Phase 2 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of thyroid cancer called differentiated thyroid cancer (confirmed by a lab test), with or without spread to other parts of the body, and it cannot be fully cured — or you have chosen to decline curative treatment
• Your cancer can be measured on a scan (tumors larger than 10mm) and has been getting worse over time based on standard measurement guidelines
• You have already tried radioactive iodine (I-131) treatment and it did not work, or your doctor has determined you are not a suitable candidate for it
• You are 18 years of age or older
• You are well enough to carry out daily activities with little to no limitation (confirm with trial site for exact fitness level required)
• You are expected to live for at least 12 weeks or more
• You have not had radioactive iodine (I-131) treatment in the past 24 weeks (or 4 weeks if a follow-up scan showed no sign of disease)
• Your blood, kidney, and liver are functioning well enough to handle treatment (confirm with trial site for specific levels required)
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 3 days before starting treatment
• You are willing and able to sign a consent form after being fully informed about the trial
• You are able and willing to attend appointments, take the study medication, and follow all trial procedures

Who may not be able to join:

• Genetic testing of your tumor tissue (called Foundation One or Next Generation Sequencing) cannot be done, or has not previously been done
• You have had chemotherapy, targeted therapy, or radiation treatment within the past 4 weeks
• You have taken part in another experimental treatment within the past 4 weeks
• You have had radioactive iodine (I-131) treatment within the past 24 weeks (or 4 weeks if a follow-up scan was clear)
• You have previously been treated with a type of drug called an mTOR inhibitor
• You are currently taking certain medicines that strongly affect how the body processes drugs (called CYP3A4 or P-glycoprotein inhibitors or inducers) and cannot stop taking them at least one week before starting this trial
• You have a stomach or bowel condition that could affect how your body absorbs the trial medications, including if you rely on a feeding tube for medicines
• You have a serious uncontrolled medical condition or active infection that could prevent you from safely receiving the treatment
• You have a known allergy or sensitivity to either of the trial drugs: cyclophosphamide or sirolimus
• You have a known blockage in your urinary tract
• You have dementia or a significant mental health condition that would prevent you from understanding and agreeing to take part in the trial
• You are able to have children but are unwilling or unable to use reliable contraception or practice abstinence during the trial
• You are currently pregnant or breastfeeding
• You are currently living in prison

Important: Always verify eligibility with the trial site directly before applying.