Phase 2 Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People diagnosed with sickle cell disease who have experienced at least one of the following complications: a stroke or nervous system event lasting more than 24 hours; frequent severe pain episodes (3 or more per year needing emergency care, hospital admission, or home bedrest causing missed work or school); repeated episodes of painful, prolonged erections (2 or more per year needing emergency care); recurring hospitalizations for a serious lung condition called acute chest syndrome (2 or more times in their lifetime); development of 2 or more blood antibodies during long-term blood transfusion treatment; serious vision problems in at least one eye due to abnormal blood vessel growth; bone damage in 2 or more joints; reduced kidney function or high levels of protein in the urine; or high blood pressure in the lungs
- People aged between 16 and 60 years old
- People who are well enough to carry out most daily activities (as measured by a standard health scoring tool — confirm with trial site)
- People whose heart is pumping adequately (as assessed by a specific heart function test — confirm with trial site)
- People whose lungs are working adequately (as assessed by a specific breathing test — confirm with trial site)
- People whose kidneys are functioning at a sufficient level (as measured by a standard kidney function calculation — confirm with trial site)
- People whose liver enzyme levels are not significantly elevated (confirm with trial site)
- People who test negative for HIV
- People who are not pregnant
- People who are willing and able to sign a consent form agreeing to take part
- People who do not have a fully matched brother or sister available to donate stem cells
- People who have a half-matched (haploidentical) blood relative willing to donate — this includes parents, children, siblings, aunts, uncles, or cousins
Who may not be able to join:
- People who do not have a half-matched relative available to donate stem cells
- People who have a fully matched sibling donor available and willing to donate stem cells, as the trial site would not consider them eligible for this particular study
- People who are pregnant
- People who test positive for HIV
- People whose heart, lung, or kidney function does not meet the minimum levels required by the trial (confirm exact thresholds with trial site)
- People whose liver enzyme levels are too high (confirm with trial site)
- People who are unable or unwilling to sign the informed consent form
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Damiano Rondelli, MD, University of Illinois at Chicago
Phone: 312 413-3547
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Estimate the number of patients who engraft by Day +60
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.