able to join this trial:** - People who are willing to take part voluntarily and agree to sign a consent form before the study begins - People aged between 40 and 80 years old (inclusive), of any gender - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to 2022 internati...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of IPF (idiopathic pulmonary fibrosis) and whose lung function test results meet the specific requirements set out in the trial protocol. - People who agree to use highly effective birth control during the trial and for 6 months after the...

**Who might be able to join this trial:** - Adults aged 18 or older - People with a primary diagnosis of one of the following: metastatic cancer, COPD (a lung condition) at stage B or E or higher, ILD (a group of lung diseases causing scarring), or CHF (a condition where the heart doesn't pump blood as well as it shoul...

Who might be able to join this trial: - People who are able to give their own informed consent to participate - People who are at least 18 years old - People who have had a High-Resolution CT (HRCT) scan of the lungs done at any point in their medical history for clinical reasons - People who have been diagnosed with r...

**Who might be able to join this trial:** - Adults who have been clearly diagnosed with Langerhans cell histiocytosis (LCH) that affects multiple body systems, or affects one body system but in more than one location - People aged between 18 and 70 years old - People who have not previously received systemic (whole-bo...

Who might be able to join this trial: - You are willing to give your consent to take part, understand what the trial involves, and agree to follow all trial procedures. - You are between 18 and 45 years old. - If male, you weigh at least 50 kg; if female, you weigh at least 45 kg; and your BMI is between 19 and 28 kg/m...

Who might be able to join this trial: - People who have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a type of long-term lung scarring disease — within the last 7 years, where the diagnosis is supported by a specific type of lung scan (called a high-resolution CT scan) taken within the past 12 months, and...

Who might be able to join this trial: - You must be 18 years of age or older - You are scheduled to have surgery to fully remove a lung cancer tumor, and after surgery the tissue is confirmed to be primary lung cancer (cancer that started in the lung) - During surgery, doctors are able to collect a sample of healthy lu...

"Who might be able to join this trial: - You must be an adult aged 18 or older. - You must have a confirmed diagnosis of PPF (confirm with trial site for full details on what this condition involves). - You must be able to speak and understand English or Spanish. For caregivers who may also be able to join: - You must...

Who might be able to join this trial: - You are male or female and are 18 years of age or older - You have been newly diagnosed with a lung condition called PID (pulmonary interstitial disease) within the last six months, confirmed by a lung specialist - You have had certain tests done within the last six months, inclu...

Who might be able to join this trial: - People who are 40 years of age or older at the time of signing the consent form - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to internationally recognised 2022 guidelines - People whose IPF diagnosis was made no more than 7 years ago - Peopl...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis), confirmed using recognised international guidelines - You are currently in hospital because your IPF has suddenly got worse (this is called an "acute e...

**Who might be able to join this trial:** - You have been newly diagnosed with, are suspected of having, or are being monitored for one of these lung conditions: idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP), or idiopathic non-specific interstitial pneumonia (iNSIP), and your doctor has already...

**Who might be able to join this trial:** - People who have already had, or have been assessed as suitable for, a cryobiopsy procedure based on national or international medical guidelines, or after a previous diagnostic test did not give a clear result and a medical team discussed the case together. - People whose pr...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with Idiopathic Pulmonary Fibrosis (IPF) — a type of lung scarring disease — at any stage of severity, based on the most recent international guidelines from 2022 Who may not be able to join: - You do not wish to take pa...

**Who might be able to join this trial:** - You are willing to take part and agree to sign a consent form - You are between 18 and 80 years old (inclusive) - You have been diagnosed with a lung disease called connective tissue disease-related interstitial lung disease, based on specific Chinese medical guidelines from...

Who might be able to join this trial: - You must be 18 years old or older at the time you agree to take part. - You must have early-stage non-small cell lung cancer (Stage I or II), confirmed by a tissue sample where possible, or by scans and specialist agreement if a biopsy is too risky. - You must have been diagnosed...

Who might be able to join this trial: - People who have been diagnosed with idiopathic pulmonary fibrosis (scarring of the lungs with no known cause) or progressive pulmonary fibrosis (lung scarring that is getting worse over time) - People who are about to start taking an anti-fibrotic medication for the first time —...

**Who might be able to join this trial:** - You are willing and able to give your formal agreement (consent) to take part in the study. - You are currently using inhaled treprostinil (a medication breathed in through an inhaler). - You have been diagnosed with a type of lung scarring or inflammation condition called I...

**Who might be able to join this trial:** - You are between 18 and 85 years old (inclusive), of any sex - You have been diagnosed with a lung cancer or a cancer that has spread to the lungs, and your doctors have recommended radiation treatment to the chest area - You are scheduled to receive a specific type of chest r...

**Who might be able to join this trial:** - People aged 40 to 85 years old at the time of signing the consent form - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) - People who are either not currently taking any IPF medication, or who have been taking pirfenidone or nerandomilast at a steady...

Who might be able to join this trial: - People who have been diagnosed with systemic sclerosis (a condition that causes hardening and tightening of the skin and connective tissues) based on recognised international classification standards Who may not be able to join: - People who have been diagnosed with mixed connec...

**Who might be able to join this trial:** - Children from birth up to 18 years old, of any sex - Children who have been diagnosed with a condition called LCH (Langerhans cell histiocytosis), confirmed through laboratory testing, and who have not yet received any treatment specifically for LCH - Children whose LCH affec...

**Who might be able to join this trial:** - People who are willing and able to provide written consent to participate. - People who are older than 40 and younger than 90 years old at the time of signing the consent form. - People who have been clinically diagnosed with interstitial lung disease (ILD) before the screen...

Who might be able to join this trial: - You are an adult between 18 and 80 years old and doctors suspect you may have pulmonary fibrosis (scarring of the lungs) - A fresh sample of lung tissue is available, either from a biopsy or from a removed lung - You are willing to sign a consent form allowing your tissue samples...

Who might be able to join this trial: - The person has agreed to take part and has signed a written consent form - A doctor has diagnosed the person with a fibrosing interstitial lung disease (a type of scarring lung condition) following recognised international guidelines - The person is 18 years of age or older - The...

**Who might be able to join this trial:** - You are between 18 and 75 years old. - You have been diagnosed with Anti-synthetase Syndrome (a type of autoimmune condition) based on recognized 2017 medical guidelines. - Scans of your lungs (a special type of CT scan) have confirmed that you have a lung condition called In...

Who might be able to join this trial: - Healthy male volunteers of Korean or Caucasian background, aged 19 to 60 years at the time of screening. - People who weigh at least 50.0 kg and have a Body Mass Index (BMI) between 18.5 and 29.9 kg/m² at the time of screening (BMI is a measure calculated from height and weight)....

**Who might be able to join this trial:** - The child must be between 0 and 18 years old (any sex). - The child must have a confirmed diagnosis of Langerhans cell histiocytosis (LCH) — a rare disease involving abnormal immune cells — proven by a laboratory test showing specific markers (CD1a and/or CD207), and must not...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form showing they understand the study and are choosing to take part voluntarily. - People who are aged 40 or older at the time of signing the consent form, of any gender. - People who have been diagnosed with idiopathic pulm...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have been diagnosed with a chronic (long-term) breathing condition and have been admitted to hospital for a lung rehabilitation program - People who, at the time of leaving hospital, have one of the following conditions: chronic obst...

Who might be able to join this trial: - People who have been diagnosed with a fibrotic interstitial lung disease (a type of lung scarring condition) as the main reason for attending pulmonary rehabilitation (this applies to participants at Berner Reha Zentrum only) - People who are already enrolled in a specific lung d...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with one of the following lung conditions: Idiopathic Pulmonary Fibrosis (IPF), Nonspecific Interstitial Pneumonia (NSIP), Pneumoconioses (lung disease caused by inhaling dust), interstitial lung disease (ILD) li...

**Who might be able to join this trial:** - People aged between 18 and 85 years old - Tumor patients who are able to have surgery or a biopsy to get a confirmed tissue diagnosis - People who are able to understand and sign a consent form agreeing to take part - People whose doctors estimate they are likely to live for...

Who might be able to join this trial: - People who have been diagnosed with idiopathic pulmonary fibrosis (IPF — a condition that causes scarring in the lungs), confirmed using a specialised chest scan (high-resolution CT) taken within the past 12 months, and where an independent panel of imaging experts has also revie...

Who might be able to join this trial: - People who have been diagnosed with IPF (a type of lung scarring disease) or a related condition called Fibrotic ILD (scarring of the lung tissue). - People who are already taking standard approved lung treatments, either nintedanib or pirfenidone, or immune-suppressing medicatio...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been referred to a specialist because interstitial lung disease (a type of lung condition) is suspected but has not yet been diagnosed - People whose CT scan shows certain lung changes — such as scarring, haziness, or structura...

**Who might be able to join this trial:** - You have been diagnosed with rheumatoid arthritis (RA) based on recognised medical guidelines - You have a form of RA that has been difficult to treat and control, as defined by specific medical guidelines (confirm with trial site) - You have been jointly assessed by a joint...

Who might be able to join this trial: - You are 18 years of age or older. - You have been diagnosed with a condition called interstitial lung disease (ILD), which is a group of conditions that cause scarring or inflammation in the lungs. - You are currently taking medication to slow lung scarring (antifibrotic therapy)...

Who might be able to join this trial: - People who have been diagnosed with early-stage IPF (idiopathic pulmonary fibrosis — a lung scarring condition) based on both clinical assessment and imaging results such as a CT scan. Who may not be able to join: - People who have a strong medical reason why they cannot safely...

Who might be able to join this trial: - You are 18 years of age or older - Your doctor suspects you may have a lung condition called interstitial lung disease, and a tissue sample is needed to confirm the diagnosis - Your chest scan (a detailed CT scan of the lungs) has not given a clear enough result to make a definit...

**Who might be able to join this trial:** - Adults aged 18 to 85 years who have been diagnosed with fibrotic interstitial lung disease (a type of scarring lung condition) or COPD (a chronic lung condition that makes breathing difficult), and who are able to agree to take part in the study. - Fibrotic lung disease in t...

**Who might be able to join this trial:** - People who have given written consent before any study procedures begin. - Men or women of any race or ethnicity who are aged 40 or older and are expected to live at least one more year, in the opinion of the study doctor. - People who weigh at least 45 kg (approximately 99...

Who might be able to join this trial: - Adults between 18 and 75 years old, both male and female, are eligible to be considered. - People who have given their written agreement (informed consent) to take part. - People who have a confirmed diagnosis of one of the following conditions: Systemic Sclerosis (SSc), Rheumato...

Who might be able to join this trial: - You are between 18 and 80 years old and have been diagnosed with chronic hypersensitivity pneumonitis, a lung disease linked to a connective tissue condition (such as rheumatoid arthritis, systemic sclerosis, or mixed connective tissue disease), or an unclassified interstitial lu...

Who might be able to join this trial: - You are an active pigeon fancier (someone who keeps or races pigeons) - You attend a clinic for the management of an interstitial lung disease (a type of condition that causes scarring or inflammation in the lungs) - You have been admitted to hospital with severe breathing proble...

Who might be able to join this trial: - You are aged 18 to 100 years old - You have a known lung condition (such as COPD, asthma, bronchiectasis, or a scarring lung disease), OR you are a healthy person with no conditions that significantly affect your breathing, heart, or movement - You experience ongoing shortness of...

Who might be able to join this trial: - People who have been diagnosed with a lung condition called IPF (idiopathic pulmonary fibrosis), confirmed by a doctor using established international guidelines. - People who have had a persistent cough lasting 8 weeks or longer before their screening appointment. - People whose...

**Who might be able to join this trial:** - People between 40 and 80 years old at the time of signing the consent form and entering the screening process. - People who have been diagnosed with IPF (idiopathic pulmonary fibrosis) according to current international medical guidelines. - People who are either not current...

Who might be able to join this trial: - People aged 18 years or older. - People who have been diagnosed with Chronic Obstructive Pulmonary Disease (COPD) and are current or former smokers, and/or people diagnosed with Idiopathic Pulmonary Fibrosis (IPF) and are current or former smokers, and/or people diagnosed with a...