Phase 3 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have between 5 and 15 spots of cancer that have spread to the brain, as seen on a specific type of brain scan (MRI with contrast dye) taken within the last 30 days.
• People who have a confirmed diagnosis of a solid tumour cancer (not a blood cancer), confirmed by a lab test on tissue or cell samples.
• People whose largest brain tumour spot measures less than 2.5 cm across at its widest point.
• People aged 18 or older.
• People who are able and willing to fill out quality-of-life questionnaires in English or French, either on their own or with help.
• People with a general health/activity level rated as ECOG 0, 1, or 2 — meaning they are fully active, restricted in strenuous activity but able to do light work, or able to care for themselves but unable to work (confirm with trial site).
• People whose kidneys are functioning at a sufficient level, based on a blood test taken within the 28 days before joining the trial.
• People who are able to attend all required treatment sessions and follow-up appointments.
• People of childbearing potential who have agreed to use a highly effective form of contraception during the trial.
• The treating centre must be approved and equipped to deliver the specific types of radiation treatment used in this trial.

Who may not be able to join:

• People who are pregnant or currently breastfeeding.
• People of childbearing potential who are unwilling to use adequate contraception.
• People who are unable to have a brain MRI scan.
• People who have a known allergy to gadolinium (the contrast dye used in MRI scans).
• People who have previously had radiation treatment to the brain.
• People who are planned to receive certain chemotherapy drugs within 48 hours before or after the radiation treatment used in this trial.
• People whose primary cancer is a germ cell tumour, small cell carcinoma, or lymphoma.
• People whose cancer has spread extensively along the lining of the brain or spinal fluid, or who show specific signs of this type of spread (confirm with trial site for details).
• People who have a brain tumour spot located very close (within 5 mm) to the optic chiasm or either optic nerve (the structures involved in vision).
• People who have had surgery to remove a brain tumour (though a biopsy — a small sample taken for testing — is allowed).
• People with more than 15 brain tumour spots on a high-detail MRI, or more than 10 spots on a standard MRI, taken within the past 14 days.
• People who have previously had an allergic reaction to a medication called memantine.
• People who currently have an alcohol or drug dependency problem.
• People who are currently taking certain medications that affect a specific brain receptor, including amantadine, ketamine, or dextromethorphan (confirm with trial site).
• People who have been diagnosed with chronic liver disease or cirrhosis of the liver at a certain level of severity (confirm with trial site).
• People whose brain structure, in the opinion of the treating doctor, makes it too difficult to accurately map a specific part of the brain needed for the treatment planning.

Important: Always verify eligibility with the trial site directly before applying.