Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Your cancer cannot be surgically removed and must test positive for a specific protein called CD70 at a certain level, based on a lab test of cancer tissue.
• Your cancer diagnosis must be confirmed by the NCI Laboratory of Pathology.
• You must have already tried at least one standard treatment for your cancer (if one was available), and either your cancer did not respond or it came back.
• If you have 3 or fewer small tumors in the brain (each no bigger than 1 cm) that are not causing symptoms, you may still be eligible — including if those tumors were previously treated or surgically removed (confirm with trial site).
• You must be between 18 and 72 years old.
• You must be well enough to carry out daily activities with little or no limitation (this is measured on a standard scale called ECOG 0 or 1).
• Both men and women must be willing to use birth control during the study and for 12 months after treatment ends (for women) or 4 months after treatment ends (for men).
• Women who could become pregnant must be willing to take a pregnancy test before starting treatment.
• You must test negative for HIV.
• You must test negative for hepatitis B and hepatitis C (if a hepatitis C screening test comes back positive, a further test must confirm you do not have an active infection).
• Your blood cell counts must meet certain minimum levels: enough white blood cells, infection-fighting cells (neutrophils), platelets, and red blood cells (a blood transfusion may be allowed to meet the red blood cell requirement).
• Your liver and kidney function must be within acceptable ranges based on blood tests.
• Any previous cancer treatment must be fully completed before you join the trial.
• You must be able to understand and be willing to sign a written consent form agreeing to take part.
• You must be willing to sign a document that names someone to make decisions on your behalf if needed (durable power of attorney).
• You must also be enrolled in a related NCI study for cell collection (protocol 03-C-0277).

Who may not be able to join:

• Women who are pregnant or breastfeeding.
• People currently taking steroid medications on an ongoing basis.
• People with active infections requiring treatment, blood clotting disorders, or other serious uncontrolled health conditions.
• People with a condition where the immune system does not work properly from birth (such as Severe Combined Immunodeficiency Disease).
• People with a history of immune system diseases affecting blood cells, or any autoimmune disease that requires medication to suppress the immune system.
• People with active opportunistic infections (infections that occur when the immune system is weakened).
• People who have had a severe allergic reaction to any of the drugs used in this trial: cyclophosphamide, fludarabine, or aldesleukin.
• People with a history of heart bypass surgery or symptoms of reduced blood flow to the heart.
• People whose heart pumping function is significantly reduced (45% or below), if a heart evaluation was done based on their medical history (confirm with trial site).
• People whose lung breathing capacity is significantly reduced (50% or below of the expected level), if a lung evaluation was done based on their medical history (confirm with trial site).
• People currently taking part in another clinical drug trial.

Important: Always verify eligibility with the trial site directly before applying.