Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged over 18 years
• People who have a first-time or returning suspected low-grade bladder cancer (called Ta or T1, Grade 1 or 2 urothelial carcinoma) with no suspicion of a type called carcinoma in situ
• People who have between 1 and 5 bladder tumours
• People who have one main tumour measuring between 0.5 cm and 1.0 cm at its widest point
• People whose physical examination after bladder inspection shows no detectable lump or mass
• People whose kidneys are working well enough, based on a blood test result (eGFR above 50 ml/min/1.73m²)
• People whose liver is working well enough, based on blood test results showing normal or near-normal levels of certain liver markers
• People who are mentally, physically, and practically able to attend treatment and follow-up appointments
• People who have been fully informed about the trial and have given written consent before any trial-related tests begin

Who may not be able to join:

• People whose urine test (cytology) suggests high-grade cancer, or who are suspected of having a Grade 3 tumour
• People with diabetes who are currently taking, or have taken, the medication metformin in the past 6 months
• People who have received treatment directly into the bladder (such as chemotherapy or immunotherapy) in the past 3 months
• People who are currently receiving any other cancer treatment
• People who have an existing urinary tract infection or a history of repeated severe bladder infections caused by bacteria
• People who need a urinary catheter as part of their ongoing care
• People whose bladder or urinary tract cancer is of a type other than urothelial carcinoma (for example, squamous cell or adenocarcinoma), or whose urothelial cancer involves the upper urinary tract or part of the prostate
• People who have been diagnosed with another cancer in the past 5 years, with some exceptions such as certain treated skin cancers, cervical carcinoma in situ treated by cone biopsy, or prostate cancer treated with curative intent and currently showing normal PSA levels
• People with serious, uncontrolled problems affecting the kidneys, liver, heart, digestive system, urinary system, nervous system, or blood — where the treating doctor believes this would increase the risk of complications from taking metformin
• People taking certain medications (including loop diuretics, cimetidine, ranitidine, cetirizine, trimethoprim, vandetanib, quinidine, or HIV medications) for which no suitable alternative is available
• People who are pregnant or breastfeeding; people of reproductive age who are not willing to use effective contraception during the trial
• People with a poor general health status rated at level 3 or 4 on the ECOG-WHO performance scale, meaning they have significant difficulty carrying out daily activities (confirm with trial site)
• People with a known history of alcohol misuse
• People with a known allergy or sensitivity to metformin
• People who, in the opinion of the treating doctor, are unable to follow the trial requirements or do not understand what the trial involves

Important: Always verify eligibility with the trial site directly before applying.