Phase 3 Endometrial Cancer Trial, Recruiting NCT03422198 Sponsor: University of Utah Condition: Endometrial Cancer
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Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial involved 108 people who had been diagnosed with endometrial (uterine) cancer and were receiving a type of internal radiation treatment called vaginal cuff brachytherapy. Participants were split into two equal groups of 54: one group received a shorter course of this radiation treatment, and the other received the standard-length course. The trial was measuring quality of life, feelings about femininity, and the cost of treatment. All 108 participants who started the trial completed it. Please note that some planned measurements — including a financial wellbeing questionnaire and questions about diet and physical activity — were not reported in the submitted data. The reported data shows that, one month after treatment, both groups had a very similar small change in their overall quality of life scores (using a 0–100 scale where higher means better quality of life): both the shorter-course group and the standard-course group showed an average increase of 2.08 points from their starting scores. For a question asking whether participants felt less feminine as a result of their disease or treatment (again on a 0–100 scale, where higher means feeling less feminine), the shorter-course group showed a small average increase of 0.65 points, while the standard-course group showed an average decrease of 6.25 points. The reported data does not include further detail explaining this difference. Regarding costs, the reported data shows that the average amount charged for procedures was approximately USD $33,205 for the shorter-course group and approximately USD $45,920 for the standard-course group — a difference of roughly USD $12,700. These figures reflect charges in the United States and may not be directly relevant to the Australian healthcare setting. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Phase 3 Endometrial Cancer Trial, Recruiting

NCT03422198
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with a confirmed type of uterine (endometrial) cancer — including endometrioid, serous, clear cell, carcinosarcoma, or other sarcomas — where the cancer started mainly in the uterus, and where a specific internal radiation treatment called vaginal cuff brachytherapy has been recommended.
  • People whose cancer is at a specific stage and grade combination: Stage IA (grade 1 with a specific spread pattern, or grades 2–3), Stage IB (grades 1–3), Stage II (grades 1–3), or Stage IIIA (grades 1–3, but only if not receiving external beam radiation therapy as part of their treatment).
  • People who have already had a hysterectomy (surgical removal of the uterus) and have no remaining signs of cancer.
  • People with a general health and activity level rated between 0 and 2 on a standard medical scale — meaning they are fully active to capable of basic self-care (confirm with trial site).
  • People who are willing and able to give informed consent by signing an approved consent form.
  • People with a life expectancy of more than 2 years.

Who may not be able to join:

  • People whose cancer stage does not match one of the specific stage and grade combinations listed above.
  • People who have previously had radiation therapy to the pelvic area.
  • People who currently have another cancer that requires anti-cancer treatment (other than surgery) outside of this trial's plan.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Cristina DeCesaris, MD, Huntsman Cancer Institute/ University of Utah

Phone: 801-585-0115

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
2 February 2018
Est. completion
30 November 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Quality of Life From Baseline to 1 Month; Cohort 2: Participant-Reported Financial Toxicity

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov