Phase 2 Leukaemia Trial, Recruiting NCT03586609 Sponsor: M.D. Anderson Cancer Center Condition: Leukaemia
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Phase 2 Leukaemia Trial, Recruiting

NCT03586609
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with acute myeloid leukemia (a type of blood cancer) that has not yet been treated, though some limited prior treatments are allowed (confirm with trial site).
  • People aged 50 years or older. People under 50 who are not suitable for standard intensive chemotherapy may also be considered after discussion with the lead researcher.
  • People whose liver is working well enough, shown by blood test results within certain limits — unless any abnormal results are thought to be caused by the leukemia itself.
  • People whose kidneys are working well enough, shown by blood test results within certain limits.
  • People who are generally well enough to carry out basic daily activities (assessed using a standard health scale where 0 means fully active and 2 means able to care for oneself but unable to work).
  • Women who could become pregnant must have a negative pregnancy test within one week before joining the trial.
  • People who are able to understand what the trial involves and are willing to sign a consent form before enrolling.

Who may not be able to join:

  • Women who are pregnant, as the treatment used in this trial carries risks of harm to an unborn baby. Women who are breastfeeding are also excluded due to potential risks to the infant.
  • People who have a serious uncontrolled illness, such as an active uncontrolled infection, certain heart conditions, or a mental health or personal situation that would make it difficult to follow the trial requirements.
  • People who have had a known allergic reaction to any of the medicines used in this trial.
  • Men and women who are able to have children and are not willing to use contraception during the trial.
  • People who have previously been treated with a medicine called venetoclax.
  • People whose blood cancer has been specifically identified as acute promyelocytic leukemia (a particular subtype, also called AML-M3).

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 13 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Tapan M Kadia, M.D. Anderson Cancer Center

Phone: 713-563-3534

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
25 October 2018
Est. completion
30 April 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Rate of complete response (CR/complete response with incomplete recovery [CRi])

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov