Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have neurological symptoms such as headaches, seizures, loss of consciousness, weakness, or nerve-related problems.
• People who have an abnormality found in the brain on a scan, whether or not it is related to cancer.
• People who have a cancer elsewhere in their body that may have spread to or affected the brain.
• People who are able to have an MRI scan without needing general anaesthesia.
• People who are at least 10 years of age.
• People (or their legal guardians) who are willing and able to sign a consent form and a privacy authorisation form, in line with the study site's requirements.
• Women who could become pregnant and are sexually active must agree to use an effective form of contraception (such as hormonal methods, barrier methods, surgical sterilisation, or abstinence) for at least two months after each study cycle, and must notify their treating doctor immediately if they become pregnant or suspect they may be pregnant during the study.

Who may not be able to join:

• People who show signs of a serious and sudden brain emergency called uncal herniation, which may include sudden pupil enlargement, rapidly worsening movement problems, or a quickly declining level of consciousness.
• People who have had an allergic or serious reaction to iron given by injection, dextran given by injection, iron-dextran, or iron-polysaccharide preparations (people with significant other allergies or autoimmune conditions may still be considered at the doctor's discretion).
• People who are pregnant, breastfeeding, or think they may be pregnant.
• People who cannot safely have an MRI scan — for example, those with certain metal implants in their body such as a pacemaker, those who are severely agitated, or those with an allergy to gadolinium-based contrast dye used in MRI scans.
• People who have a condition where the body stores too much iron (known as hemochromatosis); people with a family history of this condition must have it ruled out through specific blood tests before joining, with the cost of those tests covered by the study.
• People who have received a drug called ferumoxytol within the three weeks before joining the study.
• People who have had allergic reactions to three or more different types of medications from separate drug categories.

Important: Always verify eligibility with the trial site directly before applying.