Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with squamous cell carcinoma (a type of cancer) of the head and neck — specifically in the oral cavity, oropharynx, hypopharynx, or larynx — at stage III or IVA, confirmed by laboratory testing

• People whose cancer is located in the oropharynx must have tumours that have tested negative for HPV (human papillomavirus), confirmed through a specific laboratory test

• People who have had the entire primary tumour surgically removed with the goal of curing the cancer, with no cancer cells found at the edges of the removed tissue, no cancer spread beyond the lymph node capsule, and no visible remaining disease after surgery

• People who have had surgery within 8 weeks before joining the main part of the trial

• People who have a stored tumour tissue sample (preserved in paraffin wax) available to be sent to a testing laboratory

• People who have had a previous cancer that was treated with the intent to cure must have been free of that cancer for at least two years (exceptions apply for certain skin cancers and a cervical pre-cancer condition)

• People who have not received chemotherapy or experimental treatments within two years before their head and neck surgery

• People who have not previously had radiation therapy to the head and neck area that would overlap with the radiation area needed for this treatment

• People who have a general health and activity level rated as 0 or 1 on a standard medical scale (meaning fully active or able to carry out light activity), assessed within 2 weeks before joining the main part of the trial

• People who have had a recent check-up by a head and neck surgeon and a chest scan to check for cancer spread, both done within 8 weeks before joining the main part of the trial

• People whose blood test results within 4 weeks before joining show: adequate white blood cell levels, adequate platelet levels, normal liver function (bilirubin), and adequate kidney function

• Women who could become pregnant must not be pregnant or breastfeeding, confirmed by a blood or urine test within 2 weeks before joining the main part of the trial

• Women who could become pregnant and sexually active men must use an accepted method of contraception or abstain from sex for the duration of the trial and for 60 days after the last treatment

Who may not be able to join:

• People whose cancer has come back (recurrent disease) or who have multiple separate primary cancers
• People who had cancer cells found at the surgical margins, cancer that has broken through lymph node capsules, or visible remaining disease after surgery
• People who have previously had radiation to the head and neck in a way that would overlap with the radiation fields required for this trial
• People who have received chemotherapy or experimental treatments within two years before their head and neck surgery
• People who have another illness that is likely to interfere with the trial treatment
• People who have had a previous cancer and have not been disease-free for at least two years (with limited exceptions — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.