Phase 3 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women over 18 years old who have been diagnosed with a confirmed cancer of the uterine lining (endometrium) or a related type of uterine cancer called carcinosarcoma, of any cell type.
• People whose cancer appears to be confined to the body of the uterus (Stage I disease).
• People who are generally well enough to carry out light activity and care for themselves, based on a standard medical fitness scale (ECOG score of 0 or 1).
• People who have given signed written consent to participate in the trial.
• People whose treating doctor has determined are suitable for keyhole (laparoscopic) or robotic surgery, including being able to tolerate the required surgical position.
• People where all available tests and scans (such as CT, MRI, or ultrasound) show no sign of cancer spread outside the uterus.
• For people under 45 years old who have only low-grade (Grade 1) uterine cancer and wish to keep their ovaries: an MRI must show the cancer has grown into less than half the thickness of the uterine wall.
• People who are pre-menopausal, or who reached menopause less than 2 years ago, must have a negative pregnancy test taken within 30 days before surgery.

Who may not be able to join:

• People where examination or scans show the cancer has spread beyond the uterus — for example, to the cervix, vagina, surrounding tissue, ovaries, lymph nodes, bladder, bowel, or other areas.
• People whose scans show enlarged lymph nodes (larger than 1 cm) in the pelvis or around the main abdominal blood vessel (aorta).
• People with an estimated life expectancy of less than 6 months.
• People who have a medical reason that means they cannot receive radiotherapy or chemotherapy if needed.
• People who have previously had radiation treatment to the pelvis.
• People with serious other health conditions that the trial investigator considers incompatible with taking part.
• People who are unlikely to be able to attend all required follow-up visits, or who live too far from the trial site to do so.
• People with a known allergy to a dye used during surgery called Indocyanine Green (ICG).
• People who have previously had surgery in the area behind the abdominal lining (retroperitoneal surgery).
• People who, in the treating doctor's judgment, require a full surgical removal of lymph nodes in the pelvis or abdomen.
• People who have had another cancer within the past 5 years — except for certain treated skin cancers or a non-invasive breast condition called ductal carcinoma in situ.
• People where the uterus was accidentally punctured during a previous tissue sampling procedure.

Important: Always verify eligibility with the trial site directly before applying.