Phase 2 Multiple Sclerosis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with multiple sclerosis (MS) according to the 2017 Revised McDonald Criteria (a standard set of diagnostic rules used by neurologists)
- People who are 18 years of age or older
- People who are able to give informed consent to participate
- People who are able to take part in all study activities and provide good-quality research and brain scan data, based on previous MRI scans showing little interference or distortion
- People whose brain MRI scan (taken at the screening stage) shows a specific type of active lesion (an area of inflammation visible with a special dye called gadolinium) with a particular pattern around its edges (confirm with trial site for exact details)
- People who are already participating in another screening or natural history study within the NINDS Neuroimmunology Clinic at the time of joining this trial
- People who are willing to use contraception if there is a possibility of becoming pregnant
Who may not be able to join:
- People with medical reasons that make MRI scans unsafe, such as having a pacemaker, infusion pump, certain metal implants, or body piercings that cannot be removed and are not safe for MRI
- People with psychological reasons that make MRI difficult, such as claustrophobia, which will be assessed when medical history is collected
- People who have received steroid treatment taken throughout the whole body (for example, by mouth or injection into a vein) within the past 30 days (steroid creams or local injections are generally acceptable)
- People who have developed new neurological symptoms in the past two weeks that are thought to be caused by an MS relapse
- People who are currently pregnant or breastfeeding
- People whose kidney function blood test results fall below a certain level required by NIH Clinical Center guidelines before receiving the MRI contrast dye (confirm with trial site for current threshold details)
- People who are known to have an allergic reaction or sensitivity to the gadolinium-based dye used in MRI scans
- People who have medical reasons that make steroid treatment unsafe, such as diabetes or a gastric ulcer
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Daniel S Reich, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Phone: (301) 496-1801
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
the presence or absence of a hypointense phase rim around each lesion followed over time
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.